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1. Kidney Cell Cycle Arrest and Cardiac Biomarkers and Acute Kidney Injury Following Angiography: The Prevention of Serious Adverse Events Following Angiography (PRESERVE) StudyPlain Language Summary

Author

Raghavan Murugan, Monique Y. Boudreaux-Kelly, John A. Kellum, Paul M. Palevsky, and Steven Weisbord

Subjects
Biomarker, cell cycle arrest, chronic kidney disease, major adverse kidney events, contrast-associated acute kidney injury, angiography, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Rationale & Objective: Recent studies in patients with chronic kidney disease (CKD) indicate that most cases of contrast-associated acute kidney injury (CA-AKI) are mild and are not associated with elevation in kidney injury biomarkers. We used highly sensitive kidney cell cycle arrest and cardiac biomarkers to assess the risk of CA-AKI and major adverse kidney events in patients with CKD undergoing angiography. Study Design: A retrospective study. Setting & Participants: A subset of 922 participants from the Prevention of Serious Adverse Events following Angiography trial. Predictors: Pre- and postangiography urinary tissue inhibitor of matrix metalloproteinase [TIMP]-2 and insulin growth factor binding protein [IGFBP]-7 were measured in 742 subjects, and plasma β natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP), and serum troponin (Tn) in 854 participants using samples obtained 1-2 hours before and 2-4 hours after angiography. Outcomes: CA-AKI and major adverse kidney events. Analytical Approach: We fitted logistic regression to examine association and area under the receiver operating characteristic curves for risk prediction. Results: There were no differences in postangiography urinary [TIMP-2]•[IGFBP7], plasma BNP, serum Tn, and hs-CRP concentrations among patients with and without CA-AKI and major adverse kidney events. However, higher pre- and postangiography median plasma BNP (pre: 200.0 vs 71.5, pg/mL, P = 0.05; post: 165.0 vs 81 pg/mL, P = 0.02); serum Tn (pre: 0.03 vs 0.01, ng/mL, P

Published
2023
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2. Quality of Care for Acute Kidney Disease: Current Knowledge Gaps and Future Directions

Author

Kathleen D. Liu, Lui G. Forni, Michael Heung, Vin-Cent Wu, John A. Kellum, Ravindra L. Mehta, Claudio Ronco, Kianoush Kashani, Mitchell H. Rosner, Michael Haase, Jay L. Koyner, and Ravi Mehta

Subjects
acute kidney injury, outcomes, quality, recovery, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Acute kidney injury (AKI) and acute kidney disease (AKD) are common complications in hospitalized patients and are associated with adverse outcomes. Although consensus guidelines have improved the care of patients with AKI and AKD, guidance regarding quality metrics in the care of patients after an episode of AKI or AKD is limited. For example, few patients receive follow-up laboratory testing of kidney function or post-AKI or AKD care through nephrology or other providers. Recently, the Acute Disease Quality Initiative developed a consensus statement regarding quality improvement goals for patients with AKI or AKD specifically highlighting efforts regarding quality and safety of care after hospital discharge after an episode of AKI or AKD. The goal is to use these measures to identify opportunities for improvement that will positively affect outcomes. We recommend that health care systems quantitate the proportion of patients who need and actually receive follow-up care after the index AKI or AKD hospitalization. The intensity and appropriateness of follow-up care should depend on patient characteristics, severity, duration, and course of AKI of AKD, and should evolve as evidence-based guidelines emerge. Quality indicators for discharged patients with dialysis requiring AKI or AKD should be distinct from end-stage renal disease measures. Besides, there should be specific quality indicators for those still requiring dialysis in the outpatient setting after AKI or AKD. Given the limited preexisting data guiding the care of patients after an episode of AKI or AKD, there is ample opportunity to establish quality measures and potentially improve patient care and outcomes. This review will provide specific evidence-based and expert opinion–based guidance for the care of patients with AKI or AKD after hospital discharge.

Published
2020
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3. Demographic data for urinary Acute Kidney Injury (AKI) marker [IGFBP7]·[TIMP2] reference range determinations

Author

Nandkishor S. Chindarkar, Lakhmir S. Chawla, Joely A. Straseski, Saeed A. Jortani, Denise Uettwiller-Geiger, Robert R. Orr, John A. Kellum, and Robert L. Fitzgerald

Subjects
Reference ranges, Acute kidney injury, Biomarkers, IGFBP7, Insulin-like growth factor-binding protein 7, TIMP2, Tissue inhibitor of metalloproteinases-2, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
Abstract

This data in brief describes characteristics of chronic stable comorbid patients who were included in reference range studies of [IGFBP7]·[TIMP-2] “Reference Intervals of Urinary Acute Kidney Injury (AKI) Markers [IGFBP7]·[TIMP2] in Apparently Healthy Subjects and Chronic Comorbid Subjects without AKI” [1]. In order to determine the specificity of [IGFBP7]·[TIMP-2] for identifying patients at risk of developing AKI we studied a cohort with nine broad classification of disease who did not have AKI. Details regarding the population that was targeted for inclusion in the study are also described. Finally, we present data on the inclusion criteria for the healthy subjects used in this investigation to determine the reference range.

Published
2015
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5. Contributors

Author

Vatche G. Agopian, Ehab Al-Bizri, Benjamin Y. Andrew, Thomas L. Archer, Gareth L. Ackland, John G. Augoustides, Diana Ayubcha, Angela Bader, Shyamasundar Balasubramanya, Peyman Benharash, Miles Berger, Muath Bishawi, Victoria Bradford, Thomas Buchheit, Christopher R. Burke, Maurizio Cereda, Anne Cherry, Albert T. Cheung, Kathleen Claus, Benedict Charles Creagh-Brown, Jovany Cruz Navarro, James DeBritz, null Timothy J. Donahue, Stephen A. Esper, Amanda L. Faulkner, Duane J. Funk, Robert Gaiser, Tong J. Gan, Stephen Harrison Gregory, Michael P.W. Grocott, Taras Grosh, Holden K. Groves, Dhanesh K. Gupta, Rachel A. Hadler, Steven Ellis Hill, Michael Holmes, Q. Lina Hu, Peter Inglis, Andrew Iskander, Alexander I.R. Jackson, Amir K. Jaffer, Michael L. James, Timothy F. Jones, Tammy Ju, Lillian S. Kao, John A. Kellum, Miklos D. Kertai, Clifford Y. Ko, W. Andrew Kofke, H.T. Lee, Jane Lee, Jason B. Liu, Jessica Y. Liu, Alex Macario, G. Burkhard Mackensen, Erin Maddy, Aman Mahajan, Joseph P. Mathew, Megan Maxwell, David L. McDonagh, Meghan Michael, Carmelo A. Milano, Richard C. Month, Eugene W. Moretti, Rotem Naftalovich, Mark F. Newman, Daisuke Francis Nonaka, Prakash A. Patel, Jamie R. Privratsky, Vijay K. Ramaiah, Neil Ray, Annette Rebel, Lisbi Rivas, Kristen C. Rock, Jill S. Sage, Yas Sanaiha, Babak Sarani, Ryan D. Scully, Jyotirmay Sharma, Robert A. Sickeler, Martin I. Sigurdsson, Mervyn Singer, Pingping Song, Audrey E. Spelde, Mark Stafford-Smith, Kirsten R. Steffner, Toby B. Steinberg, Dr. Charlotte Summers, Ramesh Swamiappan, Annemarie Thompson, Rachel E. Thompson, Thomas K. Varghese, Edward D. Verrier, Nathan H. Waldron, Sophie Louisa May Walker, and Ian J. Welsby

Published
2022

6. Blood Purification for Sepsis

Author

John A. Kellum, Zhi Yong Peng, Vincenzo Cantaluppi, Claudio Ronco, Marita Marengo, and Rinaldo Bellomo

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Acute kidney injury, Blood purification, medicine.disease, law.invention, Sepsis, Continuous venovenous hemofiltration, Randomized controlled trial, law, Current practice, Hemofiltration, medicine, Hemodialysis, Intensive care medicine, business
Abstract

There is currently a clear biologic rationale for blood purification used in sepsis. Immunomodulation and organ support play important roles in the application of blood purification. Conventional continuous venovenous hemofiltration and hemodialysis have been shown not to be effective in sepsis in the absence of concomitant acute renal failure. Plasma therapies, high-volume hemofiltration, hemadsorption, or combinations of these therapies appear promising. However many questions still remain unanswered. Current technologies still remain inadequate for the removal of middle-molecular-weight substances, and the current practice worldwide is extremely variable. Moreover, there is lack of large-scale randomized clinical trials. Recently, new developing technologies may enhance the clinical results of current RRT strategies, including high-porosity of membranes to improve middle molecular clearance. Finally, multicenter randomized controlled trials are needed to test these promising blood purification technologies.

