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This study aimed to investigate the association between long-term exposure to fine particulate matter (PM 2.5 ) and its constituents (black carbon (BC), ammonium (NH 4 + ), nitrate (NO 3 - ), organic matter (OM), inorganic sulfate (SO 4 2- )) and incident female breast cancer in Beijing, China. Data from a prospective cohort comprising 85,504 women enrolled in the National Urban Cancer Screening Program in Beijing (2013-2019) and the Tracking Air Pollution in China dataset are used. Monthly exposures were aggregated to calculate 5-year average concentrations to indicate long-term exposure. Cox models and mixture exposure models (weighted quantile sum, quantile-based g-computation, and explanatory machine learning model) were employed to analyze the associations. Findings indicated increased levels of PM 2.5 and its constituents were associated with higher breast cancer risk, with hazard ratios per 1-μg/m 3 increase of 1.02 (95% confidence interval (CI): 1.01, 1.03), 1.39 (95% CI: 1.16, 1.65), 1.28 (95% CI: 1.12, 1.46), 1.15 (95% CI: 1.05, 1.24), 1.05 (95% CI: 1.02, 1.08), and 1.15 (95% CI: 1.07, 1.23) for PM 2.5 , BC, NH 4 + , NO 3 - , OM, and SO 4 2- , respectively. Exposure-response curves demonstrated a monotonic risk increase without an evident threshold. Mixture exposure models highlighted BC and SO 4 2- as key factors, underscoring the importance of reducing emissions of these pollutants., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Floating marine debris (FMD) is a pervasive problem in marginal seas worldwide. Driven by the nearshore waves, the FMD gradually accumulates shoreward and has a large chance of being beached, posing a direct threat to the coastal environment. Thus, investigating the nearshore drifting and beaching process of the FMD is of paramount importance. In this article, the trajectories of the FMD on a sloping beach are simulated by the Smoothed Particle Hydrodynamics (SPH) method, which is pre-verified through laboratory experiments. A series of sensitivity tests are conducted numerically on the influence of attributes of FMD as well as varied wave height (H 0 ), and wave period (T 0 ) on its beaching process. It is found that the beaching process of the FMD can be divided into three steps: drifting in front of surf zones, surfing and leaping with plunging waves, and advancing via wave runup. The density of the FMD combined with wave steepness determines whether the FMD can enter into the surf zone where it has a large chance to beach. Finally, this article proposed a semi-analytical model with improved Morison's equations considering the second-order Lagrangian transport on a sloping beach. This semi-analytical model is much faster and is comparable in computational accuracy to the high-resolution SPH model. It has the potential to be incorporated into the existing marine models and replace the stochastic process assumed for the FMD's tracking in the nearshore, in order to achieve more accurate assessment on the stranded FMD., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Introduction: Long-term exposure to ambient fine particulate matter (PM 2.5 ) has been linked to increases in the incidence of lung cancer. However, more evidence is needed to conclude its effects on lung cancer survival., Objectives: The study aimed to explore the relationship between long-term PM 2.5 exposure and lung cancer survival and evaluated the benefits of clean air actions in Beijing., Methods: A whole-population cohort study was conducted on lung cancer patients diagnosed between 2001 and 2017. An atmospheric chemical transport model was used to estimate exposure under a counterfactual scenario without the policy and then quantified the effect of the policy. Cox regression models were used with the seasonality-adjusted PM 2.5 as the main effect., Results: A 10 μg/m 3 increase in PM 2.5 was estimated to be with a 6.5 % (95 % CI: 4.8 %, 8.2 %) increase in the mortality rates. The association was heterogeneous and modified by individual-level characteristics. The clean air actions were estimated to have prevented 3548 (95 % CI: 3280, 3825) premature deaths and to have prolonged survival time by 4.29 months (95 % CI: 0.01, 25.11)., Conclusion: Our findings suggest that PM 2.5 exposure lowers the survival rate for lung cancer. The clean air actions implemented in Beijing can protect lung cancer patients by increasing their survival time., Synopsis: Long-term exposure to PM 2.5 can lower lung patients' survival rates whereas the clean air actions in Beijing have prolonged these patients' survival time by reducing PM 2.5 level., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)

