10 results on '"Sarmah, Deepaneeta"'
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2. List of contributors
- Author
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Abalo, Raquel, primary, Abdelghffar, Eman A., additional, Abdelkhalek, Yasmin M., additional, Acuña, Sabrina, additional, Adeyemo, Oluwatobi, additional, Ahlawat, Jyoti, additional, Ahmad, Aftab, additional, Ahsan, Khansa, additional, Ajeigbe, Olufunke Florence, additional, Alberto-Silva, Carlos, additional, Ali, Javed, additional, Almeida, Carlos Gabriel Moreira, additional, Almeida, Áurea Maria Alves Nunes, additional, Alves, Anna Beatriz Pereira Simões, additional, Anamelechi, Joy, additional, Andreatini, R., additional, Arbo, Bruno Dutra, additional, Arent, Camila O., additional, Ashraf, Hagar, additional, Aslim, Belma, additional, Atarase, Oyepeju, additional, Awasthi, Rajendra, additional, Baboota, Sanjula, additional, Bagatini, Margarete Dulce, additional, Bakrim, Saad, additional, Barajas-Saucedo, C.E., additional, Bassols, Anna, additional, Batagin-Neto, Augusto, additional, Benameur, Tarek, additional, Bermúdez-Guzmán, M.J., additional, Bernardi, María Alejandra, additional, Bertollo, Amanda Gollo, additional, Beulaja, M., additional, Bhattacharya, Pallab, additional, Binda, Nancy Scardua, additional, Bisagno, Verónica, additional, Boeira, Silvana Peterini, additional, Bonjorno, Andressa Francielli, additional, Borah, Anupom, additional, Borsini, Alessandra, additional, Botelho, Maria Eduarda M., additional, Boudreau, Luc H., additional, Bouyahya, Abdelhakim, additional, Brimson, James Michael, additional, Bujtor, Melissa, additional, Büsselberg, Dietrich, additional, Butt, Arthur Morgan, additional, Čagalj, Martina, additional, Candeias, Emanuel, additional, Cardoso, Sandra Morais, additional, Carlini, Celia R., additional, Carrazoni, Thiago, additional, Carreira, Rodrigo Barreto, additional, Carrera-González, María Pilar, additional, Castro e Silva, Juliana Helena, additional, Catherene, M. Livya, additional, Chamorro, María E., additional, Charlotte, Lechevallier, additional, Chaudhary, Antra, additional, Chiba, Diego Eidy, additional, Choonara, Yahya E., additional, Chukwudozie, Kingsley Ikechukwu, additional, Convertini, Paolo, additional, Correa, Florencia, additional, Costa, Silvia Lima, additional, Cox, Paul Alan, additional, Crispi, Stefania, additional, Cuciniello, Rossana, additional, urko-Cofek, Božena, additional, da Cunha, Israel Cordeiro Eller, additional, da Rocha Fernandes, Livia, additional, da Silva, Gilnei Bruno, additional, da Silva, Juliana Figueira, additional, da Silva, Victor Diogenes Amaral, additional, Dakka, Nadia, additional, Dal Belo, Cháriston André, additional, Datta, Aishika, additional, de Almeida, Monique Marylin Alves, additional, de Araújo, Fillipe Mendes, additional, de Bari, Lidia, additional, de Faria Lopes, Giselle Pinto, additional, de Gomes, Marcelo Gomes, additional, de Oliveira, Juciele Valéria Ribeiro, additional, de Oliveira, Marcos Roberto, additional, de Oliveira, Êndel Alves Gomes, additional, de Sampaio Schitine, Clarissa, additional, de Souza, Suzana Braga, additional, de Souza, Veronica Moreira, additional, Del Fabbro, Lucian, additional, Dhiman, Neerupma, additional, Di Meo, Francesco, additional, Dias Costa, Maria de Fatima, additional, do Nascimento, Ravena Pereira, additional, Dora, Cristiana Lima, additional, dos Santos, Balbino Lino, additional, dos