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Your search keyword '"Gasper, David J."' showing total 4 results
Start Over Author "Gasper, David J." Publisher elsevier
4 results on '"Gasper, David J."'

1. Contributors

Author

Agnew, Dalen, primary, Armien, Anibal G., additional, Braun, Josephine, additional, Buckles, Elizabeth L., additional, Burek-Huntington, Kathy A., additional, Camus, Alvin C., additional, del Carmen Carmona Muciño, María, additional, Chang, Tylis Y., additional, Church, Molly E., additional, Colegrove, Kathleen M., additional, Conley, Kenneth J., additional, Crespo, Rocio, additional, Delaney, Martha A., additional, Denk, Daniela, additional, de Wit, Martine, additional, Dorrestein, Gerry, additional, Duncan, Mary, additional, Farina, Lisa L., additional, Fenton, Heather, additional, Flint, Mark, additional, França, Monique S., additional, Frasca, Salvatore, additional, Garner, Michael M., additional, Gasper, David J., additional, Henao Duque, Ana María, additional, Higgins, Damien, additional, Höfle, Ursula, additional, Hollinger, Charlotte, additional, Howerth, Elizabeth W., additional, Jiménez Martínez, María Ángeles, additional, Jones, Megan E.B., additional, Juan-Sallés, Carles, additional, Kagan, Rebecca A., additional, Keel, M. Kevin, additional, Kinsel, Michael J., additional, Kinne, Jörg, additional, Landolfi, Jennifer A., additional, Lankton, Julia S., additional, Lombardini, Eric D., additional, Lowenstine, Linda J., additional, Mätz-Rensing, Kerstin, additional, McAloose, Denise, additional, McManamon, Rita, additional, Mena, Alexandria, additional, Miller, Melissa, additional, Mitchell (née Lane), Emily, additional, Nemeth, Nicole M., additional, Newton, Alisa L., additional, Nofs, Sally, additional, Owen, Helen, additional, Origgi, Francesco C., additional, Ossiboff, Robert J., additional, Pessier, Allan P., additional, Raverty, Stephen, additional, Reavill, Drury R., additional, Rideout, Bruce, additional, Rodriguez, Carlos E., additional, Roe, Wendi, additional, Rose, Karrie, additional, Rothenburger, Jamie L., additional, Ryser-Degiorgis, Marie-Pierre, additional, Shivaprasad, H.L., additional, Shilton, Catherine M., additional, Siebert, Ursula, additional, Smith, Dale A., additional, Smolowitz, Roxanna, additional, Spratt, David, additional, St. Leger, Judy, additional, Stacy, Nicole I., additional, Stalis, Ilse H., additional, Stedman, Nancy L., additional, Steinberg, Jennifer, additional, Stidworthy, Mark F., additional, Terio, Karen A., additional, Terrell, Scott P., additional, Treuting, Piper M., additional, Trupkiewicz, John, additional, Viner, Tabitha C., additional, Williams, Bruce H., additional, Wolf, Jeffrey C., additional, Woodburn, Daniel B., additional, and Wünschmann, Arno, additional

Published
2018
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3. Suidae and Tayassuidae

Author

Jiménez Martínez, María Ángeles, primary, Gasper, David J., additional, Carmona Muciño, María del Carmen, additional, and Terio, Karen A., additional

Published
2018
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4. Immunogenicity of trimethoprim/sulfamethoxazole in a macaque model of HIV infection.

Author

Wong YY, Rakasz EG, Gasper DJ, Friedrich TC, and Trepanier LA

Subjects
Animals, Anti-Infective Agents blood, Antioxidants analysis, Ascorbic Acid blood, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes drug effects, Cytochrome-B(5) Reductase blood, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Hypersensitivity prevention & control, Female, Glutathione blood, Interferon-gamma blood, Lipopolysaccharides blood, Lymph Nodes cytology, Lymph Nodes drug effects, Macaca mulatta, Male, Trimethoprim, Sulfamethoxazole Drug Combination blood, Anti-Infective Agents adverse effects, Drug Hypersensitivity pathology, HIV Infections drug therapy, Trimethoprim, Sulfamethoxazole Drug Combination adverse effects
Abstract

Background: Sulfonamide hypersensitivity has a high incidence in HIV infection and correlates with low CD4+ counts, but the mechanisms are not understood. The aims of this study were to determine whether trimethoprim/sulfamethoxazole (TMP/SMX) led to SMX adduct formation, immunogenicity, or signs of drug hypersensitivity in SIV-infected rhesus macaques, and whether differences in antioxidants, pro-inflammatory mediators, or SMX disposition were predictive of drug immunogenicity., Methods: Nine macaques chronically infected with SIVmac239 and 7 non-infected controls were studied. Baseline blood ascorbate, glutathione, IFN-γ, LPS, sCD14, and cytochrome b 5 reductase measurements were obtained, macaques were dosed with TMP/SMX (120mg/kg/day p.o. for 14days), and SMX metabolites, lymph node drug adducts, drug-responsive T cells, and anti-SMX antibodies were measured., Results: Four of 9 of SIV-positive (44%), and 3 of 7 SIV negative (43%) macaques had drug-responsive T cells or antibodies to SMX. Two macaques developed facial or truncal rash; these animals had the highest levels of lymph node drug adducts. Antioxidants, pro-inflammatory mediators, and SMX metabolites were not predictive of drug immunogenicity; however, the Mamu DRB1*0401/0406/0411 genotype was significantly over-represented in immune responders., Conclusions: Unlike other animal models, macaques develop an immune response, and possible rash, in response to therapeutic dosages of TMP/SMX. Studying more animals with CD4+ counts <200cells/μl, along with moderately restricted ascorbate intake to match deficiencies seen in humans, may better model the risk of SMX hypersensitivity in HIV-infection. In addition, the role of Mamu-DRB1 genotype in modeling drug hypersensitivity in retroviral infection deserves further study., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

Published
2016
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