9 results on '"Houshyar, Shadi"'
Search Results
2. List of Contributors
- Author
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Annaheim, Simon, primary, Bansal, Payal, additional, Camenzind, Martin, additional, Chatterjee, Kalesh Nath, additional, Choudhary, Awadhesh Kumar, additional, Gao, Chuansi, additional, Goyal, Ashvani, additional, Houshyar, Shadi, additional, Hovgaard, Elspa M., additional, Jhanji, Yamini, additional, Kadam, Vinod, additional, Khanna, Shelly, additional, Kuklane, Kalev, additional, Li, Jun, additional, Lu, Yehu, additional, Mandal, Sumit, additional, Manocha, Amandeep, additional, Mishra, Rajesh, additional, Nayak, Rajkishore, additional, Patnaik, Asis, additional, Psikuta, Agnes, additional, Rossi, René M., additional, Sikka, Monica P., additional, Wang, Yong-Rong, additional, Zakaria, Norsaadah, additional, and Zhai, Lina, additional
- Published
- 2017
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3. Polypropylene-nanodiamond composite for hernia mesh.
- Author
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Houshyar S, Sarker A, Jadhav A, Kumar GS, Bhattacharyya A, Nayak R, Shanks RA, Saha T, Rifai A, Padhye R, and Fox K
- Subjects
- Adsorption, Animals, Biocompatible Materials pharmacology, CHO Cells, Cattle, Cell Proliferation drug effects, Cricetinae, Cricetulus, Elastic Modulus, Plasma Gases chemistry, Serum Albumin, Bovine chemistry, Surface Properties, Biocompatible Materials chemistry, Nanodiamonds chemistry, Polypropylenes chemistry, Surgical Mesh
- Abstract
Commercial hernia mesh is commonly made from polypropylene (PP), due to its inertness, biocompatibility, physical properties, ease of processing and versatility for conversion into flexible shape. However, reportedly hernia mesh prepared from PP experienced issues such as diminished long-term strength, foreign body rejection, lack of biocompatibility and high adhesion to the abdomen wall. Infiltration of the mesh by soft tissue (called remodeling) results in an integration of mesh into the body, leading to a rapid reduction in mesh mechanical properties and potential infection. Here, this study addresses these issues through the incorporation of nanodiamond (ND) into PP filament and coating on the surface of plasma-treated PP-ND mesh. The results show that the dynamic modulus of the PP-ND mesh increased significantly, without compromising its flexibility. Coating PP-ND mesh with hydroxylated ND led to a reduction in nonspecific protein adsorption onto the surface of nanocomposite, which is an important characteristic for hernia mesh to prevent foreign body reaction, attachment of mesh to the abdominal wall and nearby organs. In-vitro study with mammalian cells shows that coated PP-ND mesh with functionalized ND exhibits a significant increase in the number of adhered cells with more elongated morphology in comparison with other PP meshes, due to the better hydrophilicity. Therefore, the ND coated nanocomposite mesh can be a promising candidate for hernia repair in the future; however, more investigation is required., Competing Interests: Declaration of competing interest There are no conflicts of interest to declare., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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4. Effect of nanocomposite coating and biomolecule functionalization on silk fibroin based conducting 3D braided scaffolds for peripheral nerve tissue engineering.
- Author
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Pillai MM, Kumar GS, Houshyar S, Padhye R, and Bhattacharyya A
- Subjects
- Cell Line, Tumor, Cell Proliferation physiology, Humans, Microscopy, Confocal, Caproates chemistry, Carbon chemistry, Fibroins chemistry, Lactones chemistry, Nanocomposites chemistry, Nanofibers chemistry, Silk chemistry, Tissue Engineering methods, Tissue Scaffolds chemistry
- Abstract
In this work, the effects of carbon nanofiber (CNF) dispersed poly-ε-caprolactone (PCL) nanocomposite coatings and biomolecules functionalization on silk fibroin based conducting braided nerve conduits were studied for enhancing Neuro 2a cellular activities. A unique combination of biomolecules (UCM) and varying concentrations of CNF (5, 7.5, 10% w/w) were dispersed in 10% (w/v) PCL solution for coating on degummed silk threads. The coated silk threads were braided to develop the scaffold structure. As the concentration of CNF increased in the coating, the electrical impedance decreased up to 400 Ω indicating better conductivity. The tensile and dynamic mechanical property analysis showed better mechanical properties in CNF coated samples. In vitro cytocompatibility analysis proved the non-toxicity of the developed braided conduits. Cell attachment, growth and proliferation were significantly enhanced on the biomolecule functionalized nanocomposite coated silk braided structure, exhibiting their potential for peripheral nerve regeneration and recovery., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2020
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5. Performance analysis of grafted poly (2-methacryloyloxyethyl phosphorylcholine) on additively manufactured titanium substrate for hip implant applications.
