Author: "Saioa Gómez-Zorita" / Publisher: elsevier - Searchworks@Jio Institute Digital Library Search Results

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Author: Leixuri Aguirre, Heliodoro Alemán-Mateo, Stephen E. Alway, Sami Antoun, Ross Arena, Janice L. Atkins, Xavier Bigard, Yves Boirie, Samantha Bond, Audrey Borghi Silva, Charlotte Breuillard, Frederic Capel, Vinicius F. Cruzat, Dominique Dardevet, Jean-Pascal De Bandt, Carla Domingues-Faria, Marie-Chantal Farges, Alfredo Fernández-Quintela, Christian M. Girgis, Saioa Gómez-Zorita, Nicolas Goncalves-Mendes, Marcela González, Emilio González-Arnay, Emilio González-Reimers, Stefan H.M. Gorissen, Arthur Goron, Christelle Guillet, Christoph Handschin, Owen Jeffries, Olivier Le Bacquer, Irène Margaritis, Candelaria Martín-González, Adriana Mazzuco, Iñaki Milton-Laskibar, Christophe Moinard, Cedric Moro, Laurent Mosoni, Isabelle Papet, Stephen D. Patterson, Bente K. Pedersen, Joaquín Pérez-Schindler, Marie-Agnès Peyron, Shane A. Phillips, Stuart M. Phillips, Sergio Polakof, Maria P. Portillo, Geraldine Quintero-Platt, Didier Rémond, Lucía Romero-Acevedo, Andrea P. Rossi, Sofia Rubele, Roxana E. Ruiz Valenzuela, Francisco Santolaria-Fernández, Isabelle Savary-Auzeloux, David Scott, Richard Severin, Gordon I. Smith, Matthew J. Sorrentino, Nobuhiko Tachibana, Mark Waldron, Stéphane Walrand, Satoshi Wanezaki, Kazumi Yagasaki, and Mauro Zamboni
Published: 2019
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Author: María P. Portillo, Saioa Gómez-Zorita, Alfredo Fernández-Quintela, Iñaki Milton-Laskibar, Marcela González, and Leixuri Aguirre
Subjects: chemistry.chemical_classification, Skeletal muscle, Mitochondrion, Pharmacology, medicine.disease, chemistry.chemical_compound, Flavonols, Insulin resistance, medicine.anatomical_structure, chemistry, Oxidative enzyme, medicine, heterocyclic compounds, Quercetin, Biogenesis, Glycemic
Abstract: Quercetin is a phenolic compound belonging to the family of flavonoids and the group of flavonols, which is present in onions, apples, various types of berries, coffee, and tea. Numerous beneficial effects on health of this bioactive molecule have been reported in the literature. The present chapter focuses on the effects of quercetin on skeletal muscle mitochondria biogenesis and their consequences in terms of physical endurance and glycemic control in rodent models and human beings. Studies carried out on rodents show that quercetin is able to induce mitochondria biogenesis through increased mitochondrial DNA, genes that play a key role in this process (sirt-1, pparα, pgc-1α) and activity of oxidative enzymes. This effect leads to the enhancement of maximal exercise capacity. It has not been reproduced in human beings so far. In animal models showing insulin resistance induced by high-fat feeding, quercetin administration improved glycemic control.
Published: 2019
Full Text: View/download PDF

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