22 results on '"Furie, Karen L."'
Search Results
2. Contributors
- Author
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Adams, Harold P., primary, Adeoye, Opeolu, additional, Albers, Gregory W., additional, Alexandrov, Andrei V., additional, Amin-Hanjani, Sepideh, additional, An, Hongyu, additional, Anderson, Craig S., additional, Anrather, Josef, additional, Aparicio, Hugo J., additional, Arai, Ken, additional, Aronowski, Jaroslaw, additional, Atchaneeyasakul, Kunakorn, additional, Audebert, Heinrich, additional, Auer, Roland N., additional, Awad, Issam A., additional, Ay, Hakan, additional, Baltan, Selva, additional, Balu, Ramani, additional, Behbahani, Mandana, additional, Benavente, Oscar R., additional, Bershad, Eric M., additional, Berthaud, Jimmy V., additional, Blackburn, Spiros L., additional, Bonati, Leo H., additional, Bösel, Julian, additional, Bousser, Marie Germaine, additional, Broderick, Joseph P., additional, Brown, Martin M., additional, Brown, Wendy, additional, Brust, John C.M., additional, Bushnell, Cheryl, additional, Canhão, Patrícia, additional, Caplan, Louis R., additional, Carrión-Penagos, Julián, additional, Castellanos, Mar, additional, Caunca, Michelle R., additional, Chabriat, Hugues, additional, Chamorro, Angel, additional, Chen, Jieli, additional, Chen, Jun, additional, Chopp, Michael, additional, Christorforids, Greg, additional, Connolly, E. Sander, additional, Cramer, Steven C., additional, Cucchiara, Brett L., additional, Czap, Alexandra L., additional, Dannenbaum, Mark J., additional, Davis, Patricia H., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, Day, Arthur L., additional, De Silva, T. Michael, additional, de Sousa, Diana Aguiar, additional, Del Brutto, Victor J., additional, del Zoppo, Gregory J., additional, Derdeyn, Colin P., additional, Di Tullio, Marco R., additional, Diener, Hans Christoph, additional, Diringer, Michael N., additional, Dobkin, Bruce H., additional, Dzialowski, Imanuel, additional, Elkind, Mitchell S.V., additional, Elm, Jordan, additional, Feigin, Valery L., additional, Ferro, José Manuel, additional, Field, Thalia S., additional, Fischer, Marlene, additional, Fornage, Myriam, additional, Furie, Karen L., additional, Garcia-Bonilla, Lidia, additional, Giannotta, Steven L., additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Larry B., additional, Gonzales, Nicole R., additional, Greer, David M., additional, Grotta, James C., additional, Guo, Ruiming, additional, Gutierrez, Jose, additional, Harmel, Peter, additional, Howard, George, additional, Howard, Virginia J., additional, Hwang, Jee-Yeon, additional, Iadecola, Costantino, additional, Jahan, Reza, additional, Jickling, Glen C., additional, Joutel, Anne, additional, Kasner, Scott E., additional, Katan, Mira, additional, Kellner, Christopher P., additional, Khan, Muhib, additional, Kidwell, Chelsea S., additional, Kim, Helen, additional, Kim, Jong S., additional, Kircher, Charles E., additional, Krings, Timo, additional, Krishnamurthi, Rita V., additional, Kurth, Tobias, additional, Lansberg, Maarten G., additional, Levy, Elad I., additional, Liebeskind, David S., additional, Liew, Sook-Lei, additional, Lin, David J., additional, Lisle, Benjamin, additional, Lo, Eng H., additional, Lyden, Patrick D., additional, Maki, Takakuni, additional, Maragkos, Georgios A., additional, Marosfoi, Miklos, additional, McCullough, Louise D., additional, Meckler, Jason M., additional, Meschia, James Frederick, additional, Messé, Steven R., additional, Mocco, J, additional, Mokin, Maxim, additional, Mooney, Michael A., additional, Morgenstern, Lewis B., additional, Moskowitz, Michael A., additional, Mullen, Michael T., additional, Nägel, Steffen, additional, Nedergaard, Maiken, additional, Neira, Justin A., additional, Newman, Sarah, additional, Nicholson, Patrick J., additional, Norrving, Bo, additional, O’Donnell, Martin, additional, Ofengeim, Dimitry, additional, Ogata, Jun, additional, Ogilvy, Christopher S., additional, Orrù, Emanuele, additional, Ortega-Gutiérrez, Santiago, additional, Padrick, Matthew Maximillian, additional, Parsha, Kaushik, additional, Parsons, Mark, additional, Patel, Neil V., additional, Patel, Virendra I., additional, Pawlikowska, Ludmila, additional, Pérez, Adriana, additional, Perez-Pinzon, Miguel A., additional, Picard, John M., additional, Polster, Sean P., additional, Powers, William J., additional, Puetz, Volker, additional, Putaala, Jukka, additional, Rabinovich, Margarita, additional, Ransom, Bruce R., additional, Roa, Jorge A., additional, Rosenberg, Gary A., additional, Rossitto, Christina P., additional, Rundek, Tatjana, additional, Russin, Jonathan J., additional, Sacco, Ralph L., additional, Safouris, Apostolos, additional, Samaniego, Edgar A., additional, Sansing, Lauren H., additional, Satani, Nikunj, additional, Sattenberg, Ronald J., additional, Saver, Jeffrey L., additional, Savitz, Sean I., additional, Schmidt, Christian, additional, Seshadri, Sudha, additional, Sharma, Vijay K., additional, Sharp, Frank R., additional, Sheth, Kevin N., additional, Siddiqi, Omar K., additional, Singhal, Aneesh B., additional, Sobey, Christopher G., additional, Sommer, Clemens J., additional, Spetzler, Robert F., additional, Stapleton, Christopher J., additional, Strickland, Ben A., additional, Su, Hua, additional, Suarez, José I., additional, Takayama, Hiroo, additional, Tarsia, Joseph, additional, Tatlisumak, Turgut, additional, Thomas, Ajith J., additional, Thompson, John W., additional, Tsivgoulis, Georgios, additional, Tournier-Lasserve, Elizabeth, additional, Vidal, Gabriel, additional, Wakhloo, Ajay K., additional, Weksler, Babette B., additional, Willey, Joshua Z., additional, Wintermark, Max, additional, Wong, Lawrence K.S., additional, Xi, Guohua, additional, Xu, Jinchong, additional, Yaghi, Shadi, additional, Yamaguchi, Takenori, additional, Yang, Tuo, additional, Yasaka, Masahiro, additional, Zahuranec, Darin B., additional, Zhang, Feng, additional, Zhang, John H., additional, Zheng, Zhitong, additional, Zukin, R. Suzanne, additional, and Zweifler, Richard M., additional
- Published
- 2022
- Full Text
- View/download PDF
3. List of Contributors
- Author