Published
2019

7. Acute Kidney Disease

Author

John A. Kellum

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Medicine, business, medicine.disease, Gastroenterology, Kidney disease
Published
2019

8. Contributors

Author

Robert C. Albright, Richard Amerling, Paolo Angeli, Maria Lucia Angelotti, Massimo Antonelli, Riccardo Antoniotti, Nishkantha Arulkumaran, Pierre Asfar, Stephen R. Ash, Filippo Aucella, Francesco Aucella, Samuele Ave, Sean M. Bagshaw, Vasanthi Balaraman, Ian Baldwin, Joanne M. Bargman, Gina-Marie Barletta, Jeffrey F. Barletta, Shriganesh R. Barnela, Hülya Bayır, Monica Beaulieu, Antonio Bellasi, Rinaldo Bellomo, François Beloncle, Arjun Bhansali, Azra Bihorac, Frederic T. Billings, Horst-Walter Birk, Luis Ignacio Bonilla-Reséndiz, Josée Bouchard, Edmund Bourke, George Braitberg, Alessandra Brendolan, Alessandra Brocca, Patrick D. Brophy, Richard Bucala, Timothy E. Bunchman, Emmanuel A. Burdmann, Laurence W. Busse, Renato Antunes Caires, Pietro Caironi, Roberta Camilla, Israel Campos, Bernard Canaud, Vincenzo Cantaluppi, Maria P. Martinez, Giovambattista Capasso, Joseph A. Carcillo, Eleonora Carlesso, Francesco G. Casino, Giuseppe Castellano, Matteo Catania, Kelly A. Cawcutt, Jorge Cerda, Elliot Charen, Lakhmir S. Chawla, Stefano Chiaramonte, Horng-Ruey Chua, Bruno Cianciaruso, Paola Ciceri, Jacek Cieslak, William R. Clark, Rolando Claure-Del Granado, Anna Clementi, Ivan N. Co, Fernanda Oliveira Coelho, Ferruccio Conte, Howard E. Corey, Laura Cosmai, Elerson Carlos Costalonga, Andrea Costamagna, Maria Rosa Costanzo, Mario Cozzolino, Carl H. Cramer, Paolo Cravedi, Carlo Crepaldi, Jacques Creteur, R. John Crew, Verônica Torres da Costa e Silva, Andrew Davenport, Andrew R. Davies, Rohit D'Costa, Dawson F. Dean, Charlotte Debiais, Massimo de Cal, Paras Dedhia, Harm-Jan de Grooth, Roberto Dell'Aquila, Sergio Dellepiane, Richard Phillip Dellinger, Lucia Del Vecchio, Thomas A. Depner, Silvia De Rosa, Clifford S. Deutschman, Prasad Devarajan, A. Dewitte, Biagio R. Di Iorio, Luca Di Lullo, Lucia Di Micco, Matteo Di Nardo, Xiaoqiang Ding, Fiorella D'Ippoliti, Salvatore Di Somma, Kent Doi, David J. Dries, Wilfred Druml, Graeme Duke, Francois Durand, Michael T. Eadon, Devin Eckstein, Moritoki Egi, Somchai Eiam-Ong, Paul W.G. Elbers, Francesca Elli, Steve Elliott, David R. Emlet, Zoltan Endre, Roger G. Evans, Vito Fanelli, Fatemeh Fattahi, Christine Kinggaard Federspiel, Marcela A. Ferrada, Fiorenza Ferrari, Enrico Fiaccadori, Marco Fiorentino, Caleb Fisher, Michael F. Flessner, Marco Formica, Lui G. Forni, Claire Francoz, Craig French, Dana Y. Fuhrman, Giordano Fumagalli, Miriam Galbusera, Maurizio Gallieni, Hilary S. Gammill, Dayong Gao, Francesco Garzotto, Giuseppe Gatta, Kelly R. Genga, Simonetta Genovesi, Yuri S. Genyk, Christel Geradin, Loreto Gesualdo, Davide Giavarina, Anna Giuliani, Ilya G. Glezerman, Stuart L. Goldstein, Thomas A. Golper, Hernando Gómez, Antonio Granata, Giuseppe Grandaliano, Giacomo Grasselli, A.B. Johan Groeneveld, Philippe Guerci, Kyle J. Gunnerson, Nikolas Harbord, Lyndsay A. Harshman, Anthony J. Hennessy, Graham L. Hill, Charles Hobson, Bernd Hohenstein, Patrick M. Honoré, Edward Horwitz, Leila Hosseinian, Eric A.J. Hoste, Andrew A. House, H. David Humes, Faeq Husain-Syed, Can Ince, Todd S. Ing, Rita Jacobs, Dharmvir Jaswal, Arun Jeyabalan, Olivier Joannes-Boyau, Michael Joannidis, Emily Joyce, Sandra L. Kane-Gill, Lewis J. Kaplan, Kianoush Kashani, Nevin Katz, John A. Kellum, Ramesh Khanna, Nahmah Kim-Campbell, Joshua D. King, Christopher J. Kirwan, Joseph E. Kiss, David Klein, Peter Kotanko, Raymond T. Krediet, Martin K. Kuhlmann, Jan Willem Kuiper, Philippe Lachance, Norbert Lameire, Thomas Langer, Yugeesh R. Lankadeva, Louis-Philippe Laurin, Elena Lazzeri, Martine Leblanc, Joannie Lefebvre, Paolo Lentini, Hélène Leray-Moragués, Adeera Levin, Susie Q. Lew, Helen Liapis, Kathleen D. Liu, Sergio Livigni, Francesco Locatelli, Anna Lorenzin, Jian-Da Lu, Renhua Lu, Nicholas Lysak, Etienne Macedo, Niti Madan, François Madore, Linda L. Maerz, Matthew J. Maiden, Rakesh Malhotra, Marita Marengo, Filippo Mariano, Paul E. Marik, John J. Marini, Rossella Marino, Mark R. Marshall, Johan Mårtensson, Ryo Matsuura, Clive N. May, Patrizio Mazzone, Jerry McCauley, Peter A. McCullough, Blaithin A. McMahon, Ravindra L. Mehta, Caterina Mele, Madhav Menon, Mario Meola, Aicha Mérouani, Jean-Yves Meuwly, Paola Milla, Madhukar Misra, Paraish S. Misra, Barry A. Mizock, Jwalant R. Modi, Gilbert Moeckel, Bruce A. Molitoris, Santo Morabito, Roberto Pozzi Mucelli, Patrick T. Murray, Raghavan Murugan, Mitra K. Nadim, Devika Nair, Federico Nalesso, Mauro Neri, Trung C. Nguyen, Zhaohui Ni, Marina Noris, Tessa Novick, John C. O'Horo, Mark Douglas Okusa, Steven M. Opal, Helen Ingrid Opdam, Marlies Ostermann, Emerenziana Ottaviano, Heleen M. Oudemans-van Straaten, Christian Overgaard-Steensen, Massimo A. Padalino, Vincenzo Panichi, Priyanka Parameswaran, Samir S. Patel, Didier Payen, Federico Pea, W. Frank Peacock, Sandrica Young Peart, Sadudee Peerapornratana, Paolo Pelosi, Zhi-Yong Peng, Norberto Perico, Licia Peruzzi, Francesco Pesce, Antonio Pesenti, Ilaria Petrucci, Phuong-Chi Pham, Phuong-Thu Pham, Richard K.S. Phoon, Salvatore Piano, Michael R. Pinsky, Lise Piquilloud, Valentina Pistolesi, Lindsay D. Plank, Frans B. Plötz, Manuel Alfredo Podestá, Camillo Porta, Marco Pozzato, Michele Prencipe, John R. Prowle, Zudin A. Puthucheary, Lirong Qu, Jean-Sebastien Rachoin, Jai Radhakrishnan, V. Marco Ranieri, Ranistha Ratanarat, Giuseppe Remuzzi, Shelby Resnick, Oleksa G. Rewa, Zaccaria Ricci, Christophe Ridel, Kinan Rifai, Troels Ring, Lilia M. Rizo-Topete, Eric Roessler, Paola Romagnani, Stefano Romagnoli, Claudio Ronco, Federico Ronco, Mitchell H. Rosner, Emanuele Rossetti, James A. Russell, Georges Saab, Alice Sabatino, Sonali S. Saboo, Sara Samoni, Penny Lynn Sappington, Marco Sartori, Judy Savige, Francesco Paolo Schena, Antoine Guillaume Schneider, Pieter Schraverus, Wibke Schulte, Giuseppe Segoloni, Matthew W. Semler, Aashish Sharma, Andrew Shaw, Naitik Sheth, Ashutosh Shukla, Eric C. Siddall, Theodore M. Sievers, Edward D. Siew, Kai Singbartl, Mervyn Singer, Pooja Singh, Loren E. Smith, Sachin S. Soni, Mara Serrano Soto, Herbert D. Spapen, Nattachai Srisawat, Ajay Srivastava, Giovanni Stellin, Jordan M. Symons, Balazs Szamosfalvi, Kian Bun Tai, Unmesh V. Takalkar, Isaac Teitelbaum, Ciro Tetta, Charuhas V. Thakar, Marta Tonon, Francesco Trepiccione, Darrell Triulzi, Chopra Tushar, Shigehiko Uchino, Ali Valika, Wim Van Biesen, Wim Vandenberghe, Raymond Vanholder, Jill Vanmassenhove, Anton Verbine, Marco Vergano, Gianluca Villa, Pierre-Marc Villeneuve, Jean-Louis Vincent, Christophe Vinsonneau, Grazia Maria Virzì, Federico Visconti, Ravindran Visvanathan, Li Van Vong, Hans-Dieter Walmrath, Peter A. Ward, Matthew A. Weir, Xiaoyan Wen, Julia Wendon, James Frank Winchester, Adrian Wong, Elke L. Woodhouse, Jun Xue, Anju Yadav, Preethi Yerram, Lenar Yessayan, Jane Y. Yeun, Alex W. Yu, Marta Zaccaria, Miriam Zacchia, Teena P. Zachariah, Nereo Zamperetti, Fernando G. Zampieri, Pierluigi Zanco, Alberto Zanella, Luca Zanoli, Michael Zappitelli, Jose J. Zaragoza, Alexander Zarbock, Marta Zaroccolo, Han Zhang, and Andrea Zimmer

