1. Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoylpyrrolato(N,O)]copper(II).
- Author
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Rubino S, Petruso S, Pierattelli R, Bruno G, Stocco GC, Steardo L, Motta M, Passerotto M, Giudice ED, and Gulì G
- Subjects
- Antineoplastic Agents chemistry, Antineoplastic Agents toxicity, Cell Death drug effects, Cell Survival, Crystallography, X-Ray, Dose-Response Relationship, Drug, Flow Cytometry, Formazans pharmacology, Humans, Hydrogen Bonding, Indicators and Reagents pharmacology, Jurkat Cells, Ligands, Magnetic Resonance Spectroscopy, Molecular Conformation, Molecular Structure, Organometallic Compounds chemistry, Organometallic Compounds toxicity, Pyrroles chemistry, Spectrophotometry, Infrared, Antineoplastic Agents chemical synthesis, Copper chemistry, Organometallic Compounds chemical synthesis, Platinum chemistry, Pyrroles chemical synthesis, Pyrroles toxicity
- Abstract
Copper(II) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, 1H and 13C NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of [Cu(II)(2-BZP)2] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes [Cu(II)(2-BZP)2] and [Pt(II)(2-BZP)2] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10 microM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10 microM. While the Pt(II) complexes may have damaged DNA to induce cell death, treatment with the Cu(II) complex did not induce Jurkat cell death.
- Published
- 2004
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