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Adams, Harold P., primary, El Ahmadieh, Tarek Y., additional, Albers, Gregory W., additional, Alexandrov, Andrei V., additional, Anrather, Josef, additional, Arai, Ken, additional, Aronowski, Jaroslaw (Jarek), additional, Auer, Roland N., additional, Awad, Issam A., additional, Ay, Hakan, additional, Baltan, Selva, additional, Batjer, Hunt H., additional, Benavente, Oscar R., additional, Bendok, Bernard R., additional, Bershad, Eric M., additional, Bonati, Leo H., additional, Bookland, Markus J., additional, Bousser, Marie-Germaine, additional, Braca, John A., additional, Broderick, Joseph P., additional, Brown, Martin M., additional, Brown, Wendy E., additional, Brust, John C.M., additional, Bushnell, Cheryl, additional, Bösel, Julian, additional, Canhão, Patrícia, additional, Caplan, Louis R., additional, Castellanos, Mar, additional, Chamorro, Angel, additional, Chandler, James P., additional, Chen, Jun, additional, Chopp, Michael, additional, Chrissobolis, Sophocles, additional, Chabriat, Hugues, additional, Cramer, Steven C., additional, Cucchiara, Brett L., additional, Dannenbaum, Mark J., additional, Davis, Patricia H., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, Day, Arthur L., additional, del Zoppo, Gregory J., additional, Diener, Hans-Christoph, additional, Di Tullio, Marco R., additional, Dobkin, Bruce H., additional, Dzialowski, Imanuel, additional, Economos, Alexis, additional, Eddleman, Christopher S., additional, Elkind, Mitchell S.V., additional, Feigin, Valery L., additional, Ferro, José M., additional, Findlay, J. Max, additional, Furie, Karen L., additional, Fusco, Matthew R., additional, Field, Thalia S., additional, Geibprasert, Sasikhan, additional, Gensic, Anna P., additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Larry B., additional, Gonzales, Nicole R., additional, Gounis, Matthew J., additional, Greenberg, Steven M., additional, Gregson, Barbara A., additional, Grotta, James C., additional, Gutierrez, Jose, additional, Hacke, Werner, additional, Hallenbeck, John M., additional, Haršány, Michal, additional, Heiferman, Daniel M., additional, Homma, Shunichi, additional, Howard, George, additional, Howard, Virginia J., additional, Hwang, Jee-Yeon, additional, Iadecola, Costantino, additional, Jahan, Reza, additional, Joutel, Anne, additional, Jüttler, Eric, additional, Kase, Carlos S., additional, Kasner, Scott E., additional, Katan, Mira, additional, Khader Eliyas, Javed, additional, Khan, Muhib, additional, Kim, Helen, additional, Kidwell, Chelsea S., additional, Kim, Jong S., additional, Krings, Timo, additional, Krishnamurthi, Rita, additional, Kurth, Tobias, additional, Lamy, Catherine, additional, Lansberg, Maarten G., additional, Levy, Elad I., additional, Liebeskind, David S., additional, Lo, Eng H., additional, Loftus, Christopher M., additional, Lyden, Patrick D., additional, Mas, Jean-Louis, additional, Massari, Francesco, additional, Meckler, Jason M., additional, Mendelow, A. David, additional, Meschia, James F., additional, Messé, Steven R., additional, Mitchel, Patrick, additional, Morgenstern, Lewis B., additional, Mokin, Maxim, additional, Moskowitz, Michael A., additional, Mullen, Michael T., additional, Nedergaard, Maiken, additional, Neugebauer, Hermann, additional, Newell, David W., additional, Norrving, Bo, additional, O'Donnell, Martin, additional, Ofengeim, Dimitry, additional, Ogata, Jun, additional, Ogilvy, Christopher S., additional, Pancioli, Arthur M., additional, Parsha, Kaushik, additional, Parsons, Mark W., additional, Pawlikowska, Ludmila, additional, Pérez, Adriana, additional, Perez-Pinzon, Miguel A., additional, Powers, William J., additional, Puetz, Volker, additional, Puri, Ajit S., additional, Ransom, Bruce R., additional, Roine, Risto O., additional, Rundek, Tatjana, additional, Russin, Jonathan J., additional, Sacco, Ralph L., additional, Spetzler, Robert F., additional, Sattenberg, Ronald J., additional, Saver, Jeffrey L., additional, Savitz, Sean I., additional, Schönenberger, Silvia, additional, Seshadri, Sudha, additional, Sharma, Vijay K., additional, Shi, Yejie, additional, Shoamanesh, Ashkan, additional, Silverboard, Gerald, additional, Singhal, Aneesh B., additional, Sobey, Christopher G., additional, Stapf, Christian, additional, Su, Hua, additional, Suarez, Jose I., additional, Sykora, Marek, additional, Tatlisumak, Turgut, additional, El Tecle, Najib, additional, terBrugge, Karel G., additional, Thompson, John W., additional, Tilley, Barbara C., additional, Tournier-Lasserve, Elisabeth, additional, Tsivgoulis, Georgios, additional, Vilela, Marcelo D., additional, von Kummer, Rüdiger, additional, Wakhloo, Ajay K., additional, Wagner, Kenneth R., additional, Warach, Steven, additional, Weksler, Babette B., additional, Werring, David, additional, Willey, Joshua Z., additional, Wintermark, Max, additional, Wolf, Philip A., additional, Wong, Lawrence K.S., additional, Woo, Daniel, additional, Wright, Clinton, additional, Xi, Guohua, additional, Yamaguchi, Takenori, additional, Yasaka, Masahiro, additional, Young, William L., additional, Zammar, Samer G., additional, Zahuranec, Darin B., additional, Zhang, Feng, additional, Zhang, Haiyue, additional, Zhang, John H., additional, Zhang, Zheng Gang, additional, Zukin, R. Suzzane, additional, and Zweifler, Richard M., additional
- Published
- 2016
- Full Text
- View/download PDF
4. Cardiac Diseases
- Author
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Greer, David M., primary, Homma, Shunichi, additional, and Furie, Karen L., additional
- Published
- 2016
- Full Text
- View/download PDF
5. Contributors
- Author
