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Your search keyword '"Li, Qiu-Rong"' showing total 2 results
Start Over Author "Li, Qiu-Rong" Publisher elsevier
2 results on '"Li, Qiu-Rong"'

1. Stigmastane-type steroid saponins from the leaves of Vernonia amygdalina Del.

Author

Zhao ML, Shan SJ, Tao R, Cui LT, Li QR, Luo J, and Li Y

Subjects
China, Drug Resistance, Multiple drug effects, Drug Resistance, Neoplasm drug effects, Humans, MCF-7 Cells, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Leaves chemistry, Saponins isolation & purification, Steroids isolation & purification, Saponins pharmacology, Steroids pharmacology, Vernonia chemistry
Abstract

Vernoramyosides A-F (1-6), six new Δ 7,9(11) stigmastane-type steroid saponins, along with four known analogues (7-10) were isolated from the leaves of Vernonia amygdalina Delile (Compositae). Their structures were determined by the combination of NMR, ECD and HR-ESI-MS data. These compounds all possessed highly oxidized side chain and a γ-lactam or α,β-unsaturated five-membered lactone ring. All isolates were screened for their activities in reversing resistance in MCF/DOX cells., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2021
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2. Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.

Author

Feng AW, Yu C, Mao Q, Li N, Li QR, and Li JS

Subjects
Acute Disease, Anilides, Animals, Coptis chemistry, Cyclooxygenase 2 Inhibitors pharmacology, Disease Models, Animal, Endotoxemia metabolism, Enzyme Inhibitors pharmacology, Imidazoles pharmacology, Intestinal Mucosa metabolism, Intestine, Small drug effects, Intestine, Small metabolism, Lipopolysaccharides, Male, PPAR gamma metabolism, Phosphorylation, Plant Extracts pharmacology, Plant Extracts therapeutic use, Pyridines pharmacology, Rats, Rats, Sprague-Dawley, Rhizome, Up-Regulation, p38 Mitogen-Activated Protein Kinases metabolism, Anti-Inflammatory Agents pharmacology, Berberine pharmacology, Cyclooxygenase 2 metabolism, Cyclooxygenase 2 Inhibitors therapeutic use, Endotoxemia drug therapy, Intestinal Mucosa drug effects, Phytotherapy
Abstract

The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR curtailed it. LPS increased phosphorylation of mucosal p38 MAPK and ATF2 as well as production of ATF2, whereas BBR attenuated these effects. LPS upregulated mucosal peroxisome proliferator-activated receptor gamma (PPARγ), but BBR reduced this receptor. GW9662 aggravated LPS-induced and reversed BBR-attenuated COX-2 expression. The findings showed that BBR ameliorated COX-2 overexpression partially via modulation of p38 and PPARγ pathways during acute endotoxemia., (Copyright © 2011 Elsevier B.V. All rights reserved.)

Published
2011
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