14 results on '"Durgun, M."'
Search Results
2. List of contributors
- Author
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Abo Dena, Ahmed S., primary, Abourehab, Mohammed A.S., additional, Abuwatfa, Waad H., additional, Agwa, Mona M., additional, Alexander, Amit, additional, Alghamdi, Maha Ali, additional, Alhamoud, Marah, additional, Ali, M. Azam, additional, AlSawaftah, Nour M., additional, Alsobyan, Faris Mohammed, additional, Aman, Waqar, additional, Amin, Mohd Cairul Iqbal Mohd, additional, Amjad, Muhammad Wahab, additional, Arafa, Kholoud K., additional, Ashi, Layal, additional, Bahman, Fatemah, additional, Bobde, Yamini, additional, Borchard, Gerrit, additional, Butt, Adeel Masood, additional, Dandela, Rambabu, additional, Deng, Xiaoxuan, additional, Dubey, Sunil Kumar, additional, Durgun, M. Ezgi, additional, El-Sherbiny, Ibrahim M., additional, Eslam, M.S., additional, Fang, Jun, additional, Farooq, Umer, additional, Fatima, Mahak, additional, Ghosh, Balaram, additional, Gould, Maree, additional, Gould, Maree L., additional, Greish, Khaled, additional, Güngör, Sevgi, additional, Haidar, Ziyad S., additional, Hazekawa, Mai, additional, Husseini, Ghaleb A., additional, Ishibashi, Daisuke, additional, Islam, Rayhanul, additional, Jain, Supriya, additional, Jasim, Anfal, additional, Johnson, Renjith P., additional, Kahraman, Emine, additional, Kanazawa, Takanori, additional, Kar, Ananya, additional, Kenguva, Gowtham, additional, Kesharwani, Prashant, additional, Khan, Arooj, additional, Khan, Rahima, additional, Kondapaneni, Likhitha Purna, additional, Mahmud, Amna Albu, additional, Marquet, Franck, additional, Mohamad, Najwa, additional, Nishinakagawa, Takuya, additional, Özsoy, Yıldız, additional, Pandey, Manisha, additional, Parayath, Neha N., additional, Pérez, Sebastián E., additional, Raja, Maria Abdul Ghafoor, additional, Raslan, Mohamed, additional, Rout, Smruti Rekha, additional, Sabra, Sally A., additional, Sabri, Nagwa A., additional, Sahebkar, Amirhossein, additional, Sara, A.R., additional, Singh, Vanshikha, additional, Talat, Maria, additional, Chen, Xiang Yi, additional, and Zaman, Muhammad, additional
- Published
- 2022
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3. Polymeric micelles as a novel carrier for ocular drug delivery
- Author
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Özsoy, Yıldız, primary, Güngör, Sevgi, additional, Kahraman, Emine, additional, and Durgun, M. Ezgi, additional
- Published
- 2019
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4. List of Contributors
- Author
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Aceves-Serrano, Lucero G., primary, Arul, K. Thanigai, additional, Bhatti, Gurjit Kaur, additional, Bhatti, Jasvinder Singh, additional, Binkhathlan, Ziyad, additional, Bozkır, Asuman, additional, Charoo, Naseem Ahmad, additional, Chircov, Cristina, additional, Das, Ishwar, additional, Dhananjayan, Venugopal, additional, Durgun, M. Ezgi, additional, Farnia, Poopak, additional, Ficai, Anton, additional, Ghanavi, Jalaledin, additional, Gherasim, Oana, additional, Grumezescu, Alexandru Mihai, additional, Grumezescu, Valentina, additional, Güngör, Sevgi, additional, Hwang, Hyundoo, additional, Jampílek, Josef, additional, Kahraman, Emine, additional, Kailasa, Suresh Kumar, additional, Karaca, Melek, additional, Kaur, Sukhjinder, additional, Khan, Mansoor A., additional, Khoee, Sepideh, additional, Koduru, Janardhan Reddy, additional, Kráľová, Katarína, additional, Küçüktürkmen, Berrin, additional, Ladchumananandasivam, Rasiah, additional, Lavasanifar, Afsaneh, additional, Manikandan, E., additional, Newton, Amaldoss M J, additional, Ordaz-Martinez, Karen A., additional, Özsoy, Yıldız, additional, Pandey, Sharad P., additional, Pandey, V.N., additional, Pandey, V.S., additional, Panjakumar, Karunamoorthy, additional, Park, Tae-Jung, additional, Rahimi, Shahnaz, additional, Rahman, Ziyaur, additional, Rao, Anita, additional, Ravichandran, Beerappa, additional, Sen, Somnath, additional, Shukla, Tripti, additional, Singh, Bhupinder, additional, Socol, Gabriel, additional, Sudheesh, M.S., additional, Tiwari, Neha, additional, Upmanyu, Neeraj, additional, Vazquez-Piñon, Matias, additional, Velayati, Ali Akbar, additional, and Vijayvergiya, Rajesh, additional
- Published
- 2019
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5. Intracellular pH-mediated induction of apoptosis in HeLa cells by a sulfonamide carbonic anhydrase inhibitor.
