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18 results on '"Pablo J. Sánchez"'

1. Prospective antimicrobial stewardship interventions by multidisciplinary teams to reduce neonatal antibiotic use in South Africa: The Neonatal Antimicrobial Stewardship (NeoAMS) study

Author

Angela Dramowski, Pavel Prusakov, Debra A. Goff, Adrian Brink, Nelesh P. Govender, Ama Sakoa Annor, Liezl Balfour, Adrie Bekker, Azraa Cassim, Michelle Gijzelaar, Sandi L. Holgate, Sonya Kolman, Angeliki Messina, Hafsah Tootla, Natalie Schellack, Andriette van Jaarsveld, Kessendri Reddy, Shakti Pillay, Lucinda Conradie, Anika M. van Niekerk, Tarina Bester, Pearl Alexander, Antoinette Andrews, Magdel Dippenaar, Colleen Bamford, Sharnel Brits, Pinky Chirwa, Hannelie Erasmus, Pieter Ekermans, Pebenita Gounden, Teresa Kriel, Dini Mawela, Masego Moncho, Tonia Mphuthi, Ronald Nhari, Esmita Charani, Pablo J. Sánchez, and Dena van den Bergh

Subjects
Antibiotic, Antimicrobial stewardship programme, Neonate, Africa, Pharmacist, Multi-disciplinary, Infectious and parasitic diseases, RC109-216
Abstract

Background: Hospitalized neonates are vulnerable to infection and have high rates of antibiotic utilization. Methods: Fourteen South African neonatal units (seven public, seven private sector) assembled multidisciplinary teams involving neonatologists, microbiologists, pharmacists, and nurses to implement prospective audit and feedback neonatal antimicrobial stewardship (NeoAMS) interventions. The teams attended seven online training sessions. Pharmacists conducted weekday antibiotic prescription reviews in the neonatal intensive care unit and/or neonatal wards providing feedback to the clinical teams. Anonymized demographic and NeoAMS interventions data were aggregated for descriptive purposes and statistical analysis. Findings: During the 20-week NeoAMS intervention in 2022, 565 neonates were enrolled. Pharmacists evaluated seven hundred antibiotic prescription episodes; rule-out sepsis (180; 26%) and culture-negative sepsis (138; 20%) were the most frequent indications for antibiotic prescription. For infection episodes with an identified pathogen, only 51% (116/229) of empiric treatments provided adequate antimicrobial coverage. Pharmacists recommended 437 NeoAMS interventions (0·6 per antibiotic prescription episode), with antibiotic discontinuation (42%), therapeutic drug monitoring (17%), and dosing (15%) recommendations most frequent. Neonatal clinicians’ acceptance rates for AMS recommendations were high (338; 77%). Mean antibiotic length of therapy decreased by 24% from 9·1 to 6·9 days (0·1 day decrease per intervention week; P = 0·001), with the greatest decline in length of therapy for culture-negative sepsis (8·2 days (95% CI 5·7-11·7) to 5·9 days (95% CI 4·6-7·5); P = 0·032). Interpretation: This neonatal AMS programme was successfully implemented in heterogenous and resource-limited settings. Pharmacist-recommended AMS interventions had high rates of clinician acceptance. The NeoAMS intervention significantly reduced neonatal antibiotic use, particularly for culture-negative sepsis. Funding: A grant from Merck provided partial support.

