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Chemical investigation of Carthamus tinctorius L. flowers resulted in isolation of seven metabolites that were identified as; p-Hydroxybenzoic acid (1), trans hydroxy cinnamic acid (2), kaempferol-6-C-glucoside (3), astragalin (4), cartormin (5), kaempferol-3-O-rutinoside (6), and kaempferol–3-O-sophoroside (7). Virtual screening of the isolated compounds against human intestinal α-glucosidase, acetylcholinesterase, and butyrylcholinesterase was carried out. Additionally, the antioxidant activity of the bioactive compounds was assessed. Compounds 1 and 5 exhibited moderate binding affinities to acetylcholinesterase (binding energy −5.33 and −4.18 kcal/mol, respectively), compared to donepezil (-83.33kcal/mol). Compounds 1–7 demonstrated weak affinity to butyrylcholinesterase. Compounds 2 and 4 displayed moderate binding affinity to human intestinal α-glucosidase,compared to Acarbose (reference compound), meanwhile compound 2 exhibited lower affinity. Molecular dynamic studies revealed that compound 4 formed a stable complex with the binding site throughout a 100 ns simulation period. The in-vitro results were consistent with the virtual experimental results, as compounds 1 and 5 showed mild inhibitory effects on acetylcholinesterase (IC50s 150.6 and 168.7 µM, respectively). Compound 4 exhibited moderate α-glucosidase inhibition with an IC50 of 93.71 µM. The bioactive compounds also demonstrated notable antioxidant activity in ABTS [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)], ORAC (oxygen radical-absorbance capacity), and metal chelation assays, suggesting their potential in improving dementia in Alzheimer’s disease (AD) and mitigating hyperglycemia.

Fiscal compensation may play either an incentive or a crowding-out role in the different enterprises of the PV industry. First, a model for evaluating the efficiency of fiscal compensation was designed. Then, an empirical analysis of the influencing factors using a panel data model was made. Results showed that fiscal compensation had an incentive effect on 73.3 % of enterprises, but it had a crowding-out effect on the remaining enterprises. The average efficiency of fiscal compensation for enterprises in the PV industry is 1.117. The average efficiency of fiscal compensation for the front-end and back-end enterprises was 1.002 and 1.231, respectively. The impact of fiscal compensation on China's photovoltaic industry has shown a downward trend over time, and the role has also changed from an incentive effect to a crowding-out effect. The size of the enterprise and the intensity of fiscal compensation will affect the efficiency of fiscal compensation. There is an inverted U-shaped relationship between the intensity of fiscal compensation in China's photovoltaic industry and the efficiency of fiscal compensation. The larger the enterprise, the more efficient the fiscal compensation will be.

The current study explored the protective potential of kaempferol 3-sophoroside-7-glucoside (KSG) against acute lung injury (ALI). Pre-treatment with KSG effectively secured mice from ALI and showed similar efficaciousness to dexamethasone. KSG markedly increased the survival rate and alleviated lung pathological lesions induced by lipopolysaccharide (LPS). Furthermore, KSG attenuated differential and total cell counts in BALF (bronchoalveolar lavage fluid) and MPO (myeloperoxidase) activity. KSG counteracted the NF-κB (nuclear factor-κB) activation and significantly ameliorated the downstream inflammatory cytokine, TNF-α (tumor necrosis factor-α). Simultaneously, KSG suppressed the over-expression of NLRP3 (NOD-like receptor protein 3), caspase-1, and pro-inflammatory cytokine interleukin IL-1β (interleukine-1β) and prohibited the elevation of the pyroptotic parameter GSDMD-N (N-terminal domain of gasdermin D) induced by LPS challenge. In addition, KSG significantly enhanced Nrf2 (nuclear-factor erythroid-2-related factor) and HO-1 (heme-oxygenase-1) expression. Meanwhile, KSG mitigated lipid peroxidative markers (malondialdehyde, protein carbonyl and 4-hydroxynonenal) and boosted endogenous antioxidants (superoxide dismutase/reduced glutathione/catalase) in lung tissue. In silico analyses revealed that KSG disrupts Keap1-Nrf2 protein–protein interactions by binding to the KEAP1 domain, consequently activating Nrf2. Specifically, molecular docking demonstrated superior binding affinity of KSG to KEAP1 compared to the reference inhibitor, with docking scores of −9.576 and −6.633 Kcal/mol, respectively. Additionally, the MM-GBSA binding free energy of KSG (−67.25 Kcal/mol) surpassed that of the reference inhibitor (−56.36 Kcal/mol). Furthermore, MD simulation analysis revealed that the KSG-KEAP1 complex exhibits substantial and stable binding interactions with various amino acids over a duration of 100 ns. These findings showed the protective anti-inflammatory and anti-oxidative modulatory efficiencies of KSG that effectively counteracted LPS-induced ALI and encouraged future research and clinical applications of KSG as a protective strategy for ALI.

The rise of antibiotic resistance in bacteria is becoming a global concern, particularly due to the dwindling supply of new antibiotics. This situation mandates the discovery of new antimicrobial candidates. Plant-derived natural compounds have historically played a crucial role in the development of antibiotics, serving as a rich source of substances possessing antimicrobial properties. Numerous studies have supported the reputation of 6-gingerol, a prominent compound found in the ginger family, for its antibacterial properties. In this study, the antibacterial activities of 6-gingerol were evaluated against Gram-negative bacteria, Acinetobacter baumannii and Klebsiella pneumoniae, with a particular focus on the clinically significant Gram-negative Pseudomonas aeruginosa and Gram-positive bacteria Staphylococcus aureus. Furthermore, the anti-virulence activities were assessed in vitro, in vivo, and in silico. The current findings showed that 6-gingerol’s antibacterial activity is due to its significant effect on the disruption of the bacterial cell membrane and efflux pumps, as it significantly decreased the efflux and disrupted the cell membrane of S. aureus and P. aeruginosa. Furthermore, 6-gingerol significantly decreased the biofilm formation and production of virulence factors in S. aureus and P. aeruginosa in concentrations below MICs. The anti-virulence properties of 6-gingerol could be attributed to its capacity to disrupt bacterial virulence-regulating systems; quorum sensing (QS). 6-Gingerol was found to interact with QS receptors and downregulate the genes responsible for QS. In addition, molecular docking, and molecular dynamics (MD) simulation results indicated that 6-gingerol showed a comparable binding affinity to the co-crystalized ligands of different P. aeruginosa QS targets as well as stable interactions during 100 ns MD simulations. These findings suggest that 6-gingerol holds promise as an anti-virulence agent that can be combined with antibiotics for the treatment of severe infections.