Published
2019

9. The Concept of Renal Replacement Therapy Dose and Efficiency

Author

Zaccaria Ricci, Rinaldo Bellomo, John A. Kellum, Claudio Ronco, and Stefano Romagnoli

Subjects
Critically ill, business.industry, Anesthesia, medicine.medical_treatment, medicine, Acute dialysis, Renal replacement therapy, Hemodialysis, Medical prescription, Best evidence, business, Dialysis, Dose prescription
Abstract

The issue of acute dialysis dose prescription has undergone significant revision in the last 10 years. The previous idea that critically ill patients' survival was proportional to delivered dialysis being the highest with the highest dose has been downplayed. The best evidence supports a continuous renal replacement therapy dose of at least 25 mL/kg/hr of effluent flow rate, for venovenous hemofiltration, hemodialysis, or hemodiafiltration. However, if standard dose prescription may be recommended at the start of an acute dialytic treatment, strict control of delivered dose is recommended for adequate delivery of the prescribed dose. Furthermore, prescription and delivery should be reassessed frequently to meet the patients' needs, tailoring the removal of solutes to the complex and rapidly changing metabolism of different patients.

Published
2019

10. Preface

Author

Claudio Ronco, Rinaldo Bellomo, John A. Kellum, and Zaccaria Ricci

Published
2019

11. The Role of Biomarkers in the Diagnosis and Management of Acute Kidney Injury

Author

Emily L Joyce, Raghavan Murugan, Zhiyong Peng, and John A. Kellum

Subjects
medicine.medical_specialty, Creatinine, business.industry, Adverse outcomes, Acute kidney injury, Psychological intervention, medicine.disease, Clinical judgment, Timely diagnosis, chemistry.chemical_compound, chemistry, Risk stratification, medicine, Intensive care medicine, business
Abstract

Acute kidney injury (AKI) is a common problem with adverse outcomes. More timely diagnosis would allow for earlier interventions and could improve patient outcomes. Due to the inherent limitation of serum creatinine, numerous novel biomarkers have been discovered for early identification of AKI. In addition to facilitating earlier diagnosis, these biomarkers have been demonstrated to play roles in risk stratification, early intervention, and prognosis. However, the diagnostic and prognostic predictive power of these biomarkers is variable, and only few biomarkers are in widespread clinical use. A panel of biomarkers or integration with clinical judgment may improve their performance.

Published
2019

13. Dedication

Author

Claudio Ronco, Rinaldo Bellomo, John A. Kellum, and Zaccaria Ricci

Published
2019

14. Remote Ischemic Preconditioning

Author

John A. Kellum, Dana Y. Fuhrman, and Alexander Zarbock

Subjects
Nephrology, medicine.medical_specialty, business.industry, Acute kidney injury, Ischemia, Context (language use), medicine.disease, Internal medicine, medicine, Ischemic preconditioning, business, Intensive care medicine, Kidney transplantation, Target organ
Abstract

Context: Remote ischemic preconditioning (RIPC), whereby providing brief episodes of ischemia and reperfusion to an organ site to provide protection to a distant target organ, has great implications for critical care nephrology. This chapter summarizes the hypothesized mechanisms, clinical utility, and future directions for RIPC. Evidence Acquisition: PubMed was searched for studies reporting the effect of RIPC on acute kidney injury (AKI), contrast-induced AKI, and kidney transplantation. Additional citations were found by reviewing the biographies of relevant articles. Results: RIPC has been explored as a renoprotective strategy for AKI, contrast-induced AKI, and kidney transplantation. The differential beneficial effect of RIPC when comparing investigations may be due to differences in study protocols, patient populations, and medications exposure. Conclusions: Recent investigations suggest that studies exploring the use of biomarkers as a method to predict which patients may ultimately benefit from the use of RIPC are needed.

Published
2019

15. Nonpharmacologic Management of Acute Renal Injury

Author

Marco Fiorentino and John A. Kellum

Subjects
medicine.medical_specialty, Resuscitation, Mean arterial pressure, business.industry, Acute kidney injury, Hemodynamics, Renal function, medicine.disease, law.invention, Distributive shock, Randomized controlled trial, law, medicine, Intravascular volume status, Intensive care medicine, business
Abstract

Specific treatments for acute kidney injury (AKI) are still not available, so prevention of AKI is fundamental to reduce the impact of AKI in critically ill patients. This chapter reviews the recent scientific literature and describes the most important nonpharmacologic approaches in preventing AKI, focusing on monitoring and optimizing hemodynamic status and minimizing nephrotoxic exposures. Critically ill patients should benefit from the maintenance of adequate volume status, but fluid overload is associated with worse outcomes and should be avoided; however, protocolized-based resuscitation is not superior to the standard care in this setting. Use of crystalloids rather than colloids is preferred and suggested. Although data from randomized controlled trials did not describe the superiority of buffered solutions, chloride-rich solutions should be avoided for patients at high risk for hyperchloremic metabolic acidosis. The persistence of hypotension after optimization of volume status should be avoided; a mean arterial pressure of 65 mm Hg or greater is required in patients with distributive shock. In patients at high risk for AKI, nephrotoxic exposure should be minimized. Low- and iso-osmolar contrast agents should be preferred and used in the lowest volume consistent with a diagnostic result; volume expansion and adequate monitoring of renal function postprocedure should be performed. Other nephrotoxic drugs, such as amphotericin B and aminoglycosides, should be used only when necessary and with caution. The maintenance of adequate hemodynamic and volume status and the minimization of nephrotoxic exposures are the most effective nonpharmacologic strategies to prevent AKI.