Published
2024
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2. A global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study

Author

Pavel Prusakov, PharmD, Debra A. Goff, PharmD, Phillip S. Wozniak, BA, Azraa Cassim, BPharm, Catherine E.A. Scipion, MD, Soledad Urzúa, MD, Andrea Ronchi, MD, Lingkong Zeng, MD, Oluwaseun Ladipo-Ajayi, MBChB, Noelia Aviles-Otero, MD, Chisom R. Udeigwe-Okeke, MBBS, Rimma Melamed, MD, Rita C. Silveira, MD, Cinzia Auriti, MD, Claudia Beltrán-Arroyave, MD, Elena Zamora-Flores, MD, Maria Sanchez-Codez, MD, Eric S. Donkor, PhD, Satu Kekomäki, MD, Nicoletta Mainini, MD, Rosalba Vivas Trochez, MD, Jamalyn Casey, PharmD, Juan M. Graus, MD, Mallory Muller, PharmD, Sara Singh, MBBS, Yvette Loeffen, MD, María Eulalia Tamayo Pérez, MD, Gloria Isabel Ferreyra, MD, Victoria Lima-Rogel, MD, Barbara Perrone, MD, Giannina Izquierdo, MD, María Cernada, MD, Sylvia Stoffella, PharmD, Sebastian Okwuchukwu Ekenze, MD, Concepción de Alba-Romero, MD, Chryssoula Tzialla, MD, Jennifer T. Pham, PharmD, Kenichiro Hosoi, MD, Magdalena Cecilia Calero Consuegra, MD, Pasqua Betta, MD, O. Alvaro Hoyos, MD, Emmanuel Roilides, MD, Gabriela Naranjo-Zuñiga, MD, Makoto Oshiro, MD, Victor Garay, MD, Vito Mondì, MD, Danila Mazzeo, MD, James A. Stahl, PharmD, Joseph B. Cantey, MD, Juan Gonzalo Mesa Monsalve, MD, Erik Normann, MD, Lindsay C. Landgrave, PharmD, Ali Mazouri, MD, Claudia Alarcón Avila, MD, Fiammetta Piersigilli, MD, Monica Trujillo, MD, Sonya Kolman, BPharm, Verónica Delgado, MD, Veronica Guzman, MD, Mohamed Abdellatif, FRCPCH, Luis Monterrosa, MD, Lucia Gabriella Tina, MD, Khalid Yunis, MD, Marco Antonio Belzu Rodriguez, MD, Nicole Le Saux, MD, Valentina Leonardi, MD, Alessandro Porta, MD, Giuseppe Latorre, MD, Hidehiko Nakanishi, MD, Michal Meir, MD, Paolo Manzoni, MD, Ximena Norero, MD, Angela Hoyos, MD, Diana Arias, MD, Rubén García Sánchez, MD, Alexandra K. Medoro, MD, and Pablo J. Sánchez

Subjects
Global point prevalence study, Neonatal infection, Neonatal antimicrobial stewardship, Antibiotics, Antifungal, Medicine (General), R5-920
Abstract

Background: Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts. Methods: We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy), antimicrobial stewardship program (ASP), and 30-day in-hospital mortality. Findings: On July 1, 2019, 26% of infants (580/2,265; range, 0–100%; median gestational age, 33 weeks; median birth weight, 1800 g) in 84 NICUs (51, high-income; 33, low-to-middle income) from 29 countries (14, high-income; 15, low-to-middle income) in five continents received ≥1 antimicrobial agent (92%, antibacterial; 19%, antifungal; 4%, antiviral). The most common reasons for antibiotic therapy were “rule-out” sepsis (32%) and “culture-negative” sepsis (16%) with ampicillin (40%), gentamicin (35%), amikacin (19%), vancomycin (15%), and meropenem (9%) used most frequently. For definitive treatment of presumed/confirmed infection, vancomycin (26%), amikacin (20%), and meropenem (16%) were the most prescribed agents. Length of therapy for culture-positive and “culture-negative” infections was 12 days (median; IQR, 8–14) and 7 days (median; IQR, 5–10), respectively. Mortality was 6% (42%, infection-related). An NICU ASP was associated with lower rate of antibiotic utilization (p = 0·02). Interpretation: Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation worldwide. Funding: Merck & Co.; The Ohio State University College of Medicine Barnes Medical Student Research Scholarship

Published
2021
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5. Contributors

