1. Multifunctional composite soluble microneedle patch based on "one stone, three birds" strategy for promoting the healing of infectious wounds.
- Author
-
Yang W, Cao M, Wang W, Diao N, Liu X, Hu Y, Wang X, Sun T, Guo C, and Chen D
- Subjects
- Animals, Mice, Indoles chemistry, Indoles pharmacology, Berberine pharmacology, Berberine chemistry, Berberine administration & dosage, Antioxidants pharmacology, Antioxidants chemistry, Antioxidants administration & dosage, Biofilms drug effects, Solubility, Nanoparticles chemistry, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents administration & dosage, Microbial Sensitivity Tests, Wound Healing drug effects, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents administration & dosage, Needles, Hyaluronic Acid chemistry, Hyaluronic Acid pharmacology, Ginsenosides pharmacology, Ginsenosides chemistry, Ginsenosides administration & dosage, Polymers chemistry, Polymers pharmacology
- Abstract
The colonisation of microorganisms such as bacteria forms a biofilm barrier on the wound's surface, preventing or delaying the penetration of antibacterial drugs. At the same time, continuous bacterial infection can cause oxidative stress and an inflammatory response and hinder angiogenesis, resulting in difficult wound healing. Based on the "one stone, three birds" strategy, a multi-functional nanoparticle composite soluble microneedle was designed and developed to solve this dilemma better. Ginsenoside-liposomes(R-Lipo) were prepared by ginsenoside Rg3, which had the effect of promoting repair, instead of cholesterol, and loaded with berberine (Ber), the antibacterial component of Coptis, together with polydopamine (PDA), which had anti-inflammatory and antioxidant properties, into microneedles based on hyaluronic acid (PDA/R-Lipo@BerMN). PDA/R-Lipo@BerMN tip can penetrate and destroy the integrity of the biofilm, dissolve under the action of hyaluronidase in the skin, and gradually release the drug to achieve rapid antibacterial, anti-inflammatory, antioxidant, and proliferation. As expected, the PDA/R-Lipo@BerMN patch effectively cleared ROS during wound closure, further promoted M2 macrophage polarisation, eradicated bacterial infection, and regulated the immune microenvironment, promoting inflammation suppression, collagen deposition, angiogenesis, and tissue regeneration., Competing Interests: Declaration of Competing Interest All the authors declare no competing interests. There is no any financial or personal relationships that may be perceived as influencing work., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF