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Distillery wastewater is a difficult type of wastewater to treat because of its low pH (pH = 3.3), high chloride and sulfate content, high organic matter concentrations (3.2 gTSS/L, 6.8 gBOD5/L and 14.6 gCOD/L). Moreover, the rum production is intermittent over the season (5 months per year). The acidity of this type of wastewater, combined with the relatively underbalanced nitrogen concentrations, requires the addition of specific chemicals such as soda solution and urea, when a biological treatment technology is envisioned. In this full scale experiment, located in a tropical zone (Martinique island), the objective was to demonstrate the ability of treatment chain composed of a sequencing batch reactor (SBR) followed by vertical flow treatment wetlands (VFTWs). The objective was to use VFTWs for treatment polishing as well as sludge/water separation and sludge treatment over years. The VFTWs are planted with Heliconia psittacorum and Cyperus papyrus. The monitoring occurred during three rum production seasons. The treatment chain allows an overall average removal of TSS of 92% and 96% for organic matter (COD and BOD5). The average annual load applied to the filter in operation was 32 kgTSS/m²/y, which is equivalent to 78 kgTSS/m²/y over the distillation period. The applied load was too high for the plants tested and lead to plant death and surface clogging of the filters. Nevertheless, this experiment allowed specifying the way to operate the whole treatment plant as well as acceptable daily loads that should be applied on the VFTWs. Even if the operation of the filters and the selection of plants in a tropical climate still need to be optimized, this combination of intensive and extensive processes is an effective and sustainable nature-based solution for rum distillery wastewater treatment.