Santos, Cleonice Creusa, additional, dos Santos, Jean Leandro, additional, dos Santos, Michele Goulart, additional, Dourado, Naiara Silva, additional, El Idrissi, Abdeslem, additional, El Menyiy, Naoual, additional, Eldahshan, Omayma A., additional, El-Nashar, Heba A.S., additional, El-Shazly, Mohamed, additional, Empadinhas, Nuno, additional, Esteban, S., additional, Esteves, A. Raquel, additional, Ezenandu, Emmanuel Obinna, additional, Ezeorba, Timothy Prince Chidike, additional, Ezeudoka, Brendan Chukwuemeka, additional, Fagiolino, Pietro, additional, Farombi, Ebenezer O., additional, Ferreira, Rafael Short, additional, Finnie, John W., additional, Furian, Ana Flávia, additional, Gaitán-Hinojosa, M.A., additional, Galván-Hernández, A.R., additional, García-Villalvazo, P.E., additional, Garg, Chahat, additional, Gazerani, Parisa, additional, Ghosh, Bijoyani, additional, Gomez, Marcus Vinícius, additional, González-Bulnes, Antonio, additional, Goyal, Lav, additional, Grewal, Amarjot Kaur, additional, Grubi Kezele, Tanja, additional, Guedes, Beatriz, additional, Guevara, Natalia, additional, Gutierrez, Antonia, additional, Habtemariam, Solomon, additional, Haghdoost-Yazdi, Hashem, additional, Hassoun, Abdo, additional, Heidari, Reza, additional, Hernández-González, Ignacio, additional, Horn, Ana Paula, additional, Hort, Mariana Appel, additional, Hritcu, Lucian, additional, Hyslop, Stephen, additional, Ibarra-Vega, R., additional, Ignácio, Zuleide Maria, additional, Ikeji, Cynthia Nwamaka, additional, Infantino, Vittoria, additional, James, Adewale Segun, additional, Jauquet, Mélissa, additional, Jimenez-García, M., additional, Jiménez-Vargas, J.M., additional, Junge, Stephanie, additional, Kalapos, Miklós Péter, additional, Kalra, Palak, additional, Kanazawa, L.K.S., additional, Kanekar, Shami, additional, Kargieman, Lucila, additional, Kaur, Jasleen, additional, Kaushik, Medha, additional, Kaushik, Pooja, additional, Khan, Farha Deeba, additional, Kharkwal, Harsha, additional, Komane, Patrick P., additional, Kubatka, Peter, additional, Kulkarni, G.T., additional, Kumar, Pradeep, additional, Kumar, Shobhit, additional, la Torre, Maria Ester, additional, Lahyaoui, Manal, additional, Lefebvre, Kathi A., additional, Leite, José Roberto S.A., additional, Lemarchand, Eloïse, additional, Lino-López, G.J., additional, Lopes, Flávia Garcia, additional, Lopes, Juliana Romano, additional, Lopez del Castillo, Ines, additional, López-Gómez, Laura, additional, Loureiro, Joana, additional, Luhach, Kanishk, additional, Magalhães, João Duarte, additional, Mahalakshmi, K., additional, Malar, Dicson Sheeja, additional, Maldonado, Cecilia, additional, Maltaneri, Romina E., additional, Manikandan, R., additional, Manosso, Luana M., additional, Marciniak, Stefan J., additional, Marín-Prida, Javier, additional, Marques, Magno da Silva, additional, Martínez-Martos, José Manuel, additional, Martyniuk, Christopher J., additional, Matosinhos, Rafaela Cunha, additional, Maurya, Shashank Kumar, additional, Melo-Marques, Inês, additional, Messina, Antonietta, additional, Messina, Giovanni, additional, Metcalf, James S., additional, Mihaiela, Cornea-Cipcigan, additional, Miralles, A., additional, Mishra, Rajeev, additional, Mishra, Rajnikant, additional, Monda, Marcellino, additional, Monda, Vincenzo, additional, Moranta, D., additional, Moreira, Daniel