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Your search keyword '"Emma M. Coomans"' showing total 2 results
Start Over Author "Emma M. Coomans" Publisher elsevier
2 results on '"Emma M. Coomans"'

1. Tau PET and relative cerebral blood flow in dementia with Lewy bodies: A PET study

Author

Frederik Barkhof, Albert D. Windhorst, Emma M. Coomans, Afina W. Lemstra, Sander C.J. Verfaillie, Ph. Scheltens, Ronald Boellaard, W.M. van der Flier, Sandeep S.V. Golla, Hayel Tuncel, Tessa Timmers, Emma E. Wolters, B.N.M. van Berckel, M. van de Beek, Denise Visser, Rik Ossenkoppele, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration, Neurology, APH - Personalized Medicine, and APH - Methodology

Subjects
Lewy Body Disease, medicine.medical_specialty, Neurology, Cognitive Neuroscience, Relative cerebral blood flow, Dementia with Lewy bodies, tau Proteins, lcsh:Computer applications to medicine. Medical informatics, behavioral disciplines and activities, 050105 experimental psychology, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Cognition, Alzheimer Disease, Internal medicine, mental disorders, medicine, Memory span, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Cognitive Dysfunction, lcsh:Neurology. Diseases of the nervous system, business.industry, 05 social sciences, Parietal lobe, Neuropsychology, Binding potential, Regular Article, medicine.disease, nervous system diseases, Cerebral blood flow, nervous system, Cerebrovascular Circulation, Positron-Emission Tomography, Cardiology, FDG PET, lcsh:R858-859.7, Neurology (clinical), Tau, business, 030217 neurology & neurosurgery, circulatory and respiratory physiology
Abstract

Highlights • The amount of tau binding in DLB was minimal and did not differ from controls. • Relative cerebral blood flow (rCBF), but not tau PET, was related to cognitive impairment. • rCBF is more strongly related to clinical characteristics in DLB than tau PET., Purpose Alpha-synuclein often co-occurs with Alzheimer’s disease (AD) pathology in Dementia with Lewy Bodies (DLB). From a dynamic [18F]flortaucipir PET scan we derived measures of both tau binding and relative cerebral blood flow (rCBF). We tested whether regional tau binding or rCBF differed between DLB patients and AD patients and controls and examined their association with clinical characteristics of DLB. Methods Eighteen patients with probable DLB, 65 AD patients and 50 controls underwent a dynamic 130-minute [18F]flortaucipir PET scan. DLB patients with positive biomarkers for AD based on cerebrospinal fluid or amyloid PET were considered as DLB with AD pathology (DLB-AD+). Receptor parametric mapping (cerebellar gray matter reference region) was used to extract regional binding potential (BPND) and R1, reflecting (AD-specific) tau pathology and rCBF, respectively. First, we performed regional comparisons of [18F]flortaucipir BPND and R1 between diagnostic groups. In DLB patients only, we performed regression analyses between regional [18F]flortaucipir BPND, R1 and performance on ten neuropsychological tests. Results Regional [18F]flortaucipir BPND in DLB was comparable with tau binding in controls (p > 0.05). Subtle higher tau binding was observed in DLB-AD+ compared to DLB-AD- in the medial temporal and parietal lobe (both p

Published
2020
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2. Hippocampal [18F]flortaucipir BPND corrected for possible spill-in of the choroid plexus retains strong clinico-pathological relationships

Author

Emma E Wolters, Rik Ossenkoppele, Sandeep SV Golla, Sander CJ Verfaillie, Tessa Timmers, Denise Visser, Hayel Tuncel, Emma M Coomans, Albert D Windhorst, Philip Scheltens, Wiesje M van der Flier, Ronald Boellaard, and Bart NM van Berckel

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
Abstract

Background: Off-target [18F]flortaucipir (tau) PET binding in the choroid plexus causes spill-in into the nearby hippocampus, which may influence the correlation between [18F]flortaucipir binding and measures of cognition. Previously, we showed that partial volume correction (combination of Van Cittert iterative deconvolution and HYPR denoising; PVC HDH) and manually eroding the hippocampus resulted in a significant decrease of the choroid plexus spill-in. In this study, we compared three different approaches for the quantification of hippocampal [18F]flortaucipir signal using a semi-automated technique, and assessed correlations with cognitive performance across methods. Methods: Dynamic 130 min [18F]flortaucipir PET scans were performed in 109 subjects (45 cognitively normal subjects (CN) and 64 mild cognitive impairment/Alzheimer's disease (AD) dementia patients. We extracted hippocampal binding potential (BPND) using receptor parametric mapping with cerebellar grey matter as reference region. PVC HDH was performed. Based on our previous study in which we manually eroded 40% ± 10% of voxels of the hippocampus, three hippocampal volumes-of-interest (VOIs) were generated: a non-optimized 100% hippocampal VOI [100%], and combining HDH with eroding a percentage of the highest hippocampus BPND voxels (i.e. lowering spill-in) resulting in optimized 50%[50%HDH] and 40%[40%HDH] hippocampal VOIs. Cognitive performance was assessed with the Mini-Mental State Examination (MMSE) and Rey auditory verbal learning delayed recall. We performed receiver operating characteristic analyses to investigate which method could best discriminate MCI/AD from controls. Subsequently, we performed linear regressions to investigate associations between the hippocampal [18F]flortaucipir BPND VOIs and MMSE/delayed recall adjusted for age, sex and education. Results: We found higher hippocampal [18F]flortaucipir BPND in MCI/AD patients (BPND100%=0.27±0.15) compared to CN (BPND100%= 0.07±0.13) and all methods showed comparable discriminative effects (AUC100%=0.85[CI=0.78–0.93]; AUC50%HDH=0.84[CI=0.74–0.92]; AUC40%HDH=0.83[CI=0.74–0.92]). Across groups, higher [18F]flortaucipir BPND was related to lower scores on MMSE (standardized β100%=-0.38[CI=-0.57−0.20]; β50%HDH= -0.37[CI=-0.54−0.19]; β40%HDH=-0.35[CI=-0.53−0.17], all p

Published
2020
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