- Author
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Koyuncu I, Temiz E, Durgun M, Kocyigit A, Yuksekdag O, and Supuran CT
- Subjects
- Cell Line, Tumor, HeLa Cells, Humans, Hydrogen-Ion Concentration, Sulfonamides chemistry, Sulfonamides pharmacology, Apoptosis, Carbonic Anhydrase Inhibitors chemistry, Carbonic Anhydrase Inhibitors pharmacology
- Abstract
Carbonic anhydrase IX (CAIX) is a hypoxia-associated transmembrane protein that is critical in the survival of cells. Because CAIX has a key role in pH regulation, its therapeutic effects have been heavily studied by different research laboratories. This study aims to investigate how a synthetic CAIX inhibitor triggers apoptosis in a cancer cell line, HeLa. In this regard, we investigated the effects of the compound I, synthesized as a CAIX inhibitor, on the survival of cancer cells. The compound I inhibited the proliferation of the CAIX+ HeLa cells, kept the cells in G0/G1 phase (74.7%) and altered the cells morphologies (AO/EtBr staining) and the nuclear structure (γ-H2AX staining). CAIX inhibition triggered apoptosis in HeLa cells with a rate of 47.4%. According to the expression of mediator genes (CASP-3, -8, -9, BAX, BCL-2, BECLIN, LC3), the both death pathways were activated in HeLa cells with the inhibition of CAIX with the compound I. The compound I was also determined to affect the genes and proteins that have a critical role in the regulation of apoptotic pathways (pro casp-3, cleaved casp-3, -8, -9, cleaved PARP and CAIX). Furthermore, CAIX inhibition caused changes in pH balance, disruption in organelle integrity of mitochondria, and increase intracellular reactive oxygen level of HeLa cells. Taken together, our findings suggest that CAIX inhibition has a potential in cancer treatment, and the compound I, a CAIX inhibitor, could be a promising therapeutic strategy in the treatment of aggressive tumours., (Copyright © 2022 Elsevier B.V. All rights reserved.)
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- 2022
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6. Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase.
- Author
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Yapar G, Esra Duran H, Lolak N, Akocak S, Türkeş C, Durgun M, Işık M, and Beydemir Ş
- Subjects
- Aldehyde Reductase metabolism, Benzaldehydes chemistry, Dose-Response Relationship, Drug, Enzyme Inhibitors chemical synthesis, Enzyme Inhibitors chemistry, Humans, Hydrazones chemical synthesis, Hydrazones chemistry, Molecular Docking Simulation, Molecular Structure, Structure-Activity Relationship, Aldehyde Reductase antagonists & inhibitors, Benzaldehydes pharmacology, Enzyme Inhibitors pharmacology, Hydrazones pharmacology
- Abstract
Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to prevent diabetic complications. In the present study, the novel bis-hydrazone compounds bearing isovanillin moiety (GY1-12) were synthesized, and various chromatographic methods were applied to purify the ALR2 enzyme. Afterward, the inhibitory effect of the synthesized compounds on the ALR2 was screened in vitro. All the novel bis-hydrazones demonstrated activity in nanomolar levels as AR inhibitors with IC
50 and KI values in the range of 12.55-35.04 nM, and 13.38-88.21 nM, respectively. Compounds GY-11, GY-7, and GY-5 against ALR2 were identified as the highly potent inhibitors, respectively, and were superior to the standard drug, epalrestat. Moreover, a comprehensive ligand-receptor interactions prediction was performed using ADME-Tox, Glide XP, and MM-GBSA modules of Schrödinger Small-Molecule Drug Discovery Suite to elucidate the novel bis-hydrazone derivatives, potential binding modes versus the ALR2. As a result, these compounds with ALR2 inhibitory effects may be potential alternative agents that can be used to treat or prevent diabetic complications., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2021
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7. Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs.
