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2 results on '"Gongqiang Wu"'

1. Targeted therapy for leukemia based on nanomaterials

Author

Suying Qian, Cuiping Zheng, Yanfang Wu, Huiyan Huang, Gongqiang Wu, and Junyu Zhang

Subjects
Leukemia, Targeted therapy, Nanomaterials, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Leukemia is a kind of hematopoietic stem cell malignant clonal disease. Drug therapy is the core treatment strategy for leukemia, but the current therapeutic drugs have defects such as low bioavailability, large adverse reactions and inconvenient intravenous administration. Targeted therapy can combine drugs with specific carcinogenic sites on cells to kill cancer cells and avoid damage to normal cells, which has gradually become the mainstream method of leukemia treatment. In addition, nanomedicine delivery systems can significantly improve drug efficacy through controlled size and targeted optimization of drug delivery by modification strategies. Therefore, the targeted treatment of leukemia based on nanomaterials has great research value and application prospect. This paper gives an overview of the current therapeutic strategies for leukemia, and then reviews the cutting-edge targeted therapeutic nanomaterials for leukemia, including organic nanomaterials (mainly carbon-based nanomaterials, lipid materials, polymers, etc.) and inorganic nanomaterials (mainly noble metal nanoparticles, magnetic nanoparticles, hollow mesoporous materials, etc.). The challenges and prospects for the future development of targeted nanomaterials in the treatment of leukemia are also briefly reviewed.

Published
2024
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2. Enhancing therapeutic efficacy of oncolytic vaccinia virus armed with Beclin-1, an autophagic Gene in leukemia and myeloma

Author

Xiaomin Chen, Shibing Wang, Gongqiang Wu, Wenbin Qian, Yu Chen, Aibin Zhang, Yin Tong, Wen Lei, and Nengwen Xu

Subjects
0301 basic medicine, Programmed cell death, Apoptosis, Vaccinia virus, Mice, SCID, Oncolytic vaccinia virus, RM1-950, Virus, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, In vivo, Mice, Inbred NOD, Cell Line, Tumor, medicine, Autophagy, Animals, Humans, Virotherapy, Pharmacology, Oncolytic Virotherapy, SIRT-1, Leukemia, Blood cancers, business.industry, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, Oncolytic virus, Oncolytic Viruses, 030104 developmental biology, Autophagic cell death, chemistry, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Beclin-1, Therapeutics. Pharmacology, Vaccinia, business, Multiple Myeloma
Abstract

Different strategies were taken to make virotherapy more effective at killing cancer cells. Among them, oncolytic virus which arms the therapeutic gene to enhance antitumor activity is a prevalent approach. In this study, a newly developed oncolytic vaccinia virus (OVV) that expresses Beclin-1 (OVV-BECN1) was tested for its in vitro and in vivo oncolytic activity in blood cancer. Results showed that the OVV exhibited higher infectivity for leukemia cells. OVV-BECN1 induced significant apoptosis-independent cell death either in wild-type leukemia and multiple myeloma (MM) cell lines or caspase-3 shRNA leukemia cell lines, and had a superior antitumor activity compared to the parent OVV. Autophagic cell death induced by OVV-BECN1 was demonstrated in vitro and in vivo experiments. Finally, upregulation of SIRT-1, a member of class III histone deacetylases, by OVV-BECN1 resulted in the deacetylation of LC3 and its distribution from the nucleus toward the cytoplasm, which might contribute to induction of autophagy. Overall, our data showed a favorable therapeutic effect of the oncolytic vaccinia virus on blood cancers through oncolytic and autophagic mechanisms, and may therefore constitute a promising and effective therapeutic strategy for treating human leukemia and MM. However, further studies are warranted for its reliable clinical translation.

Published
2020

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