C., additional, Moreno-Gonzalez, Ines, additional, Morin, Pier, additional, Munawar, Nayla, additional, Naqvi, Saba, additional, Nedel, Cláudia Beatriz, additional, Nelissen, E., additional, Nesse, Alcira B., additional, Nigdelioglu Dolanbay, Serap, additional, Nunes-Costa, Daniela, additional, Ojo, Mercy Olubunmi, additional, Okeke, Emmanuel Sunday, additional, Okoye, Charles Obinwanne, additional, Okoye, Henrietta Ukamaka, additional, Oliveira, R.M.W., additional, Oliveira, Raquel Soares, additional, Ommati, Mohammad Mehdi, additional, Onaolapo, Adejoke Y., additional, Onaolapo, Olakunle J., additional, Panaro, Maria Antonietta, additional, Pappalardo, Ilaria, additional, Parimalanandhini, D., additional, Parvez, Suhel, additional, Patel, Mayank, additional, Pavan, Aline Renata, additional, Pedro, Lucas C., additional, Pentón-Rol, Giselle, additional, Pereira, Erica Patrícia, additional, Pereira-Santos, A. Raquel, additional, Pérez-Valle, Jorge, additional, Perissinotti, Paula P., additional, Phadke, Girija Gajanan, additional, Piermartiri, Tetsade C.B., additional, Pinto, João Victor Krüger, additional, Pizzolorusso, Ilaria, additional, Polito, Rita, additional, Porro, Chiara, additional, Portaro, Fernanda Calheta Vieira, additional, Prasad, K.V.S.R.G., additional, Prasanth, Mani Iyer, additional, Prickaerts, J., additional, Prokai, Laszlo, additional, Prokai-Tatrai, Katalin, additional, Quevedo, João, additional, Rabbani, Syed Arman, additional, Raj, Khadga, additional, Ramírez-Expósito, María Jesús, additional, Ramis, M.R., additional, Rana, Nikita, additional, Rathod, Nikheel Bhojraj, additional, Rawat, Kajal, additional, Retana-Marquez, Socorro, additional, Réus, Gislaine Z., additional, Ribeiro, Paulo Roberto, additional, Ríos-Bracamontes, E.F., additional, Rivero-Echeto, María Celeste S., additional, Rodica, Mrgoan, additional, Rodríguez-Leone, Nazarena, additional, Roussel, Benoit D., additional, Ruggiero, Melania, additional, Rupasree, P., additional, Saha, Lekha, additional, Salau, Veronica F., additional, Sangeetha, R., additional, Sardana, Satish, additional, Sarduy-Chávez, Rocío de la Caridad, additional, Sarmah, Deepaneeta, additional, Sarubbo, F., additional, Schimith, Lucia Emanueli, additional, Shahidul Islam, Md., additional, Sharika, Rajasekharan, additional, Sharma, Bhupesh, additional, Sharma, Poonam, additional, Sharma, Shrestha, additional, Shrivastava, Rahul, additional, Siddique, Yasir Hasan, additional, Silva, Marilyn H., additional, Šimat, Vida, additional, Singh, Gyanendra, additional, Singh, Neha, additional, Singh, Shamsher, additional, Singh, Thakur Gurjeet, additional, Singh, Varinder, additional, Sirin, Seda, additional, Soares, Janaina Ribeiro Pereira, additional, Souza, Cleide dos Santos, additional, Souza, Nara, additional, Srivastava, Vikas, additional, Su, Kuan-Pin, additional, Sujatha, D., additional, Sukach, Volodymyr, additional, Sunitha, S., additional, Tabassum, Heena, additional, Tasca, Carla I., additional, Tasker, R. Andrew, additional, Tasleem, Ammar, additional, Tejada, S., additional, Tencomnao, Tewin, additional, Torres, Rosimere Oliveira, additional, Triniac, Hortense, additional, Tripathi, Swapnil, additional, Trotta, Teresa, additional, Ugbaja, Regina Ngozi, additional, Ugbaja, Victory Chukwudalu, additional, Ugwor, Emmanuel Ifeanyichukwu, additional, Urbano, Francisco J., additional, Uzal, Francisco A., additional, Valdez-Velazquez, L.L., additional, Vaz, Gustavo Richter, additional, Vázquez, Marta, additional, Vegas-Gomez, Laura, additional, Victor, Mauricio Moraes, additional, Villalba, Sofia, additional, Villano, Ines, additional, Vinadé, Lucia, additional, Vital, M.A.B.F., additional, Vittori, Daniela C., additional, Vivien, Denis, additional, Yachou, Yassine, additional, Yeste, Natalia, additional, Zaman, Khadiza, additional, Zavalza-Gálvez, D.I., additional, Zeb, Alam, additional, and Zhai, Kevin, additional