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Abe, Takato, primary, Adams, Harold P., additional, Adeoye, Opeolu, additional, Agarwal, Sachin, additional, Aguilar, Maria I., additional, Al-Khoury, Lama, additional, Arboix, Adrià, additional, Auer, Roland N., additional, Awad, Issam A., additional, Baird, Alison E., additional, Baltan, Selva, additional, Barnett, Henry J.M., additional, Batjer, H. Hunt, additional, Benavente, Oscar R., additional, Bendok, Bernard R., additional, Bershad, Eric M., additional, Binder, Jeffrey R., additional, Boulos, Alan S., additional, Bousser, Marie-Germaine, additional, Bova, Frank J., additional, Brainin, Michael, additional, Brisman, Jonathan L., additional, Brown, Wendy, additional, Brust, John C.M., additional, Canhão, Patrícia, additional, Caplan, Louis R., additional, Castellanos, Mar, additional, Chabriat, Hugues, additional, Chamorro, Angel, additional, Choi, Jae H., additional, Chopp, Michael, additional, Connolly, E. Sander, additional, Coull, Bruce M., additional, Cucchiara, Brett L., additional, Dalkara, Turgay, additional, Dani, Krishna A., additional, Dannenbaum, Mark J., additional, Dashti, Shervin R., additional, Davis, Patricia H., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, Day, Arthur L., additional, De Leo, Michael J., additional, del Zoppo, Gregory J., additional, Diedler, Jennifer, additional, Diener, Hans-Christoph, additional, Di Tullio, Marco R., additional, Dobkin, Bruce H., additional, Drake, Kendra, additional, Du, Rose, additional, Ducros, Anne, additional, Dzialowski, Imanuel, additional, Eddleman, Christopher S., additional, Elhammady, Mohamed Samy, additional, Elkind, Mitchell S.V., additional, Elliott, J. Paul, additional, Ferro, José M., additional, Findlay, J. Max, additional, Friedman, William A., additional, Furie, Karen L., additional, Furlan, Anthony J., additional, Geibprasert, Sasikhan, additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Larry B., additional, Gonzales, Nicole R., additional, Gounis, Matthew J., additional, Greenberg, Steven M., additional, Greer, David M., additional, Grotta, James C., additional, Hacke, Werner, additional, Hallenbeck, John, additional, Hamann, Gerhard F., additional, Hartmann, Andreas, additional, Hennerici, Michael, additional, Heros, Roberto C., additional, Higashida, Randall, additional, Homma, Shunichi, additional, Hongo, Kazuhiro, additional, Hopkins, L. Nelson, additional, Horiuchi, Tetsuyoshi, additional, Howard, George, additional, Howard, Virginia J., additional, Huddle, Daniel, additional, Iadecola, Costantino, additional, Joutel, Anne, additional, Jüttler, Eric, additional, Kakarla, Udaya K., additional, Kalafut, Mary A., additional, Kannel, William B., additional, Kase, Carlos S., additional, Kasner, Scott E., additional, Kaste, Markku, additional, Khaw, Alexander, additional, Kidwell, Chelsea S., additional, Kim, Helen, additional, Kim, Louis J., additional, Kim, Stanley H., additional, Klijn, Catharina J.M. (Karin), additional, Kobayashi, Shigeaki, additional, Komotar, Ricardo J., additional, Krings, Timo, additional, Kunz, Alexander, additional, Kurth, Tobias, additional, Lamy, Catherine, additional, Lazar, Ronald M., additional, Levy, Elad I., additional, Liebeskind, David S., additional, Lyden, Patrick D., additional, Markham, Joanne, additional, Marshall, Randolph S., additional, Martí-Vilalta, J.L., additional, Mas, Jean-Louis, additional, Mast, Henning, additional, Masuda, Junichi, additional, Mathers, Colin D., additional, Mayberg, Marc R., additional, Meairs, Stephen, additional, Mendelow, Alexander David, additional, Meschia, James F., additional, Miller, Alyson A., additional, Miyawaki, Takahiro, additional, Mocco, J, additional, Mohr, J.P., additional, Morcos, Jacques J., additional, Morgenstern, Lewis B., additional, Moskowitz, Michael A., additional, Nahed, Brian V., additional, Newell, David W., additional, Ofengeim, Dimitry, additional, Ogata, Jun, additional, Ogilvy, Christopher S., additional, Palesch, Yuko Y., additional, Pancioli, Arthur, additional, Park, Min S., additional, Pawlikowska, Ludmila, additional, Pile-Spellman, John, additional, Powers, William J., additional, Puetz, Volker, additional, Ransom, Bruce R., additional, Roine, Risto O., additional, Ruigrok, Ynte M., additional, Rundek, Tatjana, additional, Sacco, Ralph L., additional, Sattenberg, Ronald J., additional, Saver, Jeffrey L., additional, Savitz, Sean I., additional, Seshadri, Sudha, additional, Sharma, Jitendra, additional, Silverboard, Gerald, additional, Singhal, Aneesh B., additional, Sobey, Christopher G., additional, Spetzler, Robert F., additional, Stapf, Christian, additional, Starke, Robert M., additional, Stiefel, Michael F., additional, Strong, Kathleen, additional, Suarez, José I., additional, Sykora, Marek, additional, Tafreshi, Gilda, additional, Brugge, Karel ter, additional, Tilley, Barbara C., additional, Toni, Danilo, additional, Tournier-Lasserve, Elisabeth, additional, Vilela, Marcelo D., additional, von Kummer, Rüdiger, additional, Wakhloo, Ajay K., additional, Warach, Steven, additional, Weksler, Babette B., additional, Willey, Joshua Z., additional, Wintermark, Max, additional, Wolf, Philip A., additional, Woo, Daniel, additional, Yamaguchi, Takenori, additional, Yasaka, Masahiro, additional, Young, William L., additional, Zahuranec, Darin B., additional, Zazulia, Allyson R., additional, Zhang, Zheng Gang, additional, Zukin, R. Suzanne, additional, and Zweifler, Richard M., additional
- Published
- 2011
- Full Text
- View/download PDF
6. Cardiac Diseases
- Author
-
Greer, David M., primary, Homma, Shunichi, additional, and Furie, Karen L., additional
- Published
- 2011
- Full Text
- View/download PDF
7. Contributors
- Author
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Acharya, Aninda B., primary, Adams, Harold P., additional, Al-Khoury, Lama, additional, Arboix, Adria, additional, Auer, Roland N., additional, Awad, Issam A., additional, Baird, Alison E., additional, Barnett, Henry J.M., additional, Benavente, Oscar, additional, Bendok, Bernard R., additional, Binder, Jeffrey R., additional, Bogousslavsky, Julien, additional, Boulos, Alan S., additional, Bousser, Marie-Germaine, additional, Brainin, Michael, additional, Brey, Robin L., additional, Broderick, Joseph P., additional, Brust, John C.M., additional, Calderone, Agata, additional, Caplan, Louis R., additional, Chabriat, H., additional, Chamorro, Angel, additional, Cho, Sunghee, additional, Choi, Dennis W., additional, Coull, Bruce M., additional, Cunningham, Edward J., additional, Dalkara, Turgay, additional, Davis, Patricia H., additional, Davis, Stephen M., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, del Zoppo, Gregory J., additional, Diener, H.C., additional, Di Tullio, Marco R., additional, Dobkin, Bruce H., additional, Donnan, Geoffrey A., additional, Elkind, Mitchell S.V., additional, Elliott, J. Paul, additional, Erkinjuntti, Timo, additional, Faraci, Frank