Industrial development is the prerequisite for sustainable economic growth. This study has examined the impact of the interest rate imposed on advances in the small and medium enterprise (SME) industrial sector, the large industrial (LI) sector, and inflation on the total industrial development of Bangladesh. For this purpose, we have used monthly data from January 2015 to June 2021. The weighted average interest rate of advances (WAIRA) is used as a substitute for the interest rate imposed on advances that were sourced from Bangladesh Bank (BB). We have applied Johansen co integration and the VECM technique to investigate long- and short run relationships, and the results have revealed the existence of both. We have observed that, in the short run, only WAIRA on SME industries has a significant negative impact on total industrial development. In the long run, inflation and WAIRA on SME and large industry have a significant impact on industrial development. The long run relationships have indicated that, inflation and WAIRA in the SME sector have a negative influence on total industrial development, but WAIRA in the large industry (LI) sector has a positive influence. Finally, considering the entire situation of the economy of Bangladesh, especially the growing industrial sector, these findings are highly momentous for policy implications and achieving sustainable development in this sector.

The China-Europe Railway Express (CRexpress) has established a new land transportation route between Asia and Europe as part of China’s westward expansion. The resulting trade promotion effect has the potential to improve industrial development and factor flows, ultimately leading to a reduction in the income disparity between urban and rural areas in cities that use the CRexpress. The impact of the CRexpress on income disparities between urban and rural areas in cities that use the service is of particular interest, as the empirical evidence on the relationship between international trade and these disparities is inconsistent. Using a difference-in-differences model and macro panel data, this study found that the CRexpress significantly narrowed the urban-rural income gap in cities where it was operational, and that this effect had a spillover effect on nearby cities. However, the magnitude of this effect decreased with distance. The mechanism analysis indicated that the CRexpress narrowed the income gap by promoting secondary industry development, but this effect varied significantly by region, with pronounced effects in eastern coastal cities and less pronounced effects in inland cities in the central and western region. The study suggests that local governments in these regions should focus on improving the institutional environment and providing industrial support to promote industrial transfer in order to narrow the urban-rural income gap and promote overall economic development.

Based on the research and development (R&D) state of prefabricated buildings, this paper establishes an evolutionary game model involving such three parties as latecomer prefabricated building firm (LPBF), related firm, and university-research institute, and simulates the evolutionary results of the game to determine the evolutionarily stable strategy (ESS) of the game. The results show that: In the tripartite system evolution, the evolution and trend of each party are closely related with the strategies chosen by the other two parties; eventually, the LPBF strategy always converges to R&D, while the strategies of related firm, and university-research institute always converge to cooperation in R&D. Whether the game system converges to the desired equilibrium state hinges on the R&D profit and cost of, and opportunistic profit from subsequent cooperation with the LPBF. During the development of prefabricated buildings, the game parties should promote the high-quality development of the industry by stepping up technological R&D, forging a complete industrial chain, and implementing industry-university-research cooperation.

Impacted by large-scale and rapid rural industrialization in the past few decades, China's rural settlements are confronted with the risk of heavy metal pollution stemming from industrial production, which might pose a significant threat to the rural habitat and the well-beings. This study devised a relative risk model for industrial heavy metal pollution to the rural settlements based on the source-pathway-receptor risk theory. Using this model, we assessed the risk magnitudes of heavy metal pollution from industrial production at a 10 km × 10 km grid scale and identified the characteristics of the risk pattern in China. Our finding reveals: (1) the relative risk values of wastewater, waste gas and total heavy metal pollution are notably concentrated within a confined spectrum, with only a small number of units are characterized by high-risk level; (2) Approximately 21.57 % of China's rural settlements contend with heavy metal pollution, with 4.17 %, 9.84 % and 7.55 % being subjected to high, medium and low risks, respectively; (3) The high-risk units mainly is concentrated in the developed areas such as Yangtze River Delta, Pearl River Delta, and the Beijing-Tianjin metropolitan area, also dispersed in the plain areas with high rural population density. Guided by these insights, this study puts forth regionally tailored prevention and control strategies, as well as distinct process prevention and control strategies., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

As the main source of electricity from renewable energy, PV will play a key role in various fields and scenarios to achieve carbon neutrality. With technological advances in the photovoltaic industry and declining costs per kilowatt-hour, the cost of photovoltaic per kilowatt-hour has fallen by more than 90% globally in the past decade, with the biggest decline compared to wind, natural gas, coal and nuclear power. The year 2020 has been an extraordinary year. Under the pressure test and numerous challenges of the global epidemic, the global photovoltaic industry has maintained a good momentum of development thanks to the rapid and effective control of the COVID-19 in China and the obvious growth of the domestic market. Based on the domestic monocrystalline silicon photovoltaic leading A company as an example, through to the company business model and the results of data analysis in recent years, suggested that the company in the four aspects to carry on the improvement and optimization, including: further globalization, adhere to customer value orientation, implement the product strategy and tries to build up A creative organization, leading to the photovoltaic industry as A whole in China benign development help.

This study evaluates the relationship between industrial development, urbanization and pollution emission in Africa. The IPAT identity was used to examine the impact of industrial development and urbanization on pollution emissions. The validity of the existence of the Environmental Kuznets Curve (EKC) and the Pollution Haven Hypothesis (PHH) was also tested by comparing the econometric results of panel Pool Mean Group (PMG)-based autoregressive distributed lag (ARDL) for the period 1990-2019. The PMG results confirm the validity of the EKC and PHH in the countries under study in the long run when the entire panel was estimated. One of the major contributions of the study is to analyze the impact of urbanization and industrialization on carbon emissions. The results show that an increase in urbanization and industrialization leads to an increase in environmental degradation for the entire panel. This paper presents significant contributions to economic policy, showing that an association exists between industrial development, urbanization and pollution emission in Africa.

Our world is facing continued challenges of environmental and ecological pollutions due to human and industrial activities. One of the major threats is oily wastewater mainly discharged from oil fields, refineries, automobile, palm oil industries, and many others. Membrane-based technology offers an almost complete separation of oil from water. However, the technology is facing the challenge of maintaining performance over long periods of operation caused by membrane fouling as a result of interaction between oil droplets and the membrane surface. This attracts research interest mainly on developing customized polymeric, ceramic well as a metallic-based membrane material for improved performance. This paper reviews the recent advances of membrane material developments with the focus on methods of improving the surface chemistry, structure, and hydrodynamics and their implication on the filtration performances.