- Published
- 2024
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3. List of contributors
- Author
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Ahmed, Naveed, primary, Albayrak, Gulsah, additional, Amreddy, Narsireddy, additional, Baidya, Falguni, additional, Bajpai, Anil Kumar, additional, Bajpai, Jaya, additional, Bhatt, Neha, additional, Bhattacharya, Pallab, additional, Bhattacharya, Sarthak, additional, Bohra, Maria, additional, Borah, Anupom, additional, Chaudhery, Iqra, additional, Chinnappan, Mahendran, additional, Choubey, Rashmi, additional, Cimen, Zeynep, additional, Dag, Aydan, additional, Datta, Aishika, additional, Dave, Kunjan R., additional, Demirel, Gokcen B., additional, Fang, Fang, additional, Ghamsari, Morteza Sasani, additional, Goswami, Rekha, additional, Hassan, Najam ul, additional, Hazarika, Deepshikha, additional, Jagtap, Priya, additional, Jain, Preeti, additional, Karak, Niranjan, additional, Kaur, Harpreet, additional, La Prairie, Bridget, additional, Mishra, Abhilasha, additional, Munshi, Anupama, additional, Raghuvanshi, Siddarth, additional, Rajagopal, Sridaran, additional, Ramesh, Rajagopal, additional, Raut, Swapnil, additional, Saini, Rajesh Kumar, additional, Sarkar, Ankan, additional, Sarmah, Deepaneeta, additional, Shah, Birva, additional, Singh, Anamika, additional, Singh, Upasna, additional, Sonker, Neha, additional, ur.Rehman, Asim., additional, Yadav, Vikramaditya G., additional, Zhang, Jinfeng, additional, and Zhou, Mengjiao, additional
- Published
- 2021
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4. Polymeric nanomaterials in neuroscience
- Author
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Bohra, Maria, primary, Sarkar, Ankan, additional, Raut, Swapnil, additional, Singh, Upasna, additional, Jagtap, Priya, additional, Shah, Birva, additional, Baidya, Falguni, additional, Datta, Aishika, additional, Kaur, Harpreet, additional, Sarmah, Deepaneeta, additional, Borah, Anupom, additional, Dave, Kunjan R., additional, and Bhattacharya, Pallab, additional
- Published
- 2021
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5. Cerebral ischemia in diabetics and oxidative stress
- Author
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Cho, Sunjoo, primary, Fuchs, Perry, additional, Sarmah, Deepaneeta, additional, Kaur, Harpreet, additional, Bhattacharya, Pallab, additional, and Dave, Kunjan R., additional
- Published
- 2020
- Full Text
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6. List of Contributors
- Author
