Search

Your search keyword '"Rafael Solana"' showing total 9 results
Start Over Author "Rafael Solana" Publisher elsevier
9 results on '"Rafael Solana"'

1. Aging-related neoplasia

Author

Ana Bela Sarmento Ribeiro, Maria Filomena Botelho, Ana Cristina Gonçalves, Joana Barbosa Melo, Mafalda Laranjo, Raquel Alves, Joana Jorge, Ilda Patrícia Ribeiro, Salomé Pires, Margarida Abrantes, Vera Constâncio, Carmen Jerónimo, Isabel Marques Carreira, Manuel Santos Rosa, and Rafael Solana

Published
2023
Full Text
View/download PDF

2. List of contributors

Author

Margarida Abrantes, Raquel Alves, Sharath Anugula, Veronica Aran, Lina Badimon, Jorge N. Barreto, Grzegorz Bartosz, Fernanda Borges, Consuelo Borrás, Maria Filomena Botelho, Jean Bousquet, António M.D. Brehm, Gerly A.C. Brito, Daan Bultje, Ana Cristina Cabral, André Caetano, Helena Canhão, Isabel Marques Carreira, Ana Maria Carriazo, Cristina Carvalho, Eugenia Carvalho, Margarida Castel-Branco, Yaohua Chen, João M. Coelho-Filho, Vera Constâncio, António Correia e Silva, Deiziane V.S. Costa, Elísio Costa, Inês Costa, Teresa Cunha-Oliveira, Paulo de Carvalho, Vicenzo De Luca, Edoardo R. de Natale, Jorge Dias, Ronaldo P. Dias, Ana I. Duarte, John Farrel, Fernando Fernandez-Llimos, Lino Ferreira, Luigi Ferrucci, Isabel Vitoria Figueiredo, Jamie K. Ford, Claudio Franceschi, Alex A. Freitas, Maja Furlan de Brito, Karla C. Giacomin, Henrique Girao, Ilias Gkikas, Bárbara Gomes, Rodrigo M. Gomes, Ana Cristina Gonçalves, Peter Goulden, Marcus Grant, Luís F. Grilo, Nick Guldemond, Jorge Henriques, Manoela Heringer, Maddalena Illario, Carmen Jerónimo, John G. Jones, Joana Jorge, Yaschar Kabiri, Agnieszka Karkucinska-Wieckowska, George Kelly, James L. Kirkland, Kristina Kitaeva, Andrey Kiyasov, Viktor I. Korolchuk, Mafalda Laranjo, Thomas J. LaRocca, Marta Lavrador, Magdalena Lebiedzinska-Arciszewska, Zhiquan Li, Yuezhong Liu, Alexandre Lourenço, Lina Ma, João O. Malva, Christopher R. Martens, Cristina Mas-Bargues, Paulo Matafome, Joana Barbosa Melo, Maria L. Lima Mendonça, Athanasios Metaxakis, Lefkos T. Middleton, Paula I. Moreira, Judite M. Nascimento, Vivaldo M. Neto, Paulo J. Oliveira, Alessandro Ori, Reinaldo B. Oriá, Susan E. Ozanne, Miguel Padeiro, Teresa Padro, Carlos M. Palmeira, Yiming Pan, Simão Paredes, João F. Passos, Edith Pereira, Francisco B. Pereira, Susana P. Pereira, Paolo Pinton, Joana F. Pires, Salomé Pires, M. Cristina Polidori, Marios Politis, Nuno Raimundo, João Ramalho-Santos, Lene Juel Rasmussen, Fernando J. Regateiro, Dario D. Reis, Caio Ribeiro, Ilda Patrícia Ribeiro, Teresa M. Ribeiro-Rodrigues, Albert Rizvanov, Teresa Rocha, Susanne Röhr, Anabela P. Rolo, Aurora Román-Domínguez, Roman Romero-Ortuno, Manuel Santos Rosa, Catrin Rutland, Izabela Sadowska-Bartosz, Paula Santana, Deolinda Santinha, Marcos Santos, Ana Bela Sarmento Ribeiro, Deisa S.R.C. Semedo, João Sequeira, Felipe Sierra, Maria Natalina L. Silva, Rafael Solana, Valeriya Solovyeva, Hélder Spínola, Renata S. Tavares, Nektarios Tavernarakis, Tamar Tchkonia, Yin-Leng Theng, Vicente Traver-Salcedo, Chi Udeh-Momoh, Rakhi Verma, Stella Victorelli, Andreia Vilaça, Gemma Vilahur, José Viña, Thomas von Zglinicki, Devin Wahl, Berenice Maria Werle, Mariusz R. Wieckowski, Heather Wilson, Erin O. Wissler Gerdes, Lucyna A. Wozniak, Barbara Zavan, Yi Zhu, and Hans Zischka