Published
2019

16. Acute Kidney Injury in Cardiac Surgery

Author

Alexander Zarbock and John A. Kellum

Subjects
03 medical and health sciences, 0302 clinical medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology
Published
2019

18. Contributors

Author

Andrew Advani, Michael Allon, Amanda Hyre Anderson, Gerald B. Appel, Suheir Assady, Anthony Atala, Colin Baigent, Sevcan A. Bakkaloglu, Gina-Marie Barletta, Gavin J. Becker, Rinaldo Bellomo, Jeffrey S. Berns, Vivek Bhalla, Jürg Biber, Daniel G. Bichet, René J.M. Bindels, Melissa B. Bleicher, Jon D. Blumenfeld, Alain Bonnardeaux, Joseph V. Bonventre, William D. Boswell, Donald W. Bowden, Barry M. Brenner, Matthew D. Breyer, Richard M. Breyer, Dennis Brown, Carlo Brugnara, Timothy E. Bunchman, David A. Bushinsky, Stéphan Busque, Juan Jesús Carrero, Daniel Cattran, James C. Chan, Anil Chandraker, Ingrid J. Chang, Devasmita Choudhury, Fredric L. Coe, John F. Collins, H. Terence Cook, Ricardo Correa-Rotter, Shawn E. Cowper, Paolo Cravedi, Alfonso M. Cueto-Manzano, Vivette D. D’Agati, Mogomat Razeen Davids, Scott E. Delacroix, Bradley M. Denker, Thomas A. Depner, Thomas D. DuBose, Kai-Uwe Eckardt, Mohamed T. Eldehni, David H. Ellison, Michael Emmett, Ronald J. Falk, Harold I. Feldman, Robert A. Fenton, Andrew Z. Fenves, Kevin W. Finkel, Paola Fioretto, Damian G. Fogarty, John R. Foringer, Denis Fouque, Barry I. Freedman, Jørgen Frøkiaer, John W. Funder, David S. Game, Richard E. Gilbert, Jared J. Grantham, Mitchell L. Halperin, Matthew Hand, Donna S. Hanes, David C.H. Harris, Raymond C. Harris, Richard Haynes, Joost G.J. Hoenderop, Ewout J. Hoorn, Thomas H. Hostetter, Chi-yuan Hsu, Shih Hua-Lin, Hassan N. Ibrahim, Ajay K. Israni, Jossein Jadvar, J. Charles Jennette, Eric Jonasch, Kamel S. Kamel, S. Ananth Karumanchi, Bertram L. Kasiske, John A. Kellum, Carolyn J. Kelly, Ramesh Khanna, David K. Klassen, Christine J. Ko, Harbir Singh Kohli, Curtis K. Kost, L. Spencer Krane, Jordan Kreidberg, Tae-Hwan Kwon, Amit Lahoti, Martin J. Landray, John H. Laragh, Harold E. Layton, Moshe Levi, Bengt Lindholm, Frank Liu, Valerie A. Luyckx, David A. Maddox, Yoshiro Maezawa, Arthur J. Matas, Michael Mauer, Ivan D. Maya, Sharon E. Maynard, Alicia A. McDonough, Christopher W. McIntyre, Timothy W. Meyer, William E. Mitch, Orson W. Moe, Sharon M. Moe, Bruce A. Molitoris, Alvin H. Moss, David B. Mount, Karen A. Munger, Patrick H. Nachman, Saraladevi Naicker, Søren Nielsen, Eric G. Neilson, Lindsay E. Nicolle, Daniel B. Ornt, Manuel Palacín, Paul M. Palevsky, Suzanne L. Palmer, Hans-Henrik Parving, Jaakko Patrakka, David Pearce, Roberto Pecoits-Filho, Carmen A. Peralta, Norberto Perico, Neil R. Powe, Kearkiat Praditpornsilpa, Jeppe Prætorius, Susan E. Quaggin, L. Darryl Quarles, Jai Radhakrishnan, Rawi Ramadan, Piero Reggenenti, Heather N. Reich, Andrea Remuzzi, Giuseppe Remuzzi, Stephen S. Rich, Miguel C. Riella, Eberhard Ritz, Claudio Ronco, Norman D. Rosenblum, Peter Rossing, Dvora Rubinger, Robert K. Rude, Ernesto Sabath, Venkata Sabbisetti, Vinay Sakhuja, Alan D. Salama, Jeff M. Sands, Fernando Santos, Mohamed H. Sayegh, John D. Scandling, Franz Schaefer, Jon I. Scheinman, John C. Schwartz, Asif A. Sharfuddin, Susan Shaw, Visith Sitprija, Karl L. Skorecki, Itzchak N. Slotki, James P. Smith, Miroslaw J. Smogorzewski, Stuart M. Sprague, Peter Stenvinkel, John B. Stokes, Maarten W. Taal, Manjula Kurella Tamura, Jane C. Tan, Stephen C. Textor, Ravi Thadhani, Scott C. Thomson, Vincente E. Torres, Karl Tryggvason, Meryem Tuncel, Kriang Tungsanga, Joseph G. Verbalis, Jill W. Verlander, Shoyab Wadee, I. David Weiner, Matthew R. Weir, Steven D. Weisbord, David C. Wheeler, Christopher S. Wilcox, Christopher G. Wood, Stephen H. Wright, Jane Y. Yeun, Alan S.L. Yu, Kambiz Zandi-Nejad, and Mark L. Zeidel

