3 results on '"Pinto, Daniel V."'
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2. Contributors
- Author
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Cortes, Carmen, primary, AboEllail, Mohamed Ahmed, additional, Ahkin Chin Tai, Janiel, additional, Ahumada-Juárez, Juan C., additional, Anderson, Peter J., additional, Andreu- Fernández, Vicente, additional, Antsaklis, Panagiotis, additional, Armstrong, R.A., additional, Ausó, Eva, additional, Avagliano, Laura, additional, Aye, Tandy, additional, Bassani, Silvia, additional, Bernardino, Inês, additional, Blanchett, Reid, additional, Blossom, Sarah J., additional, Bottini, Gabriella, additional, Bou Diab, Zeina, additional, Breit, Kristen R., additional, Bárez-López, Soledad, additional, Bulfamante, Gaetano P., additional, Castelo-Branco, Miguel, additional, Charney, Rebekah M., additional, Dale, Karina, additional, Daou, Arij, additional, Daskalakis, George, additional, De Asis-Cruz, Josepheen, additional, Deeb, George, additional, DeMaster, Dana, additional, De Miranda, Briana R., additional, Dias, Ronaldo P., additional, Drobnič Radobuljac, Maja, additional, Eguibar, Jose R., additional, Elkaim, Lior M., additional, Ellingsen, Ståle, additional, Fazzari, Pietro, additional, Fejzo, Marlena S., additional, Ferrón, Sacri R., additional, Finnell, Richard H., additional, Flores, Cecilia, additional, Foley, Patricia L., additional, Freeman, Jennifer L., additional, Galindo, Máximo Ibo, additional, García-Algar, Oscar, additional, García-Castro, Martín I., additional, George, Timothy M., additional, Gerlai, Robert, additional, Gloston, Gabrielle, additional, Gonçalves, Joana, additional, Granana, N., additional, Grazioli, Paolo, additional, Grijota-Martínez, Carmen, additional, Guadaño-Ferraz, Ana, additional, Guerrant, Richard L., additional, Hata, Toshiyuki, additional, Hernandez Gonzalez, Victor Hugo, additional, Holmbeck, Grayson N., additional, Ibrahim, George M., additional, Klamt, F., additional, Knickmeyer, Rebecca C., additional, Kohlmeier, Kristi A., additional, Komada, Munekazu, additional, Korzeniewski, Steven J., additional, Kurjak, Asim, additional, Limon, Danica, additional, Limperopoulos, Catherine, additional, Lozano-Ureña, Anna, additional, López del Castillo, Inés, additional, Malva, João O., additional, Manganas, Louis N., additional, Marini, Carla, additional, Masino, Mark A., additional, Massa, Valentina, additional, Maćkowiak, Marzena, additional, Medina–Alva, Pilar, additional, Mhanna, Rami, additional, Montero-Pedrazuela, Ana, additional, Montgomery, Jacob E., additional, Moore, Bartlett D., additional, Mullin, Patrick M., additional, Nicholson, Laura M., additional, Noda, Yoshihiro, additional, Nohejlová, Kateryna, additional, Ohanian, Diana M., additional, Oriá, Reinaldo B., additional, Ortinau, Cynthia, additional, Parodi, Chiara, additional, Parsons, R.B., additional, Pascoe, Leona, additional, Passafaro, Maria, additional, Perez, Mayra I., additional, Peviani, Valeria, additional, Piazza, Valeria, additional, Pinto, Daniel V., additional, Plemeniti Tololeski, Barbara, additional, Polli, Filip S., additional, Pollock, Shannon, additional, Prasad, Maneeshi S., additional, Preedy, Victor R., additional, Rajendram, Rajkumar, additional, Ramirez, Ana C., additional, Raposo, Ramon S., additional, Rasinger, Josef Daniel, additional, Reynolds, Lauren M., additional, Rodríguez-Prieto, Angela, additional, Romero Otalvaro, A.M., additional, Sailer, Sebastian, additional, Saliba, Jessica, additional, Scarpa, Pina, additional, Schneider, Sophie C., additional, Schonhofen, P., additional, Sebastiani, Giorgia, additional, Shaaban, Sherif G., additional, Shrestha, Merina, additional, Storch, Eric A., additional, Sustaíta, Michael A., additional, Terezakis, Stephanie A., additional, Šlamberová, Romana, additional, Vargas, D.M., additional, Vaughn, Kelly A., additional, Viana, Andres G., additional, Weinzimmer, Saira A., additional, Widerstrom-Noga, Eva, additional, Winning, Adrien M., additional, Wong, Marlon L., additional, Zegarra, Walter, additional, Zhou, Shao Jia, additional, and Zwicker, Jill G., additional
- Published
- 2021
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3. Methylmercury chronic exposure affects the expression of DNA single-strand break repair genes, induces oxidative stress, and chromosomal abnormalities in young dyslipidemic APOE knockout mice.
- Author
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Roque CR, Sampaio LR, Ito MN, Pinto DV, Caminha JSR, Nunes PIG, Raposo RS, Santos FA, Windmöller CC, Crespo-Lopez ME, Alvarez-Leite JI, Oriá RB, and Pinheiro RF
- Subjects
- Animals, DNA, Single-Stranded genetics, DNA, Single-Stranded metabolism, Dyslipidemias metabolism, Environmental Pollutants toxicity, Lipid Peroxidation drug effects, Liver drug effects, Liver metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, ApoE, Chromosome Aberrations chemically induced, DNA Repair drug effects, Methylmercury Compounds toxicity, Oxidative Stress drug effects
- Abstract
Mercury (Hg) is one of the most toxic environmental pollutants, especially when methylated, forming methylmercury (MeHg). MeHg affects DNA repair, increases oxidative stress, and predisposes to cancer. MeHg neurotoxicity is well-known, but recently MeHg-associated cardiovascular effects were recognized. This study evaluated circulating lipids, oxidative stress, and genotoxicity after MeHg-chronic exposure (20 mg/L in drinking water) in C57BL/6J wild-type and APOE knockout (ko) mice, the latter, being spontaneously dyslipidemic. Experimental mice were assigned to four groups: non-intoxicated and MeHg-intoxicated wild-type mice and non-intoxicated and MeHg-intoxicated APOE ko mice. Plasma levels of triglycerides, total cholesterol (TC), HDL, and LDL were analyzed. Liver lipid peroxidation and splenic gene expression of xeroderma pigmentosum complementation groups A, C, D, and G (XPA, XPC, XPD, and XPG), X-ray repair cross-complementing protein 1 (XRCC1), and telomerase reverse transcriptase (TERT) were measured. Fur Hg levels confirmed chronic MeHg intoxication. MeHg exposure raises TC levels both in wild-type and APOE ko mice. HDL and LDL-cholesterol levels were increased only in the MeHg-challenged APOE ko mice. MeHg increased liver lipid peroxidation, regardless of the genetic background. Unintoxicated APOE ko mice showed higher expression of TERT than all other groups. APOE deficiency increases XPA expression, regardless of MeHg intoxication. Furthermore, MeHg-intoxicated mice had more cytogenetic abnormalities, effect which was independent of APOE deficiency. More studies are needed to dissect the interactions between circulating lipids, MeHg intoxication, and DNA-repair pathways even at young age, interactions that likely play critical roles in cell senescence and the risk for chronic disorders later in life., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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