Published
2023
Full Text
View/download PDF

3. Contributors

Author

Giulia Acccardi, Aamir Ahmad, Maarten Albersen, Cristina Alonso, Frank Antonicelli, Kazutetsu Aoshiba, Asfar Azmi, Carmela Rita Balistreri, Bin Bao, Aaron Barett, Moisés Evandro Bauer, Dawn Blatt, Edward J. Calabrese, Vittorio Calabrese, Giuseppina Candore, Calogero Caruso, Marta Castro, Chih-Chiang Chen, Wen-Chieh Chen, Chandra Sekhar Chirumamilla, Carolin Cornelius, Carla Costa, Salvatore Cuzzocrea, Mónica De la Fuente, Hans Degens, Evelyna Derhovanassian, Jolien Diddens, Gilles Dupuis, Martine Exterman, Jeff Fang, Agustin F. Fernandez, Mario F. Fraga, Tamas Fülöp, Jose E. Galgani, Diego García, Cheri L. Gostic, Antonio Graziano, William Hornebeck, Manley Huang, Jae-Woong Hwang, Bianca K. Itariu, Masayuki Itoh, Kai Kaarniranta, Kyung-Sun Kang, Anu Kauppinen, Mi-Kyung Kim, Roman V. Kondratov, Anna A. Kondratova, Rami Kotb, Madhura Kulkarni, Anis Larbi, James W. Larrick, Yiwei Li, Jamie S. McPhee, Andrew Mendelsohn, Keith C. Meyer, Hiroyuki Nakamura, Ya Fatou Njie-Mbye, Sunny E. Ohia, Catherine A. Opere, Ajay Palagani, Giovambattista Pani, Hye Yun Park, Rosanna Di Paola, Graham Pawelec, Rosario Perrotta, Ananda Prasad, Irfan Rahman, Donna Ray, S.K. Raychaudhuri, S.P. Raychaudhuri, Leocadio Rodriguez-Mañas, Sandra Rodriguez-Rodero, Antero Salminen, Fazlul H. Sarkar, Ankit Saxena, Vik Sharma, Don D. Sin, Rafael Solana, Yong Sang Song, Benjamin Sopczynski, Thomas M. Stulnig, Isaac K. Sundar, Katarzyna Szarc vel Szic, Mei-Hui Tai, James E. Trosko, Takao Tsuji, Rocio G. Urdinguio, Wim Vanden Berghe, Pim van der Harst, John M. Wages, Jianming Wang, Susan C. Wright, Kazuhiro Yamaguchi, Chao-Chun Yang, Hongwei Yao, Raymond Yung, and Haidong Zhu

Published
2014
Full Text
View/download PDF

4. Aging, Immunosenescence, and Cancer

Author

Anis Larbi, Martine Exterman, Tamas Fulop, Gilles Dupuis, Evelyna Derhovanassian, Rami Kotb, Graham Pawelec, and Rafael Solana

Subjects
Innate immune system, Cancer, Inflammation, Immunosenescence, Biology, Acquired immune system, medicine.disease_cause, medicine.disease, Metastasis, Immune system, Immunology, medicine, medicine.symptom, Carcinogenesis
Abstract