Published
2012

19. Polyuria

Author

Ramesh Venkataraman and John A. Kellum

Published
2011

20. Contributors

Author

Edward Abraham, Peter Abrams, Kareem Abu-Elmagd, Yasir Abu-Omar, Carlos Agustí, William C. Aird, Philip Alapat, Ali H. Al-Khafaji, Gustavo G. Angaramo, Derek C. Angus, Anastasia Antoniadou, Anupam Anupam, Andrew C. Argent, John H. Arnold, Anna Arroyo, Stephen Ashwal, Mark E. Astiz, Elie Azoulay, Omer A. Bajwa, Anthony Baldea, Marie R. Baldisseri, Zsolt J. Balogh, Rasheed Abiodun Balogun, Arna Banerjee, Philip S. Barie, Brendan Barrett, Robert Bartlett, John G. Bartlett, Gianluigi Li Bassi, Sarice L. Bassin, Julie A. Bastarache, Colin Bauer, Daniel G. Bausch, Hülya Bayýr, David T. Bearden, Gregory J. Beilman, Rinaldo Bellomo, E. David Bennett, Gordon R. Bernard, Jay K. Bhama, Joost J.L.M. Bierens, Walter L. Biffl, Thomas P. Bleck, Thomas A. Bledsoe, Karen C. Bloch, Frank Bloos, Desmond Bohn, Nicole C. Bouchard, Arthur J. Boujoukos, William J. Brady, Serge Brimioulle, Daniel E. Brooks, Richard C. Brundage, Jeffrey P. Burns, Belén Cabello, Karen H. Calhoun, Clifton W. Callaway, Peter M.A. Calverley, John Camm, Diane M. Cappelletty, Joseph A. Carcillo, Anthony J. Carlese, Juan Carlos-Puyana, Franco A. Carnevale, Edward D. Chan, Sanjay Chawla, Lakshmipathi Chelluri, David C. Chen, Annie S. Chevrier, Su Min Cho, Robert S.B. Clark, Michael A. Coady, Stephen M. Cohn, Alan D. Cook, Deborah J. Cook, Robert N. Cooney, Susan J. Corbridge, Thomas C. Corbridge, Howard L. Corwin, Mark A. Crowther, Burke A. Cunha, Cheston B. Cunha, J. Randall Curtis, Vincenzo D’Intini, Pirouz Daeihagh, Joseph M. Darby, James M. Dargin, Michaël Darmon, Joseph F. Dasta, John D. Davies, Robert W. Derlet, Mark Dershwitz, Anne Marie G.A. de Smet, Monica Dhand, Anahat Dhillon, Rajeev Dhupar, Michael N. Diringer, Peter Doelken, Michael Donahoe, Timothy R. Donahue, David J. Dries, Thomas D. DuBose, Susan Duthie, Randy Edwards, Philippe Eggimann, Waleed A. Elhassan, E. Wesley Ely, Guillaume Emeriaud, Gregory A. Eschenauer, Joel H. Ettinger, Joshua H. Ettinger, David Clay Evans, Gregory T. Everson, Derek V. Exner, Ronald J. Falk, Jeremy Farrar, Alan P. Farwell, Kathryn Felmet, Niall D. Ferguson, Miguel Ferrer, Mitchell P. Fink, Ericka L. Fink, Douglas N. Fish, Diana F. Florescu, Brett E. Fortune, Bradley D. Freeman, Blake Froberg, John J. Fung, Brent Furbee, Richard L. Gamelli, Raúl J. Gazmuri, Robert H. Geelkerken, Todd W.B. Gehr, Michael A. Gentile, M. Patricia George, Herwig Gerlach, R. Mark Ghobrial, Helen Giamarellou, Fredric Ginsberg, Thomas G. Gleason, Jacques P. Goldstein, Hernando Gomez, Sherilyn Gordon Burroughs, Jeremy David Gradon, Cornelia R. Graves, Cesare Gregoretti, Jeffrey S. Groeger, R. Michael Grounds, Paul O. Gubbins, Kyle J. Gunnerson, Fahim A. Habib, Mitchell L. Halperin, Mary E. Hartman, Maurene A. Harvey, Moustafa A. Hassan, Yoshiro Hayashi, Jan A. Hazelzet, Stephen O. Heard, Paul C. Hébert, Elizabeth D. Hermsen, Daren K. Heyland, Jonathan R. Hiatt, Robert W. Hickey, Tran Tinh Hien, Thomas L. Higgins, Nicholas S. Hill, Horacio Hojman, Steven M. Hollenberg, J. Terrill Huggins, David T. Huang, Christopher G. Hughes, Russell D. Hull, Margaret Isaac, James P. Isbister, Connie Jastremski, Larry Jenkins, Paul Jodka, Robert G. Johnson, Philippe G. Jorens, Vern C. Juel, Rose Jung, Christina R. Kahl, Andre C. Kalil, Edo Kaluski, Kamel S. Kamel, Sandra Kane-Gill, Jeffrey P. Kanne, Lionel Karlin, Marinka Kartalija, James Kasiewicz, Kenneth D. Katz, David Kaufman, John A. Kellum, Rick Kingston, Orlando C. Kirton, Kurt Kleinschmidt, Jason Knight, Patrick M. Kochanek, W. Andrew Kofke, Jeroen J. Kolkman, Robert L. Kormos, Rosemary A. Kozar, David J. Kramer, John W. Kreit, James A. Kruse, Anand Kumar, Vladimir Kvetan, Jacques Lacroix, Gilles Lebuffe, Virginie Lemiale, Angela M. Leung, Sharon Leung, Allan D. Levi, Phillip D. Levin, Mitchell M. Levy, Mah Chou Liang, Scott Liebman, Stuart L. Linas, Gregory Y.H. Lip, Pamela A. Lipsett, Alan Lisbon, Carmen Lucena, Andrew I.R. Maas, Neil R. MacIntyre, Duncan Macrae, Bernhard Maisch, Amer M. Malik, Jordi Mancebo, Henry J. Mann, Sanjay Manocha, Stéphane Manzo-Silberman, Paul E. Marik, John J. Marini, Donald W. Marion, Steven J. Martin, Alvaro Martinez-Camacho, Anne Marie Mattingly, Gary R. Matzke, Adeline Max, George V. Mazariegos, Joanne Mazzarelli, Stephen A. McClave, Ryan M. McEnaney, John K. McIllwaine, Michelle K. McNutt, Sangeeta Mehta, Dieter Mesotten, Kimberly S. Meyer, David J. Michelson, Saar Minha, Marek A. Mirski, Rima A. Mohammad, Xavier Monnet, Frederick A. Moore, Laura J. Moore, Anne-Sophie Moreau, Delphine Moreau, Alison Morris, Amy E. Morris, Bruno Mourvillier, Mark A. Munger, Raghavan Murugan, Claus-Martin Muth, Kurt G. Naber, Lena M. Napolitano, Stanley A. Nasraway, Jovany Cruz Navarro, Lewis S. Nelson, Michael S. Niederman, Jessica C. Njoku, Scott Norwood, Juan B. Ochoa, Mark D. Okusa, Keith M. Olsen, Steven M. Opal, James P. Orlowski, Catherine M. Otto, Heleen M. Oudemans-van Straaten, Pratik P. Pandharipande, Joseph E. Parrillo, David L. Paterson, Frédéric L. Paulin, Andrew B. Peitzman, Daleen Aragon Penoyer, Bradley Peterson, Graham F. Pineo, Michael R. Pinsky, Greta Piper, Didier Pittet, Fred Plum, Murray M. Pollack, Lucido L. Ponce, Robert Pousman, Peter J. Pronovost, Przemyslaw B. Radwański, Thomas G. Rainey, Thomas Rajan, Vito Marco Ranieri, Konrad Reinhart, Jorge Reyes, Andrew Rhodes, Zaccaria Ricci, Christian Richard, John R. Richards, John Riordan, Arsen D. Ristic, Sandro Rizoli, Claudia S. Robertson, Emmanuel Robin, Ferran Roche-Campo, Paul Rogers, Claudio Ronco, John C. Rotschafer, Gordon D. Rubenfeld, Randall A. Ruppel, Laura T. Russo, Daniel E. Rusyniak, Steven A. Sahn, Juan C. Salgado, Cristina Santonocito, Penny Lynn Sappington, John Sarko, Richard H. Savel, Irina Savelieva, Benoit Schlemmer, Minka Schofield, Kristine S. Schonder, Anton C. Schoolwerth, Robert W. Schrier, Carl Schulman, Evan Schwarz, Aaron M. Scifres, Donna L. Seger, Amelie Seguin, Frank W. Sellke, Sajid Shahul, M. Khaled Shamseddin, Erik S. Shank, Eduard Shantsila, Kapil Sharma, Robert L. Sheridan, Ariel L. Shiloh, Debra J. Skaar, Anthony D. Slonim, Teresa L. Smith Jacobs, Pablo Solís-Muñoz, Michael D. Sosin, Charles L. Sprung, Vincenzo Squadrone, Thomas E. Starzl, Steven M. Steinberg, David M. Steinhorn, Eric J. Stern, Thomas E. Stewart, Nino Stocchetti, Joerg-Patrick Stübgen, Sanjay Subramanian, Justin Szawlewicz, David Szpilman, David P. Taggart, Daniel Talmor, Jean-Louis Teboul, Isaac Teitelbaum, Stephen R. Thom, C. Louise Thwaites, Jean-François Timsit, Alan Tinmouth, Samuel A. Tisherman, S. Rob Todd, Antoni Torres, Robert D. Truog, Krista Turner, Edith Tzeng, Nir Uriel, Benoit Vallet, Greet Van den Berghe, P. Vernon van Heerden, Benjamin W. Van Tassell, Frédéric Vanden Eynden, Olivier Varenne, Ramesh Venkataraman, Kathleen M. Ventre, Zvi Vered, Jean-Louis Vincent, Elizabeth A. Vitarbo, Louis Voigt, Florian M.E. Wagenlehner, Christina J. Wai, Keith R. Walley, Nicholas S. Ward, Lorraine B. Ware, Robert J. Weber, Lawrence R. Wechsler, David Weill, Craig R. Weinert, Julia Wendon, Michel Wolff, Benjamin Wrigley, Richard G. Wunderink, Lam M. Yen, Sergio L. Zanotti-Cavazzoni, Allyson R. Zazulia, Janice Zimmerman, and Walter Zingg

Published
2011

21. Acid-Base Disorders

Author

John A. Kellum

Subjects
Biochemistry, business.industry, Medicine, business, Acid-base disorders
Published
2011

22. Evidence-Based Critical Care

Author

Mary E. Hartman, John A. Kellum, and Derek C. Angus

Subjects
medicine.medical_specialty, Evidence-based practice, business.industry, medicine, Intensive care medicine, business
Published
2011

23. Oliguria

Author

Sanjay Subramanian, Ramesh Venkatarman, and John A. Kellum

Published
2011

25. Oliguria

Author

Sanjay Subramanian, John A. Kellum, and Claudio Ronco

Published
2009

26. Disorders of Chronic Metabolic Alkalosis

Author

John A. Kellum, Nicholas J. Madden, Matthew A. Butkus, and Raghavan Murugan

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, medicine, Metabolic alkalosis, business, medicine.disease
Published
2009