M., additional, Feuerstein, Giora, additional, Findlay, J. Max, additional, Fleetwood, Ian G., additional, Furie, Karen L., additional, Furlan, Anthony J., additional, Gautier, Jean Claude, additional, Georgiadis, Dimitrios, additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Steven, additional, Greenberg, Steven M., additional, Grotta, James C., additional, Grubb, Robert L., additional, Guterman, Lee R., additional, Hacke, Werner, additional, Hallenbeck, John, additional, Hammann, Gerhard F., additional, Hartmann, Andreas, additional, Hashi, Kazuo, additional, Heistad, Donald D., additional, Hennerici, Michael, additional, Hernesniemi, Juha, additional, Hier, Daniel B., additional, Higashida, Randall T., additional, Homma, Shunichi, additional, Hongo, Kazuhiro, additional, Hopkins, L. Nelson, additional, Howard, George, additional, Howard, Virginia, additional, Huddle, Daniel, additional, Hupperts, Raymond M.M., additional, Iadecola, Costantino, additional, Infeld, Bernard, additional, Iyer, Sriram S., additional, Joutel, A., additional, Jover, Teresa, additional, Jungreis, Charles A., additional, Kalafut, Mary A., additional, Kase, Carlos S., additional, Kasner, Scott E., additional, Kaste, Markku, additional, Kidwell, Chelsea S., additional, Kim, Louis J., additional, Kim, Stanley H., additional, Kistler, J. Philip, additional, Kobayashi, Shigeaki, additional, Labiche, Lise A., additional, Lamy, Catherine, additional, Lau, C. Geoff, additional, Lawton, Michael T., additional, Lazar, Ronald M., additional, Lemole, G. Michael, additional, Le Roux, Peter D., additional, Levy, Elad I., additional, Lodder, Jan, additional, Lyden, Patrick D., additional, Ma, H., additional, Macdonald, R. Loch, additional, Maeder, Philippe, additional, Marchak, B. Elaine, additional, Markham, Joanne, additional, Marshall, Randolph S., additional, Marti-Vilalta, J.L., additional, Mas, Jean-Louis, additional, Mast, Henning, additional, Masuda, Junichi, additional, Mayberg, Marc R., additional, Meairs, Stephen, additional, Mendelow, Alexander David, additional, Mohr, J.P., additional, Morgenstern, Lewis B., additional, Moskowitz, Michael A., additional, Nitta, Junpei, additional, Ogata, Jun, additional, Oyelese, Adetokunbo A., additional, Palesch, Yuko Y., additional, Pancioli, Arthur M., additional, Parsa, Andrew T., additional, Piechowski-Jóźwiak, Bartlomiej, additional, Pile-Spellman, John, additional, Powers, William J., additional, Qureshi, Adnan I., additional, Ransom, Bruce R., additional, Riina, Howard A., additional, Roine, Risto O., additional, Ronkainen, Antti, additional, Roubin, Gary S., additional, Rundek, Tanja, additional, Sacco, Ralph L., additional, Sattenberg, Ronald J., additional, Saver, Jeffrey, additional, Schumacher, Herrmann-Christian, additional, Schwab, Stefan, additional, Sherman, David G., additional, Silverboard, Gerald, additional, Simionescu, Monica, additional, Sobey, Christopher G., additional, Solomon, Robert A., additional, Spetzler, Robert F., additional, Stapf, Christian, additional, Steinberg, Gary K., additional, Sudlow, Cathie, additional, Tilley, Barbara C., additional, Toni, Danilo, additional, Tournier-Lasserve, E., additional, Vahedi, K., additional, Vates, G. Edward, additional, Vitek, Jiri J., additional, Wanibuchi, Masahiko, additional, Warach, Steven, additional, Warlow, Charles P., additional, Weir, Bryce, additional, Weisz, Giora, additional, Weksler, Babette B., additional, Welch, K. M.A., additional, Winn, H. Richard, additional, Wolf, Philip A., additional, Xavier, Andrew R., additional, Yahia, Abutaher M., additional, Yamaguchi, Takenori, additional, Yamaura, Akira, additional, Yokota, Hidenori, additional, Zabramski, Joseph M., additional, Zazulia, Allyson R., additional, Zukin, R. Suzanne, additional, and Zweifler, Richard M., additional
- Published
- 2004
- Full Text
- View/download PDF
8. Cardiac Diseases
- Author
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Furie, Karen L., primary, Homma, Shunichi, additional, and Kistler, J. Philip, additional
- Published
- 2004
- Full Text
- View/download PDF
9. Comparison of the Effects of Blood Pressure Parameters on Rebleeding and Outcomes in Unsecured Aneurysmal Subarachnoid Hemorrhage.
- Author
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Haripottawekul A, Persad-Paisley EM, Paracha S, Haque D, Shamshad A, Furie KL, Reznik ME, and Mahta A
- Subjects
- Humans, Female, Middle Aged, Male, Aged, Retrospective Studies, Adult, Treatment Outcome, Arterial Pressure physiology, Subarachnoid Hemorrhage physiopathology, Subarachnoid Hemorrhage complications, Recurrence, Blood Pressure physiology
- Abstract
Background: Elevated systolic blood pressure (SBP) has been linked to preprocedural rebleeding risk and poor outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). This study seeks to compare the effects of SBP and mean arterial pressure (MAP) on rebleeding and functional outcomes in aSAH patients., Methods: We performed a retrospective study of a prospectively collected cohort of consecutive patients with aSAH admitted to an academic center in 2016-2023. Binary regression analysis was used to determine the association between BP parameters and outcomes including rebleeding and poor outcome defined as modified Rankin Scale 4-6 at 3 months postdischarge., Results: The cohort included 324 patients (mean age 57 years [standard deviation 13.4], 61% female). Symptomatic rebleeding occurred in 34 patients (11%). Higher BP measurements were recorded in patients with rebleeding and poor outcome, however, only MAP met statistical significance for rebleeding (odds ratio {OR} 1.02 for 1 mmHg increase in MAP, 95% confidence interval {CI}: 1.001-1.03, P = 0.043; OR 1 per 1 mmHg increase in SBP, 95% CI 0.99-1.01; P = 0.06)) and for poor outcome (OR 1.01 for 1 mmHg increase in MAP, 95% CI: 1.002-1.025, P = 0.025; OR 1 for 1 mmHg increase in SBP, 95% CI: 0.99-1.02, P = 0.23) independent of other predictors., Conclusions: MAP may appear to be slightly better correlated with rebleeding and poor outcomes in unsecured aSAH compared to SBP. Larger prospective studies are needed to identify and mitigate risk factors for rebleeding and poor outcome in aSAH patients., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
