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1. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Laura Herrera-Hidalgo, Patricia Muñoz, Ana Álvarez-Uría, David Alonso-Menchén, Rafael Luque-Marquez, Encarnación Gutiérrez-Carretero, María Del Carmen Fariñas, Jose Maria Miró, Miguel Angel Goenaga, Luis Eduardo López-Cortés, Basilio Angulo-Lara, Lucia Boix-Palop, Arístides de Alarcón, Fernando Fernández Sánchez, José Mª García de Lomas, Gabriel Rosas, Javier de la Torre Lima, Elena Bereciartua, María José Blanco Vidal, Roberto Blanco, María Victoria Boado, Marta Campaña Lázaro, Alejandro Crespo, Laura Guio Carrión, Mikel Del Álamo Martínez de Lagos, Gorane Euba Ugarte, Ane Josune Goikoetxea, Marta Ibarrola Hierro, José Ramón Iruretagoyena, Josu Irurzun Zuazabal, Leire López-Soria, Miguel Montejo, Javier Nieto, David Rodrigo, Regino Rodríguez, Yolanda Vitoria, Roberto Voces, Mª Victoria García López, Radka Ivanova Georgieva, Guillermo Ojeda, Isabel Rodríguez Bailón, Josefa Ruiz Morales, Ignacio Álvarez Rodríguez, Harkaitz Azkune Galparsoro, Elisa Berritu Boronat, Mª Jesús Bustinduy Odriozola, Cristina del Bosque Martín, Tomás Echeverría, Alberto Eizaguirre Yarza, Ana Fuentes, Miguel Ángel Goenaga, Muskilda Goyeneche del Río, Ángela Granda Bauza, José Antonio Iribarren, Xabier Kortajarena Urkola, José Ignacio Pérez-Moreiras López, Ainhoa Rengel Jiménez, Karlos Reviejo, Alberto Sáez Berbejillo, Elou Sánchez Haza, Rosa Sebastián Alda, Itziar Solla Ruiz, Irati Unamuno Ugartemendia, Diego Vicente Anza, Iñaki Villanueva Benito, Mar Zabalo Arrieta, Rafael Carrasco, Vicente Climent, Patricio Llamas, Esperanza Merino, Joaquín Plazas, Sergio Reus, Alberto Bouzas, Brais Castelo, José Cuenca, Laura Gutiérrez, Lucía Ramos, María Rodríguez Mayo, Joaquín Manuel Serrano, Dolores Sousa Regueiro, Francisco Javier Martínez, Mª del Mar Alonso, Beatriz Castro, Teresa Delgado Melian, Javier Fernández Sarabia, Dácil García Rosado, Julia González González, Juan Lacalzada, Lissete Lorenzo de la Peña, Alina Pérez Ramírez, Pablo Prada Arrondo, Fermín Rodríguez Moreno, Antonio Plata Ciezar, José Mª Reguera Iglesias, Víctor Asensi Álvarez, Carlos Costas, Jesús de la Hera, Jonnathan Fernández Suárez, Lisardo Iglesias Fraile, Víctor León Arguero, José López Menéndez, Pilar Mencia Bajo, Carlos Morales, Alfonso Moreno Torrico, Carmen Palomo, Begoña Paya Martínez, Ángeles Rodríguez Esteban, Raquel Rodríguez García, Mauricio Telenti Asensio, Manuel Almela, Juan Ambrosioni, Manuel Azqueta, Mercè Brunet, Marta Bodro, Ramón Cartañá, Guillermo Cuervo, Carlos Falces, Mariana J Fernández-Pittol, Guillermina Fita, David Fuster, Cristina García de la Mària, Delia García-Pares, Marta Hernández-Meneses, Jaume Llopis Pérez, Francesc Marco, José M. Miró, Asunción Moreno, David Nicolás, Salvador Ninot, Eduardo Quintana, Carlos Paré, Daniel Pereda, Juan M. Pericás, José L. Pomar, José Ramírez, Mercè Roque, Irene Rovira, Elena Sandoval, Marta Sitges, Dolors Soy, Adrián Téllez, José M. Tolosana, Bárbara Vidal, Jordi Vila, Iván Adán, David Alonso, Juan Carlos Alonso, Javier Bermejo, Emilio Bouza, Gregorio Cuerpo Caballero, Antonia Delgado Montero, Agustín Estévez, Ramón Fortuny Ribas, Esther Gargallo, Mª Eugenia García Leoni, Ana González Mansilla, Francisco Javier González Moraga, Víctor González Ramallo, Martha Kestler Hernández, Amaia Mari Hualde, Marina Machado, Mercedes Marín, Manuel Martínez-Sellés, Rosa Melero, Diego Monzón, María Olmedo, Álvaro Pedraz, Blanca Pinilla, Ángel Pinto, Cristina Rincón, Hugo Rodríguez-Abella, Marta Rodríguez-Créixems, Eduardo Sánchez-Pérez, Antonio Segado, Neera Toledo, Maricela Valerio, Pilar Vázquez, Eduardo Verde Moreno, Sofía de la Villa, Isabel Antorrena, Belén Loeches, Mar Moreno, Ulises Ramírez, Verónica Rial Bastón, María Romero, Sandra Rosillo, Jesús Agüero Balbín, Cristina Amado Fernández, Carlos Armiñanzas Castillo, Francisco Arnaiz de las Revillas, Manuel Cobo Belaustegui, María Carmen Fariñas, Concepción Fariñas-Álvarez, Marta Fernández Sampedro, Iván García, Claudia González Rico, Laura Gutiérrez-Fernández, Manuel Gutiérrez-Cuadra, José Gutiérrez Díez, Marcos Pajarón, José Antonio Parra, Ramón Teira, Jesús Zarauza, Jorge Calderón Parra, Marta Cobo, Fernando Domínguez, Pablo García