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Achike, Francis I., primary, Ahiante, Blessing O., additional, Aissaoui, Ourida, additional, Akinosun, Olubayo Michael, additional, Alabi, Toyin Dorcas, additional, Alvarez, Silvina, additional, Anari, Razieh, additional, Anlar, Hatice Gül, additional, Arnal, Emma, additional, Arokoyo, Dennis S., additional, Bacanlı, Merve, additional, Bagyánszki, Mária, additional, Balistreri, Carmela Rita, additional, Bamidele, Olubayode, additional, Basu, Arpita, additional, Beręsewicz, Andrzej, additional, Berinstein, Elliot M., additional, Bhattacharya, Pallab, additional, Bitam, Arezki, additional, Bitencourt, Paula E.R., additional, Bódi, Nikolett, additional, Bolajoko, Elizabeth Bosede, additional, Borba, Helena H., additional, Bordin, Antonella, additional, Buranasin, Prima, additional, Butkowski, Eugene, additional, Casaroli-Marano, Ricardo P., additional, Cho, Sunjoo, additional, Choi, Siu-Wai, additional, Chun, Hajung, additional, Conaldi, Pier Giulio, additional, Costacou, Tina, additional, Daiber, Andreas, additional, Das, Joydeep, additional, Dave, Kunjan R., additional, De Falco, Elena, additional, del-Rio-Vellosillo, Monica, additional, Desjardins, Yves, additional, Dilworth, Lowell, additional, Dinić, Svetlana, additional, Eddaikra, A., additional, Fernandez-Llimos, Fernando, additional, Ferreira, María del Rosario, additional, Foulquie-Moreno, Elisa, additional, Frenis, Katie, additional, Friedrich, Julian, additional, Fuchs, Perry, additional, Garcia-Medina, Jose Javier, additional, Ghosh, Sumit, additional, Giménez, María Sofía, additional, Grdović, Nevena, additional, Ho, Cyrus Kin-chun, additional, Illesca, Paola, additional, Iwasaki, Kengo, additional, Jacques, Hélène, additional, Jatavan, Phudit, additional, Jimenez, Maria Teresa Bayo, additional, Johnsen-Soriano, Siv, additional, Jovanović, Jelena Arambašić, additional, Kalinovic, Sanela, additional, Kaur, Harpreet, additional, Khine, Aye Aye, additional, Kim, Sung-Jin, additional, Krenning, Guido, additional, Kröller-Schön, Swenja, additional, Lau-Cam, Cesar A., additional, Levy, Andrew P., additional, Lin, Ming-Tsan, additional, Lombardo, Yolanda B., additional, López-Malo, Daniel, additional, Lyons, Timothy J., additional, Mahrous, Engy A., additional, Masola, Bubuya, additional, Medina-Larqué, Ana Sofía, additional, Mendes, Talita Biude, additional, Miceli, Vitale, additional, Mihailović, Mirjana, additional, Miraglia, Sandra Maria, additional, Miranda, Maria, additional, Mizutani, Koji, additional, Münzel, Thomas, additional, Murrow, Jonathan R., additional, Murugan, Dharmani D., additional, Neyestani, Tirang R., additional, Nikooyeh, Bahareh, additional, Nooh, Mohammed M., additional, Oelze, Matthias, additional, Oguntibeju, Oluwafemi Omoniyi, additional, Olabiyi, Folorunso Adewale, additional, Omoruyi, Felix, additional, Oyenihi, Ayodeji B., additional, Oyenihi, Omolola R., additional, Park, Yongsoo, additional, Patel, Vinood B., additional, Pinazo-Duran, Maria Dolores, additional, Pontarolo, Roberto, additional, Poznanović, Goran, additional, Preedy, Victor R., additional, Rajendram, Rajkumar, additional, Romero, Francisco J., additional, Rubio-Velazquez, Elena, additional, Sarmah, Deepaneeta, additional, Scaccia, Eleonora, additional, Shih, Yao-Ming, additional, Sil, Parames C., additional, Simas, Joana Noguères, additional, Sparks, Jean, additional, Stennett, Dewayne, additional, Steven, Sebastian, additional, Tonin, Fernanda S., additional, Touil Boukoffa, C., additional, Uskoković, Aleksandra, additional, Vendramini, Vanessa, additional, Vidaković, Melita, additional, Vujacic-Mirski, Ksenija, additional, Wiener, Joshua B., additional, Wiens, Astrid, additional, Yeh, Sung-Ling, additional, and Zanon-Moreno, Vicente, additional
- Published
- 2020
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7. Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling.
