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7 results on '"Dolovich, Myrna B."'

1. Contributors

Author

Aceves, Seema S., primary, Adcock, Ian M., additional, Adkinson, N. Franklin, additional, Akdis, Cezmi A., additional, Akdis, Mübeccel, additional, Allen, Keith C., additional, Apter, Andrea J., additional, Bachert, Claus, additional, Baines, Katherine J., additional, Ballow, Mark, additional, Barnes, Peter J., additional, Barney, Neal P., additional, Baroody, Fuad M., additional, Behrendt, Heidrun, additional, Bender, Bruce G., additional, Berin, M. Cecilia, additional, Bertics, Paul J., additional, Bieber, Thomas, additional, Bielory, Leonard, additional, Black, Judith, additional, Bochner, Bruce S., additional, Boguniewicz, Mark, additional, Borish, Larry, additional, Boulet, Louis-Philippe, additional, Bousquet, Jean, additional, Boyce, Joshua A., additional, Bradding, Peter, additional, Brightling, Christopher E., additional, Broide, David H., additional, Brown, Simon G.A., additional, Buckley, Rebecca H., additional, Burgess, Janette K., additional, Burks, A. Wesley, additional, Burney, Peter G.J., additional, Bush, Robert K., additional, Busse, William W., additional, Buters, Jeroen, additional, Calus, Lien, additional, Camargo, Carlos A., additional, Canning, Brendan J., additional, Casale, Thomas B., additional, Castro, Mario, additional, Çelik, Gülfem E., additional, Chambers, Christina, additional, Chinen, Javier, additional, Chiriac, Anca Mirela, additional, Christiansen, Sandra C., additional, Chung, Kian Fan, additional, Cockcroft, Donald W., additional, Cohn, Lauren, additional, Cook, Ellen B., additional, Corren, Jonathan, additional, Custovic, Adnan, additional, Demoly, Pascal, additional, Desai, Dhananjay, additional, Devereux, Graham, additional, Diepgen, Thomas, additional, Dolovich, Myrna B., additional, Dorward, David A., additional, Douglass, Jo A., additional, Durham, Stephen R., additional, Durrani, Sandy R., additional, Dykewicz, Mark S., additional, Eccles, Ronald, additional, Edwards, Alan M., additional, Engler, Renata J.M., additional, Esch, Robert E., additional, Fain, Sean B., additional, Falkoff, Reuben, additional, Fenton, Matthew J., additional, Fleisher, Thomas A., additional, Fontana, Joseph R., additional, Frank, Michael M., additional, Frew, Anthony J., additional, Furuta, Glenn T., additional, Garn, Holger, additional, Gavala, Monica L., additional, Gevaert, Philippe, additional, Ghanim, Viviane, additional, Gibson, Peter G., additional, Golden, David B.K., additional, Greenhawt, Matthew J., additional, Grumach, Anete S., additional, Guilbert, Theresa W., additional, Gupta, Sudhir, additional, Halayko, Andrew J., additional, Hallstrand, Teal S., additional, Hamilton, Robert G., additional, Hammad, Hamida, additional, Hansel, Trevor T., additional, Hawrylowicz, Catherine, additional, Hernandez, Michelle L., additional, Hester, C. Garren, additional, Hirota, Jeremy, additional, Holgate, Stephen T., additional, Holloway, John W., additional, Irvin, Charles G., additional, Irwin, Richard S., additional, Israel, Elliot, additional, Jackson, Daniel J., additional, Jeffery, Peter K., additional, Jelinek, Diane F., additional, Johnston, Richard B., additional, Jones, Stacie M., additional, Kelly, H. William, additional, Kelso, John M., additional, Kemp, Stephen