Search

Your search keyword '"Laino, Gregorio"' showing total 4 results
Start Over Author "Laino, Gregorio" Publisher elsevier
4 results on '"Laino, Gregorio"'

1. Hereditary gingival fibromatosis associated with the missense mutation of the KCNK4 gene.

Author

Mariani P, Zhurakivska K, Santoro R, Laino G, Russo D, and Laino L

Subjects
Humans, Mutation, Mutation, Missense genetics, Phenotype, Potassium Channels, Syndrome, Fibromatosis, Gingival genetics
Abstract

Hereditary gingival fibromatosis (HGF) is a rare oral condition that may appear as an isolated entity or as part of a genetic disease or syndrome. Molecular and biochemical mechanisms that trigger this pathologic process are not completely understood. In this article, we present a rare case of hereditary gingival fibromatosis in conjunction with a syndromic phenotype, associated with a rare missense mutation of the KCNK4 gene. This mutation induces a change in the structure of the TRAAK channel belonging to the 2-pore potassium channels. The gain of function promoted by the mutation could represent the pathogenetic basis of gingival fibromatosis., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2021
Full Text
View/download PDF

2. An unusual case of recurrent gingival hirsutism.

Author

Zhurakivska K, Toni G, Laino G, Franco R, Troiano G, Laino L, and Ronchi A

Subjects
Adult, Face, Female, Gingiva, Hirsutism, Humans, Mouth Diseases, Polycystic Ovary Syndrome
Abstract

Objectives: The occurrence of hairs in the oral cavity is an exceedingly rare event, with unknown etiology. A literature review found only 5 cases, most of which described a single hair localized in various sites of the oral cavity. The aim of the present article is to report a follow-up presentation of a rare case of oral hirsutism detected in a young woman., Case Presentation: A 25-year-old woman with previously diagnosed polycystic ovary syndrome returned to our attention 6 years after the first intervention, complaining of the presence of oral hairs. Extraoral facial examination revealed the presence of exuberant hair on the chin and neck regions. Intraoral examination showed some brown hair, similar to eyelashes, which were removed and the underlying tissue histologically analyzed. One year later, the patient came back with even more widespread presence of oral hairs distributed on the gingivae of both arches., Conclusions: The occurrence of hairs in the oral cavity is an extremely rare finding. The etiology is still unknown; however, an investigation of systemic health is always desirable because more complex medical conditions may be present and not recognized., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2020
Full Text
View/download PDF

3. An unusual case of oral hirsutism in a patient with polycystic ovarian syndrome.

Author

Femiano F, Rullo R, Serpico R, Lanza A, Festa VM, and Laino G

Subjects
Choristoma pathology, Choristoma surgery, Epithelium, Female, Hirsutism pathology, Hirsutism surgery, Humans, Mouth Diseases pathology, Mouth Diseases surgery, Palate pathology, Palate surgery, Polycystic Ovary Syndrome pathology, Reoperation, Treatment Outcome, Young Adult, Choristoma etiology, Hair, Hirsutism complications, Mouth Diseases etiology, Polycystic Ovary Syndrome complications
Abstract

Hirsutism is the presence of terminal hair in women in a male-like pattern, which represents the clinical expression of an underlying excess of androgen (hyperandrogenism). Numerous conditions and serious diseases can result in high levels of circulating androgens, although the most common cause of hirsutism is polycystic ovary syndrome (PCOS). The following classic clinical features characterize PCOS: irregular menstrual periods, infertility, excess hair growth, and obesity. The diagnosis of this disease is related to the discovery of clinical signs that are confirmed by hematochemical examinations. We present a clinical case that is relatively unusual owing to the appearance of black hairs that are similar to nasal hair in the oral mucosa, which is an atypical location. This unusual case was considered to be oral hirsutism, and its presence constituted the essential element in the diagnosis of PCOS. The hypothesis proposed for this unusual condition could be correlated to the high rate of circulating testosterone that may have influenced and led to the development and appearance of the hair follicles in the oral mucosa.

Published
2009
Full Text
View/download PDF

4. Genetic portrait of mild and severe lingual dysplasia.

Author

Carinci F, Lo Muzio L, Piattelli A, Rubini C, Palmieri A, Stabellini G, Maiorano E, Pastore A, Laino G, Scapoli L, Martinelli M, and Pezzetti F

Subjects
Adult, Aged, Aged, 80 and over, Biomarkers, Tumor metabolism, Carcinoma, Squamous Cell metabolism, DNA, Complementary genetics, DNA, Neoplasm genetics, Disease Progression, Down-Regulation, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Oligonucleotide Array Sequence Analysis methods, Precancerous Conditions metabolism, Tongue Neoplasms metabolism, Up-Regulation, Biomarkers, Tumor genetics, Carcinoma, Squamous Cell genetics, Precancerous Conditions genetics, Tongue pathology, Tongue Neoplasms genetics
Abstract

Squamous cell carcinoma is the most frequent malignant tumor of the oral cavity and often arises from premalignant lesions. Traditional methods used by the pathologist are subjective and lack the sensitivity to predict accurately which precancers may progress with time. Therefore, it is important to search for markers that may identify progression of premalignant lesions. Microarray technology can be use with this aim. Here, we define the genetic expression profile of lingual dysplasia (DS) progression. By using cDNA microarray containing 19.2K clones and a baseline of 11 normal tissues, we compared 5 mild and 4 severe DS. We identified 270 genes differentially expressed in normal tissue vs. mild DS (i.e. 161 up- and 109 down-regulated) and 181 genes differentially expressed in mild vs. severe DS (i.e. 63 up- and 118 down-regulated). The described genes cover a broad range of functional activities: (a) anti-oxidative, (b) DNA-repair, (c) inflammatory response, (d) cell-adhesion/mobility, (e) extracellular matrix depolymerization, and (f) cell-cycle regulation. The data reported better define DS progression and can help in classifying premalignant lesions.

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results