Author

Enrico Bertini, Adrienne Bingham, Vann Chau, Maria Roberta Cilio, Adele D’Amico, Linda S. de Vries, Donna M. Ferriero, Dawn Gano, Torin J.A. Glass, Nazia Kabani, Ericalyn Kasdorf, David Kaufman, David W. Kimberlin, Abbot R. Laptook, Jean-Baptiste Le Pichon, Neil Marlow, Claire McLean, Shahab Noori, Jeffrey M. Perlman, Francesco Pisani, Sean M. Riordan, Pablo J. Sánchez, Tristan T. Sands, Michael Seed, Istvan Seri, Steven M. Shapiro, Carlotta Spagnoli, Mona C. Toet, Lauren C. Weeke, Tai Wei-Wu, Andrew Whitelaw, Jerome Y. Yager, Vivien Yap, and Santina Zanelli

Published
2019
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8. Neonatal Meningitis

Author

David A. Kaufman, Joseph B. Cantey, Pablo J. Sánchez, and Santina A. Zanelli

Subjects
medicine.medical_specialty, business.industry, medicine, Treatment options, Current (fluid), Intensive care medicine, medicine.disease, business, Neonatal meningitis
Published
2012
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9. Contributors

Author

Joseph B. Cantey, Rowena G. Cayabyab, Keung-kit Chan, Basil T. Darras, Jahannaz Dastgir, Linda S. de Vries, Lisa Eiland, Petra S. Hüppi, Ericalyn Kasdorf, David Kaufman, David W. Kimberlin, Abbot R. Laptook, Gregory A. Lodygensky, Claire W. McLean, Caroline C. Menache, Laura R. Ment, Eliza H. Myers, Shahab Noori, Jeffrey M. Perlman, Pablo J. Sánchez, Mark S. Scher, Istvan Seri, Steven M. Shapiro, Toshiki Takenouchi, Mona C. Toet, Betty R. Vohr, Andrew Whitelaw, Jerome Y. Yager, and Santina Zanelli

Published
2012
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12. CONTRIBUTORS

