Search

At Olkaria II power plant located in Kenya, the brine from the separator is re-injected back into the ground. This study analyzes a flash geothermal-solar hybrid cycle using the working fluids n-butane, n-pentane, cyclopentane, hexamethyldisiloxane and toluene in order to utilize the brine. The studied working fluids have no potential to deplete the ozone or cause global warming. The working fluids were analyzed in terms of net power output and pump power required. This was done by heating Therminol VP-1 fluid to a maximum temperature of 400 °C using the parabolic trough solar collector and varying the working fluids mass flow rate, Therminol VP-1 flow rate and pressure, and the brine pressure and flow rate. They were varied to investigate their effect on the power output of the Organic Rankine Cycle. The working fluid with higher net power output was selected as a suitable working fluid for the hybrid cycle. The selected working fluid was used to determine the average hourly power output in each month of the hybrid system using the irradiance of Olkaria II power station. N-butane showed the best results in net power output hence it was selected as a suitable working fluid as compared to the other working fluids. When the hybrid system was analyzed using n-butane to obtain the hourly average power output in each month, the results revealed that the month of February has the highest hourly average power output where the Steam Turbine has an average hourly power output of 10.48 MW and Binary Turbine net power output of 18.56 MW. The minimum average hourly power output was obtained in the month of June where the Steam Turbine has an average hourly power output of 9.08 MW and Binary Turbine net power output of 16.88 MW.

The main objective of this project was to formulate novel decorated amphiphilic PLGA nanoparticles aiming for the selective delivery of the novel peptide (CK-10) to the cancerous/tumor tissue. Novel modified microfluidic techniques were used to formulate the nanoparticles. This technique was modified by using of Nano Assemblr associated with salting out of the organic solvent using K 2 HPO 4 . This modification is associated with higher peptide loading efficiencies, smaller size and higher uniformity. Size, zeta potential & qualitative determination of the adsorbed targeting ligands were measured by dynamic light scattering and laser anemometry techniques using the zeta sizer. Quantitative estimation of the adsorbed targeting ligands was done by colorimetry and spectrophotometric techniques. Qualitative and quantitative uptakes of the various PLGA nanoparticles were examined by the fluorescence microscope and the flow cytometer while the cytotoxic effect of the nanoparticles was measured by the colorimetric MTT assay. PLGA/poloxamer.FA, PLGA/poloxamer.HA, and PLGA/poloxamer.Tf have breast cancer MDA. MB321 cellular uptakes 83.8, 75.43 & 69.37 % which are higher than those of the PLGA/B cyclodextrin.FA, PLGA/B cyclodextrin.HA and PLGA/B cyclodextrin.Tf 80.87, 74.47 & 64.67 %. Therefore, PLGA/poloxamer.FA and PLGA/poloxamer.HA show higher cytotoxicity than PLGA/ poloxamer.Tf with lower breast cancer MDA-MB-231 cell viabilities 30.74, 39.15 & 49.23 %, respectively. The design of novel decorated amphiphilic CK-10 loaded PLGA nanoparticles designed by the novel modified microfluidic technique succeeds in forming innovative anticancer formulations candidates for therapeutic use in aggressive breast cancers., Competing Interests: Conflict of Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.)