Cancer is one of the most devastating diseases and occurs with higher frequency as we age. Indeed, one of the most important risk factors for most solid cancers is age. It is very difficult to define what links aging to cancer, considering the existence of multiple different cancers, the time needed for their development, and the multi-hit theory of carcinogenesis. Recently, eight hallmarks of cancer have been identified: these include having the ability to sustain proliferative signaling, evade growth suppressors, resist cell death, enable replicative immortality, induce angiogenesis, activate invasion and metastasis, reprogram energy metabolism, and escape the immune response. The immune system seems to play a crucial role in the control of cancer development and progression through its ability to mount an appropriate response, but it also favors cancer development by participating in the development of chronic inflammation. The apparent disequilibrium between retaining a relatively reactive innate immune response and developing a severely altered adaptive immune response with aging leads to the low-grade inflammatory status commonly observed in the elderly, termed inflammaging . Although the cause of this increased basal inflammatory state is certainly multifactorial, it is likely that one of the most important causes is chronic antigenic stimulation. Thus, in this chapter we will review the role of age-related dysregulated immunity in tumorigenesis.

Published
2014
Full Text
View/download PDF

5. Contributors

Author

Claude Alain, Mikhail F. Alexeyev, David B. Allison, Gro V. Amdam, Thomas P. Andriacchi, Robert Arking, Volker Arndt, Thiruma V. Arumugam, Ragnar Asplund, Steven N. Austad, Gustavo Barja, Yvonne Barnett, Andrzej Bartke, Barry D. Bavister, Stephen A. Benjamin, Carlo Bertoni-Freddari, Jennifer L. Bizon, Klaus Bobacz, Carol A. Brenner, Hermann Brenner, Anja Brunet-Rossinni, André C. Carpentier, Tiziana Casoli, Carlo Cavallotti, Peter Celec, Christiane Charriaut-Marlangue, Andrew Chin, Alan Cohen, Klaus-Günter Collatz, P. Michael Conn, Judith Corr, Glen R. Cunningham, R. John Davenport, Mary E. Delany, Olga Dela Rosa, João Pedro de Magalhães, Giuseppina Di Stefano, Inga J. Duignan, Benjamin J. Dyson, Jay M. Edelberg, Rita B. Effros, Paola Fabrizio, Patrizia Fattoretti, Caleb E. Finch, Harry Fisch, Alfred L. Fisher, Kevin R. Fontaine, Rosalyn Forsey, Lourdes A. Fortepiani, D. Robert Frisina, Robert D. Frisina, Tamas Fülöp, Michael P. Gardner, Leonid A. Gavrilov, Natalia S. Gavrilova, David Gems, Paolo U. Giacomoni, Gavin Gillespie, Andrea C. Gore, Adalsteinn Gudmundsson, John C. Guerin, Paul Hasty, J. Fielding Hejtmancik, Kevin P. High, Rabih Hijazi, David B. Hogan, Jacquelyne M. Holm, Donna J. Holmes, C. Christopher Hook, Radu Iliescu, Donald K. Ingram, Takeshi Iwata, Pudur Jagadeeswaran, Jean-Paul Janssens, Christopher A. Jolly, Palmi V. Jonsson, Matt Kaeberlein, Mark Kantorow, Scott W. Keith, Evan T. Keller, Jill M. Keller, R. Lee Kennedy, E.Y.H. Khoo, Shuji Kishi, Steven G. Kohama, Jens Krøll, Dolores J. Lamb, Sarah M. Lambert, Mark A. Lane, Frieder R. Lang, Anis Larbi, Keith E. Latham, Susan P. LeDoux, Harry LeVine, Kirk C. Lo, Valter D. Longo, Jacqueline A. Maffucci, Erminia Mariani, Puneet Masson, Julie A. Mattison, Mark P. Mattson, Samy I. McFarlane, William Meier-Ruge, Keith C. Meyer, Richard A. Miller, Satomi Miwa, Raymond J. Monnat, Arshag D. Mooradian, Paul S. Mueller, Annegret Mündermann, Ranganath Muniyappa, Nancy L. Nadon, J.O. Nehlin, James F. Nelson, Simone Neri, John Nicasio, Michelle Nicolle, S. Jay Olshansky, Mary Ann Ottinger, Joel D. Parker, Karen M. Parker, Cam Patterson, Graham Pawelec, Thomas Perls, Nicola Pescosolido, Kiran Rabheru, Jane F. Reckelhoff, Sylvain Renolleau, Rocco Rossinni, George S. Roth, Mary Ellen Rousseau, Olav Rueppell, Kurt W. Runge, David C. Samuels, Alberto Sanz, Peter N. Schlegel, Christian Schöneich, Isao Shimokawa, Christina T. Siwak, Scott A. Small, Michael D. Smith, Roy G. Smith, Joel S. Snyder, Rafael Solana, Richard L. Sprott, Evelyn Strauss, Ilse-Gerlinde Sunk, Susan E. Swanberg, P. Dwight Tapp, Loraine Tarou, Daniel Tessier, Jon Tolson, Jan Vijg, Mark E. Viney, Hans-Werner Wahl, Lary C. Walker, Jeremy D. Walston, Chenxi Wang, Lawrence J. Whalley, Shannon Whirledge, John R. Williams, Glenn L. Wilson, Iain A. Wilson, Julie M. Wu, Zhun Xu, Licy Yanes, and Mary B. Zelinski