F., additional, Kita, Hirohito, additional, Klion, Amy D., additional, Knight, Darryl, additional, Kowalski, Marek L., additional, Koziol-White, Cynthia J., additional, Kumar, Rakesh K., additional, Lack, Gideon, additional, Lambrecht, Bart N., additional, Laube, Beth L., additional, Lehman, Heather K., additional, Lemanske, Robert F., additional, Lemière, Catherine, additional, Leung, Donald Y.M., additional, Lewkowich, Ian P., additional, Li, James T., additional, Li, Xiu-Min, additional, Lieberman, Phillip L., additional, Liu, Andrew H., additional, Lloyd, Clare, additional, Lucas, Christopher D., additional, Luster, Andrew D., additional, Macy, Eric, additional, Madison, J. Mark, additional, Matsui, Elizabeth C., additional, Mellon, Michael H., additional, Metcalfe, Dean D., additional, Mikhak, Zamaneh, additional, Mills, E.N. Clare, additional, Nelson, Harold S., additional, Nicholas, Sarah K., additional, Nixon, Rosemary L., additional, Nowak-We˛grzyn, Anna, additional, O'Byrne, Paul M., additional, Oettgen, Hans C., additional, O'Hehir, Robyn E., additional, Oliver, Brian G., additional, Orange, Jordan S., additional, Ownby, Dennis R., additional, Page, C.P., additional, Panettieri, Reynold A., additional, Park, Hae-Sim, additional, Paul, Mary E., additional, Pavord, Ian D., additional, Pawankar, Ruby, additional, Peden, David B., additional, Peebles, R. Stokes, additional, Peters, Stephen P., additional, Pichler, Werner J., additional, Pittelkow, Mark R., additional, Plager, Douglas A., additional, Platts-Mills, Thomas A.E., additional, Prescott, Susan L., additional, Raby, Benjamin A., additional, Raissy, Hengameh H., additional, Rand, Cynthia S., additional, Ray, Anuradha, additional, Renz, Harald, additional, Richardson, Jonathan P., additional, Ring, Johannes, additional, Robinson, Clive, additional, Rogers, Duncan F., additional, Rosenwasser, Lanny J., additional, Rossi, Adriano G., additional, Rothenberg, Marc E., additional, Rowe, Brian H., additional, Saglani, Sejal, additional, Saini, Sarbjit S., additional, Saito, Hirohisa, additional, Sampson, Hugh A., additional, Sanchez-Borges, Mario, additional, Sandrini, Alessandra, additional, Scadding, Guy W., additional, Schatz, Michael, additional, Schroeder, John T., additional, Sears, Malcolm R., additional, Seroogy, Christine, additional, Shearer, William T., additional, Shelhamer, James H., additional, Sicherer, Scott H., additional, Simons, F. Estelle R., additional, Simpson, Jodie L., additional, Slater, Jay E., additional, Sly, Peter D., additional, Smith, Philip H., additional, Sneller, Michael C., additional, Spina, Domenico, additional, Sriramarao, P., additional, Stahl, James L., additional, Steinke, John W., additional, Stewart, Geoffrey A., additional, Stokes, Jeffrey R., additional, Sullivan, Kathleen E., additional, Taylor, Steve L., additional, Terr, Abba I., additional, Tovey, Euan, additional, Tran, Thai, additional, Undem, Bradley J., additional, Valent, Peter, additional, Vandenplas, Olivier, additional, von Gunten, Stephan, additional, Weber, Richard W., additional, Weller, Peter F., additional, Wenzel, Sally E., additional, Wiepz, Gregory J., additional, Wills-Karp, Marsha, additional, Wood, Robert A., additional, Yel, Leman, additional, Zeiger, Robert S., additional, Zhang, Jihui, additional, and Zuraw, Bruce L., additional

