1. Numerical analysis of micro- and nano-particle deposition in a realistic human upper airway.
- Author
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Farhadi Ghalati P, Keshavarzian E, Abouali O, Faramarzi A, Tu J, and Shakibafard A
- Subjects
- Aerosols, Computer Simulation, Female, Humans, Hydrodynamics, Inhalation physiology, Models, Statistical, Particle Size, Respiratory System anatomy & histology, Respiratory System diagnostic imaging, Tomography, X-Ray Computed, Young Adult, Computational Biology methods, Models, Biological, Nanoparticles, Respiratory System metabolism
- Abstract
A computational model was developed for studying the flow field and particle deposition in a human upper airway system, including: nasal cavity, nasopharynx, oropharynx, larynx and trachea. A series of coronal CT scan images of a 24 year old woman was used to construct the 3D model. The Lagrangian and Eulerian approaches were used, respectively, to find the trajectories of micro-particles and concentration of nano-particles. The total and regional deposition fractions of micro/nanoparticles were evaluated and the major hot spots for the deposition of inhaled particles were found., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Published
- 2012
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