10. Highs and Lows: Dysnatremia and Patient Outcomes in Aneurysmal Subarachnoid Hemorrhage.
- Author
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Helliwell A, Snow R, Wendell LC, Thompson BB, Reznik ME, Furie KL, and Mahta A
- Subjects
- Humans, Female, Middle Aged, Male, Retrospective Studies, Sodium, Subarachnoid Hemorrhage complications, Subarachnoid Hemorrhage therapy, Hypernatremia, Hyponatremia complications, Vasospasm, Intracranial complications
- Abstract
Background: Disturbances in serum sodium concentration (dysnatremia) are common following aneurysmal subarachnoid hemorrhage (aSAH), but its direct impact on outcomes is not well understood. This study aimed to examine the association between dysnatremia following aSAH and patient outcomes., Methods: A retrospective cohort study of consecutive patients with aSAH who were admitted to an academic referral center between 2015 and 2021 was performed. Multivariate logistic regression was used to test the association of dysnatremia and outcomes including modified Rankin Scale score at 3 months after discharge and vasospasm. Multiple linear regression was used to test the association of hospital length of stay and dysnatremia., Results: We included 320 patients with confirmed aneurysmal etiology (mean [SD] age = 57.8 [14.3] years; 61% female; 70% White). No independent associations were found between hyponatremia or hypernatremia and functional outcome or vasospasm. However, hospital length of stay was longer in patients with hypernatremia (7 more days; 95% confidence interval = 4.4-9.6, P < 0.001) independent of age, Hunt and Hess grade, modified Fisher score, delayed cerebral ischemia, and other hospital complications., Conclusions: Although dysnatremia may not directly impact functional outcome or vasospasm risk, hypernatremia may prolong hospital length of stay. Judicious use of hypertonic saline solutions and avoidance of unnecessary dysnatremia in patients with aSAH should be considered., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
11. Safety of Modified Nimodipine Dosing in Aneurysmal Subarachnoid Hemorrhage.
- Author
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Mahmoud L, Zullo AR, Blake C, Dai X, Thompson BB, Wendell LC, Furie KL, Reznik ME, and Mahta A
- Subjects
- Female, Humans, Male, Middle Aged, Outcome Assessment, Health Care, Prospective Studies, Retrospective Studies, Treatment Outcome, Nimodipine, Subarachnoid Hemorrhage complications, Subarachnoid Hemorrhage drug therapy
- Abstract
Background: Nimodipine improves outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, the impact of alternative dosing strategies on outcome remains unclear., Methods: We performed a retrospective cohort study of consecutive patients admitted with aSAH to an academic referral center from 2016 to 2019. Patients with a confirmed aneurysm cause who received nimodipine were included; patients who died or had withdrawal of life-sustaining treatment within 24 hours of admission were excluded. Univariable and multivariable modified Poisson regression models were used to identify predictors of using modified nimodipine dosing (30 mg every 2 hours) versus standard dosing (60 mg every 4 hours). Inverse probability weighted and modified Poisson regression models were used to estimate adjusted risk ratios (RRs) for outcome measures, with poor outcome defined as modified Rankin Scale score 4-6 at 3 months., Results: We identified 175 patients with aSAH who met eligibility criteria (mean [SD] age = 57 [13.2] years, 62% female, 73% White); 49% (n = 86) received modified nimodipine dosing. A modified dose was used more frequently in women (RR 2.08, 95% confidence interval [CI] 1.11-3.89, P = 0.02), patients with vasospasm (RR 3.47, 95% CI 1.84-6.51, P < 0.001), and patients who required vasopressors (RR 1.73, 95% CI 1.3-2.32, P < 0.001). Modified dosing was not associated with poor functional outcome (inverse probability weighted RR 1.1, 95% CI 0.8-1.4, P = 0.65)., Conclusions: Modified dosing of nimodipine is well tolerated and may not be associated with worse functional outcome. Prospective studies are needed to better assess the relationship between nimodipine dosing and outcomes in patients with aSAH., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2022
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12. In Reply to the Letter to the Editor Regarding "Association of Early White Blood Cell Trend with Outcomes in Aneurysmal Subarachnoid Hemorrhage".
- Author
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Mahta A, Reznik ME, Thompson BB, Wendell LC, and Furie KL
- Subjects
- Humans, Leukocytes, Subarachnoid Hemorrhage
- Published
- 2021
- Full Text
- View/download PDF
13. Short- and long-term opioid use in survivors of subarachnoid hemorrhage.
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Mahta A, Anderson MN, Azher AI, Mahmoud LN, Dakay K, Abdulrazeq H, Abud A, Moody S, Reznik ME, Yaghi S, Thompson BB, Wendell LC, Rao SS, Potter NS, Cutting S, Mac Grory B, Stretz C, Doberstein CE, and Furie KL
- Subjects
- Adult, Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Pain etiology, Pain psychology, Risk Factors, Subarachnoid Hemorrhage complications, Subarachnoid Hemorrhage therapy, Analgesics, Opioid therapeutic use, Opioid-Related Disorders epidemiology, Pain drug therapy, Subarachnoid Hemorrhage psychology, Survivors
- Abstract
Objectives: Opioids are frequently used for analgesia in patients with acute subarachnoid hemorrhage (SAH) due to a high prevalence of headache and neck pain. However, it is unclear if this practice may pose a risk for opioid dependence, as long-term opioid use in this population remains unknown. We sought to determine the prevalence of opioid use in SAH survivors, and to identify potential risk factors for opioid utilization., Methods: We analyzed a cohort of consecutive patients admitted with non-traumatic and suspected aneurysmal SAH to an academic referral center. We included patients who survived hospitalization and excluded those who were not opioid-naïve. Potential risk factors for opioid prescription at discharge, 3 and 12 months post-discharge were assessed., Results: Of 240 SAH patients who met our inclusion criteria (mean age 58.4 years [SD 14.8], 58% women), 233 (97%) received opioids during hospitalization and 152 (63%) received opioid prescription at discharge. Twenty-eight patients (12%) still continued to use opioids at 3 months post-discharge, and 13 patients (6%) at 12-month follow up. Although patients with poor Hunt and Hess grades (odds ratio 0.19, 95% CI 0.06-0.57) and those with intraventricular hemorrhage (odds ratio 0.38, 95% CI 0.18-0.87) were less likely to receive opioid prescriptions at discharge, we did not find significant differences between patients who had long-term opioid use and those who did not., Conclusion: Opioids are regularly used in both the acute SAH setting and immediately after discharge. A considerable number of patients also continue to use opioids in the long-term. Opioid-sparing pain control strategies should be explored in the future., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
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14. Association of Early White Blood Cell Trend with Outcomes in Aneurysmal Subarachnoid Hemorrhage.