- Author
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Kaur H, Sarmah D, Datta A, Borah A, Yavagal DR, and Bhattacharya P
- Subjects
- Animals, Rats, Apoptosis, Brain-Derived Neurotrophic Factor metabolism, Coculture Techniques, Endoplasmic Reticulum Stress, Glucose metabolism, Oxygen metabolism, PC12 Cells, Stem Cells metabolism, Adrenal Gland Neoplasms, Pheochromocytoma, Reperfusion Injury drug therapy
- Abstract
Apoptosis mediated by endoplasmic reticulum (ER) stress plays a crucial role in several neurovascular disorders, including ischemia/reperfusion injury (I/R injury). Previous in vitro and in vivo studies have suggested that following I/R injury, ER stress is vital for mediating CCAT-enhancer-binding protein homologous protein (CHOP) and caspase-12-dependent apoptosis. However, its modulation in the presence of stem cells and the underlying mechanism of cytoprotection remains elusive. In vivo studies from our lab have reported that post-stroke endovascular administration of stem cells renders neuroprotection and regulates apoptosis mediated by ER stress. In the current study, a more robust in vitro validation has been undertaken to decipher the mechanism of stem cell-mediated cytoprotection. Results from our study have shown that oxygen-glucose deprivation/reoxygenation (OGD/R) potentiated ER stress and apoptosis in the pheochromocytoma 12 (PC12) cell line as evident by the increase of protein kinase R (PKR)-like ER kinase (p-PERK), p-Eukaryotic initiation factor 2α subunit (EIF2α), activation transcription factor 4 (ATF4), CHOP, and caspase 12 expressions. Following the co-culture of PC12 cells with MSCs, ER stress was significantly reduced, possibly via modulating the brain-derived neurotrophic factor (BDNF) signaling. Furthermore, inhibition of BDNF by inhibitor K252a abolished the protective effects of BDNF secreted by MSCs following OGD/R. Our study suggests that inhibition of ER stress-associated apoptotic pathway with MSCs co-culture following OGD/R may help to alleviate cellular injury and further substantiate the use of stem cells as a therapeutic modality toward neuroprotection following hypoxic injury or stroke in clinical settings., (© 2023. The Author(s), under exclusive licence to Cell Stress Society International.)
- Published
- 2023
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8. Inosine attenuates post-stroke neuroinflammation by modulating inflammasome mediated microglial activation and polarization.
- Author
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Datta A, Suthar P, Sarmah D, Jadhav P, Shah J, Katamneni M, Bhosale N, Gupta V, Bohra M, Baidya F, Rana N, Ghosh B, Kaur H, Borah A, Rathod R, Sengupta P, and Bhattacharya P
- Subjects
- Rats, Animals, Male, Microglia metabolism, Inflammasomes metabolism, Neuroinflammatory Diseases, Rats, Sprague-Dawley, Anti-Inflammatory Agents, Infarction, Stroke complications, Stroke drug therapy, Stroke metabolism, Ischemic Stroke metabolism
- Abstract
To date, various agents and molecules have been developed to treat post-stroke neuroinflammation; however, none of them are clinically successful. Post-stroke neuroinflammation is primarily attributed to microglial polarization as the generation of inflammasome complexes shifts microglia to their M1 phenotype and regulates the downstream cascade. Inosine, an adenosine derivative reported to maintain cellular energy homeostasis in stressed conditions. Although the exact mechanism is still unexplored, various studies have reported that it can stimulate axonal sprouting in different neurodegenerative diseases. Hence, our present study aims to decipher the molecular mechanism of inosine mediated neuroprotection by modulating inflammasome signaling towards altered microglial polarization in ischemic stroke. Inosine was administered intraperitoneally to male Sprague Dawley rats at 1 h post-ischemic stroke and was further evaluated for neurodeficit score, motor coordination and long-term neuroprotection. Brains were harvested for infarct size estimation, biochemical assays and molecular studies. Inosine administration at 1 h post ischemic stroke decreased infarct size, neurodeficit score, and improved motor co-ordination. Normalization of biochemical parameters were achieved in the treatment groups. Microglial polarization towards its anti-inflammatory phenotype and modulation of inflammation were evident by relevant gene and protein expression studies. The outcome provides preliminary evidence of inosine mediated alleviation of post-stroke neuroinflammation via modulation of microglial polarization towards its anti-inflammatory form through regulating the inflammasome activation., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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9. Stroke and stroke prevention in sickle cell anemia in developed and selected developing countries.