- Author
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Lolak N, Akocak S, Türkeş C, Taslimi P, Işık M, Beydemir Ş, Gülçin İ, and Durgun M
- Subjects
- Acetylcholinesterase metabolism, Carbonic Anhydrase I antagonists & inhibitors, Carbonic Anhydrase I metabolism, Carbonic Anhydrase II antagonists & inhibitors, Carbonic Anhydrase II metabolism, Carbonic Anhydrase Inhibitors chemical synthesis, Carbonic Anhydrase Inhibitors chemistry, Cholinesterase Inhibitors chemical synthesis, Cholinesterase Inhibitors chemistry, Glycoside Hydrolase Inhibitors chemical synthesis, Glycoside Hydrolase Inhibitors chemistry, Humans, Molecular Docking Simulation, Structure-Activity Relationship, Sulfonamides chemical synthesis, Sulfonamides chemistry, Triazines chemical synthesis, Triazines chemistry, alpha-Glucosidases metabolism, Benzenesulfonamides, Carbonic Anhydrase Inhibitors pharmacology, Cholinesterase Inhibitors pharmacology, Glycoside Hydrolase Inhibitors pharmacology, Sulfonamides pharmacology, Triazines pharmacology
- Abstract
Some metabolic enzyme inhibitors can be used in the treatment of many diseases. Therefore, synthesis and determination of alternative inhibitors are essential. In this study, the inhibition effect of newly synthesized compounds on carbonic anhydrase (cytosolic isoforms, hCA I and hCA II), α-glycosidase (α-GLY), and acetylcholinesterase (AChE) were investigated. The possible binding mechanism of the compounds with a high inhibitory effect on the active site of the enzyme was demonstrated by molecular docking method. We investigated the inhibition effects of novel synthesized compounds (MZ1-MZ11) on metabolic enzymes such as α-GLY, AChE, and hCA I and II. The compound MZ6 for AChE, MZ8 for CA I and CA II and MZ7 for α-GLY showed a very active inhibition profile (K
I s 51.67 ± 4.76 for hCA I, 40.35 ± 5.74 nM for hCA II, 41.74 ± 8.08 nM for α-GLY and 335.76 ± 46.91 nM for AChE). The novel synthesized compounds (MZ1-MZ11) have a higher enzyme (α-GLY, AChE, hCA I, and II) inhibitory potential than ACR, TAC, and AZA, respectively. The compounds may have the potential to be used as alternative medicines after further research in the treatment of many diseases such as diabetes, Alzheimer's disease, heart failure, ulcer, and epilepsy., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Inc. All rights reserved.)- Published
- 2020
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8. Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies.
- Author
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Işık M, Beydemir Ş, Demir Y, Durgun M, Türkeş C, Nasır A, Necip A, and Akkuş M
- Subjects
- Aryldialkylphosphatase isolation & purification, Aryldialkylphosphatase metabolism, Humans, Inhibitory Concentration 50, Models, Molecular, Paraoxon chemistry, Paraoxon toxicity, Structure-Activity Relationship, Sulfonamides chemistry, Benzenesulfonamides, Amines chemistry, Aryldialkylphosphatase antagonists & inhibitors, Enzyme Inhibitors pharmacology, Imines chemistry, Molecular Docking Simulation, Sulfonamides pharmacology
- Abstract
Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory activities of benzenesulfonamide derivatives on human paraoxonase-I (hPON1). For this aim, PON1 was purified from human serum with a specific activity of 2603.57 EU/mg and 8.34% yield using simple chromatographic methods. The various concentrations of early-synthesized sixteen sulfonamide derivatives were tested on the paraoxonase activity. K
i values of compounds were found in the range of 0.28-357.70 µM. Compound H4 had the highest inhibitory activity on hPON1 as competitive. Estimated structure-activity relationship (SAR) for compounds was done based on different substituents and their positions in the compounds. Besides, the molecular docking analysis of compound H4 was performed to understand the binding interactions on the active site of the enzyme. According to these experimental results, compound H4 was a potential inhibitor of PON1., (Copyright © 2019 Elsevier B.V. All rights reserved.)- Published
- 2020
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9. Synthesis, characterization, in vitro cytotoxicity and antimicrobial investigation and evaluation of physicochemical properties of novel 4-(2-methylacetamide)benzenesulfonamide derivatives.
