1. A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population
- Author
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Marta Mellai, Giuseppe Salemi, Anna Maria Repice, Efrosini Setakis, Giovanni Ristori, Franca Rosa Guerini, Domenico Caputo, Francesca De Robertis, Ida Biunno, Maurizio Leone, Isabella Ferro, Stephen Sawcer, Maria Liguori, Paola Naldi, Giancarlo Comi, Stefania Cannoni, Giovanni Savettieri, Luigi M.E. Grimaldi, Giulia Malferrari, Tiziana Biagioli, Roberto Bomprezzi, Maria Trojano, Luca Massacesi, Patricia Momigliano-Richiardi, Marco Salvetti, Paolo Aridon, Sandra D'Alfonso, Alastair Compston, Paolo Livrea, Cinzia Gellera, La Mantia Loredana, Pasquale Ferrante, Clara Ballerini, Clara Milanese, Mara Giordano, Liguori, M., Sawcer, S., Setakis, E., Compston, A., Giordano, M., D'Alfonso, S., Mellai, M., Malferrari, G., Trojano, M., Livrea, P., De Robertis, F., Massacesi, L., Repice, A., Ballerini, C., Biagioli, T., Bomprezzi, R., Cannoni, S., Ristori, G., Salvetti, M., Grimaldi, L., Biunno, I., Comi, G., Leone, M., Ferro, I., Naldi, P., Milanese, C., Gellera, C., Loredana, L., Savettieri, G., Salemi, G., Aridon, P., Caputo, D., Guerini, F., Ferrante, P., and Momigliano-Richiardi, P.
- Subjects
Male ,Linkage disequilibrium ,Multiple Sclerosis ,Genotype ,International Cooperation ,Immunology ,Biology ,Genome ,Linkage Disequilibrium ,Whole genome linkage disequilibrium ,Gene Frequency ,medicine ,Humans ,Immunology and Allergy ,Genetic Predisposition to Disease ,Multiple sclerosi ,Genetic Testing ,Genotyping ,Allele frequency ,Alleles ,Genetic testing ,Genetics ,medicine.diagnostic_test ,Genome, Human ,Racial Groups ,DNA pool ,Microsatellite ,Settore BIO/18 - Genetica ,Italy ,Neurology ,Case-Control Studies ,Human genome ,Female ,Settore MED/26 - Neurologia ,Neurology (clinical) ,Microsatellite Repeats - Abstract
We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association. © 2003 Elsevier B.V. All rights reserved.
- Published
- 2003