Author

John G. Aaskov, Susan M. Abdel-Rahman, Christoph Aebi, Marvin E. Ament, Marsha S. Anderson, Stephen S. Arnon, Ann M. Arvin, Jane T. Atkins, Robert L. Atmar, Carol J. Baker, Robert S. Baltimore, Stephen J. Barenkamp, Elizabeth D. Barnett, Robert D. Basow, William R. Beisel, Beth P. Bell, Gil Benard, David I. Bernstein, Kathrin M. Bernt, Andrea A. Berry, Charles D. Bluestone, Jeffrey L. Blumer, Robert Bortolussi, Bobby L. Boyanton, Kenneth M. Boyer, John S. Bradley, Michael T. Brady, William J. Britt, Annemarie Broderick, David E. Bronstein, David A. Bruckner, Steven C. Buckingham, Ana Burgos, Carrie L. Byington, Judith R. Campbell, Samson Cantu, Mariam R. Chacko, Louisa E. Chapman, Rémi N. Charrel, Tempe K. Chen, James D. Cherry, P. Joan Chesney, Madhuri C. Chilakapati, Javier Chinen, Natascha Ching, H. Fred Clark, Thomas G. Cleary, David K. Coats, Armando G. Correa, J. Thomas Cross, William B. Cutrer, Ronald Dagan, David E. Dassey, Jeffrey P. Davis, Gail J. Demmler-Harrison, Penelope H. Dennehy, Minh L. Doan, Simon R. Dobson, Jan E. Drutz, Paul H. Edelstein, Kathryn M. Edwards, Morven S. Edwards, B. Keith English, Dora Estripeaut, Leland L. Fan, Ralph D. Feigin, George D. Ferry, Anthony E. Fiore, Philip R. Fischer, Randall G. Fisher, Patricia M. Flynn, Thomas R. Flynn, Lisa M. Frenkel, Ellen M. Friedman, Richard A. Friedman, Lynne S. Garcia, Patrick J. Gavin, Michael A. Gerber, Anne A. Gershon, Mark A. Gilger, Susan L. Gillespie, Daniel G. Glaze, W. Paul Glezen, Mary P. Glodé, Donald A. Goldmann, Ellie J.C. Goldstein, Nira A. Goldstein, Edmond T. Gonzales, Mark P. Gorman, Michael D. Green, David Greenberg, Andreas H. Groll, Charles Grose, Duane J. Gubler, Roberto A. Guerrero, Javier Nieto Guevara, Kathleen M. Gutierrez, Caroline Breese Hall, Scott B. Halstead, Shinjiro Hamano, Richard J. Hamill, Margaret R. Hammerschlag, I. Celine Hanson, Nada Harik, Rick E. Harrison, C. Mary Healy, Ulrich Heininger, Gloria P. Heresi, Peter W. Hiatt, Harry R. Hill, David C. Hilmers, Jill A. Hoffman, Ellis K.L. Hon, Margaret K. Hostetter, Peter J. Hotez, Walter T. Hughes, Kristina G. Hulten, David A. Hunstad, Eugene S. Hurwitz, W. Charles Huskins, David Y. Hyun, Mary Anne Jackson, Michael R. Jacobs, Richard F. Jacobs, Jenifer L. Jaeger, Ravi R. Jhaveri, Samantha Johnston, Maureen M. Jonas, Meena R. Julapalli, Edward L. Kaplan, Sheldon L. Kaplan, Saul J. Karpen, Gregory L. Kearns, Margaret A. Keller, Chaouki K. Khoury, Martin B. Kleiman, Jerome O. Klein, Mark W. Kline, Katherine M. Knapp, Heidi M. Kokkinos, Peter J. Krause, Leonard R. Krilov, Paul Krogstad, Thomas L. Kuhls, Xavier de Lamballerie, Timothy R. La Pine, Matthew B. Laurens, Charles T. Leach, Robert J. Leggiadro, Diana R. Lennon, Carolyn Lentzsch-Parcells, Eric Leroy, Chi Wai Leung, Moise L. Levy, Karen Lewis, Phyllis T. Losikoff, Timothy Edward Lotze, Adam W. Lowry, Timothy Mailman, Susan A. Maloney, Laurene Mascola, Edward O. Mason, David O. Matson, Alan N. Mayer, Marc A. Mazade, James B. McAuley, George H. McCracken, Kenneth McIntosh, James E. McJunkin, Kelly T. McKee, Rima L. McLeod, Valérie A. McLin, Maria José Soares Mendes-Giannini, Wayne M. Meyers, Marian G. Michaels, Ian C. Michelow, Vladana Milisavljevic, Aaron M. Miller, James N. Miller, Marjorie J. Miller, James N. Mills, Linda L. Minnich, Ann Moran, James R. Murphy, Pratip K. Nag, Joseph J. Nania, James P. Nataro, Roger K. Nicome, Karin Nielsen-Saines, Delma J. Nieves, Richard A. Oberhelman, Theresa J. Ochoa, Christopher M. Oermann, Alina Olteanu, Gary D. Overturf, Debra L. Palazzi, Pia S. Pannaraj, Janak A. Patel, Christian C. Patrick, Evelyn A. Paysse, Norma Pérez, C.J. Peters, William A. Petri, Brandon Lane Phillips, Larry K. Pickering, Joseph F. Piecuch, Francisco P. Pinheiro, Stanley A. Plotkin, Scott L. Pomeroy, Alice Pong, David L. Pugatch, Joan S. Purcell, Ramya Ramraj, Jack S. Remington, Carina A. Rodriguez, José R. Romero, Benjamin A. Ross, Lawrence A. Ross, Judith L. Rowen, Charles E. Rupprecht, Xavier Sáez-Llorens, Lisa Saiman, Joseph W. St. Geme, Pablo J. Sánchez, Laura A. Sass, Carlos A. Sattler, Danica J. Schulte, Gordon E. Schutze, Filiz O. Seeborg, Eugene D. Shapiro, Nina L. Shapiro, William T. Shearer, Ziad M. Shehab, Jerry L. Shenep, W. Donald Shields, Robyn Shimizu-Cohen, Stanford T. Shulman, Constantine Simos, Arnold L. Smith, Jason S. Soden, Mary Allen Staat, Jeffrey R. Starke, Barbara W. Stechenberg, William J. Steinbach, Paul G. Steinkuller, E. Richard Stiehm, Stephanie H. Stovall, Jeffrey Suen, Ciro V. Sumaya, Andrea P. Summer, Douglas S. Swanson, Tina Q. Tan, Herbert B. Tanowitz, Robert B. Tesh, Philip Toltzis, Richard G. Topazian, Michael F. Tosi, Amelia P.A. Travassos da Rosa, Theodore F. Tsai, Tulio A. Valdez, Jesus G. Vallejo, John A. Vanchiere, Pedro Fernando da C. Vasconcelos, Jorge J. Velarde, James Versalovic, Ellen R. Wald, Douglas S. Walsh, Edward E. Walsh, Thomas J. Walsh, Mark A. Ward, Richard L. Ward, Michelle Weinberg, Robert C. Welliver, J. Gary Wheeler, A. Clinton White, Suzanne Whitworth, Bernhard L. Wiedermann, Natalie Williams-Bouyer, Murray Wittner, Charles R. Woods, Kimberly G. Yen, Ram Yogev, Edward J. Young, and Theoklis E. Zaoutis