Industrial development has resulted in economic progress and the well-being of the society. At the same time, the impact of the industrial complex has disrupted the environment and resulted in climate change related impacts. The purpose of this study was to carry out an exploratory diagnosis and propose a technological change and sustainable industrial development index at the international level. Therefore, a network study was conducted to identify the main nodes and thematic clusters associated with cleaner production. A patent analysis was applied to technologies related three selected/relevant areas of cleaner production, i.e. carbon footprint, wastewater treatment, and renewable energy. Additionally, based on factor analysis, an index including different indicators related to scientific, technological, economic, environmental, and social issues was developed and proposed in this study., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

It is believed that polysaccharides will become a focal point for future production of food, pharmaceuticals, and materials due to their ubiquitous and renewable nature, as well as their exceptional properties that have been extensively validated in the fields of nutrition, healthcare, and materials. Sulfated polysaccharides derived from seaweed sources have attracted considerable attention owing to their distinctive structures and properties. The genus Codium, represented by the species C. fragile, holds significance as a vital economic green seaweed and serves as a traditional Chinese medicinal herb. To date, the cell walls of the genus Codium have been found to contain at least four types of sulfated polysaccharides, specifically pyruvylated β-d-galactan sulfates, sulfated arabinogalactans, sulfated β-l-arabinans, and sulfated β-d-mannans. These sulfated polysaccharides exhibit diverse biofunctions, including anticoagulant, immune-enhancing, anticancer, antioxidant activities, and drug-carrying capacity. This review explores the structural and biofunctional diversity of sulfated polysaccharides derived from the genus Codium. Additionally, in addressing the impending challenges within the industrialization of these polysaccharides, encompassing concerns regarding scale-up production and quality control, we outline potential strategies to address these challenges from the perspectives of raw materials, extraction processes, purification technologies, and methods for quality control., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)

The Red Sea has been recognized as a coral reef refugia, but it is vulnerable to warming and pollution. Here we investigated the spatial and temporal trends of 15 element concentrations in 9 coral reef sediment cores (aged from the 1460s to the 1980s AD) to study the influence of global warming and industrialization on the Eastern Red Sea coral reefs. We found Na, Ca, Cr, Fe, Co, Ni, and Sr concentrations were higher in the northern Red Sea (i.e., Yanbu), whereas Mg, P, S, Mn, and Cd concentrations were higher in the southern Red Sea (i.e., Thuwal & Al Lith) reef sediments. In the central (i.e., Thuwal) to southern (i.e., Al Lith) Red Sea, the study revealed diverse temporal trends in element concentrations. However, both reef sedimentation rates (-36.4 % and -80.5 %, respectively) and elemental accumulation rates (-49.4 % for Cd to -12.2 % for Zn in Thuwal, and -86.2 % for Co to -61.4 % for Cu in Al Lith) exhibited a declining pattern over time, possibly attributed to warming-induced thermal bleaching. In the central to northern Red Sea (i.e., Yanbu), the severity of thermal bleaching is low, while the reef sedimentation rates (187 %), element concentrations (6.7 % for S to 764 % for Co; except Na, Mg, Ca, Sr, and Cd), and all elemental accumulation rates (190 % for Mg to 2697 % for Co) exponentially increased from the 1970s, probably due the rapid industrialization in Yanbu. Our study also observed increased trace metal concentrations (e.g., Cu, Zn, and Ni) in the Thuwal and Al Lith coral reefs with severe bleaching histories, consistent with previous reports that trace metals might result in decreased resistance of corals to thermal stress under warming scenarios. Our study points to the urgent need to reduce the local discharge of trace metal pollutants to protect this biodiversity hotspot., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

This study examines the determinants of the ecological footprint of production in European countries from 1992 to 2020. Using partial and semipartial correlation analyses and Bayesian Model Averaging (BMA) approach for the first time, the research identifies key variables affecting ecological footprint. Using Bayesian methods, posterior inclusion probabilities (PIPs) were calculated for each variable's coefficient estimates, revealing their relative importance. Biocapacity, energy consumption, industrialization, financial development, life expectancy, and globalization displayed notably high PIPs, indicating their strong influence on the ecological footprint. In addition, the study employs cointegration tests to examine the long-run relationship between ecological footprint and explanatory variables. The results indicate significant cointegration between these variables across panels, supported by various test statistics. In the Weighted Pooled DOLS estimation, biocapacity, energy consumption, and life expectancy significantly influence the ecological footprint, while industrialization, financial development, and globalization exert a comparatively smaller impact. Researchers and policymakers should consider these determinants for effective sustainable development planning. These findings underscore the intricate interplay of factors shaping the ecological footprint and offer insights for effective policy interventions towards sustainable development., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The fast development of urbanisation and industrialisation has led to a rise in nitrogen oxide (NO x ) emissions, specifically nitric oxide (NO). One effective method for reducing the harmful effects of this dangerous air pollutant on both human health and the environment is the photocatalytic oxidation of NO. Z-scheme heterojunctions enhance incident light utilisation and increase photocatalytic activity, eventually leading to better NO oxidation performance by encouraging the effective separation of charges and migration. A comprehensive discussion of Z-scheme-based heterojunctions is provided in this review paper, with a focus on their applications in the photocatalytic oxidation of NO. Significant progress has been made in the fabrication of efficient photocatalytic devices in recent years, with Z-scheme-based heterojunctions proving to be particularly successful. The review looks into the various methodologies used to create Z-scheme-based heterojunctions as well as photocatalytic NO oxidation mechanisms. Recent studies on photocatalysts employing Z-scheme heterojunctions for the photocatalytic oxidation of NO are also discussed. The possibilities for new opportunities as well as the present challenges, barriers, advances, and solutions have been emphasized., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)

With increasing human population, large scale climate changes, and the interaction of multiple stressors, understanding cumulative effects on marine ecosystems is increasingly important. Two major drivers of change in coastal and marine ecosystems are industrial developments with acute impacts on local ecosystems, and global climate change stressors with widespread impacts. We conducted a cumulative effects mapping analysis of the marine waters of British Columbia, Canada, under different scenarios: climate change and planned developments. At the coast-wide scale, climate change drove the largest change in cumulative effects with both widespread impacts and high vulnerability scores. Where the impacts of planned developments occur, planned industrial and pipeline activities had high cumulative effects, but the footprint of these effects was comparatively localized. Nearshore habitats were at greatest risk from planned industrial and pipeline activities; in particular, the impacts of planned pipelines on rocky intertidal habitats were predicted to cause the highest change in cumulative effects. This method of incorporating planned industrial development in cumulative effects mapping allows explicit comparison of different scenarios with the potential to be used in environmental impact assessments at various scales. Its use allows resource managers to consider cumulative effect hotspots when making decisions regarding industrial developments and avoid unacceptable cumulative effects. Management needs to consider both global and local stressors in managing marine ecosystems for the protection of biodiversity and the provisioning of ecosystem services.

