1. Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Malignant and Benign Biliary Obstructions.
- Author
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Abdel-Razik A, ElMahdy Y, Hanafy EE, Elhelaly R, Elzehery R, M Tawfik A, and Eldars W
- Subjects
- Adult, Aged, Bile Duct Neoplasms blood, Bile Duct Neoplasms diagnosis, Biomarkers blood, Biomarkers metabolism, Biomarkers, Tumor blood, Cholangiocarcinoma blood, Cholangiocarcinoma diagnosis, Cholestasis blood, Cholestasis diagnosis, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Vascular Endothelial Growth Factor A blood, Bile Duct Neoplasms metabolism, Biomarkers, Tumor metabolism, Cholangiocarcinoma metabolism, Cholestasis metabolism, Insulin-Like Growth Factor I metabolism, Vascular Endothelial Growth Factor A metabolism
- Abstract
Background: Despite the presence of various diagnostic tools, the differential diagnosis between malignant and benign biliary obstructions is so difficult. This study aimed to evaluate the role of serum and biliary insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in this differential diagnosis., Materials and Methods: Patients (n = 109, 61 men and 48 women) with diagnosis of benign (n = 62) or malignant (n = 47) biliary obstruction were included. Serum and biliary IGF-1 and VEGF markers were analyzed by the chemiluminescent immunometric method., Results: Mean age was 62.7 ± 8.1 years for the malignant group and 58.5 ± 15.4 years for the benign group (P = 0.092). Choledocholithiasis (79%), cancer head of the pancreas (53.2%) and cholangiocarcinoma (38.3%) were the most common etiologies. No statistical difference was detected regarding serum IGF-1 and VEGF levels between 2 groups. At a cutoff value of 308.55 and 0.5ng/mL, biliary IGF-1 and VEGF had (91.4% and 90.3%) sensitivity and (89.5% and 84.9%) specificity differential diagnosis between malignant and benign biliary obstructions (area under the curve: 0.943, 0.915), respectively., Conclusions: Biliary levels of IGF-1 and VEGF significantly increase in malignant than benign obstructive lesions. Measurement of these markers in the bile of these patients may aid in the detection of biliary tumors., (Copyright © 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
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