- Author
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Bhattacharya P, Sarmah D, Dave KR, Goswami A, Watanabe M, Wang X, Kalia K, Plesnila N, Yavagal DR, and Alvarez O
- Subjects
- Antisickling Agents, Child, Developing Countries, Humans, Hydroxyurea therapeutic use, Ultrasonography, Doppler, Transcranial, Anemia, Sickle Cell complications, Anemia, Sickle Cell therapy, Stroke epidemiology, Stroke etiology, Stroke prevention & control
- Abstract
This comprehensive review provides an insight into the pathophysiology, epidemiology, evaluation, and treatment of sickle cell anemia (SCA)-related stroke in developed and developing countries. Vascular injury, hypercoagulability and vaso-occlusion play a role in the pathophysiology of stroke in SCA. Transcranial Doppler ultrasound (TCD) has lowered the incidence of ischemic stroke from 11% to 1% as TCD identifies children who are at risk for stroke, providing opportunities for interventions to reduce this risk. Whereas blood exchange is indicated in acute stroke, chronic transfusions (either simple or exchange on a monthly basis) are used for primary as well as secondary stroke prevention in developed countries. Children with abnormally high TCD velocities (≥ 200 cm/s) are at high risk of stroke and might benefit from hydroxyurea or hydroxycarbamide (HU) after a period of a successful transition from chronic transfusions. Hematopoietic stem cell transplant presents a cure for SCA. Gene therapy is currently investigated and may be offered to patients with SCA who had a stroke or who are at high risk of stroke if proven efficacious and safe. However, gene therapy is not likely to be implemented in low-income countries due to cost. Alternatively, HU is utilized for primary and secondary stroke prevention in developing countries. Further expansion of TCD implementation should be a priority in those settings., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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10. Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke.
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Pravalika K, Sarmah D, Kaur H, Vats K, Saraf J, Wanve M, Kalia K, Borah A, Yavagal DR, Dave KR, and Bhattacharya P
- Subjects
- Alkaloids administration & dosage, Aniline Compounds pharmacology, Animals, Antioxidants metabolism, Blotting, Western, Brain Ischemia pathology, Cerebral Infarction drug therapy, Cerebral Infarction pathology, Disease Models, Animal, Dose-Response Relationship, Drug, Glutathione metabolism, Male, Neuroprotective Agents administration & dosage, Rats, Rats, Sprague-Dawley, Stroke pathology, Alkaloids pharmacology, Brain Ischemia drug therapy, Neuroprotective Agents pharmacology, Peroxidase metabolism, Stroke drug therapy
- Abstract
Aim: Stroke is devastating with a limited choice of intervention. Many pharmacological entities are available but none of them have evolved successfully in counteracting the multifaceted molecular alterations following stroke. Myeloperoxidase (MPO) has been reported to play an important role in neuroinflammation following neurodegenerative diseases. Therefore, using it as a therapeutic target may be a strategy to confer neuroprotection in stroke. Trigonelline (TG), a plant alkaloid has shown neuroprotective effects in the past. Here we explore its neuroprotective effects and its role in glutathione mediated MPO inhibition in ischemic stroke., Methods: An in silico study was performed to confirm effective TG and MPO interaction. An in vitro evaluation of toxicity with biochemical estimations was performed. Further, in vivo studies were undertaken where rats were treated with 25, 50 and 100 mg/kg TG or standard MPO inhibiting drug4‑Aminobenzoic hydrazide (4‑ABH) at 60 min prior, post immediate and an hour post 90 min of middle cerebral artery occlusion (MCAo) followed by 24 h reperfusion. Rats were evaluated for neurodeficit and motor function tests. Brains were further harvested for infarct size evaluation, biochemical analysis, and western blot experiments., Key Findings: TG at 100 mg/kg dose i.p. administered immediately post ischemia confers neuroprotection by reducing cerebral infarct with improvement in motor and neurodeficit scores. Furthermore, elevated nitrite and MDA levels were also found to be reduced in brain regions in the treated group. TG also potentiated intrinsic antioxidant status and markedly inhibited reduced glutathione mediated myeloperoxidase expression in the cortical brain region., Significance: TG confers neuroprotection by reduced glutathione mediated myeloperoxidase inhibition in ischemic stroke., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
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