30. Anion Gap and Strong Ion Gap

Author

John A. Kellum and Raghavan Murugan

Subjects
Materials science, Strong ion gap, Chemical physics, Anion gap
Published
2009

31. Preface

Author

Claudio Ronco, Rinaldo Bellomo, and John A. Kellum

Published
2009

32. What Is Acute Kidney Injury?

Author

John A. Kellum, Eric Hoste, Claudio Ronco, and Rinaldo Bellomo

Subjects
medicine.medical_specialty, business.industry, medicine, Acute kidney injury, Intensive care medicine, business, medicine.disease
Published
2009

33. Acute Metabolic Alkalosis

Author

Raghavan Murugan, Nicholas J. Madden, John A. Kellum, and Matthew A. Butkus

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, medicine, Metabolic alkalosis, medicine.disease, business
Published
2009

36. The Kidney in Acute Heart Failure Syndromes and Cardiogenic Shock

Author

John A. Kellum, Vijay Karajala-Subramanyam, and Adrian A. Salmon

Subjects
Kidney, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Heart failure, Cardiogenic shock, Internal medicine, medicine, Cardiology, medicine.disease, business
Published
2009

37. Genetic Variation and Critical Illness

Author

Zhiyong Peng, Matthew A. Butkus, Neeta Kannan, and John A. Kellum

Subjects
Critical illness, Genetic variation, Biology, Demography
Published
2009

39. Principles of Fluid Therapy

Author

John A. Kellum and Ramesh Venkataraman

Subjects
medicine.medical_specialty, Fluid therapy, business.industry, medicine, Intensive care medicine, business
Published
2009

40. Case Studies: Acid-Base Problems

Author

John A. Kellum, Raghavan Murugan, Matthew A. Butkus, and Neeta Kannan

Subjects
Computer science, Polymer chemistry, Base (exponentiation)
Published
2009

41. Diagnosis and Therapy of Metabolic Alkalosis

Author

Raghavan Murugan, John A. Kellum, Nicholas J. Madden, and Alan C. Heffner

Subjects
business.industry, Metabolic alkalosis, medicine, Physiology, medicine.disease, business
Published
2009