Pavía, Ana Fernández Cruz, Antonio Ramos-Martínez, Isabel Sánchez Romero, Tomasa Centella, José Manuel Hermida, José Luis Moya, Pilar Martín-Dávila, Enrique Navas, Enrique Oliva, Alejandro del Río, Jorge Rodríguez-Roda Stuart, Soledad Ruiz, Carmen Hidalgo Tenorio, Sergio Sequera, Manuel Almendro Delia, Omar Araji, José Miguel Barquero, Román Calvo Jambrina, Marina de Cueto, Juan Gálvez Acebal, Irene Méndez, Isabel Morales, José Antonio Lepe, José López-Haldón, Rafael Luque-Márquez, Guillermo Marín, Antonio Ortiz-Carrellán, Eladio Sánchez-Domínguez, Luis Javier Alonso, Pedro Azcárate, José Manuel Azcona Gutiérrez, José Ramón Blanco, Estíbaliz Corral Armas, Lara García-Álvarez, José Antonio Oteo, Antonio Barros Membrilla, Antonino Ginel Iglesias, Sara Grillo, Rubén Leta Petracca, Joaquín López-Contreras, María Alba Rivera Martínez, M. Álvarez, A.L. Fernández, Amparo Martínez, A. Prieto, Benito Regueiro, E. Tijeira, Marino Vega, Amaia Aguirre Quiñonero, Ángela Alonso Miñambres, Juan Carlos Gainzarain Arana, Sara González de Alaiza Ortega, Miguel Ángel Morán Rodríguez, Anai Moreno Rodríguez, Zuriñe Ortiz de Zárate, José Joaquín Portu Zapirain, Ester Sáez de Adana Arroniz, Daisy Carolina Sorto Sánchez, Sánchez-Porto Antonio, Úbeda Iglesias Alejandro, José Mª Arribas Leal, Elisa García Vázquez, Alicia Hernández Torres, Ana Blázquez, Gonzalo de la Morena Valenzuela, Ángel Alonso, Javier Aramburu, Felicitas Elena Calvo, Paola Tarabini-Castellani, Eva Heredero Gálvez, Carolina Maicas Bellido, José Largo Pau, Mª Antonia Sepúlveda, Pilar Toledano Sierra, Sadaf Zafar Iqbal-Mirza, Eva Cascales Alcolea, Ivan Keituqwa Yañez, Julián Navarro Martínez, Ana Peláez Ballesta, Eduardo Moreno Escobar, Alejandro Peña Monje, Valme Sánchez Cabrera, David Vinuesa García, María Arrizabalaga Asenjo, Carmen Cifuentes Luna, Juana Núñez Morcillo, Mª Cruz Pérez Seco, Aroa Villoslada Gelabert, Carmen Aured Guallar, Nuria Fernández Abad, Pilar García Mangas, Marta Matamala Adell, Mª Pilar Palacián Ruiz, Juan Carlos Porres, Begoña Alcaraz Vidal, María Jesús Del Amor Espín, Francisco Buendía, Roberto Jiménez Sánchez, Rosario Mármol, Francisco Martínez, Antonio Meseguer, Beatriz Pérez, Leticia Risco, Zoser Saura, Vanina Silva, Mª Belén Villmarín, Mª Ángels Ribas Blanco, Enrique Ruiz de Gopegui Bordes, Laura Vidal Bonet, Miquel Vives Borràs, Mª Carmen Bellón Munera, Elena Escribano Garaizabal, Antonia Tercero Martínez, Juan Carlos Segura Luque, Cristina Badía, Lucía Boix Palop, Mariona Xercavins, Sónia Ibars, Xerach Bosch, Eloy Gómez Nebreda, Ibalia Horcajada Herrera, Irene Menduiña Gallego, Imanol Pulido, Héctor Marrero Santiago, Isabel de Miguel Martínez, Elena Pisos Álamo, Daniel San Román Sánchez, Jorge Boan Pérez, Eva Mª Aguilar Blanco, Mercedes Catalán González, María Angélica Corres Peiretti, Andrea Eixerés Esteve, Laura Domínguez Pérez, Santiago de Cossío Tejido, Francisco Galván Román, José Antonio García Robles, Francisco López Medrano, Mª Jesús López Gude, Mª Ángeles Orellana Miguel, Patrick Pilkington, Yolanda Revilla Ostalaza, Juan Ruiz Morales, Sebastián Ruiz Solís, Ana Sabín Collado, Marcos Sánchez Fernández, Javier Solera Rallo, Jorge Solís Martín, Francesc Escrihuela-Vidal, Jordi Carratalà, Inmaculada Grau, Carmen Ardanuy, Dámaris Berbel, José Carlos Sánchez Salado, Oriol Alegre, Alejandro Ruiz Majoral, Fabrizio Sbraga, Arnau Blasco, Laura Gracia Sánchez, Iván Sánchez-Rodríguez, Gonzalo Aldamiz, Beatriz Álvarez, Marina Bernal Palacios, Alfonso Cabello Úbeda, Ricardo Fernández Roblas, Rafael Hernández, Victoria Andrea Hortigüela Martín, Andrea Kallmeyer, Cristina Landaeta Kancev, Marta Martín, Miguel Morante Ruiz, Miguel Ángel Navas Lobato, Ana María Pello, Laura Prieto, Marta Tomás Mallebrera, Laura Varela, Mireia de la Peña Triguero, Ruth Esther Figueroa Cerón, Lara Ruiz Gómez, Mireia Ble, Juan Pablo Horcajada Gallego, Antonio José Ginel, Inmaculada López, Alexandra Mas, Antoni Mestres, Lluís Molina, Ramón Serrat, Núria Ribas, Francisca Sánchez, Ana Silverio, Marina Suárez, Luisa Sorlí, Lluís Recasens, Manuel Taurón, María Fernández Regueras, María Ángeles Mantecón Vallejo, José Ángel Pérez Rivera, Nuria Sánchez Mata, Antonia Calvo Cano, Miguel Fajardo Olivares, María Victoria Millán Núñez, and Agustín Muñoz Sanz