China needs to address the environmental costs to participate in global value chains (GVCs) more sustainably. Digitalization presents a potential solution to overcome information barriers and improve energy efficiency in global production networks. However, the impact of digital technology on GVC-related carbon intensity has not been systematically studied. This paper utilizes embedded multi-regional input-output (EMRIO) tables to analyze the relationship between digital technology and GVC-related carbon intensity in China's 28 regions and 11 manufacturing sectors. The study calculates three indexes: digital technology development, the openness degree of digital technology, and the carbon intensity related to GVCs for the years 2002, 2007, 2010, and 2012. Through a fixed-effect model, the paper examines how digital technology can reduce domestic embodied carbon intensity related to GVCs in China. The findings indicate that: (1) digital technology development has a negative impact on GVC-related domestic embodied carbon intensity; (2) digital technology development indirectly reduces domestic embodied carbon intensity by decreasing energy consumption intensity and increasing foreign services' input intensity; (3) enhancing the openness of digital technology in China can strengthen the reduction effect of digital technology development on the environmental cost related to GVCs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Mercury (Hg) in coastal wetlands is of great concern due to its acute toxicity. We measured the total Hg content (THg) from a 210 Pb-dated sediment core obtained from the Futian mangrove wetland in Shenzhen Bay, South China to explore the historical variation and possible sources. Our results extend the sediment THg record back to 1960 and reveal three distinct intervals. Interval I (1960-1974) has low and increasing THg values, averaging 83.0 μg/kg; Interval II (1975-1984) witnesses a remarkably increase, peaking in 1980 (261.6 μg/kg) then remaining elevated; Interval III (1985-2014) shows a steady reduction, averaging 118.4 μg/kg. The good correlation among THg, TOC, and Hg/TOC, and the downstream decrease in monitoring sediment THg consistently suggest that the bulk THg are mainly sourced from the Shenzhen River discharge. The different timing in industrial development attributes the elevated THg concentrations during 1975-1984 to Hong Kong industrial sewage pollution., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Many studies have confirmed the co-emission characteristics of air pollution and carbon emissions. However, studies on the evolution and synergistic factors of the symbiosis of air pollution and carbon emissions over long time scales from a spatial spillover perspective are rare. Here, we identify the spatial evolution and agglomeration characteristics of carbon emissions and air pollution symbiosis by applying local autocorrelation analysis and geographical concentration and by using the dynamic spatial autoregressive model for multiple synergistic factors at city levels during 2006-2019 in China. The results are: (1) The spatial agglomeration and symbiosis of carbon emission and air pollution are similar and show strong spatial locking, as well as path-dependent properties. (2) The spatial imbalance of carbon emission agglomeration and pollution agglomeration gradually improved over time; the concentration centers are all located in Henan province, shifting northward. (3) The symbiosis between both carbon emission agglomeration and pollution agglomeration has significant "spatial and temporal scale effects", and the economic growth is nonlinear. Additionally, innovation vitality has a negative synergistic driving effect on this relationship. In addition to the results above, rapid industrialization and urbanization are taking place in China. Hence, serious actions against greenhouse gases and air pollutants are imminently needed., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Developing economies are an important engine of world economic growth. However, ensuring the quality of environmental assets is maintained amid rapid economic change remains a major challenge for most developing countries. Using the Panel Autoregressive Distributed Lag (ARDL) approach and the heterogeneous causality test, this study analyzes the combined effects of energy usage, industrialization, gross domestic product (GDP) growth, and urbanization on CO 2 emissions for 23 developing countries across the 1995 to 2018 period. From our analysis, the long-run results reveal that a 1% increase in energy use, economic growth, industrialization, and urbanization increases CO 2 emissions by 0.23%, 0.17%, 0.54%, and 2.32%, respectively. Moreover, our model's short- to long-term equilibriums are adjusted at a yearly rate of 0.19%. Finally, to verify the panel ARDL long-run results, robustness tests were carried out using the Fully Modified Ordinary Least Squares (FMOLS) and Dynamic Ordinary Least Squares (DOLS) approaches. Our results confirm that in the case of developing countries, CO 2 emissions are primarily influenced by GDP growth, energy use, industrialization, and urbanization. Furthermore, the panel causality analysis identified a bidirectional causal relationship between energy use, GDP growth, urbanization, industrialization, and CO 2 emissions. While these results can play an instrumental role in formulating CO 2 emission policies among our selected countries, our research can also assist policy makers and stakeholders in other developing economies implement important policy initiatives. These include, tax incentives and infrastructural developments that nurture environmentally friendly industrialization, deploy low-carbon technologies, promote sustainable forms of urbanization and urban planning, while also facilitating increases in both the investment in and adoption of renewable energy platforms. The establishment of such a comprehensive policy agenda can help emerging economies achieve strong and environmentally sustainable GDP growth over the long-term., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Objective: The increasing prevalence of malignant disease has been associated with shifts in environmental, socioeconomic, and lifestyle risk factors as well as increased adult lifespan. We examine the relationship between malignant neoplasms affecting bone, age and industrialization., Materials: Pre-existing skeletal data from 11 medieval (1066-1547, n = 8973) and 14 industrial (1700-1890, n = 4748) cemeteries (N = 13,721) from England., Methods: Context number, sex, age-at-death, evidence of skeletal malignancy, and diagnosis were collated. The data were compared using chi square, Kolmogorov-Smirnov tests and logistic regression (α = 0.01)., Results: There was a statistically significant increase in skeletal malignancy from 0.06 % in the medieval sample to 0.36 in the industrial sample (p < 0.001). Age had a strong relationship with malignancy (p = 0.003), sex did not (p = 0.464). Logistic regression revealed that time-period (p < 0.001) was a stronger predictor of skeletal malignancy than age-at-death (p = 0.002)., Conclusion: Our results confirm that even with the temporal increase in adult human lifespan the increase of malignant neoplasms of bone between the medieval and industrial time periods is still statistically significant., Significance: The augmented exposure to carcinogens and pollution during the Industrial Revolution had a strong effect on an individual's susceptibility to developing malignant disease of bone., Limitations: This meta-analysis relies upon previously gathered data and diagnosis from a large number of researchers and did not include radiographic or CT screening. Only malignant neoplasms that affected bone could be included., Suggestions for Further Research: Increasing excavation and analysis of post-medieval cemeteries will provide more data. Multimethod approaches (radiography, CT, Micro-CT and histology) are encouraged., (Copyright © 2022 Elsevier Inc. All rights reserved.)