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Mahta A, Azher AI, Moody S, Spinney M, Andrews N, Chen J, Dakay KB, Dai X, Reznik ME, Thompson BB, Wendell LC, Rao SS, Potter NS, Stretz C, Burton T, Cutting S, and Furie KL
- Subjects
- Adult, Aged, Brain Ischemia etiology, Female, Humans, Inflammation blood, Inflammation etiology, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Biomarkers blood, Leukocyte Count, Subarachnoid Hemorrhage blood, Subarachnoid Hemorrhage complications
- Abstract
Background: An increasing white blood cell (WBC) count in early course of aneurysmal subarachnoid hemorrhage (SAH) can indicate a systemic inflammatory state triggered by the initial insult. We sought to determine the significance of the early WBC trend as a potential predictor of outcomes., Methods: We analyzed a cohort of consecutive patients with aneurysmal SAH. The WBC values in first 5 days of admission, plus relevant clinical and imaging data, and modified Rankin Scale (mRS) at 3 months after hospital discharge were retrieved and analyzed. Favorable outcome was defined as mRS 0-3. The association between WBC counts and outcomes including mRS and delayed cerebral ischemia (DCI) was determined using binary logistic regression models. We used receiver operating characteristic curve analysis to assess accuracy of WBC in predicting outcomes., Results: We included 167 patients in final analysis. Mean age was 56.4 (standard deviation [SD] 14.8) years, and 65% (109) of patients were female. Peak WBC was greater in patients with poor functional outcome (mean 17 × 10
9 cells/L, SD 6.4 vs. 13.5 × 109 cells/L SD 4.7). Combining peak WBC with modified Fisher scale slightly increased accuracy in predicting DCI (area under the curve 0.670, 95% confidence interval 0.586-0.755) compared with each component alone., Conclusions: WBC count in the early course of SAH may have prognostic values in predicting DCI and functional outcome. WBC count monitoring may be used in conjunction with other clinical and radiographic tools to stratify patients with SAH into high- and low-risk groups to tailor neuromonitoring and treatment strategies., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2021
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15. Arrival blood pressure in hypertensive and non-hypertensive spontaneous intracerebral hemorrhage.
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Reznik ME, Fakhri N, Moody S, Murray K, Costa S, Yaghi S, Schrag M, Madsen TE, Burton TM, Cutting S, Mahta A, Wendell LC, Thompson BB, Rao SS, Stretz C, Furie KL, and Mac Grory B
- Subjects
- Aged, Aged, 80 and over, Blood Pressure, Cerebral Hemorrhage complications, Cohort Studies, Female, Humans, Male, Middle Aged, Cerebral Amyloid Angiopathy, Hypertension complications, Hypertension epidemiology, Intracranial Hemorrhage, Hypertensive diagnosis, Intracranial Hemorrhage, Hypertensive diagnostic imaging
- Abstract
Background and Purpose: Hypertension is a known risk factor for intracerebral hemorrhage (ICH), but it is unclear whether blood pressure (BP) at hospital arrival can be used to distinguish hypertensive ICH from non-hypertensive etiologies., Patients and Methods: We performed a single-center cohort study using data from consecutive ICH patients over 12 months. ICH characteristics including etiology were prospectively adjudicated by two attending neurologists. Using adjusted linear regression models, we compared first recorded systolic BPs (SBP) and mean arterial pressures (MAP) in patients with hypertensive vs. other ICH etiologies. We then used area under the ROC curve (AUC) analysis to determine the accuracy of admission BP in differentiating between hypertensive and non-hypertensive ICH., Results: Of 311 patients in our cohort (mean age 70.6 ± 15.6, 50% male, 83% white), the most frequent ICH etiologies were hypertension (50%) and cerebral amyloid angiopathy (CAA; 22%). Mean SBP and MAP for patients with hypertensive ICH was 175.1 ± 32.9 mmHg and 120.4 ± 22.9 mmHg, respectively, compared to 156.4 ± 28.0 mmHg and 109.6 ± 20.3 mmHg in non-hypertensive ICH (p < .001). Adjusted models showed that hypertensive ICH patients had higher BPs than those with CAA (mean SBP difference 10.7 mmHg [95% CI 0.8-20.5]; mean MAP difference 8.1 mmHg [1.1-15.0]) and especially patients with other non-CAA causes (mean SBP difference 23.9 mmHg [15.3-32.4]; mean MAP difference 14.5 mmHg [8.5-20.6]). However, on a patient-level, arrival BP did not reliably discriminate between hypertensive and non-hypertensive etiologies (AUC 0.660 [0.599-0.720])., Conclusions: Arrival BP differs between hypertensive and non-hypertensive ICH but should not be used as a primary determinant of etiology, as hypertension may be implicated in various subtypes of ICH., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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16. 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.
- Author
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January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, Ellinor PT, Ezekowitz MD, Field ME, Furie KL, Heidenreich PA, Murray KT, Shea JB, Tracy CM, and Yancy CW
- Subjects
- Atrial Fibrillation physiopathology, Humans, United States, Advisory Committees standards, American Heart Association, Atrial Fibrillation therapy, Cardiology standards, Disease Management, Practice Guidelines as Topic
- Published
- 2019
- Full Text
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17. Level of consciousness at discharge and associations with outcome after ischemic stroke.
