1. Recurrence After Operative Management of Intrahepatic Cholangiocarcinoma
- Author
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Dustin M. Walters, Kevin Nguyen, Sorin Alexandrescu, Catherine Hubert, Hugo Marques, Ryan S. Turley, Carlo Pulitano, T. Clark Gamblin, Gilles Mentha, Eduardo Barroso, Cristina R. Ferrone, Andrew X. Zhu, Todd W. Bauer, Andreas Paul, Irinel Popescu, Bryan M. Clary, J. Wallis Marsh, Luca Aldrighetti, Ryan T. Groeschl, Ioannis Hatzaras, Georgios C. Sotiropoulos, Omar Hyder, Stephanie Meyer, Jean-François Gigot, Timothy M. Pawlik, Michael A. Choti, Hyder, O, Hatzaras, I, Sotiropoulos, Gc, Paul, A, Alexandrescu, S, Marques, H, Pulitano, C, Barroso, E, Clary, Bm, Aldrighetti, L, Ferrone, Cr, Zhu, Ax, Bauer, Tw, Walters, Dm, Groeschl, R, Gamblin, Tc, Marsh, Jw, Nguyen, Kt, Turley, R, Popescu, I, Hubert, C, Meyer, S, Choti, Ma, Gigot, Jf, Mentha, G, and Pawlik, Tm
- Subjects
Male ,Neoplasias Hepáticas ,Medizin ,Cholangiocarcinoma/pathology/secondary/surgery ,Kaplan-Meier Estimate ,Gastroenterology ,Bile Duct Neoplasms/pathology/surgery ,Cholangiocarcinoma ,Vias Biliares Intra-Hepáticas ,Neoplasm Invasiveness/prevention & control ,Risk Factors ,Intrahepatic Cholangiocarcinoma ,Neoplasias das Vias Biliares ,Aged, 80 and over ,Sobrevivência Livre de Doença ,ddc:617 ,Nodal metastasis ,Liver Neoplasms ,Hazard ratio ,Recurrent Intrahepatic Cholangiocarcinoma ,Middle Aged ,Lymphatic Metastasis ,Metástases Linfáticas ,Female ,Adult ,medicine.medical_specialty ,Invasão Neoplásica ,Estimativa de Kaplan-Meier ,Article ,Disease-Free Survival ,Factores de Risco ,Lymphatic Metastasis/prevention & control ,Neoplasm Recurrence, Local/etiology/prevention & control ,Text mining ,Median follow-up ,Nodal status ,Internal medicine ,medicine ,Humans ,Neoplasm Invasiveness ,Aged ,business.industry ,Colangiocarcinoma ,Recidiva Neoplásica Local ,digestive system diseases ,Confidence interval ,Surgery ,Bile Ducts, Intrahepatic ,Bile Duct Neoplasms ,Neoplasm Recurrence, Local ,Liver Neoplasms/pathology/secondary/surgery ,business - Abstract
Introduction: Data on recurrence after operation for intrahepatic cholangiocarcinoma (ICC) are limited. We sought to investigate rates and patterns of recurrence in patients after operative intervention for ICC. Methods: We identified 301 patients who underwent operation for ICC between 1990 and 2011 from an international, multi-institutional database. Clinicopathologic data, recurrence patterns, and recurrence-free survival (RFS) were analyzed. Results: During the median follow up duration of 31 months (range 1-208), 53.5% developed a recurrence. Median RFS was 20.2 months and 5-year actuarial disease-free survival, 32.1%. The most common site for initial recurrence after operation of ICC was intrahepatic (n = 98; 60.9%), followed by simultaneous intra- and extrahepatic disease (n = 30; 18.6%); 33 (21.0%) patients developed extrahepatic recurrence only as the first site of recurrence. Macrovascular invasion (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.34-3.21; P
- Published
- 2013