While Indigenous food systems remain critical for community well-being, traditionally harvested foods are a potential source of toxic exposures. The Tsleil-Waututh Nation (TWN) is seeking to restore shellfish harvesting in Burrard Inlet (British Columbia [BC], Canada), where the cumulative effects of industrial activity have nearly eliminated safe harvesting. The Trans Mountain Expansion project would triple the capacity to transport oil through the inlet, threatening TWN's progress to restore shellfish harvesting. To inform ongoing efforts we assessed contamination by heavy metals (arsenic, cadmium, lead, and mercury) and 48 polycyclic aromatic hydrocarbons (PAHs) congeners in different shellfish species (Softshell clams, Varnish clams, and Dungeness crab) in three areas. We compared our results against local screening values (SVs) established by the TWN and BC Ministry of Environment and Climate Change Strategy, as well as provincial and national benchmarks. In total, we analyzed 18 composite samples of Softshell clams and Varnish clams (5 individuals per sample), as well as 17 individual crabs. We found chemical contamination in all species at all sites. PAHs were most frequently detected in Softshell clams, highest in the site closest to the pipeline terminus. Clams presented higher levels of contamination than crabs for PAHs, but not for heavy metals. For Softshell and Varnish clams, all heavy metals across study sites exceeded at least one of the population-specific SVs. Of the 14 PAHs detected, benzo(a)pyrene presented a median concentration in Softshell clams of 3.25 μ/kg, exceeding local SV for subsistence fisher. Our results call for further assessment of human health impacts related to food harvesting within Burrard Inlet and establishing a long-term coordinated program co-led by the TWN to monitor contamination and inform future harvesting programs. The study draws attention to the need to consider locally-relevant toxicity benchmarks, and include potential health impacts of food contamination in appraising development project proposals., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)

Urbanization and industrialization produce substantial changes in biodiversity and in the functionality of ecosystems. However, little is known about how anthropic pressures might drive these changes and about their functional consequences. We aimed to determine the responses of macroinvertebrate biological traits to urban and industrial pollution and assess the impacts of these disturbances on the functional diversity of these assemblages. We sampled benthic macroinvertebrates in 27 sites of four basins with different urban disturbance gradients (rural, peri-urban, and urban-industrial), among them the Matanza-Riachuelo River, one of the most polluted basins in the world. We classified macroinvertebrates into 11 traits and 56 categories. Then, we performed an RLQ analysis and computed functional richness, evenness, divergence and Rao diversity indexes for each site and community weighted means for each trait category. The urban and industrial sites (mainly low and middle Matanza-Riachuelo River Basin) showed high concentrations of ammonium, SRP, conductivity, COD, BOD, and organic matter, as well as the lowest values of DO. The functional richness and Rao index of these sites were significantly lower than that of the other sites. Macroinvertebrate traits associated with urban and industrial sites were aerial respiration (spiracles), forms of resistance (eggs or statoblast), cylindrical body shape, oviparity, feeding on microinvertebrates, and full water swimmers. These traits potentially enabled tolerant species persistence at polluted sites while gills, grazers, and crawlers were sensitive to these disturbances. Urban and industrial activities influence biological traits, producing the disappearance or dominance of certain traits in macroinvertebrate assemblages. As a consequence, extreme pollution caused predictable trait-based community changes resulting in reduced functional diversity, and potentially altered the ecosystem function., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. All rights reserved.)

The current industrial structure of eco-fragile areas fails to reverse the trend of the deterioration of the ecological environment and severely affects the sustainable development of eco-fragile areas, so conducting scientific and technological studies of ecological industries and ecological products helps eco-fragile areas recover their degraded ecosystem. The results of a statistical analysis of 159 related documents show: (1) the number of documents published rises wave upon wave in time series, which indicates that this area of study is still at the stage of rising; (2) research contents concentrate on five dimensions-theoretical research, technology research and development, model building, demonstration and promotion, and efficiency analysis, among which theoretical research chiefly discusses environmental costs and effects of ecological industries, regional organizational layout, industrial chain construction, market supply and demand of biological products, discrimination of the nature of biological products, and value assessment and realization of biological products; (3) study areas are largely distributed in the Loess Plateau area in the north and karst areas in the south in China, which suggests that studies of biological industries and biological products in eco-fragile areas concentrate on arid and semi-arid areas and engineered arid areas. Furthermore, from five aspects-theoretical study, technology research and development, model building, experiment and demonstration, and monitoring and evaluation, this study reveals cutting-edge theories about ecological industries and ecological products in eco-fragile areas. At last, it is found that comprehensive theoretical research of the market circulation of ecological products in eco-fragile areas and the research and development of key technologies to enhance the value of ecological products lag behind, and it is necessary to deepen the studies about the whole industry chain development for ecological industries, the valuation of ecological effect, the standardization of ecological industry management, the circulation mechanism of ecological products, brand building and other aspects., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Objective: This study explores whether data relating to rickets from the French medico-historical literature (FMHL) and bioarchaeological grey literature are useful in evaluating its epidemiology during the industrialisation of France. Unlike other European countries such as England, industrialisation in France was a slow and continuous process with two phases: the first in 1830-1870 and the second in 1870-1914., Materials and Methods: A bibliographical analysis of 2800 FMHL sources from the 18th to the early 20th centuries and 50 archaeological excavation reports from the last 21 years was undertaken., Results: The FMHL data is very heterogeneous and predominantly dates to the second phase of industrialisation. The bioarchaeological data is very incomplete and predominantly relates to the period before industrialisation. At the same time, knowledge improvement and institutional changes to protect children could explain more systematic registration of cases of rickets., Conclusions: No solid conclusions can be made regarding the prevalence of rickets at present, however these data hold great potential., Significance: In comparison to England, no systematic investigation of rickets prevalence during the period of industrialisation in France has been undertaken to date., Limitations: The lack of archaeological excavations from this period and the limited paleopathological analysis of the sites excavated have contributed to our current lack of understanding regarding the impact of industrialization on the prevalence of rickets on the French population., Suggestions for Further Work: The FMHL data needs to be homogenized and osteoarchaeological collections need to be restudied with a common protocol focusing on signs of vitamin D deficiency., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Objective: This study tests the hypothesis that industrial development and urbanization negatively impacted the living circumstances and health of inhabitants., Materials: The materials used in this study included 881 human skeletons aged 15 years and older from the Medieval (1185-1573), Edo (1603-1867), and Meiji (1868-1912) periods. The Meiji period corresponds to the period when the industrial revolution spread in Japan., Methods: Age at death and sex were estimated for each skeleton, and demographic profiles of the Medieval, Edo, and Meiji periods were compared., Results: The rate of young deaths was higher in the Meiji period than in preceding periods, and urban inhabitants had a higher proportion of young deaths than rural inhabitants in the Edo period., Conclusions: The results suggest that industrial development and urbanization led to a decline in human health., Limitations: The results produced through Bayesian methods are likely tentative, because they vary according to the priors and reference sample., Significance: Paleodemographic approaches are a useful method to elucidate the impact of industrialization and urbanization on health., Suggestions for Further Research: Decline of health associated with industrialization should be examined combining paleopathological and paleodemographic methods., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Worry is influenced by environmental pollution and affects individual health and well-being; however, little is known about this association in Indigenous communities. Using logistic regression models, we examined self-reported responses among Cree adults to the question "Are you worried about the pollution of the environment (land, water or air) in Iiyiyiu Aschii?" to assess if increased worry was associated with proximity to industrial and hydroelectric development, whether increased worry was associated with self-reported behavioural changes of water consumption type in the community or bush, and days spent on-the-land. Proximity to multiple industrial and hydroelectric development sites was associated with increased worry about pollution. Notably, the decreased consumption of tap water in the community was significantly associated with increased worry, but time-on-the land was not. Overall, our study provides new findings concerning development in a Cree territory in northern Quebec, Canada, and the worry about pollution's association with self-reported behavioural changes., (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)