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Reznik ME, Yaghi S, Jayaraman MV, McTaggart RA, Hemendinger M, Mac Grory BC, Burton TM, Cutting SM, Thompson BB, Wendell LC, Mahta A, Potter NS, Daiello LA, Kosar CM, Jones RN, and Furie KL
- Subjects
- Aged, Aged, 80 and over, Brain Ischemia epidemiology, Comorbidity, Female, Humans, Male, Prospective Studies, Retrospective Studies, Skilled Nursing Facilities, Stroke epidemiology, Stroke Rehabilitation, Treatment Outcome, Brain Ischemia therapy, Consciousness, Patient Discharge, Stroke therapy
- Abstract
Background: Many factors may potentially complicate the stroke recovery process, including persistently impaired level of consciousness (LOC)-whether from residual stroke effects or from superimposed delirium. We aimed to determine the degree to which impaired LOC at hospital discharge is associated with outcomes after ischemic stroke., Methods: We conducted a single-center retrospective cohort study using prospectively-collected data from 2015 to 2017, collecting total NIHSS-LOC score at discharge as well as subscores for responsiveness (LOC-R), orientation questions (LOC-Q), and command-following (LOC-C). We determined associations between LOC scores and 3-month outcome using logistic regression, with discharge location (skilled nursing facility [SNF] vs. inpatient rehabilitation) representing a pre-specified secondary outcome., Results: We identified 1003 consecutive patients with ischemic stroke who survived to discharge, of whom 32% had any LOC score > 0. Total LOC score at discharge was associated with unfavorable 3-month outcome (OR 4.9 [95% CI 2.4-9.8] for LOC = 1; OR 8.0 [2.7-23.9] for LOC = 2-3; OR 6.3 [2.1-18.5] for LOC = 4-5; all patients with LOC = 6-7 had poor outcomes), as were subscores for LOC-R (OR 5.3 [1.3-21.2] for LOC-R = 1; all patients with LOC-R = 2-3 had poor outcomes) and LOC-Q (OR 4.1 [2.1-8.3] for LOC-Q = 1; OR 4.9 [1.8-13.5] for LOC-Q = 2). Total LOC score (OR 2.6 [1.3-5.3] for LOC = 1; OR 3.1 [1.2-8.2] for LOC = 2-3) and LOC-Q (OR 3.3 [1.6-6.6] for LOC-Q = 1; OR 3.4 [1.3-9.0] for LOC-Q = 2) were also associated with discharge to SNF rather than to inpatient rehabilitation., Conclusions: The presence of impaired consciousness or disorientation at discharge is associated with markedly worse outcomes after ischemic stroke. Further studies are necessary to determine the separate effects of residual stroke-related LOC changes and those caused by superimposed delirium., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2018
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18. Mechanical embolectomy for acute ischemic stroke beyond six hours from symptom onset using MRI based perfusion imaging.
- Author
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McTaggart RA, Yaghi S, Sacchetti DC, Haas RA, Hemendinger M, Arcuri D, Rogg JM, Furie KL, and Jayaraman MV
- Subjects
- Aged, Aged, 80 and over, Brain Ischemia complications, Cerebral Angiography, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Severity of Illness Index, Stroke etiology, Treatment Outcome, Embolectomy methods, Magnetic Resonance Angiography, Stroke diagnostic imaging, Stroke surgery
- Abstract
Introduction: There is very limited data on the use of MRI based perfusion imaging to select patients with acute ischemic stroke and large vessel occlusion (LVO) for intraarterial therapy beyond 6h from onset. Our aim is to report the outcome of patients with acute ischemic stroke and large artery occlusion who presented beyond 6h from onset, had favorable MRI imaging profile, and underwent mechanical embolectomy., Methods: This is a single institution (Rhode Island Hospital) retrospective study between December 1st, 2015, and July 30th, 2016 that included patients with acute ischemic stroke and proximal LVO with CT ASPECTS of 6 or more and 6-24h from symptom onset who were assessed for mechanical embolectomy using MRI based perfusion imaging. Favorable imaging profile was defined based on prior studies as 1) DWI lesion volume (as defined as apparent diffusion coefficient<620×10
-6 mm2 /s) of 70ml or less; 2) Penumbra volume (as defined by volume of tissue with Tmax >6s) of 15ml or greater; 3) A mismatch ratio of 1.8 or more; and 4) Volume of tissue with perfusion lesion with Tmax >10s is <100ml. Good outcome was defined as a 90-day mRS≤2., Results: 41 patients met the inclusion criteria; 22 (53.7%) had favorable imaging profile and underwent mechanical embolectomy. The rate of good outcomes in this series was similar to that in a patient level pooled meta-analysis of the recent endovascular trials (63.6% vs. 46%, p=0.13). None of the patients in our cohort had symptomatic intracereberal hemorrhage., Conclusions: MRI perfusion based imaging may help select patients with acute ischemic stroke and proximal emergent LVO for embolectomy beyond the treatment window used in most endovascular trials. This provides compelling evidence for stroke centers to participate in ongoing trials using advanced imaging to study endovascular treatment in this patient population., (Copyright © 2017 Elsevier B.V. All rights reserved.)- Published
- 2017
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19. Metabolic determinants of white matter hyperintensity burden in patients with ischemic stroke.
- Author
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Cloonan L, Fitzpatrick KM, Kanakis AS, Furie KL, Rosand J, and Rost NS
- Subjects
- Aged, Aged, 80 and over, Algorithms, Biomarkers blood, Boston, Brain Ischemia diagnosis, Brain Ischemia physiopathology, Endothelium, Vascular physiopathology, Female, Homocysteine blood, Humans, Leukoencephalopathies diagnosis, Leukoencephalopathies physiopathology, Linear Models, Magnetic Resonance Imaging, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prognosis, Retrospective Studies, Risk Factors, Severity of Illness Index, Signal Processing, Computer-Assisted, Stroke diagnosis, Stroke physiopathology, Up-Regulation, Brain Ischemia blood, Endothelium, Vascular metabolism, Glycated Hemoglobin analysis, Leukoencephalopathies blood, Stroke blood
- Abstract
Objective: Increasing white matter hyperintensity (WMH) burden is linked to risk of stroke and poor post-stroke outcomes. While the biology of WMH remains ill-defined, several lines of evidence implicate endothelial dysfunction. In this study, we sought to assess the association between metabolic markers of endothelial dysfunction and WMH severity in patients with acute ischemic stroke (AIS)., Methods: In this retrospective study, consecutive subjects, ≥18 years of age, admitted to our ED with AIS, brain MRI, and blood homocysteine (Hcy) and hemoglobin A1c (HgbA1c) measurements were eligible for this analysis. WMH volume (WMHV) was quantified using a validated semi-automated algorithm and log-transformed for linear regression analyses., Results: There were 809 AIS subjects included (mean age 65.57±14.7, median WMHV 6.25 cm3 (IQR 2.8-13.1)). In univariate analysis, age, female gender, race, ethnicity, systolic blood pressure, history of hypertension, atrial fibrillation, coronary artery disease, prior stroke, and current alcohol and tobacco use (all p<0.05), as well as Hcy (p<0.0001) and HgbA1c levels (p=0.0005) were associated with WMHV. However, only Hcy (β=0.11, p=0.003) and HgbA1c levels (β=0.1, p=0.008) independently predicted WMHV in the multivariate model, along with age (β=0.03, p<0.0001), race (β=0.39, p=0.01), ethnicity (β=-0.11, p=0.03), and current alcohol use (β=0.26, p=0.002)., Conclusions: Elevated levels of Hcy and HgbA1c have been previously linked to endothelial dysfunction related to oxidative stress. The association between Hcy and HgbA1c and WMH burden in AIS suggests that the degree of endothelial dysfunction may be greater in patients with increased WMHV, and may in part explain the relationship between WMHV and poor post-stroke outcomes., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
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20. Comparative sensitivity of computed tomography vs. magnetic resonance imaging for detecting acute posterior fossa infarct.