Subjects
Infective endocarditis, Methicillin-susceptible Staphylococcus aureus, Cefazolin, Antistaphylococcal penicillin, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P

Published
2023
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3. Proposal of new Natura 2000 network boundaries in Spain based on the value of importance for biodiversity and connectivity analysis for its improvement

Author

Víctor Rincón, Javier Velázquez, Javier Gutiérrez, Ana Hernando, Alexander Khoroshev, Inmaculada Gómez, Fernando Herráez, Beatriz Sánchez, Juan Pablo Luque, Antonio García-abril, Tomás Santamaría, and Daniel Sánchez-Mata

Subjects
Connectivity, MSPA, PC Index, Natura 2000, Conservation, Ecology, QH540-549.5
Abstract

The aim of the Natura 2000 Network is to ensure the conservation of habitats and species in their natural areas of distribution. Connectivity is an essential part of this conservation. For this purpose, a value map of importance for biodiversity (V.I.B) was generated proposing 4 levels of protection and overlapped with the Natura 2000 network. New boundaries for the zoning are proposed adding 1.600.000 ha. Two connectivity indices (MSPA and PC) are calculated in the 4 different scenarios. With these indices it is possible to know the number of existing nuclei and connectors in each of the scenarios. New boundaries cover more areas of interest for biodiversity as well as zones of great importance in relation to connectivity. We propose a uniform method that can be extrapolated to any European territory.