Industrialization and urbanization have aggravated the contradiction between environmental protection and economic growth, leading to health issues. While there are considerable interests in understanding the health effects of carbon emissions in the context of climate change, little is observed at regional scale and by econometric methods. Applying regression analysis on 2002-2017 Chinese provincial-level panel data, this study explores the intermediary mechanisms and regional differences of carbon emissions on residents' health. The results indicate that: (1) Carbon emissions have a long-term adverse impact on residents' health-a 1% rise in carbon emission adds 0.298% more outpatients and 0.162% more inpatients; (2) The rise in carbon emissions impairs residents' health mainly by raising the temperature; (3) In areas with high levels of industrialization and urbanization, increased carbon emissions bring greater health risks; and (4) In terms of China's unique "leading industrialization and lagging urbanization" situation, only by upgrading industrial structure, improving urbanization quality, and promoting coordinated industrialization and urbanization can the harm of carbon emissions to residents' health be reduced. Therefore, the "one-size-fits-all" policy model is not suitable for China's current situation. To address global "climate change" issues, China must act according to local conditions by applying mitigating (adaptive) measures in economically developed (less developed) regions. Simultaneously, the authorities must focus on the interaction and synergy between industrialization and urbanization., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Nicotinamide cofactors enable oxidoreductases to catalyze a myriad of important reactions in biomanufacturing. Decades of research has focused on optimizing enzymes which utilize natural nicotinamide cofactors, namely nicotinamide adenine dinucleotide (phosphate) (NAD(P) + ). Recent findings reignite the interest in engineering enzymes to utilize noncanonical cofactors, the mimetics of NAD + (mNADs), which exhibit superior industrial properties in vitro and enable specific electron delivery in vivo. We compare recent advances in engineering natural versus noncanonical cofactor-utilizing enzymes, discuss design principles discovered, and survey emerging high-throughput platforms beyond the traditional 96-well plate-based methods. Obtaining mNAD-dependent enzymes remains challenging with a limited toolkit. To this end, we highlight design principles and technologies which can potentially be translated from engineering natural to noncanonical cofactor-dependent enzymes., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

We report on Baltic Sea polycyclic aromatic hydrocarbon (PAH) pressure based on the U.S. EPA PAHs in view of millennial and decadal developments utilizing data from sediment deposits and seawater. Pre-industrial PAH contents ranged from 500 to 4500 ng/g TOC. Maximum PAH contents were up to 100,000 ng/g TOC and date back to the 1960s to 1970s with maximum pollutant inputs. Contemporary sediment PAH contents with 10,000 to 35,000 ng/g TOC and seawater concentrations with about 1 to 16 ng/l show spatial variability due to different local inputs and sediment characteristics. Pre-industrial compositional change from low molecular weight to high molecular weight (HMW) PAH indicates changing sources from mostly petroleum to combustion. Application of diagnostic ratios reveals petroleum and combustion as contemporary PAH sources and that traffic emissions continuously contribute to the Baltic PAH profile. Medium to high toxicological risk to the marine community might arise from current HMW PAH contents., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

In this study, the recent history of heavy metal pollution in the Fangcheng Bay (South China) was reconstructed utilizing three 210 Pb-dated sediment cores. The metal concentration profiles display three trends since the 1970s and clearly reflect local urbanization and industrialization. The metals in the Fangcheng Bay started to accumulate in the 1970s but remained relatively low until the 1990s which corresponds to the slow urbanization and industrialization. The metal accumulation in the eastern Fangcheng Bay peaked in the early 2000s following the steep increases in accordance with the rapid industrialization of the eastern Fangcheng Bay where the core HSL was collected. Conversely, the heavy metal profiles in the western Fangcheng Bay present slight step increases in the early 2000s followed by a dramatic metal enrichment in the late 2000s; the expansion of these two cores, which begins in the early 2000s, concurs well with the rapid local urbanization and industrialization., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

The study of a Posidonia sinuosa sedimentary archive has delivered a millenary record of environmental change in Cockburn Sound (Western Australia). Ecosystem change is a major environmental problem challenging sustainable coastal development worldwide, and this study shows baseline trends and shifts in ecological processes in coastal ecosystems under environmental stress. The concentrations and fluxes of biogeochemical elements over the last 3,500 years indicate that important changes in ecosystem dynamics occurred over the last 1,000 years, in particular after ~1900's, probably related to establishment of seagrass meadows in the area and to local and regional human activities (industry and coastal development), respectively. The establishment of seagrasses ~1,000 years ago in the area of study is supported by the appearance of Posidonia fibres from ~40 cm soil depth until the core top, higher δ 13 C values indicating a larger contribution of seagrass-matter to the soil organic carbon pool, and increased concentration of fine sediments driven by the effect of seagrass canopy in enhancing sedimentation. The comparison of organic carbon, nutrients and metal concentrations and fluxes between pre- and post-establishment of seagrasses shows that seagrass establishment resulted in up to 9-fold increase in the soil biogeochemical sink. In ~1900's, shifts in the concentrations of metals, carbonates, organic carbon, sediment grain size, and δ 13 C and δ 15 N values of the organic matter were detected, demonstrating an alteration in seagrass ecosystem functioning following the onset of European settlement. Anthropogenic activities, and in particular the construction of a causeway in 1970's, enhanced seagrass soil organic carbon and metal accumulation rates by 36- and 39-fold, respectively, showing that human-made structures can enhance the biogeochemical sink capacity of seagrasses. Here we reconstruct the impact of human activities on seagrass ecosystem dynamics and blue carbon, which can inform local management of Cockburn Sound and seagrass conservation for climate change mitigation and adaptation., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