- Author
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Durgun M, Turkmen H, Zengin G, Zengin H, Koyunsever M, and Koyuncu I
- Subjects
- Acetamides chemical synthesis, Acetamides chemistry, Acetamides pharmacology, Anti-Infective Agents chemical synthesis, Antineoplastic Agents chemical synthesis, Bacteria drug effects, Bacterial Infections drug therapy, Cell Line, Tumor, Drug Screening Assays, Antitumor, Fungi drug effects, Humans, Microbial Sensitivity Tests, Mycoses drug therapy, Neoplasms drug therapy, Sulfonamides chemical synthesis, Benzenesulfonamides, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Sulfonamides chemistry, Sulfonamides pharmacology
- Abstract
In this study, several sulfonamide derivatives, 4-(2-methylacetylamino)benzenesulfonamides were synthesized. Chemical structures of the derivatives were characterized by
1 H NMR,13 C NMR, LC-MS-MS, UV-Vis, FTIR, photoluminescence and elemental analysis. Sulfanilamide was reacted with 2-bromopropionyl bromide, in the presence of pyridine, to form bromo-substituted sulfonamide key intermediates, which were subsequently treated with secondary amines to obtain novel sulfonamide derivatives. All the synthesized compounds were evaluated for in vitro antimicrobial activities and cytotoxicity. Increases in ring size, and rings bearing a nitrogen heteroatom led to improvements in antimicrobial activities. As the presence of CA IX and CA XII enzymes have been implicated in some cancerous tumors, the studies presented herein focuses on targeting these enzymes. It was found that the synthesized derivatives had in vitro anti-cancer properties, where compounds (3-6) were found to be active against all cancerous cells, and no cytotoxic effects on normal cells were observed., (Copyright © 2016 Elsevier Inc. All rights reserved.)- Published
- 2017
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10. Synthesis, spectroscopic and catalytic properties of some new boron hybrid molecule derivatives by BF2 and BPh2 chelation.
- Author
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Kilic A, Alcay F, Aydemir M, Durgun M, Keles A, and Baysal A
- Subjects
- Benzene Derivatives chemical synthesis, Boron Compounds chemical synthesis, Catalysis, Chelating Agents chemical synthesis, Fluorescence, Fluorine Compounds chemical synthesis, Halogenation, Hydrogenation, Magnetic Resonance Spectroscopy, Mass Spectrometry, Organometallic Compounds chemical synthesis, Organometallic Compounds chemistry, Schiff Bases chemical synthesis, Spectrophotometry, Ultraviolet, Spectroscopy, Fourier Transform Infrared, Benzene Derivatives chemistry, Boron Compounds chemistry, Chelating Agents chemistry, Fluorine Compounds chemistry, Schiff Bases chemistry
- Abstract
A new series of Schiff base ligands (L1-L3) and their corresponding fluorine/phenyl boron hybrid complexes [LnBF2] and [LnBPh2] (n=1, 2 or 3) have been synthesized and well characterized by both analytical and spectroscopic methods. The Schiff base ligands and their corresponding fluorine/phenyl boron hybrid complexes have been characterized by NMR ((1)H, (13)C and (19)F), FT-IR, UV-Vis, LC-MS, and fluorescence spectroscopy as well as melting point and elemental analysis. The fluorescence efficiencies of phenyl chelate complexes are greatly red-shifted compared to those of the fluorine chelate analogs based on the same ligands, presumably due to the large steric hindrance and hard π→π(∗) transition of the diphenyl boron chelation, which can effectively prevent molecular aggregation. The boron hybrid complexes were applied to the transfer hydrogenation of acetophenone derivatives to 1-phenylethanol derivatives in the presence of 2-propanol as the hydrogen source. The catalytic studies showed that boron hybrid complexes are good catalytic precursors for transfer hydrogenation of aromatic ketones in 0.1M iso-PrOH solution. Also, we have found that both steric and electronic factors have a significant impact on the catalytic properties of this class of molecules., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2015
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11. Reconstruction of vaginal agenesis with pudendal thigh flaps thinned with liposuction.
