Search

Your search keyword '"Froio, Danielle"' showing total 2 results
Start Over Author "Froio, Danielle" Publisher elsevier
2 results on '"Froio, Danielle"'

1. Contributor contact details

Author

Doona, C.J., primary, Feeherry, F.E., additional, Kustin, K., additional, Chen, P., additional, Deng, S., additional, Cheng, Y., additional, Lin, X., additional, Metzger, L., additional, Ruan, R., additional, Gassiot, M., additional, Masoliver, P., additional, Sampedro, F., additional, Fan, X., additional, Rodrigo, D., additional, Kempkes, M.A., additional, Davis, J., additional, Moates, G., additional, Waldron, K., additional, Bates, D., additional, Patist, A., additional, Pan, Z., additional, Atungulu, G.G., additional, Ho, K.-L.G., additional, Sanguansri, P., additional, Knoerzer, K., additional, Coventry, J., additional, Versteeg, C., additional, Rice, Rip G., additional, Niemira, Brendan A., additional, Delves-Broughton, J., additional, Steenson, Larry, additional, Dorko, Cathy, additional, Erdmann, Jerry, additional, Norbury, Fritz, additional, Mallory, Steven, additional, Thompson, Brett, additional, Navarro, Shlomo, additional, Taoukis, P.S., additional, Thellen, Christopher, additional, Ratto, Jo Ann, additional, Froio, Danielle, additional, Lucciarini, Jeanne, additional, Walden, R., additional, Emanuel, John, additional, Schiffmann, R.F., additional, Eustice, R.F., additional, Bruhn, C.M., additional, Peleg, Micha, additional, Corradini, Maria G., additional, Doona, C.J., additional, and Ross, E.W., additional

Published
2010
Full Text
View/download PDF

2. Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors.

Author

Hoque M, Abbassi RH, Froio D, Man J, Johns TG, Stringer BW, Day BW, Pajic M, Kassiou M, and Munoz L

Subjects
Cell Cycle drug effects, Cell Line, Tumor, Cell Survival drug effects, Humans, Microtubules metabolism, Microtubules pathology, Neoplasms enzymology, Neoplasms pathology, Neoplastic Stem Cells enzymology, Neoplastic Stem Cells pathology, Time Factors, Antineoplastic Agents pharmacology, Cell Shape drug effects, Microtubules drug effects, Neoplasms drug therapy, Neoplastic Stem Cells drug effects, Protein Kinase Inhibitors pharmacology, Tubulin metabolism, Tubulin Modulators pharmacology
Abstract

In the field of kinase inhibitors for applications in cancer research, tubulin is emerging as a targeted cellular protein that can significantly contribute to their activities. However, investigation of kinase inhibitors beyond the kinome is an area often neglected. Herein, we describe the results of pharmacological studies using drugs targeting kinases, tubulin or both. A key finding is that if cells are treated with a kinase inhibitor unintentionally targeting tubulin, their characteristic shape will diminish within a short timeframe. These changes in cell morphology are not seen when cells are treated with bona fide kinase inhibitors that do not directly target tubulin. Thus, early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin. Recognizing tubulin as a target of kinase inhibitors will build confidence in the future mechanistic studies using kinase inhibitors., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results