Published
2021
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4. Retrospective analysis of two diagnostic tests: Carotid Doppler ultrasound and diagnostic cerebral angiography for carotid disease in the Mexican population

Author

Daniel Alejandro Vega-Moreno, María Elena Cordoba-Mosqueda, José Ramón Aguilar-Calderón, María del Rosario López-Zapata, Ulises García-González, Martha Elena González-Jiménez, Diego Ochoa-Cacique, Mauricio Daniel Sánchez-Calderón, José Omar Santellán-Hernández, and Rafael Sánchez-Mata

Subjects
Carotid Doppler ultrasound (CDU), Diagnostic cerebral angiography (DCA), Carotid disease, Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429
Abstract

Objective: To know the clinical presentation and affected vessels as well as evaluate the carotid Doppler ultrasound (CDU) vs. diagnostic cerebral angiography (DCA) both due to the percentage of significant stenosis (>50%), and the presence of carotid ulcers in Mexican population. Patients and Methods: In Mexico City, from January 2018 to January 2020, was realized a retrospective analysis in a third-level hospital, which qualitative variables were studied. In the case of the percentage of stenosis, the existence -or not- of significant stenosis was considered. The sensitivity, specificity, negative predictive value and positive predictive value of ultrasound vs. angiography for significant stenosis and for the detection of ulcers was also calculated. Results: A total of 30 patients were analyzed, 18 men and 12 women with an age range between 47 and 89 years and an average age of 71 years. The arterial locations most frequently reported by ultrasound and angiography were graphed, as well as the mean percentage of stenosis. Regarding the evaluation of the Doppler ultrasound as a diagnostic test, 78% of sensitivity and a 53% of specificity for the percentage of stenosis, so it was greater than or equal to 50%; and a sensitivity of 0% and specificity of 90% for the detection of ulcers. Conclusions: The value of ultrasound as a diagnostic test compared to gold standard, contrasts with the result that was reported in the reading. We consider that the intentional search for carotid ulcers in patients who have already presented medical history compatible with carotid disease should be more exhaustive, based on studies with greater sensitivity, although they could be more invasive or more expensive.

Published
2021
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5. Hovenia dulcis Thunb. pseudofruits as functional foods: Phytochemicals and bioactive properties in different maturity stages

Author

Patricia Morales, Helayne Aparecida Maieves, Maria Inês Dias, Ricardo C. Calhella, María Cortes Sánchez-Mata, Celestino Santos-Buelga, Lillian Barros, and Isabel C.F.R. Ferreira

Subjects
Hovenia dulcis Thunb., Pseudofruits, Phytochemicals, Antioxidant/antitumor/antimicrobial capacity, Ripening process, Nutrition. Foods and food supply, TX341-641
Abstract

Pseudofruits of Hovenia dulcis, at five different ripening stages, were evaluated in order to characterize their bioactive compounds (phenolic compounds, tocopherols and fatty acids), and determine their biofunctionality (antitumor, antimicrobial and antioxidant activity). Epi(gallochatechin) was the main phenolic compound (24.7 mg/g, Hd05), α-tocopherol was the main isoform, increasing its content with the maturity process (5.43 mg/100 g, Hd04), C18:2 was the main polyunsaturated fatty acid (35.5%, Hd04), while C16:0 was the predominant saturated fatty acids (38%, Hd01). The most immature stages (Hd01-Hd02) showed antitumor activity against all tested tumor cell lines, mainly against NCI-H460; also Hd01 and Hd02 presented the highest antimicrobial activity, mainly against Pseudomonas aeruginosa and Staphylococcus aureus. This underutilized product demonstrated to be a rich source of phenolic compounds and tocopherols showing an interesting activity in immature stages (unfit for consumption in natura) and could be use as alternative bioactive ingredient for functional foods, dietary supplements or nutraceuticals.

Published
2017
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6. Antioxidant phytochemicals of Hovenia dulcis Thunb. peduncles in different maturity stages

Author

Helayne Aparecida Maieves, Rebeca López-Froilán, Patricia Morales, María Luisa Pérez-Rodríguez, Rosemary Hoffmann Ribani, Montaña Cámara, and María Cortes Sánchez-Mata

Subjects
Hovenia dulcis Thunb, Maturation, Organic acids, Polyphenols, Antioxidant capacity, Nutrition. Foods and food supply, TX341-641
Abstract

During development of plant products metabolic changes in bioactive compounds occur. The main objective of this work was to evaluate peduncles of H. dulcis Thunb. at five different stages of maturation, for antioxidant compounds contents (including phenols and organic acids) and antioxidant capacity. This is the first report on the evolution of antioxidants in H. dulcis pseudofruits through maturation process. The organic acids profile in the peduncules of H. dulcis evolves from majority of tartaric acid to citric acid. Immature peduncles (at a developmental stage not suitable for food consumption) are better functional ingredient with higher polyphenols and antioxidant capacity.

Published
2015
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