42. Contributors

Author

Cataldo Abaterusso, Stéphane P. Ahern, Maria Cristina Aisa, Robert C. Albright, Vicente Alfaro, Ali Al-Khafaji, Jean-Christophe Allo, Richard Amerling, Alessandro Amore, Robert J. Anderson, Michele Andreucci, Vittorio E. Andreucci, Emilios Andrikos, Vicente Arroyo, John M. Arthur, Stephen R. Ash, Emilio Assanelli, Filippo Aucella, Sean M. Bagshaw, Olga Balafa, André Luís Balbi, Ian Baldwin, Marco Ballestri, Joanne M. Bargman, Gina-Marie Barletta, Jeffrey F. Barletta, Libero Barozzi, Rashad S. Barsoum, Monica Beaulieu, Donna Beer-Stolz, Rinaldo Bellomo, Jose Bernardo, Michele Bertolotto, John T. Bestoso, Gerard A. Betro, Mallar Bhattacharya, Geoffrey R. Bihl, Stijn I. Blot, Willem Boer, Mirian A. Boim, Monica Bonello, Joseph V. Bonventre, A.D. Booth, Edmund Bourke, George Braitberg, Diego Brancaccio, Alessandra Brendolan, Brigida Brezzi, James C. Brodie, Patrick D. Brophy, Ryan Brown, Richard Bucala, Jonathan Buckmaster, Milos N. Budisavljevic, Timothy E. Bunchman, Emmanuel A. Burdmann, Benedetta Bussolati, Matthew A. Butkus, Daniela Buzzelli, Paolo Calzavacca, Giovanni Camussi, Bernard Canaud, Noël J.M. Cano, Vincenzo Cantaluppi, Giovambattista Capasso, Gianni Cappelli, Eleonora Carlesso, Francesco G. Casino, Leticia Castillo, Roberta Cerutti, Lakhmir S. Chawla, Chang Yin Chionh, Alexander Chiu, May T. Chow, Kirpal S. Chugh, Bruno Cianciaruso, Mauro Cignarelli, Yann-Erick Claessens, John A. Clark, William R. Clark, David J. Cohen, Scott D. Cohen, Peter Constable, Rosanna Coppo, Howard E. Corey, Mario Cozzolino, Maureen Craig, Carl H. Cramer, Mark Crandall, Paolo Cravedi, Carlo Crepaldi, R. John Crew, Donald F. Cronin, Dinna N. Cruz, Antonio Dal Canton, Maurizio Dan, Angela D'Angelo, Andrew Davenport, Andrew R. Davies, James W. Dear, Andrea De Gasperi, Roberto Dell'Aquila, Giorgio Della Rocca, Dorella Del Prete, Russell L. Delude, Thomas Depner, Lorenzo E. Derchi, Prasad Devarajan, Jan J. De Waele, Jean-François Dhainaut, José A. Diaz-Buxo, Lucia Di Micco, José Carolina Divino-Filho, Sarah Doernberg, Gordon S. Doig, David J. Dries, Francesco Maria Drudi, Wilfred Druml, Graeme Duke, Andrew Durward, Moritoki Egi, Ciro Esposito, Pieter Evenepoel, Teresa Faga, Sheung Tat Fan, Donald A. Feinfeld, Eric Féraille, Javier Fernández, Simon Finfer, Mitchell P. Fink, Kevin W. Finkel, Michael F. Flessner, Marco Formica, Lui G. Forni, James D. Fortenberry, Craig French, Roberto Fumagalli, Mario Furlanut, Micheline Djouguela Fute, Daniela Ponce Gabriel, Andrea Galassi, Miriam Galbusera, Francesco Galli, Giovanni Galli, Maurizio Gallieni, Giampiero Gallo, Giovanni Gambaro, Hilary S. Gammill, Ezio Nicola Gangemi, Dayong Gao, Susan Garwood, Francesco Garzotto, Antonietta M. Gatti, Luciano Gattinoni, John P. Geibel, Stephen George, Loreto Gesualdo, R.T. Noel Gibney, Debbie S. Gipson, Ilya G. Glezerman, Griet Glorieux, Stuart L. Goldstein, Thomas A. Golper, Manjula Gowrishankar, Fabio Grandi, Cesare Gregoretti, Brian W. Grinnell, A.B. Johan Groeneveld, Steven J. Gruber, Gualtiero Guadagni, Kyle J. Gunnerson, Akanksha Gupta, Victor Gura, Isabella Guzzo, Richard Hackbarth, Mitchell L. Halperin, Nikolas Harbord, Jean-Philippe Haymann, Alan C. Heffner, Anthony J. Hennessy, Samuel N. Heyman, Graham L. Hill, Philip J. Hilton, Jonathan Himmelfarb, Hiroyuki Hirasawa, Nicholas A. Hoenich, Stephen R. Holdsworth, Anthony Holley, Patrick M. Honoré, Eric A.J. Hoste, Andrew A. House, David T. Huang, Zhongping Huang, Rolf D. Hubmayr, Alun D. Hughes, H. David Humes, T. Alp Ikizler, Barbara Imberti, Todd S. Ing, Bertrand L. Jaber, Gérard Janvier, Arundhathi Jeyabalan, Vivekanand Jha, Olivier Joannes-Boyau, Michael Joannidis, Daryl A. Jones, Achim Jörres, Kamel S. Kamel, Ryan C. Kamp, Neeta Kannan, Lewis J. Kaplan, Özgür Karacan, Vijay Karajala-Subramanyam, Gur P. Kaushal, John A. Kellum, Markus J. Kemper, Asjad Khan, Ramesh Khanna, Vijay Kher, Paul L. Kimmel, Detlef Kindgen-Milles, A. Richard Kitching, Carl M. Kjellstrand, Orly F. Kohn, Laura A. Kooienga, Jeroen P. Kooman, Peter Kotanko, Raymond T. Krediet, A.A. Kroon, Dingwei Kuang, Martin K. Kuhlmann, Jan Willem Kuiper, Man-Fai Lam, Olga Lamacchia, Norbert Lameire, Christoph Langenberg, Gianfranco Lauri, Martine Leblanc, Ingrid Ledebo, Paolo Lentini, Edward F. Leonard, Jeffrey J. Letteri, Karel M. Leunissen, Xavier M. Leverve, Adeera Levin, John K. Leypoldt, Orfeas Liangos, Elisa Licari, Wilfred Lieberthal, Peter K. Linden, Jeffrey Lipman, Kathleen D. Liu, Shiguang Liu, Sergio Livigni, Wai-Kei Lo, Manuela Lugano, Sing-Leung Lui, Antonio Lupo, Valerie A. Luyckx, William L. Macias, Nicholas Madden, François Madore, Daniel S. Majors, Elena Mancini, Filippo Mangione, Sunil Mankad, Pier Paolo Manzini, Martino Marangella, Giancarlo Marenzi, Filippo Mariano, Paul E. Marik, John J. Marini, François Marquis, John C. Marshall, Mark R. Marshall, Roy Mathew, Kenichi Matsuda, Michael A. Matthay, Norma J. Maxvold, Clive N. May, Jerry McCauley, Maureen McCunn, Joseph McKenna, Ravindra L. Mehta, Caterina Mele, Aicha Merouani, Laurent Mesnard, Piergiorgio Messa, Philipp G.H. Metnitz, Madhukar Misra, Steffen R. Mitzner, Barry A. Mizock, Babak Mokhlesi, Bruce A. Molitoris, Andrea Morelli, Thomas John Morgan, Marina Morigi, Peter Mount, Roberto Pozzi Mucelli, Bruce A. Mueller, Patrick Murray, Raghavan Murugan, Masataka Nakamura, Federico Nalesso, Carla M. Nester, Allen Nissenson, Karl Nolph, Catalina Ocampo, Shigeto Oda, Mark D. Okusa, Steven M. Opal, Helen Opdam, Hartmut Osswald, Heleen M. Oudemans–van Straaten, Massimo A. Padalino, Matthew L. Paden, Emil P. Paganini, Paul M. Palevsky, Mani John Panat, Francesco Paolini, Dipen Parikh, Nicolò Patroniti, Pietro Pavlica, Didier Payen de La Garanderie, Federico Pea, Zhiyong Peng, Mark A. Perazella, Angelo F. Perego, Estela Regina Pereira, Evans R. Fernández Pérez, Norberto Perico, Nicoletta Pertica, Giovanni Pertosa, Licia Peruzzi, Dimitris Petras, Phuong-Chi Pham, Phuong-Thu Pham, Richard K.S. Phoon, Stefano Picca, Pasquale Piccinni, Maury N. Pinsk, Michael R. Pinsky, Marta Piroddi, Isabelle Plamondon, Lindsay D. Plank, Frans B. Plötz, Lusine Poghosyan, Natalia Polanco, Patricio M. Polanco, Hans Dietrich Polaschegg, Rafael Ponikvar, Silvia Porecca, Didier Portilla, T. Brian Powell, Raymond Quigley, Hamid Rabb, Maximilian Ragaller, Teresa Rampino, Reena Ranpuria, Anjay Rastogi, Ranistha Ratanarat, Naem Raza, Michael C. Reade, John H. Reeves, Karl Reiter, Giuseppe Remuzzi, Zaccaria Ricci, Sven-Erik Ricksten, Christophe Ridel, Kinan Rifai, Troels Ring, Julie Riopel, Eduardo Rocha, Eric Roessler, Roberto Rona, Claudio Ronco, Eric Rondeau, Seymour Rosen, Christian Rosenberger, Shane Rowan, Thomas Roy, Georges Saab, Tomohito Sadahiro, Carla Sala, Chiara Sala, Alan D. Salama, Adrian Salmon, Gabriela Salvatori, Ramin Sam, Ruben M. Sandoval, Antonio Santoro, Takao Saotome, Penny L. Sappington, J. Vidya Sarma, Judy Savige, Francesco Paolo Schena, Eva Schepers, Miet Schetz, Gregory A. Schmidt, Nestor Schor, Nicola Schusterschitz, Giuseppe Segoloni, Nirva Shah, Shamik H. Shah, Sudhir V. Shah, Asif A. Sharfuddin, Andrew Shaw, Hidetoshi Shiga, Hisataka Shoji, Ashutosh Shukla, Fiona Simpson, Kai Singbartl, Mervyn Singer, Kim Solez, Kevin M. Sowinski, Mark Stafford-Smith, Jan Stange, Luca Stefanelli, Deborah M. Stein, Maurizio Stella, Giovanni Stellin, David A. Story, Sanjay Subramanian, Kristina Swärd, Jordan M. Symons, Kian Bun Tai, James Tattersall, Luisa Tedeschi, Isaac Teitelbaum, Vicente P. Castro Teixeira, Ciro Tetta, Charuhas V. Thakar, Hermann Theilen, Karl W. Thomas, Ashita Tolwani, Francesco Trepiccione, Giorgio Triolo, Jennifer L.Y. Tsang, Emre Tutal, Shigehiko Uchino, Mark Unruh, G. Matthew Vail, Massimo Valentino, Volker Vallon, Wim Van Biesen, Frank M. van der Sande, Dominique M. Vandijck, Raymond Vanholder, Sanju A. Varghese, Ramesh Venkataraman, Bala Venkatesh, Anton Verbine, Jean-Louis Vincent, Christophe Vinsonneau, Ravindran Visvanathan, Alexandra Voinescu, Scott Walters, Li Wan, Peter A. Ward, Richard A. Ward, Stephen Warrillow, Steve Webb, Kenneth Scott Whitlow, Anders Wieslander, Alan H. Wilkinson, Keith Wille, James Frank Winchester, Christine Wu, James Yassin, Jane Y. Yeun, Terence Pok-Siu Yip, Alex W. Yu, Miriam Zacchia, Najam Zaida, Nereo Zamperetti, Michael Zappitelli, and Alexander Zarbock

Published
2009

43. Acid-Base Balance and Kidney-Lung Interaction

Author

John A. Kellum and Rinaldo Bellomo

Subjects
medicine.medical_specialty, Kidney, Lung, medicine.anatomical_structure, Endocrinology, business.industry, Internal medicine, medicine, Acid–base homeostasis, business
Published
2008

44. CONTRIBUTORS

Author

Michael J. Apostolakos, Joan R. Badia, Sean M. Bagshaw, David J. Baker, Rinaldo Bellomo, Sven Bercker, Zaida D. Bisbal, Anthony F.T. Brown, Gustavo Buchele, Thilo Busch, Enrico Calzia, Annalisa Carlucci, Jean Chastre, Sanjeev V. Chhangani, Davide Chiumello, Alain Combes, Edgardo D'Angelo, Gary Dudek, Michael Ebsen, Brigitte Fauroux, Terence R. Flotte, Saskia Gischler, Diederik Gommers, Hérve Guénard, Claude Guérin, Jack J. Haitsma, Robert-Jan Houmes, Yuh-Chin T. Huang, Shazia M. Jamil, Jens Ingemann Jensen, Keith E. Johnson, Gavin M. Joynt, Udo Kaisers, George E. Karras, Hans-Ulrich Kauczor, John A. Kellum, Nick H. Kim, Younsuck Koh, Antonia Koutsoukou, Werner Kuckelt, Burkhard Lachmann, Chae-Man Lim, Jeffrey Lipman, Frédéric Lofaso, Charles-Edouard Luyt, Paul E. Marik, Klaus Markstaller, Jürgen P. Meinhardt, Joseph Milic-Emili, Konrad Morgenroth, Iqbal Mustafa, Claus-Martin Muth, Rahul Nanchal, Stefano Nava, Michael S. Niederman, Gustavo A. Ospina-Tascón, Jaideep J. Pandit, Peter J. Papadakos, Paolo Pelosi, Irene Perillo, Michael R. Pinsky, Christian Putensen, Michael Quintel, Milena Racagni, Peter Radermacher, Jayashree Raikhelkar, Miranda D. Reis, Irwin Reiss, Andreas Reske, Hans Ulrich Rothen, Charis Roussos, Dierk Schreiter, Marcus J. Schultz, Thomas P. Shanley, Ioanna Sigala, Indra Singh, Jaspal Singh, Arthur S. Slutsky, Pejman Soheili, Roger G. Spragg, Robert W. Taylor, Per A.J. Thorborg, Dick Tibboel, Antonio Torres, Mark J. Utell, Robert A. van Hulst, A.H.L.C. van Kaam, Joseph Varon, Theodoros Vassilakopoulos, Bala Venkatesh, Jean-Louis Vincent, Denham S. Ward, Helmar Wauer, Steffen Wolf, and Hector R. Wong

