1. Expanding the toolbox for enantioselective sulfide oxidations: Streptomyces strains as biocatalysts
- Author
-
María Laura Mascotti, Marcela Kurina-Sanz, Elizabeth Sandra Lewkowicz, and Martín Alejandro Palazzolo
- Subjects
Sulfide ,Stereochemistry ,Bioengineering ,Applied Microbiology and Biotechnology ,Streptomyces ,chemistry.chemical_compound ,Biotransformation ,Organic chemistry ,chemistry.chemical_classification ,Dialkyl sulfides ,biology ,Asymmetric sulfoxidation ,Ciencias Químicas ,Sulfoxide ,biology.organism_classification ,Enantiopure drug ,Química Orgánica ,chemistry ,Biocatalysis ,Streptomyces hiroshimensis ,Enantiomer ,Agronomy and Crop Science ,CIENCIAS NATURALES Y EXACTAS ,Food Science ,Biotechnology - Abstract
Sulfide oxidase activity ofStreptomyces genus is reported here for the first time. Three Streptomyces strains were selected as new tools to access to enantioenriched R- and S-dialkyl sulfoxides. The bacterial screening was carried out using cyclohexyl methyl sulfide as model substrate.Both sulfoxide antipodes were obtained in a one-pot, time-dependent biotransformation employing S. phaeochromogenes NCIMB 11741 as biocatalyst. S. flavogriseus ATCC 33331produced mainly the S-enantiomer, while S. hiroshimensis ATCC 27429 yielded enantiopure R-cyclohexyl methyl sulfoxide. Fil: Mascotti, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina Fil: Palazzolo, Martín Alejandro. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Area Química. Laboratorio de Biotransformaciones; Argentina Fil: Lewkowicz, Elizabeth Sandra. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Area Química. Laboratorio de Biotransformaciones; Argentina Fil: Kurina Sanz, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
- Published
- 2013