1. Clofibrate-induced muscular syndrome. Report of a case with clinical, electromyographic and pathologic observations.
- Author
-
Abourizk N, Khalil BA, Bahuth N, and Afifi AK
- Subjects
- Adult, Capillaries ultrastructure, Creatine Kinase blood, Diabetes Insipidus drug therapy, Electromyography, Female, Humans, Microscopy, Electron, Muscular Diseases diagnosis, Muscular Diseases pathology, Myofibrils ultrastructure, Organoids ultrastructure, Clofibrate adverse effects, Muscles ultrastructure, Muscular Diseases chemically induced
- Abstract
In this report the clinical features of a case of clofibrate-induced muscular syndrome, as well as the electromyographic, histochemical, light- and electron-microscopic findings are described. The clinical features are similar to those of previously reported cases. Electromyography was consistent with a myopathy. Histochemical profile was normal. The myopathology included breakdown of contractile material, deranged mitochondria, dilated sarcoplasmic reticulum profiles, accumulation of membrane bound dense bodies, discontinuities in sarcolemma and thickening of capillary basement membrane. Macrophages invaded severely affected fibers.
- Published
- 1979
- Full Text
- View/download PDF