- Author
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Hwang DY, Silva GS, Furie KL, and Greer DM
- Subjects
- Acute Disease, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prospective Studies, Sensitivity and Specificity, Cerebral Infarction diagnosis, Cranial Fossa, Posterior blood supply, Magnetic Resonance Imaging standards, Tomography, X-Ray Computed standards
- Abstract
Background: Posterior fossa strokes, particularly those related to basilar occlusion, pose a high risk for progression and poor neurological outcomes. The clinical history and examination are often not adequately sensitive or specific for detection., Study Objectives: Because this population stands to benefit from acute interventions such as intravenous and intra-arterial tissue plasminogen activator, mechanical thrombectomy, and intensive monitoring for neurologic deterioration, this study examined the sensitivity of non-contrast head computed tomography (NCCT) for diagnosing posterior fossa strokes in the emergency department., Methods: This study analyzed a prospectively collected database of acute ischemic stroke patients who underwent head NCCT within 30 h of symptom onset and who were subsequently found to have a posterior fossa infarct on brain magnetic resonance imaging (MRI) performed within 6 h of the NCCT., Results: There were 67 patients identified who had restricted diffusion on MRI in the posterior fossa. The National Institutes of Health Stroke Scale (NIHSS) scores ranged from 0 to 36, median 3. Only 28 patients had evidence of infarction on the initial NCCT scan. The timing of NCCT scans ranged from 1.2 to 28.9 h after symptom onset. The sensitivity of NCCT was 41.8% (95% confidence interval 30.1-54.4). The longest period of time between symptom onset and a negative NCCT with a subsequent positive diffusion-weighted imaging MRI was 26.7 h., Conclusions: Head NCCT imaging is frequently insensitive for detecting posterior fossa infarction. Temporal evolution of strokes in this distribution, coupled with beam-hardening artifact, may contribute to this limitation. When a posterior fossa stroke is suspected and the NCCT is non-diagnostic, MRI is the preferred imaging modality to exclude posterior fossa infarction., (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Published
- 2012
- Full Text
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21. Clinical predictors of significant findings on head computed tomographic angiography.
- Author
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Jamshidi S, Kandiah PA, Singhal AB, Resnick JB, Furie KL, Borczuk P, Parry BA, Lev M, Koroshetz WJ, Chang Y, and Nagurney JT
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Headache etiology, Humans, Male, Middle Aged, Movement Disorders, Neurologic Examination, Predictive Value of Tests, Regression Analysis, Retrospective Studies, Vision Disorders etiology, Angiography methods, Brain Diseases diagnostic imaging, Head diagnostic imaging, Tomography, X-Ray Computed methods
- Abstract
Background: Although head computed tomographic angiography (CTA) is a sensitive tool for the evaluation of neurological symptoms in the emergency department (ED), little is known about which clinical signs predict significant CTA findings., Objectives: To identify clinical factors that predict significant findings on head CTA in patients presenting to the ED with neurological complaints., Methods: Retrospective chart review of consecutive adult patients undergoing head CTA over a 6-month period in an urban, tertiary care ED with an annual volume of 76,000. Significant head CTA findings were defined as clinically significant neurological abnormalities undetected by previous imaging studies. Demographics, chief complaint, results of the neurological examinations (NE), and head non-contrast computed tomography (CT) results were used as predictors of significant head CTA. All predictors with a univariate p < 0.2 using Pearson's chi-squared were entered stepwise into a multivariable logistic regression including odds ratios (OR), with inclusion restricted to p < 0.05., Results: Chart review yielded 456 cases; 215 (47%) were male. Mean age was 62 (SD 20) years. There were 189 patients (41%) with abnormal CTAs. Multivariable logistic regression indicated five variables that predicted a clinically significant CTA: abnormal CT (OR 3.72), chief complaint of subarachnoid hemorrhage-type headache (OR 2.30), and motor deficit (OR 2.23), visual deficit (OR 2.23), and other focal deficit (OR 2.18) on NE. A chief complaint of trauma (OR 0.23) predicted a normal CTA., Conclusions: Specific historical and focal neurological findings are useful for predicting clinically significant findings on head CTA., (Copyright © 2011. Published by Elsevier Inc.)
- Published
- 2011
- Full Text
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22. Lack of replication in polymorphisms reported to be associated with atrial fibrillation.
- Author
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Sinner MF, Lubitz SA, Pfeufer A, Makino S, Beckmann BM, Lunetta KL, Steinbeck G, Perz S, Rahman R, Sonni A, Greenberg SM, Furie KL, Wichmann HE, Meitinger T, Peters A, Benjamin EJ, Rosand J, Ellinor PT, and Kääb S
- Subjects
- Aged, Gene Frequency, Genome-Wide Association Study, Humans, Logistic Models, Middle Aged, Polymorphism, Single Nucleotide, Reproducibility of Results, Atrial Fibrillation genetics
- Abstract
Background: Atrial fibrillation (AF) is the most common sustained arrhythmia and has a substantial heritable component. Numerous associations between single nucleotide polymorphisms (SNPs) and AF have been described, but few have been replicated., Objective: We sought to systematically replicate SNPs that are reported to be associated with AF in two large study samples of European descent., Methods: We searched PubMed for studies reporting associations between SNPs and AF published before July 1, 2007. SNPs were genotyped in two independent case-control samples from Germany and the United States. Associations between SNPs and AF were assessed using logistic regression models adjusting for age, sex, and hypertension. A meta-analysis of the results from the two studies was performed., Results: We identified 21 SNPs and the angiotensin-converting enzyme insertion/deletion polymorphism that were reported to be associated with AF in the literature. Nine of these genetic variants were not represented on common genome-wide SNP arrays. We successfully genotyped 21 of these 22 variants in 2,145 cases with AF from the German Competence Network for Atrial Fibrillation and 4,073 controls from the KORA S4 study and 16 variants in 790 cases and 1,330 controls from the Massachusetts General Hospital. None of the SNPs replicated in independent populations with AF., Conclusion: Our results suggest that previously reported associations to AF were likely false positives and highlight the need for systematic replication of genetic associations in large, independent cohorts to accurately detect variants associated with disease., (Copyright © 2011 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
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