- Author
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Selçuk CT, Evsen MS, Ozalp B, and Durgun M
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- 46, XX Disorders of Sex Development diagnosis, 46, XX Disorders of Sex Development surgery, Cohort Studies, Congenital Abnormalities diagnosis, Congenital Abnormalities surgery, Female, Graft Rejection, Graft Survival, Humans, Lipectomy methods, Mullerian Ducts abnormalities, Mullerian Ducts surgery, Recovery of Function, Retrospective Studies, Risk Assessment, Urogenital Abnormalities diagnosis, Wound Healing physiology, Young Adult, Plastic Surgery Procedures methods, Surgical Flaps blood supply, Urogenital Abnormalities surgery, Vagina abnormalities, Vagina surgery
- Abstract
Aim: The aim of this study is to describe a technique for and data from vaginoplasty surgeries performed using a pudendal thigh flap (PTF) thinned with liposuction., Method: A total of six patients diagnosed with Müllerian agenesis underwent vaginoplasty procedures using this technique between January 2009 and April 2012. The age range of the patients was 19-24 years. In the first stage, the subcutaneous fat tissue under the planned skin flap islands was thinned with liposuction. After 3 months, the second stage of the procedure was carried out and the PTFs were elevated., Results: Complications such as infection, dehiscence of the suture line and haematoma were not observed in any of the patients. Although a partial flap loss was observed at the distal aspect of a flap in one patient, total healing was achieved through debridement and local wound care. Mean tissue flap thickness was found to be thinner, and adequate vaginal depth was achieved in all patients on average 13 months following surgery., Conclusion: We are of the opinion that PTFs thinned with liposuction enable both a thinner tissue flap and a vaginal reconstruction that more closely resembles natural anatomy., (Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2013
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12. The coupling of carbon dioxide and epoxides by phenanthroline derivatives containing different Cu(II) complexes as catalyst.
- Author
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Kilic A, Palali AA, Durgun M, Tasci Z, and Ulusoy M
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- Catalysis, Coordination Complexes chemistry, Ligands, Phenanthrolines chemistry, Pressure, Styrene chemistry, Temperature, Time Factors, Carbon Dioxide chemistry, Coordination Complexes chemical synthesis, Copper chemistry, Epoxy Compounds chemistry, Phenanthrolines chemical synthesis
- Abstract
A series of the mononuclear Cu(II) metal complexes containing the ligand Bdppz [(9a,13a-dihydro-4,5,9,14-tetraaza-benzo[b]triphenylene-11-yl)-phenyl-methanone] (L1) and Aqphen [(12,17-dihydronaphthol[2,3-h]dipyrido[3,2-a:2',3'-c]-phenazine-12,17-dione)] (L2) were synthesized and used as catalyst for the coupling of carbon dioxide (CO2) and liquid epoxide which served as both reactant and solvent. Dimethylamino pyridine (DMAP) was used as co-catalyst. The yields of epoxides to corresponding cyclic carbonates were determined by comparing the ratio of product to substrate in the (1)H NMR spectrum of an aliquot of the reaction mixture. The mononuclear Cu(II) complexes of these ligands were synthesized by treating an ethanol solvent of the appropriate ligand with a different molar amount of CuCl2·2H2O. The Cu(II) complexes were characterized by FT-IR, UV-Vis, elemental analysis, melting point analysis, mass spectra, molar conductivity measurements and magnetic susceptibility techniques. The reaction of the Bdppz and Aqphen ligands in a 1:1, 1:2 or 1:3 mole ratio with CuCl2·2H2O afforded ionic Cu(II) complexes in the presence of Et3N., (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Published
- 2013
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13. Comparison of the antibacterial effect of silver sulfadiazine 1%, mupirocin 2%, Acticoat and octenidine dihydrochloride in a full-thickness rat burn model contaminated with multi drug resistant Acinetobacter baumannii.
