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Background: Ongoing research in the dental field has begun to focus on the use of injectable platelet-rich fibrin (I-PRF) as a regenerative tool with the potential to prompt tissue regeneration. In this regard, this systematic scoping review aimed to collect, map, and appraise the in vitro and in vivo studies regarding the role of I-PRF in or soft and hard tissue regeneration in relation to oral and maxillofacial structures., Methods: A systematic electronic search of Medline, Scopus, Web of Science, and Embase databases was performed from 2000 to December 2021 using a combination of keywords. All in vitro and in vivo studies, written in English and concerning the potential role of I-PRF in regenerative dentistry were considered., Results: In total, 18 in vitro studies, 5 animal studies, 6 case reports, and 31 clinical studies have evaluated the effect of I-PRF on oral and maxillofacial soft and hard tissue regeneration. The investigated studies verified the anti-inflammatory, anti-microbial efficacy and the positive effects of I-PRF application for wound, periodontal, bone, cartilage, and pulp regeneration, as well as acceleration in tooth movement during orthodontic treatment., Conclusions: Current literature approves the feasibility of I-PRF application as a promising regenerative adjunct to dental procedures., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/.)

Cone beam computed tomography (CBCT) is being widely used in recent years and has modernized the practice of oral and maxillofacial radiology by its inherent advantages, such as short scanning time, high resolution, and low dose of radiation to the patient. Sialography can be considered as the second step of assessment of space-occupying masses after initial diagnosis with ultrasonography. Sialography is combined with plain radiographs in routine practice. It can also be combined with advanced modalities such as computed tomography (CT), magnetic resonance imaging (MRI), and CBCT. In this report, we describe 3 cases to confirm the feasibility and superiority of sialography using CBCT and 3-dimensional (3D) images in space-occupying lesions of major salivary glands when conventional sialography is not diagnostic or MRI and CT are not easily available or affordable. CBCT sialography and its 3D images can be helpful in the diagnosis of space-occupying lesions of major salivary glands., (Copyright © 2014 Elsevier Inc. All rights reserved.)