Published
2006
Full Text
View/download PDF

6. Human T Cell Clones in Long-Term Culture as Models for the Impact of Chronic Antigenic Stress in Aging

Author

Jon Tolson, Yvonne Barnett, Anis Larbi, Olga Dela Rosa, Erminia Mariani, Rafael Solana, Tamas Fulop, Graham Pawelec, Simona Neri, and Rosalyn Forsey

Subjects
T cell, media_common.quotation_subject, Clone (cell biology), Longevity, Immunosenescence, Biology, Telomere, Tissue culture, medicine.anatomical_structure, Antigen, Immunology, Monoclonal, medicine, media_common
Abstract

Monoclonal human T lymphocytes can be maintained untransformed in tissue culture by intermittent antigen restimulation in the presence of growth factors for only a finite period (which, however, varies greatly from clone to clone). This tissue culture model can be employed to examine many aspects of clonal expansion and contraction under conditions of chronic antigenic stress, such as that which occurs in vivo in the elderly (where herpes viruses represent an important chronic stressor), as well as in cancer. In this context, the model can be used for biomarker discovery at the genomic, proteomic, and functional levels, and to test remedial interventions of possible utility in vivo. Furthermore, the clonal characteristics of cells from donors of different ages and states can be compared using this model (cloning efficiency, mean longevity, maximum longevity, aging behavior, etc.). This chapter briefly describes techniques for the production and maintenance of human T cell clones, their growth characteristics and longevity in vitro, culture age-associated changes of parameters such as telomere lengths, DNA damage, surface molecules and so on, and the application of proteomic analyses to study this model of immunosenescence in detail.

Published
2006
Full Text
View/download PDF

9. 4 Generation and Characterization of Killer Cells

Author

Erminia Mariani, Rienk Offringa, Graham Pawelec, C. J. M. Melief, and Rafael Solana

Subjects
Interleukin 21, Lymphokine-activated killer cell, NK-92, Immunology, CD1, Interleukin 12, Cytotoxic T cell, Biology, Natural killer T cell, Antigen-presenting cell, Cell biology
Abstract

Publisher Summary This chapter discusses the generation and characterization of killer cells. Many immunocytes have the capacity to kill other cells or each other. The killer cells of the lymphocyte type fall into two main categories distinguished by their major histocompatibility complex (MHC) restriction or lack and their ability to be primed to the sensitizing antigen and to generate immunological memory. MHC-restricted effectors are exclusively T lymphocytes and are commonly known as “cytotoxic T lymphocytes (CTLs).” Several surface markers are useful in distinguishing NK cells from other cell types, although many are shared with T cells. Natural killer (NK) cells also express the members of the β 2 -integrin family shared with myelomonocytic cells. The relatively small amount of NK cells within the blood has made it difficult to obtain these cells in pure form and in large enough numbers to perform functional tests. Cytotoxic NK cells can be purified by cell sorting, immunomagnetic purification, or complement-dependent depletion of other cell types. The preparation of human natural killer cells by immunomagnetic separation is also elaborated in the chapter.

Published
1998
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results