Published
2014
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4. Contributors

Author

Adamko, Darryl J., primary, Franklin Adkinson, N., additional, Akdis, Cezmi A., additional, Amrani, Yassine, additional, Apter, Andrea J., additional, Avila-Tang, Erika, additional, Bachert, Claus, additional, Baines, Katherine J., additional, Ballow, Mark, additional, Bankers-Fulbright, Jennifer L., additional, Barnes, Peter J., additional, Barney, Neal P., additional, Bellehsen, Leah, additional, Bender, Bruce G., additional, Bertics, Paul J., additional, Bleecker, Eugene R., additional, Bochner, Bruce S., additional, Boguniewicz, Mark, additional, Borish, Larry, additional, Boulet, Louis-Philippe, additional, Bousquet, Jean, additional, Boyce, Joshua A., additional, Broide, David H., additional, Buckley, Rebecca H., additional, Wesley Burks, A., additional, Bush, Robert K., additional, Busse, Paula J., additional, Busse, William W., additional, Calhoun, William J., additional, Camargo, Carlos A., additional, Canning, Brendan J., additional, Casale, Thomas B., additional, Elif Çelik, Gülfem, additional, Chambers, Christina D., additional, Chan-Yeung, Moira, additional, Chinen, Javier, additional, Cockcroft, Donald W., additional, Cohn, Lauren, additional, Cook, Ellen B., additional, Corren, Jonathan, additional, Covar, Ronina, additional, Custovic, Adnan, additional, DeCapite, Timothy, additional, Demoly, Pascal, additional, Dixon, Anne E., additional, Dolovich, Myrna B., additional, Durham, Stephen R., additional, Eccles, Ronald, additional, Edwards, Alan M., additional, Esch, Robert E., additional, Fahy, John V., additional, Falkoff, Reuben, additional, Fleisher, Thomas A., additional, Foley, Susan C., additional, Frank, Michael M., additional, Fryer, Allison D., additional, Gaspari, Anthony A., additional, Gevaert, Philippe, additional, Gibson, Peter G., additional, Gober, Michael D., additional, Golden, David B.K., additional, Graziano, Frank M., additional, Guilbert, Theresa, additional, Gupta, Sudhir, additional, Hamid, Qutayba, additional, Hamilton, Robert G., additional, Hammad, Hamida, additional, Garren Hester, C., additional, Holgate, Stephen T., additional, Hsu, Florence Ida, additional, Irvin, Charles G., additional, Israel, Elliot, additional, Jacoby, David B., additional, Jeffery, Peter K., additional, Johnson, Christine Cole, additional, Johnston, Richard B., additional, Kakumanu, Sujani, additional, Kaplan, Allen P., additional, Kavanaugh, Arthur, additional, Kelkar, Pramod, additional, William Kelly, H., additional, Kelso, John M., additional, Kita, Hirohito, additional, Koziol, Cynthia J., additional, Lacy, Paige, additional, Lambrecht, Bart N., additional, Lemanske, Robert F., additional, Leung, Donald Y.M., additional, Levi-Schaffer, Francesca, additional, Lewkowich, Ian P., additional, Li, James T., additional, Lieberman, Phillip L., additional, Liu, Andrew H., additional, Lockey, Richard F., additional, Luster, Andrew D., additional, Macglashan, Donald W., additional, Macy, Eric, additional, Malo, Jean-Luc, additional, Matsui, Elizabeth, additional, McFadden, E.R., additional, Mellon, Michael H., additional, Metcalfe, Dean D., additional, Meyers, Deborah A., additional, Mikhak, Zamaneh, additional, Moqbel, Redwan, additional, Moss, Mark H., additional, Murphy, Hedwig S., additional, Nagler, Arnon, additional, Nelson, Harold S., additional, Niżankowska-Mogilnicka, Ewa, additional, O'Byrne, Paul M., additional, (Wole) Odemuyiwa, Solomon O., additional, Orban, Nara T., additional, Ownby, Dennis R., additional, Panettieri, Reynold A., additional, Paul, Mary E., additional, Peden, David B., additional, Stokes Peebles, R., additional, Pichler, Werner J., additional, Pittelkow, Mark R., additional, Plager, Douglas A., additional, Platts-Mills, Thomas A.E., additional, Proud, David, additional, Raissy, Hengameh Heidarian, additional, Rand, Cynthia S., additional, Ray, Anuradha, additional, Reed, Charles E., additional, Robinson, Clive, additional, Romano, Antonino, additional, Rosenwasser, Lanny J., additional, Rothenberg, Marc E., additional, Rowe, Brian H., additional, Saavedra, Michael C., additional, Sadeghnejad, Alireza, additional, Saleh, Hesham, additional, Samet, Jonathan M., additional, Sampson, Hugh A., additional, Sanak, Marek, additional, Schatz, Michael, additional, Robert Schellenberg, R., additional, Schleimer, Robert P., additional, Schroeder, John T., additional, Seow, Chun Y., additional, Shearer, William T., additional, Shelhamer, James H., additional, Simon, Hans-Uwe, additional, Simons, F Estelle R., additional, Simpson, Jodie L., additional, Slater, Jay E., additional, Smith, Philip H., additional, Sneller, Michael C., additional, Sorkness, Christine A., additional, Spahn, Joseph D., additional, Sriramarao, P., additional, Stahl, James L., additional, Stewart, Geoffrey A., additional, Stokes, Jeffrey R., additional, Sullivan, Kathleen E., additional, Szczeklik, Andrzej, additional, Szefler, Stanley J., additional, Taylor, Stephen L., additional, Terr, Abba I., additional, Thomas, Shibu, additional, Tliba, Omar, additional, Togias, Alkis, additional, Undem, Bradley J., additional, Cauwenberge, Paul van, additional, Varani, James, additional, Vercelli, Donata, additional, Gunten, Stephan Von, additional, Wagenmann, Martin, additional, Wahn, Ulrich, additional, Ward, Peter A., additional, Wechsler, Michael E., additional, Weiler, Catherine R., additional, Weldon, David, additional, Weller, Peter F., additional, Wenzel, Sally E., additional, Wiepz, Gregory J., additional, Wiesch, Denise G., additional, Wills-Karp, Marsha, additional, Wood, Robert A., additional, Yel, Leman, additional, Yunginger, John W., additional, Zasloff, Michael A., additional, Zeiger, Robert S., additional, and Zhang, Jihui, additional

