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Severely ill influenza patients are at increased risk of invasive pulmonary aspergillosis (IPA). Previous reports suggest that Coronavirus Disease 2019 (COVID-19) patients may also be at increased risk of IPA. Here we present an Aspergillus co-infection in a COVID-19 immunocompetent patient, complicated by bacteremia and persistent hyperthermia. We describe the challenges in diagnosing IPA in COVID-19 immunocompetent patients and how the patient responded to the treatment., Competing Interests: Authors Anne Haglund, Lone Buus, Steffen Christensen and Lise Kristensen reported no conflicts of interest. Jan Berg Gertsen has over the past 5 years received travel grants from Gilead and Roche, and speaker honoraria from Gilead. Karen Rokkedal Lausch has over the past 5 years received unrestricted research grants and travel grants from Gilead. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (© 2020 The Authors.)