Published
2009
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13. Neonatal Meningitis: Current Treatment Options

Author

Joseph B. Cantey, Santina A. Zanelli, Pablo J. Sánchez, and David Kaufman

Subjects
medicine.medical_specialty, business.industry, medicine, Treatment options, Current (fluid), Intensive care medicine, medicine.disease, business, Neonatal meningitis
Published
2008
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14. Contributors

Author

Rowena G. Cayabyab, Keung-kit Chan, Basil T. Darras, Gabrielle de Veber, Petra S. Hüppi, David Kaufman, Abbot R. Laptook, Claire W. McLean, Caroline C. Menache, Laura R. Ment, Shahab Noori, Koray Özduman, Jeffrey M. Perlman, Kenneth J. Poskitt, Pablo J. Sánchez, Mark S. Scher, Istvan Seri, Steven M. Shapiro, Betty R. Vohr, Andrew Whitelaw, Jerome Y. Yager, and Santina Zanelli

Published
2008
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15. Syphilis

Author

David Ingall, Pablo J. Sánchez, and Carol J. Baker

Subjects
medicine.medical_specialty, Foetal disease, Obstetrics, business.industry, embryonic structures, Immunology, medicine, Syphilis, Disease, medicine.disease, business, female genital diseases and pregnancy complications, reproductive and urinary physiology
Abstract

Foetal syphilis is the malady that most medical men think of when reference is made to foetal disease. It has been studied in all its aspects and at very considerable length by a multitude of careful observers. It has been taken as the type of antenatal maladies, as the typical disease of the foetus; it may almost be said that, to some investigators, foetal pathology and foetal syphilis have been synonymous terms. 1

Published
2006
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17. Contributors

