1. History of peripheral artery disease and cardiovascular risk of real-word patients with acute coronary syndrome: Role of inflammation and comorbidities
- Author
-
Denegri, Andrea, Magnani, Giulia, Kraler, Simon, Bruno, Francesco, Klingenberg, Roland, Mach, Francois, Gencer, Baris, Räber, Lorenz, Rodondi, Nicolas, Rossi, Valentina A, Matter, Christian M, Nanchen, David, Obeid, Slayman, and Lüscher, Thomas F
- Subjects
Humans ,Acute Coronary Syndrome/diagnosis ,Acute Coronary Syndrome/epidemiology ,Acute Coronary Syndrome/chemically induced ,Cardiovascular Diseases/chemically induced ,Platelet Aggregation Inhibitors/adverse effects ,Prospective Studies ,Risk Factors ,Hemorrhage/diagnosis ,Hemorrhage/epidemiology ,Hemorrhage/chemically induced ,Inflammation/diagnosis ,Inflammation/epidemiology ,Inflammation/chemically induced ,Peripheral Arterial Disease/diagnosis ,Peripheral Arterial Disease/epidemiology ,Heart Disease Risk Factors ,Acute coronary syndrome ,Peripheral artery disease ,Personalized therapy ,Residual risk ,Risk stratification ,360 Social problems & social services ,610 Medicine & health ,Cardiology and Cardiovascular Medicine - Abstract
BACKGROUND Patients with acute coronary syndromes (ACS) remain at risk of cardiovascular disease (CVD) recurrences. Peripheral artery disease (PAD) may identify a very high risk (VHR) group who may derive greater benefit from intensified secondary prevention. METHODS Among ACS-patients enrolled in the prospective multi-center Special Program University Medicine (SPUM), we assessed the impact of PAD on major cardiovascular events (MACE: composite of myocardial infarction, stroke and all-cause death) and major bleeding. Multivariate analysis tested the relation of each significant variable with MACE, as well as biomarkers of inflammation and novel markers of atherogenesis. RESULTS Out of 4787 ACS patients, 6.0% (n = 285) had PAD. PAD-patients were older (p
- Published
- 2023