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Highlights • Lip metastasis of Renal Neoplasia is a very unusual oncological manifestation and difficult to differentiate. • That’s the first case related on Brazil, the second described in the literature. • This case contributes to the knowledge of the manifestations of neoplastic dissemination and cell differentiation., Introduction Cutaneous spread of solid visceral metastasis is very unusual presentation, usually in breast, lung, colon, ovarian carcinomas, and malignant melanoma. Less than 5% of cases of cutaneous spread are from renal neoplasms. Presentation of case We present the case of a 48-year-old woman with a large lower lip tumor whose anatomopathological analysis of the lesion led us to identify a Clear Cell Renal Cell Carcinoma (ccRCC). Discussion The clinical manifestations of the ccRCC can be mild, generating a late diagnosis through metastasis of primary neoplasia. Their presentations can be varied, as described in this report. Conclusion The knowledge of the different types of presentation of CCCR metastases can assist in decision making, but the progression of staging often only allows palliative measures.