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Intravascular papillary endothelial hyperplasia (IPEH) is an uncommon reactive lesion that shares some features with, and thus can be misdiagnosed as, hemangiosarcoma. Most are associated with a thrombus. Oral cases are rare, only 105 being reported through 2020, and only one has been reported in the hard palate. The stroma of the papillary structures has been described as fibrous, hyalinized, or hypocellular and hyalinized. Presented here is a case of IPEH of the hard palate with no associated thrombus and a myxoid stroma of the papillary structures and wall. The significance of the myxoid stroma is that it has the potential to confound the diagnosis and, by analogy to odontogenic and other myxomas, for concern regarding a tendency to recur.

Masson's tumor, also known as intravascular papillary endothelial hyperplasia (IPEH), is a rare and benign vascular disease in which there is a reactive hyperplasia of intravascular endothelial cells. This tumor is most commonly found in soft tissues in the head, neck and upper extremities. We report a rare case of IPEH on the vulva. A Hispanic woman in her mid-thirties presented with a painful and pruritic left vulvar mass. On physical examination, a pedunculated mass was visualized on the left labia majora. Under pathologic examination, it was concluded the lesion was IPEH and it was surgically excised. This is a rare case of IPEH located on the vulva. However, despite this rarity, a simple local excision could be used to manage IPEH.

Background: Intravascular papillary endothelial hyperplasia (IPEH) is a benign vascular lesion that is uncommon in the central nervous system. To our knowledge, there has been only one previous report of occurrence in the pineal region. We present a second case and a review of the literature., Case Description: A 28-year-old woman presented with 1 month of headaches and visual auras. Brain magnetic resonance imaging scan demonstrated a 2.6- × 1.8- × 1.3-cm nonenhancing T1-hypointense, T2-/fluid-attenuated inversion recovery-hyperintense pineal region mass with cerebral aqueduct obstruction and hydrocephalus. She underwent placement of a right extraventricular drain followed by complete surgical resection. Histologic analysis was consistent with IPEH., Conclusions: Although rare, IPEH is an entity that should be considered in the differential diagnosis for intracranial masses with radiographic features characteristic of vascular lesions. Tissue sampling is imperative for distinction from more malignant entities. Complete resection is curative and is the standard of care when feasible. Given the risk of local progression and neurologic compromise with subtotal resection of central nervous system lesions, further study regarding adjuvant treatment options is warranted., (Copyright © 2019 Elsevier Inc. All rights reserved.)