Published
2009
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5. Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects.

Author

Yaghi A, Zaman A, Cox G, and Dolovich MB

Subjects
Adult, Aged, Bronchodilator Agents pharmacology, Case-Control Studies, Cilia drug effects, Cilia physiology, Ciliary Motility Disorders physiopathology, Female, Humans, Male, Middle Aged, Mucociliary Clearance physiology, Nasal Mucosa drug effects, Pulmonary Disease, Chronic Obstructive physiopathology, Respiratory Mechanics physiology, Severity of Illness Index, Specimen Handling methods, Sputum cytology, Ciliary Motility Disorders etiology, Nasal Mucosa physiopathology, Pulmonary Disease, Chronic Obstructive complications
Abstract

Unlabelled: COPD is characterized by increased cough, mucus production, and airway inflammation. Beating epithelial cell cilia contribute to mucociliary clearance with ciliary beat frequency (CBF) an important measure of cilia function. However, whether CBF varies with COPD severity is unknown., Aims: 1) to compare nasal cilia samples and their CBF from healthy non-smokers (Control), COPD and At Risk (cough and sputum production) subjects. 2) to determine the effect of pharmacologic agents that modulate mediators implicated in the pathogenesis of COPD on nasal CBF. Nasal brushings of ciliated cells were obtained from Control, At Risk and COPD subjects. Using high speed digital imaging, we measured baseline CBF ex vivo. Then, CBF was re-measured after 30 min perfusion with pharmacologic agents that modulate mediators implicated in COPD (salmeterol xinafoate, tiotropium bromide, licofelone, luteolin, YM976, Defensin HNP-1) and again after 30 min washout. CBF was significantly depressed in moderate and severe COPD compared to At Risk and Control subjects. There was an evident and persistent rise in CBF with all agents tested in COPD cilia except that YM976 effects persisted only in severe COPD. Only YM976 and tiotropium caused a persistent increase in CBF in At Risk cilia. The reduction of nasal CBF in moderate and severe COPD implies that impaired ciliary function may impact mucociliary clearance in COPD, potentially contributing to retention of secretions and infection. Pharmacologic agents with different mechanisms of action can increase CBF of COPD cilia. Further investigation of the signalling pathways influencing CBF of COPD cilia is needed., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Published
2012
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6. Aerosol drug delivery: developments in device design and clinical use.