- Author
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Selçuk CT, Durgun M, Ozalp B, Tekin A, Tekin R, Akçay C, and Alabalık U
- Subjects
- Administration, Topical, Animals, Burns drug therapy, Burns pathology, Disease Models, Animal, Imines, Mupirocin pharmacology, Muscles microbiology, Polyesters pharmacology, Polyethylenes pharmacology, Pyridines pharmacology, Random Allocation, Rats, Rats, Sprague-Dawley, Silver Sulfadiazine pharmacology, Skin microbiology, Acinetobacter Infections drug therapy, Acinetobacter baumannii drug effects, Anti-Infective Agents pharmacology, Burns microbiology, Drug Resistance, Multiple, Bacterial drug effects
- Abstract
In this study, our aim is to compare the efficacy of different topical antibacterial agents in a rat model contaminated with a multi drug resistant (MDR) standard Acinetobacter baumannii strain. The study was carried out on 40 Sprague-Dawley rats of 250-300 g each. For the purposes of this study, the rats were divided into 5 groups, with 8 rats in each group: Group 1 control; Group 2 silver sulfadiazine; Group 3 mupirocin; Group 4 Acticoat group; and Group 5 octenidine dihydrochloride group. Following to the formation of the full-thickness burn areas in rats, the MDR A. baumannii standard strain was inoculated into the burned area. The rats in all the groups were sacrificed at the end of the 10th day and subjected to histopathological and microbiological evaluation. In the histopathological evaluation, the lowest inflammatory cell response and bacterial density in the eschar and muscle tissues were observed in the Acticoat group. While these results were found to be statistically significant compared to the silver sulfadiazine group, only the bacterial density in the muscle tissue was found as significant in comparison to the mupirocin and octenidine groups. In the microbiological evaluation, the lowest growth in the muscle tissue culture among all the groups was observed in the Acticoat group. The growth in the eschar tissue culture was significantly lower in the Acticoat and octenidine groups in comparison to the silver sulfadiazine group. At the end of the study, it has been observed that Acticoat was effective both in eschar and muscle, while octenidine was effective in eschar tissues in a rat burn model contaminated with MDR A. baumannii., (Copyright © 2012 Elsevier Ltd and ISBI. All rights reserved.)
- Published
- 2012
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14. Cu(II), Co(II), Ni(II), Mn(II), and Fe(II) metal complexes containing N,N'-(3,4-diaminobenzophenon)-3,5-Bu(t)(2)-salicylaldimine ligand: Synthesis, structural characterization, thermal properties, electrochemistry, and spectroelectrochemistry.
- Author
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Tas E, Kilic A, Durgun M, Küpecik L, Yilmaz I, and Arslan S
- Subjects
- Aldehydes chemistry, Coordination Complexes, Electrochemistry, Ligands, Magnetic Resonance Spectroscopy, Schiff Bases, Spectrophotometry, Infrared, Spectroscopy, Fourier Transform Infrared, Benzophenones chemistry, Cobalt chemistry, Copper chemistry, Ferrous Compounds chemistry, Manganese chemistry, Nickel chemistry, Organometallic Compounds chemical synthesis, Organometallic Compounds chemistry, Salicylates chemistry
- Abstract
The synthesis, structure, spectroscopic and electro-spectrochemical properties of steric hindered Schiff-base ligand [N,N'-(3,4-benzophenon)-3,5-Bu(t)(2)-salicylaldimine (LH(2))] and its mononuclear Cu(II), Co(II), Ni(II), Mn(II) and Fe(II) complexes are described in this work. The new dissymmetric steric hindered Schiff-base ligand containing a donor set of NONO was prepared through reaction of 3,4-diaminobenzophenon with 3,5-Bu(t)(2)-salicylaldehyde. Certain metal complexes of this ligand were synthesized by treating an ethanolic solution of the ligand with an equimolar amount of metal salts. The ligand and its complexes were characterized by FT-IR, UV-vis, (1)H NMR, elemental analysis, molar conductivity and thermal analysis methods in addition to magnetic susceptibility, electrochemistry and spectroelectrochemistry techniques. The tetradentate and mononuclear metal complexes were obtained by reacting N,N'-(3,4-benzophenon)-3,5-Bu(t)(2)-salicylaldimine (LH(2)) with some metal acetate in a 1:1 mole ratio. The molar conductance data suggest metal complexes to be non-electrolytes., (Copyright (c) 2009 Elsevier B.V. All rights reserved.)
- Published
- 2010
- Full Text
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