1. Mast cells and histamine alter intestinal permeability during malaria parasite infection.
- Author
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Potts RA, Tiffany CM, Pakpour N, Lokken KL, Tiffany CR, Cheung K, Tsolis RM, and Luckhart S
- Subjects
- Animals, Coinfection, Disease Models, Animal, Female, Histamine blood, Histamine Antagonists pharmacology, Macaca mulatta, Malaria drug therapy, Malaria immunology, Malaria, Falciparum immunology, Malaria, Falciparum metabolism, Mast Cells immunology, Mast Cells pathology, Mastocytosis immunology, Mastocytosis metabolism, Mice, Mice, Knockout, Mucous Membrane drug effects, Mucous Membrane microbiology, Permeability, Salmonella Infections immunology, Salmonella Infections metabolism, Histamine metabolism, Malaria metabolism, Malaria parasitology, Mast Cells metabolism, Mucous Membrane metabolism, Mucous Membrane parasitology
- Abstract
Co-infections with malaria and non-typhoidal Salmonella serotypes (NTS) can present as life-threatening bacteremia, in contrast to self-resolving NTS diarrhea in healthy individuals. In previous work with our mouse model of malaria/NTS co-infection, we showed increased gut mastocytosis and increased ileal and plasma histamine levels that were temporally associated with increased gut permeability and bacterial translocation. Here, we report that gut mastocytosis and elevated plasma histamine are also associated with malaria in an animal model of falciparum malaria, suggesting a broader host distribution of this biology. In support of mast cell function in this phenotype, malaria/NTS co-infection in mast cell-deficient mice was associated with a reduction in gut permeability and bacteremia. Further, antihistamine treatment reduced bacterial translocation and gut permeability in mice with malaria, suggesting a contribution of mast cell-derived histamine to GI pathology and enhanced risk of bacteremia during malaria/NTS co-infection., (Copyright © 2015 Elsevier GmbH. All rights reserved.)
- Published
- 2016
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