1. Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK
- Author
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Chris Griffiths, Richard Hooper, Aklak Choudhury, Claire L. Greiller, Christopher Corrigan, David A. Jolliffe, Wai Yee James, Elina Hyppönen, Angshu Bhowmik, David E. Simcock, Kamrul Islam, Peter Timms, Neil Barnes, Raj K Rajakulasingam, Robert Walton, Adrian R. Martineau, Jolliffe, David A, James, Wai Yee, Hooper, Richard L, Barnes, Neil C, Greiller, Claire L, Islam, Kamrul, Bhowmik, Angshu, Timms, Peter M, Rajakulasingam, Raj K, Choudhury, Aklak B, Simcock, David E, Hyppönen, Elina, Walton, Robert T, Corrigan, Christopher J, Griffiths, Christopher J, Martineau, Adrian R, and 5th International Conference on Vitamin D Deficiency, Nutrition and Human Health Abu Dhabi, U Arab Emirates 24-25 March 2016
- Subjects
Male ,Vital capacity ,Neutrophils ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,spirometry ,vitamin D ,Biochemistry ,Gastroenterology ,Calcitriol receptor ,Severity of Illness Index ,Body Mass Index ,FEV1 ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Endocrinology ,Cytochrome P-450 Enzyme System ,single nucleotide polymorphism ,London ,Prevalence ,030212 general & internal medicine ,Vitamin D ,Aged, 80 and over ,COPD ,medicine.diagnostic_test ,Continental Population Groups ,Middle Aged ,Respiratory Function Tests ,DNA-Binding Proteins ,Low Density Lipoprotein Receptor-Related Protein-2 ,Molecular Medicine ,Female ,medicine.symptom ,Spirometry ,Adult ,medicine.medical_specialty ,Oxidoreductases Acting on CH-CH Group Donors ,Receptors, Cell Surface ,vitamin D deficiency ,03 medical and health sciences ,FEV1/FVC ratio ,Endocrinology & Metabolism ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,Molecular Biology ,Aged ,business.industry ,Racial Groups ,0601 Biochemistry And Cell Biology ,Cell Biology ,medicine.disease ,Vitamin D Deficiency ,FVC ,respiratory tract diseases ,Single nucleotide polymorphism ,Eosinophils ,Cross-Sectional Studies ,030228 respiratory system ,Gene Expression Regulation ,Immunology ,Sputum ,Receptors, Calcitriol ,business ,Transcription Factors - Abstract
Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), yet a comprehensive analysis of environmental and genetic determinants of serum 25-hydroxyvitamin D (25[OH]D) concentration in patients with this condition is lacking. We conducted a multi-centre cross-sectional study in 278 COPD patients aged 41–92 years in London, UK. Details of potential environmental determinants of vitamin D status and COPD symptom control and severity were collected by questionnaire, and blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction. All participants perform ed spirometry and underwent measurement of weight and height. Quadriceps muscle strength (QS) was measured in 134 participants, and sputum induction with enumeration of lower airway eosinophil and neutrophil counts was performed for 44 participants. Thirty-seven single nucleotide polymorphisms (SNP) in 11 genes in the vitamin D pathway (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, CYP27A1, CYP3A4, LRP2, CUBN, RXRA, and VDR) were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration and to determine whether vitamin D status or genetic factors independently associated with % predicted forced expiratory volume in one second (FEV 1 ), % predicted forced vital capacity (FVC), the ratio of FEV 1 to FVC (FEV 1 :FVC), daily inhaled corticosteroid (ICS) dose, respiratory quality of life (QoL), QS, and the percentage of eosinophils and neutrophils in induced sputum. Mean serum 25(OH)D concentration was 45.4 nmol/L (SD 25.3); 171/278 (61.5%) participants were vitamin D deficient (serum 25[OH]D concentration < 50 nmol/L). Lower vitamin D status was independently associated with higher body mass index (P = 0.001), lower socio-economic position (P = 0.037), lack of vitamin D supplement consumption (P < 0.001), sampling in Winter or Spring (P for trend = 0.006) and lack of a recent sunny holiday (P = 0.002). Vitamin D deficiency associated with reduced % predicted FEV 1 (P for trend = 0.060) and % predicted FVC (P for trend = 0.003), but it did not associate with FEV 1 :FVC, ICS dose, QoL, QS, or the percentage of eosinophils or neutrophils in induced sputum. After correction for multiple comparisons testing, genetic variation in the vitamin D pathway was not found to associate with serum 25(OH)D concentration or clinical correlates of COPD severity. Vitamin D deficiency was common in this group of COPD patients in the UK, and it associated independently with reduced % predicted FEV1 and FVC. However, genetic variation in the vitamin D pathway was not associated with vitamin D status or severity of COPD. Refereed/Peer-reviewed
- Published
- 2017