Soil microbial communities influence soil biogeochemical cycling by affecting the production of extracellular enzymes and the release of carbon dioxide. Changes in litter input or stand density due to thinning can affect soil microbial communities and their function by altering soil biochemical properties. However, it is unclear how or to what extent different amounts of litter input affect soil microbial communities and their function in forest stands with different densities. Therefore, we simulated litter removal, 50 % litter reduction, normal litter input, and double litter increase under field conditions by applying different amounts of litter to soils with different stand densities in the laboratory. We then measured soil biochemical properties, microbial communities, enzyme activity, and respiration rate. Our results revealed that the responses of soil dissolved organic carbon and total nitrogen to litter input were more pronounced in the high-density forest stand with poor soil than in the low-density forest stand with nutrient-rich soil, which was mainly reflected in that the addition of litter significantly decreased the concentration of dissolved organic carbon while increasing the content of total nitrogen in the soil of the high-density forest stand. In comparison to the soil carbon component, the nitrogen component of the soil was more affected by stand density. The responses of soil fungal and bacterial communities to leaf litter treatment varied with stand density, as reflected primarily in changes in the relative abundances of Ascomycota, unclassified_K_fungi, and Proteobacteria, and changes in the relative abundances of their functional groups (ectomycorrhizal fungi, saprophytic fungi, pathogens, parasites, and bacteria involved in the nitrogen cycle). Soil fungal community responses to changes in litter input are more sensitive in the high-density forest with nutrient-poor soil than in the low-density forest stand. Furthermore, litter input inhibited the activities of soil β-glucuronidase, N-acetyl-β-d-glucosaminidase, and acid phosphatase more strongly in the low-density forest stand. Litter manipulation primarily affected enzymatic activity in the high-density forest stand by changing the diversity and composition of the soil fungal community. However, in the low-density forest stand, litter treatment affected soil enzyme activity, primarily through changes in soil bacterial and fungal community composition, as well as soil respiration through changes in bacterial richness (Chao 1) and community composition. We conclude that how the change in litter input impacts the soil microbial community and its function, or the magnitude of the effects, is largely dependent on soil quality. Relationships among soil variables, microbial communities, and function differ between stand densities. Our study contributes to an enhanced understanding of the impact of changes in litter input due to climate change or anthropogenic activities on soil biogeochemical cycles and can also guide rationally formulating forest management approaches to improve microbial function under climate change., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Objective: We aimed to establish a representative exposure response function between PM 2.5 and lung cancer to evaluate the impact on lung cancer burden and the benefits gained in association with the environmental policy change in Beijing, China., Methods: Based on population-based cancer registration data during 2001-2016, using a spatiotemporal Poisson regression model, long-term concentrations of PM 2.5 were linked to sex-age adjusted incidence rates of total lung cancer and its pathological subtypes. We calculated the health and monetary benefits associated with air quality improvement using the cost of illness method., Results: In the constructed regression model, a 10 μg/m 3 increment of PM 2.5 was associated with increases of 6.0% (95% confidence interval [95% CI]: 4.3%, 7.7%), 14.8% (10.3%, 19.4%), and 6.5% (3.3%, 9.8%) in the incidence of total lung cancer, squamous cell carcinoma, and adenocarcinoma, respectively. The estimated associations indicate that long-term exposure to PM 2.5 contributed 1947 to 3059 incident cases of lung cancer per year among the residents in Beijing during the study period. Clean air actions saved 4978 (95% CI: 2711, 7417) lung cancer cases, which brought a savings of 218 (118, 324) million RMB (~31 [17, 46] million US dollars) in direct inpatient medical expenditures. If air quality had met national standards of long-term PM 2.5 (35 μg/m 3 ) in 2014-2016, 10,003 (95% CI: 9325, 10,650) lung cancer cases could have been prevented and direct inpatient medical expenditures of 438 (409, 466) million RMB (~63 [58, 67] million US dollars) could have been saved., Conclusions: This study enriches epidemiological study, confirming the association between exposure to PM 2.5 and lung cancer or its subtypes, and provides novel evidence for the notable reduction in lung cancer burden and medical expenditure savings that were achieved through air quality improvements in Beijing from 2014 to 2016., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)

