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1. Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp

Author

Ayako Kawakami, Takeshi Uchiumi, Tomofumi Miyamoto, Michihiko Kuwano, Rob W. M. Van Soest, Ryuichi Higuchi, and Systematische en Geografische Dierkunde (inactive) (IBED, FNWI)

Subjects
chemistry.chemical_classification, biology, Chemistry, Stereochemistry, Organic Chemistry, Fatty acid, Isethionic acid, biology.organism_classification, Biochemistry, Multiple drug resistance, Membrane glycoproteins, Sponge, chemistry.chemical_compound, Multidrug Resistance Modulator, Drug Discovery, biology.protein, Ircinia
Abstract

Irciniasulfonic acid was obtained from a marine sponge of Ircinia sp. Spectroscopic and chemical analyses revealed its structure consists of three different kinds of acids, i.e. common fatty acids, a novel unsaturated branched C-10 fatty acid and an isethionic acid. Irciniasulfonic acid and deacyl irciniasulfonic acid reverse multidrug resistance in human carcinoma cells caused by overexpression of membrane glycoprotein.

Published
2001

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