- Author
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Ghosh S, Abanteriba S, Wong S, and Houshyar S
- Subjects
- Alloys, Biocompatible Materials chemistry, Calorimetry, Differential Scanning, Hip Joint physiopathology, Hot Temperature, Humans, Materials Testing, Phosphorylcholine chemistry, Polyethylene chemistry, Polymers chemistry, Prosthesis Design, Prosthesis Failure, Stress, Mechanical, Surface Properties, Thermogravimetry, Arthroplasty, Replacement, Hip instrumentation, Hip Prosthesis, Methacrylates chemistry, Phosphorylcholine analogs & derivatives, Titanium chemistry
- Abstract
The incidence of total hip arthroplasty (THA) has been evidently growing over the last few decades. Surface modification, such as polymer grafting onto implant surfaces using poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC), has been gaining attention due to its excellent biocompatibility and high lubricity behaviour resulting in reducing surgical recurrence number and increasing implant lifetime. Investigating thermal stability and mechanical properties of the grafted polymer is, therefore, extremely important as these properties define the failure mechanism of implants. This study focuses on optimising monomer concentration to achieve the best physical, thermal and mechanical properties of the grafted additively manufactured titanium (Ti6Al4V) implants. Three different concentration of monomers, 0.4 M, 0.6 M and 0.8 M, were investigated, and grafted implants were characterised. The results from thermal analysis confirmed that the PMPC polymer is thermally stable for implant applications regardless of the monomer concentrations. A significant reduction in Young's modulus of polymer grafted samples (33.2-42.9%), in comparison with untreated Ti6Al4V samples and consequent improvement of wear resistance and elasticity behaviour, proved the potentiality of polymer films for implant applications. In summary, polymer grafted implant prepared with 0.6 M monomer concentration showed the optimal thermal, physical and wear resistance properties., (Copyright © 2019. Published by Elsevier Ltd.)
- Published
- 2019
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6. Optimisation of grafted phosphorylcholine-based polymer on additively manufactured titanium substrate for hip arthroplasty.
- Author
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Ghosh S, Abanteriba S, Wong S, Brkljača R, and Houshyar S
- Subjects
- Arthroplasty, Replacement, Hip methods, Humans, Methacrylates chemistry, Phosphorylcholine analogs & derivatives, Phosphorylcholine chemistry, Polymers chemistry, Titanium chemistry
- Abstract
Despite the tremendous acceptance of additively manufactured (AM) Titanium alloys (Ti6Al4V) in the field of biomedical engineering, the high surface roughness due to partially-melted particles (fabricated in selective laser melting (SLM) process), limits their uses as hip implants. The objective of this study, therefore, is to modify the SLM fabricated Ti6Al4V implant interfaces with 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer, in the hope of enhancing surface properties and preventing the attachment of the cell simultaneously without affecting the mechanical properties significantly. Three different monomer concentrations were examined to determine the influence of monomer concentrations on polymerisation rate, chain length, and surface properties of the implants. Samples grafted with 0.6 M monomer concentration showed more uniform surface and less surface roughness in comparison with other samples and untreated Ti6Al4V surfaces. 0.6 M monomer concentration was found to be the best option for grafting PMPC to the hip implant interfaces because of its improved surface morphology, surface roughness, polymerisation rate, penetration depth and hardness results. Moreover, cell study on optimal surfaces revealed that PMPC grafted surfaces prevent the implant interfaces from uncontrollable cell attachment which is of utmost importance in smoothing the motion of the hip implant under cyclic loading. Overall, the PMPC grafting demonstrated the potentiality of its application on SLM Ti6Al4V substrate for improved hip arthroplasty performance., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
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7. Nanodiamond/poly-ε-caprolactone nanofibrous scaffold for wound management.
- Author
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Houshyar S, Kumar GS, Rifai A, Tran N, Nayak R, Shanks RA, Padhye R, Fox K, and Bhattacharyya A
- Subjects
- Animals, CHO Cells, Calorimetry, Differential Scanning, Cell Proliferation, Cricetinae, Cricetulus, Nanodiamonds ultrastructure, Nanofibers ultrastructure, Spectroscopy, Fourier Transform Infrared, Staphylococcus aureus drug effects, Thermogravimetry, Nanodiamonds chemistry, Nanofibers chemistry, Polyesters pharmacology, Tissue Scaffolds chemistry, Wound Healing drug effects
- Abstract
We describe preparation, characterization and cytocompatibility of nanodiamond (ND) dispersed in poly (ε-caprolactone) (PCL) based nanofibrous scaffold. The results show that this unique scaffold potentially provides essential properties for wound healing by enhancing proliferation of epithelial cells, in addition to restricting the microbial activities. Electrospinning technique was used to fabricate and develop PCL-NDs nanocomposite scaffold. The developed nanocomposites were characterized for morphology, thermal, surface and biological properties. The incorporation of ND into the PCL matrix resulted in better moisture management and higher thermal stability. Transmission electron microscopy images and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy showed existence of ND particles on the surface of the nanofibers. The aggregation of ND particles increased with the increase in their concentration in nanofiber. The developed scaffolds showed no cytotoxicity and, due to improved hydrophilicity, better cellular activities with Chinese hamster ovarian (CHO) cells, 43%, 38% and 22% more cell proliferation for PCL-5% ND for 1, 3- and 7-days incubations in compare with PCL. Furthermore, Staphylococcus aureus (S. aureus) showed significantly less affinity to the scaffold surface with the increase in ND concentration, ~56% less for PCL-5% ND in compare with PCL, indicating that such ND dispersed nanofibrous scaffold maybe asuitable choice for complex wound management., (Crown Copyright © 2019. Published by Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
8. Selective laser melted titanium alloys for hip implant applications: Surface modification with new method of polymer grafting.