Background: Double eye-lid surgery is one of the most popular performed aesthetic procedures in young Asians. Reliable measurement of patient reported outcomes is crucial for facial aesthetics. The FACE-Q is a new patient-reported outcome tool (PRO) composed of numerous independently functioning scales and checklists designed to measure outcomes. Here we described FACE-Q scales for double eye-lid surgery with minor incision in young Asians., Methods: 200 patients (400 eyes) aged from 21 to 30 years-old were recruited from 2012 to 2014. They underwent minor incision procedure for double-eyelid blepharoplasty, epicanthic fold correction, excessive orbit fat removal and blepharoptosis correction simultaneously. An incision of 1 cm long in the middle of upper eyelid and modified Park's Z-plasty for epicanthus correction were designed. Three stitches were carried out in levator aponeurosis-inferior dermis procedure. By the middle incision in the upper eyelid, blepharoptosis correction and excessive orbit fat removal can be executed. Those patients were asked to complete anonymously the FACE-Q by e-mail. FACE-Q scores were assessed for each domain (range, 0 to 100), with higher scores indicating greater satisfaction with appearance or superior quality of life., Results: After a mean of 2 years' follow-up, postoperative complications included partial or complete loss of the double-eyelid fold in 8 and 0 cases, respectively, no hypertrophic scar formation, and asymmetric fold in four cases. One patient received re-operation on blepharoptosis correction. Except hematoma occurring in one female case, no obvious edema was observed. Patients demonstrated high levels of satisfaction with eye appearance overall (mean ± SD, 81.7 ± 18.3). Quality of Life Patients exhibited high levels of quality of life, including in social confidence (95.4 ± 12.6), psychological well-being (97.8 ± 10.3), and early life impact of the procedure (90.2 ± 13.4). Patients reported high satisfaction with the decision to undergo and the outcome of the procedure., Conclusions: Minimally invasive procedure is a reliable tool for correcting disfigurement in double-eyelid blepharoplasty. However, this method is not suitable for those cases whose upper eyelids are featured by relaxation. Excessive amount of skin must be removed. Patients who responded in this study were extremely satisfied with their decision to undergo double-eyelid surgery and the outcomes and quality of life following the procedure., (Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)

The present paper reported an one-pot synthesis of Co nanoparticles doped amino-graphene nanocomposites (Co-amino-Gr), involving in situ generation of Co nanoparticles (NPs). The simultaneous reduction of graphene oxide (GO) and Co 2+ to produce Co-amino-Gr had been achieved under mild reaction conditions using an environmentally benign reducing agent, glycine. By combining the merits of amino-Gr and the Co NPs, a highly sensitive electrochemical sensor was erected to detect baicalin based on the Co-amino-Gr nanocomposites. Under optimum conditions, the response peak currents were linear related with baicalin concentrations in the range of 1.0×10 -8 -8.0×10 -7 molL -1 with a lower detection limit of 5.0×10 -9 molL -1 (S/N=3). Additionally, the proposed method was used to detect baicalin in the medicinal capsules with satisfactory results., (Copyright © 2016 Elsevier B.V. All rights reserved.)

The nanocomposites of titanium dioxide nanoparticles decorated poly(diallyldimethylammonium chloride)-functionalized graphene (TiO 2 -PDDA-Gr) were successfully synthesized via a facile and green strategy. The prepared nanocomposites were characterized by X-ray diffraction (XRD), UV-visible spectrophotometry (UV-vis), Fourier Transform infrared spectroscopy (FT-IR) and transmission electron microscopy (TEM). By combining the merits of the PDDA-Gr and TiO 2 NPs, a highly sensitive electrochemical sensor was erected to detect esculetin based on the TiO 2 -PDDA-Gr nanocomposites. Under the optimized conditions, a lower detection limit of 4×10 -9 molL -1 (S/N=3) and a wide linear detection range from 1×10 -8 to 3.5×10 -6 molL -1 were achieved by differential pulse voltammetry (DPV). Additionally, the proposed electroanalytical methodology was applied in Chinese herb Viola yedoensis Makino and Cortex Fraxini with satisfactory results, showing that fabricated sensor has potential to be applied., (Copyright © 2016 Elsevier B.V. All rights reserved.)

A simple, inexpensive and highly sensitive voltammetric method for the determination of tectoridin was developed using a poly(L-Arginine) modified electrode. The redox character of tectoridin at proposed electrode was studied systematically and some dynamic parameters were calculated for the first time. A reasonable reaction mechanism of tectoridin on the poly(L-Arginine)/GCE was also dicussed and proposed, which could be a reference for the pharmacological action of tectoridin in clinical study. And the electroanalytical method for determination of tectoridin was established by differential pulse voltammograms (DPV). Under optimum conditions, the response peak currents were linear relationship with tectoridin concentrations in the range of 5.0×10(-8)-2.0×10(-6) mol L(-1) with a detection limit of 4.0×10(-8) mol L(-1). Therefore, the high sensitivity for tectoridin sensing at the proposed electrode was achieved, and the proposed method could also be used to detect tectoridin in the Chinese medicinal herb Blackberrylily with satisfactory results., (Copyright © 2015 Elsevier B.V. All rights reserved.)