Published
2008

45. Contributors

Author

P. David Adelson, David B. Allen, Estella M. Alonso, Gülay Pinar Alper, Derek C. Angus, Sidney Anthone, Andrew Argent, John H. Arnold, Barbara Bambach, Hülya Bayir, Pierre Beaulieu, Laurie O. Beitz, Jorge R. Beltrán, Wade W. Benton, Robert A. Berg, Ira Bergman, Julie Blatt, Douglas L. Blowey, Jeffrey L. Blumer, John S. Bradley, Barbara W. Brandom, Martin L. Brecher, Richard J. Brilli, Guy F. Brisseau, Thomas V. Brogan, Timothy E. Bunchman, Sean P. Bush, Joseph Carcillo, Aaron L. Carrel, Hector Carrillo-Lopez, Victoria Cartwright, Hugo F. Carvajal, Leticia Castillo, Michael G. Caty, Pelin Cengiz, Anthony C. Chang, John R. Charpie, Adrián Chávez, Russell W. Chesney, Michael A. Cimino, Robert S.B. Clark, Jacqueline J. Coalson, D. Ryan Cook, Craig M. Coopersmith, Christopher P. Coppola, Seth J. Corey, Peter N. Cox, Kathleen Culver, James J. Cummings, Martha A.Q. Curley, Marek Czosnyka, Heidi J. Dalton, Stéphane Dauger, Peter J. Davis, Jenina Deshler, Sonny Dhanani, Rhonda M. Dick, Emily L. Dobyns, Elizabeth J. Donner, Didier Dreyfuss, Philippe Durand, Susan Duthie, Richard G. Ellenbogen, Jacqueline Evans, James C. Fackler, Kathryn Felmet, Jeffrey R. Fineman, Debra H. Fiser, Frank A. Fish, James E. Fletcher, J. Julio Pérez Fontán, Michael L. Forbes, Norman Fost, Joel E. Frader, Deborah Franzon, F. Jay Fricker, Aaron L. Friedman, Bradley P. Fuhrman, France Gauvin, Eli Gilad, James C. Gilbert, Brett P. Giroir, Stuart L. Goldstein, James Graham, Jerril W. Green, Thomas P. Green, Stephanie Greene, James A. Griffith, Mauro Grossi, Björn Gunnarsson, Scott A. Hagen, Cecil D. Hahn, Craig Hallstrom, Yong Y. Han, Cary O. Harding, William G. Harmon, Eric Harry, Mary E. Hartman, Christopher Heard, Lynn Hernan, Mark J. Heulitt, Robert W. Hickey, Julien I.E. Hoffman, Karen T. Hofmann, Gregory A. Hollman, James C. Huhta, Hector E. James, David Jardine, Alberto Jarillo, Etienne Javouey, James A. Johns, Kristin K. Johnson, Michael V. Johnston, Deborah P. Jones, Prashant Joshi, Prince J. Kannankeril, Robert K. Kanter, John A. Kellum, Michael Kelly, Patrick M. Kochanek, Samuel A. Kocoshis, Thomas J. Kulik, Vasanth H. Kumar, Jacques Lacroix, Yichen Lai, Joanne M. Langley, Stanley T. Lau, Peter Laussen, Yi-Horng Lee, Mary W. Lieh-Lai, D. Michael Lindsay, Catherine Litalien, Naomi L.C. Luban, Robert E. Lynch, Frank Maffei, James P. Marcin, Mary Michele Mariscalco, Barry P. Markovitz, Lynn D. Martin, Anne G. Matlow, John E. Mayer, Paula Mazur, E. Dean McKenzie, Gwenn E. McLaughlin, Nilesh Mehta, Renuka Mehta, Ann J. Melvin, Jean-Christophe Mercier, Kelly Michelson, Kelly A. Michienzi, Patricia A. Moloney-Harmon, Frederick C. Morin, Michele Moss, Vinay Nadkarni, Carol E. Nicholson, Victoria F. Norwood, Daniel Notterman, Alan Nugent, Peter Oishi, Victor Olivar, Richard A. Orr, Yves Ouellette, Daiva Parakininkas, Margaret M. Parker, Anthony L. Pearson-Shaver, Mary Jane F. Petruzzi, Maury N. Pinsk, Murray M. Pollack, Steven Pon, Alice Pong, Lara Primak, Audra Prince, Jean-Damien Ricard, Tom B. Rice, Gail E. Richards, Debra Ann Ridling, Joan Roberts, Kimberly Roth, Alexandre T. Rotta, Daniel Rubens, Jeffrey S. Rubenstein, Christopher M. Rubino, Randall Ruppel, Peter J. Safar, Ashok P. Sarnaik, Joel B. Sarner, Georges Saumon, Matthew C. Scanlon, Kenneth Schenkman, Stephen M. Schexnayder, Charles L. Schleien, Timothy A. Sentongo, Thomas P. Shanley, Frank Shann, Dennis W.W. Shaw, Sam D. Shemie, Peter Skippen, Anthony D. Slonim, Laurie Smith, Lincoln Smith, David M. Steinhorn, Waldemar E. Storm, Marc Sturgill, Marianne T. Sweetser, Jordan M. Symons, Robert C. Tasker, Ann E. Thompson, Ann Henderson Tilton, Nicole H. Tobin, I. David Todres, Peter Trinkaus, David J. Vaughan, Shekhar T. Venkataraman, Rapheus C.Q. Villanueva, Patricia C. Wankum, R. Scott Watson, Wayne R. Waz, Carl G.M. Weigle, Maria B. Weimer, Ed Weinberger, David L. Wessel, William T. West, Randall C. Wetzel, Dale Whitby, Hector R. Wong, Ellen G. Wood, Alan D. Woolf, James Woytash, Ofer Yanay, Arno Zaritsky, Danielle M. Zerr, and Jerry J. Zimmerman

Published
2006

47. Modern Acid-Base Physiology

Author

Rinaldo Bellomo, David A Story, and John A. Kellum

Subjects
Biochemistry, business.industry, Medicine, business
Published
2005

48. Management of the critically ill patient with cirrhosis: A multidisciplinary perspective

Author

Jody C. Olson, Pere Ginès, Mitra K. Nadim, Rajiv Jalan, Jasmohan S. Bajaj, Michael G. Ison, Randolph H. Steadman, Ram M. Subramanian, Richard Moreau, Yuri Genyk, Constantine J. Karvellas, Paolo Angeli, Ravindra L. Mehta, Guadalupe Garcia-Tsao, Jacqueline G. O'Leary, François Durand, Josh Levitsky, Elizabeth A. Pomfret, David C. Mulligan, Jean Louis Vincent, Stephen H. Caldwell, Javier Fernández, Claire Francoz, John A. Kellum, Andrew Davenport, Marco Senzolo, David J. Kramer, and Universitat de Barcelona

Subjects
Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, Hepatorenal Syndrome, Cirrosi hepàtica, Critical Illness, Peritonitis, law.invention, 03 medical and health sciences, 0302 clinical medicine, Hepatorenal syndrome, Multidisciplinary approach, law, Intensive care, Acute on chronic liver failure, Cardiopulmonary dysfunction, Hematologic dysfunction, Hepatic encephalopathy, Infectious disease, Renal dysfunction, Acute Kidney Injury, Acute-On-Chronic Liver Failure, Antibiotic Prophylaxis, Blood Coagulation, Fluid Therapy, Hepatic Encephalopathy, Humans, Hepatology, medicine, 030212 general & internal medicine, Intensive care medicine, Critically ill, Liver diseases, business.industry, Malalties del fetge, Glasgow Coma Scale, medicine.disease, Intensive care unit, Malalts en estat crític, Hepatic cirrhosis, West Haven Criteria, 030211 gastroenterology & hepatology, business

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