1. Stress Responsiveness of BDNF/TrkB Signaling in the Neuroendocrine System and Future Implications
- Author
-
Idu Azogu-Sepe and Hélène Plamondon
- Subjects
biology ,business.industry ,Stressor ,Tropomyosin receptor kinase B ,Stress adaptation ,Allostatic load ,Reward system ,Crosstalk (biology) ,Neurotrophic factors ,biology.protein ,Medicine ,business ,Neuroscience ,Neurotrophin - Abstract
The extensive literature on stress effects support that chronic and repeated stress exposure can lead to dysregulation of the hypothalamic–pituitary–adrenal axis, cause a gradual decrease in its activity, or facilitate axis responses to subsequent stressors, thereby influencing active coping mechanisms and the ability to prevent allostatic load on the brain. Despite the large number of studies establishing the crosstalk between the plasticity-related neurotrophin brain-derived neurotrophic factor (BDNF) and the stress hormone glucocorticoids (GCs) in the pathophysiology of depression, a lack of information exists with respect to sex differences and the translational perspective of BDNF signaling as a potential drug target in modulating stress-related psychiatric diseases. Thus understanding the network of interconnected structures within the brain's stress and reward systems may further highlight the mechanistic relationship between BDNF and GCs in stress adaptation and susceptibility and may provide avenues for clinical relevance in attenuating the deleterious effects of stress exposure.
- Published
- 2021