1. Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination
- Author
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Merve Hafızoğlu, Arzu Okyar Bas, Ece Tavukçuoğlu, Zeynep Sahiner, Merve Güner Oytun, Sıla Ulutürk, Hamdullah Yanık, Burcu Balam Doğu, Mustafa Cankurtaran, Güneş Esendağlı, Filiz Akbıyık, Banu Çakır, Serhat Ünal, and Meltem Gülhan Halil
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COVID-19 ,Memory T cell responses ,Vaccine ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Generating memory T cell responses besides humoral immune responses is essential when it comes to the efficacy of a vaccine. In this study, the presence of memory T cell responses after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac) in seronegative and seropositive elderly individuals were examined. CD4+ and CD8+ memory T cell proliferation and IFN-γ production capacities were evaluated. Additionally, clinical frailty scale (CFS) and FRAIL scales of the individuals were scored. CD4+ memory T cell responses more prominent than CD8+ memory T cells. In seronegative individuals, 80% of them had memory CD4+ and IFN-γ, whereas 50% of them had memory CD4+ and all of them had IFN-γ responses. Additionally, 40% of seronegative patients and 50% of seropositive patients had memory CD8+ responses. To sum up, humoral immune responses are not associated with memory T cell responses, and in seronegative individuals, memory T cell responses can be detected.
- Published
- 2022
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