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In this paper, the influence of the bonding materials on the failure modes and the critical energy release rate (CERR) is studied through the double cantilever beam (DCB) test. The test results show that the failure mode and CERR of the bonded structure are closely related to the bonding materials, and three failure modes, i.e., the cohesive failure, the interface failure and the mixed-mode failure are identified on the bonding surface. The finite element method is used to simulate the interface debonding behavior of the DCB test specimens, and the influence of material randomness on the interface failure is introduced. A XFEM/CZM coupled approach is proposed to model the crack migration phenomena. The predicted results have a good agreement with the experimental results.

The fiber reinforced polymer/plastic (FRP) laminates are often subjected to random block spectrum loading in engineering. The simplified regular load in the laboratory fatigue tests is not sufficient to describe the actual fatigue damage history of FRP laminates. In order to explore the fatigue damage evolution of FRP laminates characterized by the residual stiffness degradation under complex random loads, some random block spectra are compiled based on the real engineering fatigue loads, and the fatigue tests of two FRP laminates, the E-glass/YPX-3300 glass fiber laminate and T700/YPX-3001 carbon fiber laminate, were conducted under the random block spectra. Four kinds of differently stacked laminates were prepared for each material. The residual stiffness degradation curves are obtained from the experiments. A stiffness degradation model proposed by the authors are used to correlate the residual stiffness evolution data. The results show that the residual stiffness degradation curves of different specimens can reach satisfactory consistency after correlation, though the original experiment data show a large dispersion. The residual stiffness degradation law of FRP laminates under random block spectrum is the same as that under constant amplitude spectrum. The proposed model can well characterize the residual stiffness degradation law of RRP laminates under random block spectrum.

Maintaining and restoring ecological connectivity (EC) are important measures of mitigating habitat isolation caused by urbanization. Considering the prominent contradiction of land use in highly urbanized areas, the EC protection measures proposed in the previous studies, such as expanding the ecological sources and widening the ecological corridors, are unrealistic. By using the stepping-stone and complex network theories, this paper simulated the ecological network (EN), evaluated the centrality of each ecological source and stepping-stone, and analysed the network robustness under different damage scenarios, then identified the optimal strategy and key patches for EC maintaining. Meanwhile, this paper evaluated whether the key patches are protected by China’s new policies, which are, Ecological Protection Red Line (EPRL) and the Three Lines One Permit (TLOP). The results were as follows: (1) The EN is composed of 53 ecological sources and 291 stepping-stones, with 591 links between them. (2) The network stability can be optimally maintained by prioritizing the protection of stepping-stones with high centrality. (3) The 53 ecological sources and 51 stepping-stones with the highest centrality can ensure the stable operation of the EN, that is, they are key patches for EC maintaining. (4) Compared with EPRL, the protection rate for ecological sources and stepping-stones are significantly improved by TLOP; however, stepping-stones with high centrality require stronger protection. This study enriched the research cases of complex network theory applied in landscape ecology, and provided references for the improvement of policies in the future.

Pruritus, also known as itching, is a complex sensation that involves the activation of specific physiological and cellular receptors. The skin is innervated with sensory nerves as well as some receptors for various sensations, and its immune system has prominent neurological connections. Sensory neurons have a considerable impact on the sensation of itching. However, immune cells also play a role in this process, as they release pruritogens. Disruption of the dermal barrier activates an immune response, initiating a series of chemical, physical, and cellular reactions. These reactions involve various cell types, including keratinocytes, as well as immune cells involved in innate and adaptive immunity. Collective activation of these immune responses confers protection against potential pathogens. Thus, understanding the molecular and cellular mechanisms that contribute to pruritus in host skin is crucial for the advancement of effective treatment approaches. This review provides a comprehensive analysis of the present knowledge concerning the molecular and cellular mechanisms underlying itching signaling in the skin. Additionally, this review explored the integration of these mechanisms with the broader context of itch mediators and the expression of their receptors in the skin., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024. Published by Elsevier Inc.)

Overexpression of epidermal growth factor receptor (EGFR) in cancer is a key cause of recurrence of cervical cancer (CC). Although the EGF-EGFR pathway has been studied for decades, preventing tumor growth and recurrence caused by peripheral EGF remains a great challenge. In this work, a strategy is proposed to reduce the stimulation of high concentration EGF on tumor growth by using a thermo-sensitive hydrogel. The hydrogel is a triblock copolymer composed of polyethylene glycol (PEG) and poly (lactide glycolide) (PLGA). Based on the excellent temperature sensitivity, carrier capacity, swelling property and biocompatibility, the hydrogel can absorb the liquid around the tumor by injection and release EGF continuously at low concentration. The inhibitory effect of hydrogel on tumor growth is fully confirmed by an implanted tumor mouse model with human cervical cancer cell lines (HeLa) using triple-immunodeficient NCG mice. Compared with free EGF, the EGF-loaded hydrogel can hardly induce surface plasmon resonance (SPR) response, which proves that hydrogel can effectively weaken cytoskeleton rearrangement and inhibit cell migration by continuously releasing low concentration EGF. In addition, the EGF-loaded hydrogel can reduce cell proliferation by delaying the progress of cell cycle progression. Taken together, the hydrogel can effectively protect tumor microenvironment from the stimulation of high concentration EGF, delay cancer cellular processes and tumor growth, and thus providing an approach for inhibiting tumor recurrence of CC., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)