Author

Dolovich MB and Dhand R

Subjects
Administration, Inhalation, Cyclosporine administration & dosage, Drug Delivery Systems, Equipment Design, Genetic Therapy methods, Helium administration & dosage, Humans, Iloprost administration & dosage, Immunosuppressive Agents administration & dosage, Oxygen administration & dosage, Particle Size, Respiration, Artificial, Vaccines administration & dosage, Vasodilator Agents administration & dosage, Aerosols administration & dosage, Nebulizers and Vaporizers
Abstract

Aerosolised drugs are prescribed for use in a range of inhaler devices and systems. Delivering drugs by inhalation requires a formulation that can be successfully aerosolised and a delivery system that produces a useful aerosol of the drug; the particles or droplets need to be of sufficient size and mass to be carried to the distal lung or deposited on proximal airways to give rise to a therapeutic effect. Patients and caregivers must use and maintain these aerosol drug delivery devices correctly. In recent years, several technical innovations have led to aerosol drug delivery devices with efficient drug delivery and with novel features that take into account factors such as dose tracking, portability, materials of manufacture, breath actuation, the interface with the patient, combination therapies, and systemic delivery. These changes have improved performance in all four categories of devices: metered dose inhalers, spacers and holding chambers, dry powder inhalers, and nebulisers. Additionally, several therapies usually given by injection are now prescribed as aerosols for use in a range of drug delivery devices. In this Review, we discuss recent developments in the design and clinical use of aerosol devices over the past 10-15 years with an emphasis on the treatment of respiratory disorders., (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Published
2011
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7. Device selection and outcomes of aerosol therapy: Evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology.

Author

Dolovich MB, Ahrens RC, Hess DR, Anderson P, Dhand R, Rau JL, Smaldone GC, and Guyatt G

Subjects
Adrenergic beta-Agonists administration & dosage, Anti-Asthmatic Agents administration & dosage, Cholinergic Antagonists administration & dosage, Equipment Design, Evidence-Based Medicine, Glucocorticoids administration & dosage, Humans, Inhalation Spacers, Metered Dose Inhalers, Practice Guidelines as Topic, Pulmonary Disease, Chronic Obstructive drug therapy, Randomized Controlled Trials as Topic, Nebulizers and Vaporizers standards
Abstract

Background: The proliferation of inhaler devices has resulted in a confusing number of choices for clinicians who are selecting a delivery device for aerosol therapy. There are advantages and disadvantages associated with each device category. Evidence-based guidelines for the selection of the appropriate aerosol delivery device in specific clinical settings are needed., Aim: (1) To compare the efficacy and adverse effects of treatment using nebulizers vs pressurized metered-dose inhalers (MDIs) with or without a spacer/holding chamber vs dry powder inhalers (DPIs) as delivery systems for beta-agonists, anticholinergic agents, and corticosteroids for several commonly encountered clinical settings and patient populations, and (2) to provide recommendations to clinicians to aid them in selecting a particular aerosol delivery device for their patients., Methods: A systematic review of pertinent randomized, controlled clinical trials (RCTs) was undertaken using MEDLINE, EmBase, and the Cochrane Library databases. A broad search strategy was chosen, combining terms related to aerosol devices or drugs with the diseases of interest in various patient groups and clinical settings. Only RCTs in which the same drug was administered with different devices were included. RCTs (394 trials) assessing inhaled corticosteroid, beta2-agonist, and anticholinergic agents delivered by an MDI, an MDI with a spacer/holding chamber, a nebulizer, or a DPI were identified for the years 1982 to 2001. A total of 254 outcomes were tabulated. Of the 131 studies that met the eligibility criteria, only 59 (primarily those that tested beta2-agonists) proved to have useable data., Results: None of the pooled metaanalyses showed a significant difference between devices in any efficacy outcome in any patient group for each of the clinical settings that was investigated. The adverse effects that were reported were minimal and were related to the increased drug dose that was delivered. Each of the delivery devices provided similar outcomes in patients using the correct technique for inhalation., Conclusions: Devices used for the delivery of bronchodilators and steroids can be equally efficacious. When selecting an aerosol delivery device for patients with asthma and COPD, the following should be considered: device/drug availability; clinical setting; patient age and the ability to use the selected device correctly; device use with multiple medications; cost and reimbursement; drug administration time; convenience in both outpatient and inpatient settings; and physician and patient preference.

Published
2005
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