In low concentration, fluoride is considered a necessary compound for human health. Exposure to high concentrations of fluoride is the reason for a serious disease called fluorosis. Fluorosis is categorized as Skeletal and Dental fluorosis. Several Asian countries, such as India, face contamination of water resources with fluoride. In this study, a comprehensive overview on fluoride contamination in Asian water resources has been presented. Since water contamination with fluoride in India is higher than other Asian countries, a separate section was dedicated to review published articles on fluoride contamination in this country. The status of health effects in Asian countries was another topic that was reviewed in this study. The effects of fluoride on human organs/systems such as urinary, renal, endocrine, gastrointestinal, cardiovascular, brain, and reproductive systems were another topic that was reviewed in this study. Different methods to remove fluoride from water such as reverse osmosis, electrocoagulation, nanofiltration, adsorption, ion-exchange and precipitation/coagulation were introduced in this study. Although several studies have been carried out on contamination of water resources with fluoride, the situation of water contamination with fluoride and newly developed technology to remove fluoride from water in Asian countries has not been reviewed. Therefore, this review is focused on these issues: 1) The status of fluoride contamination in Asian countries, 2) health effects of fluoride contamination in drinking water in Asia, and 3) the existing current technologies for defluoridation in Asia., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Siloxanes have been used as chemical additives in various products since the 1940s. They are known to have potentially toxic effects, to be environmentally persistent, and to be bioaccumulative. Previous studies have reported high levels of siloxanes in various environmental matrices. In this study, 6 cyclic siloxanes (D4-D9) and 13 linear siloxanes (L3-L15) in coastal sediment collected from southeastern bays adjacent to industrial zones in South Korea (Busan, Ulsan, Jinhae, and Gwangyang) were analyzed. The contamination levels and spatial distribution of siloxanes in the coastal sediment samples were investigated, with the hazard quotients (HQs) for siloxanes evaluated using Monte Carlo simulation. Across all samples, the total concentration (Σ 19 ) of siloxanes was in the range of 11.6-3877 (mean: 305; median: 133) ng/g dry weight (dw). The highest average concentration of Σ 19 siloxanes was found in Busan (mean: 580; median: 233 ng/g dw), followed by Ulsan (mean: 316; median: 209 ng/g dw), Jinhae (mean: 266; median: 125 ng/g dw), and Gwangyang (mean: 33; median: 27 ng/g dw), all of which are suggested to be affected by both industrial and domestic activities. The highest contributions were from D5 (18%) and D6 (34%), followed by D9 (7.3%) and L11 (5.8%). The HQs for siloxanes were less than 1, indicating that there was no risk to benthic organisms in the study areas; however, further monitoring of various environmental matrices is required to fully assess the potential ecological risks., (Copyright © 2019 Elsevier Inc. All rights reserved.)

This paper presented the historical data on the temporal trends of polybrominated diphenyl ethers (PBDEs) in the sediment cores collected from the Huaihe River, Yellow River and Chaohu Lake, China. Among the 40 targeted PBDE congeners, only 10, 6, and 9 of them were detected respectively in the samples from the Huaihe River, Yellow River and Chaohu Lake. On average, the total PBDEs concentrations in sediments were highest in Chaohu Lake followed by the Huaihe River and the Yellow River. As compared to other PBDE congeners, BDE-209 had higher concentrations and detection rates. The similar down core variation between PBDEs and total organic carbon (TOC) suggests that TOC is an important factor influencing PBDEs distribution in the sediments. The total PBDEs concentrations showed an increasing trend from bottom to upper sediments before a decreasing trend in the topmost sediments. The rapid urbanization and industrialization of these regions in recent decades may cause the historically increasing concentrations of sedimentary PBDEs, especially BDE-209. The decreasing PBDEs concentrations in topmost sediments was probably related to the strict environmental policies at present., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Emissions from vehicles include particles from tire and brake wearing that can settle down and join industrial discharges into street dust. Metals present in street dust may create ecological and health threats and their analysis is of great environmental relevance. The city of Monterrey, Mexico is an industrial pillar of the country and shows an increasing fleet during the last years, which has yielded higher traffic and emissions. This study analyzes 44 street dust samples taken across the city for total element concentrations by using X-ray fluorescence. Associations and indicators are calculated to define possible origins, levels of pollution, natural or anthropogenic sources, and ecological and human health risks. High concentrations of As, Ba, Cu, Fe, Mo, Ni, Pb, Ti, and Zn were found. Main sources of metals were defined as: tire wearing for Zn and Fe; brake wearing for Ba, Cu, Fe, Pb and Zr; additional industrial sources for Mo, Ni, Pb, and Ti; and other natural sources for As. Ecological risk was found to be moderate across the city and risk due to Pb concentrations was established for children., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Urbanization and industrialization have increased groundwater resource demands, and may drive the change of heavy metal(loid)s and organic chemicals in groundwater in the Pearl River Delta (PRD), southern China. Thus, a comprehensive understanding of the distributions, sources, and driving forces of heavy metal(loid)s and organic chemicals in groundwater in the PRD is vital for water resource management in this region. In this study, eight heavy metal(loid)s and fifty-five organic chemicals in groundwater across the PRD were investigated. The results show that undrinkable groundwater related to heavy metal(loid)s was mainly due to high concentrations of Fe (19.3%) and As (6.8%). Eighteen organic contaminants were detected in groundwater in the PRD, where the most frequently detected organic contaminant was naphthalene, and its detection rate was 2.51%. In 5.3% of all groundwater samples, one or more organic contaminants were found. All detected organic contaminants, except ones without allowable limits, in groundwater were at concentrations below allowable limits of China. The mean concentrations of heavy metal(loid)s in granular aquifers were higher than those in fissured and karst aquifers, especially for Fe and As. Except Se, the mean concentrations of other heavy metal(loid)s and the frequency of detection of organic contaminants in groundwater in urbanized and peri-urban areas were higher than those in non-urbanized areas, especially for Hg, Co, and organic contaminants. Fe, As, and Se in groundwater mainly originated from the release of Fe/As/Se rich sediments. The former two were driven by reduction reactions, while the latter was driven by oxidation resulting from the infiltration of NO 3 - . In contrast, other five heavy metal(loid)s and organic contaminants in groundwater mainly originated from the anthropogenic sources, such as the infiltration of industrial sewage. It is evident that urbanization and industrialization are two powerful driving forces for heavy metal(loid)s and organic contaminants in groundwater in the PRD., (Copyright © 2018 Elsevier B.V. All rights reserved.)