Author

Ira Adams-Chapman, Anne M. Ades, Amina Ahmed, Simone Albers, Marilee C. Allen, Maureen Andrew, Stephen A. Back, H. Scott Baldwin, Philip L. Ballard, Roberta A. Ballard, Beverly A. Banks-Randall, Stephen Baumgart, Karen P. Beckerman, Thomas J. Benedetti, Gerard T. Berry, Carol Lynn Berseth, Kathleen E. Bethin, Diana W. Bianchi, Mitchell S. Cairo, Anthony Caldamone, Sudhish Chandra, Ramen Chmait, Ronald I. Clyman, Bernard A. Cohen, Meryl S. Cohen, Mitchell I. Cohen, Robert M. Cohn, F. Sessions Cole, Anthony Corbet, Scott C. Denne, Theresa J. Di Maggio, Eric C. Eichenwald, Jacquelyn R. Evans, Nick Evans, Avroy A. Fanaroff, Donna M. Ferriero, Delbert A. Fisher, Laura Flores-Sarnat, Philippe S. Friedlich, J. William Gaynor, Alfred L. Gest, Tal Geva, Mary Ann E. Gibbons, William M. Gilbert, Bertil E. Glader, Christine A. Gleason, Michael J. Goldberg, William V. Good, Gregory Goodwin, Sameer Gopalani, Carol L. Greene, Brian E. Grottkau, Peter J. Gruber, Jean-Pierre Guignard, Susan Guttentag, Shannon E.G. Hamrick, Thomas N. Hansen, Margaret K. Hostetter, Samuel C. Hughes, Andrew D. Hull, Roy Jedeikin, Sandra E. Juul, Bernard S. Kaplan, Paige Kaplan, Rebecca A. Kazin, Thomas F. Kelly, Stefan Kuhle, Ian A. Laing, Harvey L. Levy, Mignon L. Loh, Scott A. Lorch, Ralph A. Lugo, Geoffrey A. Machin, James R. MacMahon, George A. Macones, Ashima Madan, Bradley S. Marino, Alma Martinez, Kathryn L. Maschoff, Patricia Massicotte, Katherine K. Matthay, William C. Mentzer, Jeffrey D. Merrill, Carol A. Miller, Lesley Mitchell, Alicia A. Moise, Thomas J. Mollen, Timothy P. Monahan, Thomas R. Moore, Louis J. Muglia, Robert M. Nelson, Thomas B. Newman, Eugenia K. Pallotto, Erica S. Pan, Elvira Parravicini, J. Colin Partridge, Dan Poenaru, Brenda B. Poindexter, Richard A. Polin, Daniel H. Polk, DeWayne M. Pursley, Rangasamy Ramanathan, Daniela Ramierez-Schrempp, Joan A. Regan, Elisabeth G. Richard, Richard L. Robertson, Mark A. Rosen, Lewis P. Rubin, Jack Rychik, Sulagna C. Saitta, Pablo J. Sánchez, Harvey B. Sarnat, Richard J. Schanler, Mark S. Scher, Istvan Seri, Elaine C. Siegfried, Gary A. Silverman, Rebecca Simmons, Susan Sniderman, Thomas L. Spray, Charles A. Stanley, David K. Stevenson, Barbara J. Stoll, H. William Taeusch, Peter Tarczy-Hornoch, George A. Taylor, Janet A. Thomas, Tivadar Tulassay, Carmella van de Ven, Betty R. Vohr, Robert M. Ward, Peggy Sue Weintrub, Stephen Welty, Gil Wernovsky, Calvin B. Williams, Linda L. Wright, Alison Z. Young, Elaine H. Zackai, and Stephen A. Zderic

Published
2005
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18. Empiric therapy with vancomycin in the neonatal intensive care unit: let's 'get smart' globally!

Author

Mohannad Moallem, Joseph B. Cantey, Ian C. Michelow, Pablo J. Sánchez, and Avante D Milton

Subjects
Coagulase, medicine.medical_specialty, Neonatal intensive care unit, Staphylococcus, 03 medical and health sciences, 0302 clinical medicine, Vancomycin, Intensive Care Units, Neonatal, 030225 pediatrics, Humans, Medicine, 030212 general & internal medicine, Pediatrics, Perinatology, and Child Health, Intensive care medicine, business.industry, Infant, Newborn, lcsh:RJ1-570, Vancomycin Resistance, lcsh:Pediatrics, Staphylococcal Infections, Anti-Bacterial Agents, Latin America, Pediatrics, Perinatology and Child Health, Neonatal Sepsis, business, Empiric therapy, medicine.drug

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