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Start Over Author "Hong-Feng, Jiang" Publisher elsevier
1 results on '"Hong-Feng, Jiang"'

1. The establishment of a homozygous SNTA1 knockout human embryonic stem cell line (WAe009-A-50) using the CRISPR/Cas9 system

Author

Tao Dong, Siyao Zhang, Yun Chang, Rui Bai, Youxu Jiang, Shuhong Ma, Ya'nan Li, Hong Feng Jiang, and Wen-Jing Lu

Subjects
Biology (General), QH301-705.5
Abstract

SNTA1 encodes α1-syntrophin, a scaffold protein, which is a component of the dystrophin-associated protein complex. Additionally, α1-syntrophin interacts with SCN5A and nNOS–PMCA4b complex in cardiomyocytes. SNTA1 is a susceptibility locus for arrhythmia and cardiomyopathy. We generated a homozygous SNTA1 knockout human embryonic stem cell (H9SNTA1KO) using the CRISPR/Cas9 system. H9SNTA1KO maintained pluripotency and a normal karyotype and differentiated into three germ layers in vivo.

Published
2021
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