The content of metal(loid)s in particulate matter (PM) is of special concern due to their contribution to overall (PM) toxicity. In this study, the bioaccessibility and human health risk of potentially toxic metal(loid)s associated with PM 10 were investigated in two areas of the Cantabrian region (northern Spain) with different levels of exposure: an industrial area mainly influenced by a ferromanganese alloy plant; and an urban area consisting mainly of residential and commercial activities, but also affected, albeit to a lesser extent by the ferroalloy plant. Total content and bioaccessible fractions in simulated lung fluids (SLFs) of Fe, Mn, Zn, Ni, Cu, Sb, Mo, Cd and Pb were determined by ICP-MS. Gamble's solution and artificial lysosomal fluid (ALF) were used to mimic different conditions inside the human respiratory system. A health risk assessment was performed based on the United States Environmental Protection Agency's (USEPA) methodology. Most metal(loid)s showed moderate and high bioaccessibility in Gamble's solution and ALF, respectively. Despite the high variability between the samples, metal(loid) bioaccessibility was found to be higher on average at the industrial site, suggesting a greater hazard to human health in the proximity of the main metal(loid) sources. Based on the results of the risk assessment, the non-carcinogenic risk associated with Mn exposure was above the safe limit (HQ> 1) under all the studied scenarios at the industrial site and under some specific scenarios at the urban location. The estimated carcinogenic inhalation risk for Cd exposure at the industrial site was found to be within the range between 1.0 × 10 -6 to 1.0 × 10 -4 (uncertainty range) under some scenarios. The results obtained in this study indicate that Mn and Cd inhalation exposure occurring in the vicinities of the studied areas may pose a human health risk., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Background: Organoid technology enables the cultivation of human tissues in a dish. Its precision medicine potential could revolutionize the Cystic Fibrosis (CF) field. We provide a first thematic exploration of the patient perspective on organoid technology to set the further research agenda, which is necessary for responsible development of this ethically challenging technology., Methods: 23 semi-structured qualitative interviews with 14 Dutch adult CF patients and 12 parents of young CF patients to examine their experiences, opinions, and attitudes regarding organoid technology., Results: Four themes emerged: (1) Respondents express a close as well as a distant relationship to organoids; (2) the open-endedness of organoid technology sparks hopes and concerns, (3) commercial use evokes cautiousness. (4) Respondents mention the importance of sound consent procedures, long-term patient engagement, responsible stewardship, and stringent conditions for commercial use., Conclusions: The precision medicine potential of organoid technology can only be realized if the patient perspective is taken adequately into account., (Copyright © 2018 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)

Background: The thyroid cancer (TC) incidence in China has increased dramatically during the last three decades. Typical in this respect is the case of Hangzhou city (China), where 7147 new TC cases were diagnosed during the period 2008-2012. Hence, the assessment of the TC incidence risk increase due to environmental exposure is an important public health matter., Methods: Correlation analysis, Analysis of Variance (ANOVA) and Poisson regression were first used to evaluate the statistical association between TC and key risk factors (industrial density and socioeconomic status). Then, the Bayesian maximum entropy (BME) theory and the integrative disease predictability (IDP) criterion were combined to quantitatively assess both the overall and the spatially distributed strength of the "exposure-disease" association., Results: Overall, higher socioeconomic status was positively correlated with higher TC risk (Pearson correlation coefficient=0.687, P<0.01). Compared to people of low socioeconomic status, people of median and high socioeconomic status showed higher TC risk: the Relative Risk (RR) and associated 95% confidence interval (CI) were found to be, respectively, RR=2.29 with 95% CI=1.99 to 2.63, and RR=3.67 with 95% CI=3.22 to 4.19. The "industrial density-TC incidence" correlation, however, was non-significant. Spatially, the "socioeconomic status-TC" association measured by the corresponding IDP coefficient was significant throughout the study area: the mean IDP value was -0.12 and the spatial IDP values were consistently negative at the township level. It was found that stronger associations were distributed among residents mainly on a stripe of land from northeast to southwest (consisting mainly of sub-district areas). The "industrial density-TC" association measured by its IDP coefficient was spatially non-consistent., Conclusions: Socioeconomic status is an important indicator of TC risk factor in Hangzhou (China) whose effect varies across space. Hence, socioeconomic status shows the highest TC risk effect in sub-district areas., (Copyright © 2017. Published by Elsevier B.V.)

This paper addresses recent government initiatives in biotechnology and various federal and regional initiatives. It presents an overview of the most visible industrial biotechnology projects under implementation and highlights changes in legislation affecting development of the bioeconomy in the Russian Federation., (Copyright © 2017. Published by Elsevier B.V.)

The bioeconomy transforms the fossil-based economy by forming new value chains and linking until now distinct industrial sectors. It provides an opportunity for rural as well as industrialized regions. The transformation process can be accelerated by building bioeconomy clusters comprising industries, academia and investors. Using the model of the German cluster CLIB2021 the role of cluster organisations and professional cluster management in moderating the transformation process and gaining a competetive advantage is discussed. In addition examples of how cluster management supports the formation of an industrial consortium and the analysis of regional options are presented., (Copyright © 2017 Elsevier B.V. All rights reserved.)

To transform developing and least developing countries into industrialised ones, biotechnology could be deployed along the value chain, to provide support to the development of the bio-based industries in such a way to ensure sustainability of the sector and to reduce negative environmental impacts that might otherwise occur. In agribusiness development, for instance, interventions could start from inputs and agricultural mechanization, modern processing technologies, packaging of perishable products, the promotion of food safety in the processing and regulatory environment; and interventions to improve competitiveness and productivity. Worth over USD 300 billion in revenue, the role of the biotechnology goes beyond industrial growth, since it provides opportunities for progress towards many of the UN sustainable development goals (SDGs). This paper reviews the status of industrial biotechnology as it relates to inclusive and sustainable industrial development., (Copyright © 2017 Elsevier B.V. All rights reserved.)