- Author
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Ghosh S, Abanteriba S, Wong S, and Houshyar S
- Subjects
- Adhesiveness, Adsorption, Alloys, Osseointegration drug effects, Phase Transition, Phosphorylcholine chemistry, Phosphorylcholine pharmacology, Polymethacrylic Acids pharmacology, Serum Albumin chemistry, Wettability, Hip Prosthesis, Lasers, Phosphorylcholine analogs & derivatives, Polymethacrylic Acids chemistry, Titanium chemistry
- Abstract
A significant number of hip replacements (HR) fail permanently despite the success of the medical procedure, due to wear and progressive loss of osseointegration of implants. An ideal model should consist of materials with a high resistance to wear and with good biocompatibility. This study aims to develop a new method of grafting the surface of selective laser melted (SLM) titanium alloy (Ti-6Al-4V) with poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC), to improve the surface properties and biocompatibility of the implant. PMPC was grafted onto the SLM fabricated Ti-6Al-4V, applying the following three techniques; ultraviolet (UV) irradiation, thermal heating both under normal atmosphere and UV irradiation under N
2 gas atmosphere. Scanning electron microscopy (SEM), 3D optical profiler, energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FTIR) were used to characterise the grafted surface. Results demonstrated that a continuous PMPC layer on the Ti-6Al-4V surface was achieved using the UV irradiation under N2 gas atmosphere technique, due to the elimination of oxygen from the system. As indicated in the results, one of the advantages of this technique is the presence of phosphorylcholine, mostly on the surface, which reveals the existence of a strong chemical bond between the grafted layer (PMPC) and substrate (Ti-6Al-4V). The nano-scratch test revealed that the PMPC grafted surface improves the mechanical strength of the surface and thus, protects the underlying implant substrate from scratching under high loads., (Copyright © 2018 Elsevier Ltd. All rights reserved.)- Published
- 2018
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9. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children.
- Author
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Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, and Gelernter J
- Subjects
- Adolescent, Case-Control Studies, Chi-Square Distribution, Child, Child, Preschool, DNA Mutational Analysis methods, Female, Gene Frequency, Genetic Variation, Genotype, Humans, Male, Methionine genetics, Predictive Value of Tests, Psychiatric Status Rating Scales statistics & numerical data, Risk Factors, Severity of Illness Index, Social Support, Surveys and Questionnaires, Valine genetics, Brain-Derived Neurotrophic Factor genetics, Child Abuse psychology, Depression genetics, Depression psychology, Environment, Serotonin Plasma Membrane Transport Proteins genetics
- Abstract
Background: Child abuse and genotype interact to contribute to risk for depression in children. This study examined gene-by-gene and gene-by-environment interactions., Methods: The study included 196 children: 109 maltreated and 87 nonmaltreated comparison subjects. Measures of psychiatric symptomatology and social supports were obtained using standard research instruments, and serotonin transporter (5-HTTLPR) (locus SLC6A4) and brain-derived neurotrophic factor (BDNF) (variant val66met) genotypes were obtained from saliva-derived DNA specimens. Population structure was controlled by means of ancestral proportion scores computed based on genotypes of ancestry informative markers in the entire sample., Results: There was a significant three-way interaction between BDNF genotype, 5-HTTLPR, and maltreatment history in predicting depression. Children with the met allele of the BDNF gene and two short alleles of 5-HTTLPR had the highest depression scores, but the vulnerability associated with these two genotypes was only evident in the maltreated children. A significant four-way interaction also emerged, with social supports found to further moderate risk for depression., Conclusions: To the best of our knowledge, this is the first investigation to demonstrate a gene-by-gene interaction conveying vulnerability to depression. The current data also show a protective effect of social supports in ameliorating genetic and environmental risk for psychopathology.
- Published
- 2006
- Full Text
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