1. The role of FOXP3 in autoimmunity.
- Author
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Pesenacker AM, Cook L, and Levings MK
- Subjects
- Alternative Splicing, Animals, Autoimmunity, Diabetes Mellitus, Type 1 therapy, Forkhead Transcription Factors genetics, Graft Rejection immunology, Humans, Immunomodulation, Protein Processing, Post-Translational, Protein Transport, Self Tolerance, Signal Transduction, T-Lymphocytes, Regulatory transplantation, Transplantation, Diabetes Mellitus, Type 1 immunology, Forkhead Transcription Factors metabolism, Graft Rejection prevention & control, Immunotherapy methods, T-Lymphocytes, Regulatory immunology
- Abstract
FOXP3 controls the development and function of T regulatory cells (Tregs). Autoimmunity is linked to changes in FOXP3 activity that can occur at multiple levels and lead to Treg dysfunction. For example, changes in IL-2 signaling, FOXP3 transcription and/or post-translational modifications can all contribute to loss of self-tolerance. As additional pathways of FOXP3 regulation are elucidated, new therapeutic approaches to increase Treg activity either by cell therapy or pharmacological intervention are being tested. Early success from pioneering studies of Treg-based therapy in transplantation has promoted the undertaking of similar studies in autoimmunity, with emerging evidence for the effectiveness of these approaches, particularly in the context of type 1 diabetes., (Copyright © 2016. Published by Elsevier Ltd.)
- Published
- 2016
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