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56 results on '"Segura‐Carretero, Antonio"'

2. Contributors

Author

Ahmed, Idris Adewale, primary, Argüelles, Sandro, additional, Arráez-Román, David, additional, Ayala, Antonio, additional, Barlit, Hanna, additional, Bartke, Andrzej, additional, Booz, George W., additional, Braidy, Nady, additional, Brannan, Savannah, additional, Buheruk, Viktoriia, additional, Campbell, Jared M., additional, Cano, Mercedes, additional, Cádiz-Gurrea, María de la Luz, additional, Eid, Ali E., additional, Guerrero-Castilla, Angélica, additional, Guo, Xiaofang, additional, Koliada, Alexander, additional, Koltover, Vitaly K., additional, Kuzub, Nataliia, additional, Labunskyy, Vyacheslav M., additional, Lamming, Dudley W., additional, Lushchak, Oleh V., additional, Marotta, Francesco, additional, Massoud, Gaelle P., additional, Mikail, Maryam Abimbola, additional, Muñoz, Mario F., additional, Naumova, Nataliia, additional, Patnaik, Praveen K., additional, Piskovatska, Veronika, additional, Rached, Layale, additional, Sachdev, Perminder S., additional, Segura-Carretero, Antonio, additional, Shoushtari, Sara, additional, Skipa, Tatjana A., additional, Strilbytska, Olha, additional, Vaiserman, Alexander M., additional, Villegas-Aguilar, María del Carmen, additional, Xiong, Xiwen, additional, Yabluchanskiy, Andriy, additional, Yeung, Yiu To, additional, Zayachkivska, Alina, additional, Zhao, Lijun, additional, Zhong, Genshen, additional, Zhu, Xiaofei, additional, and Zouein, Fouad A., additional

Published
2023
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3. Clean and green analytical techniques

Author

Leyva-Jiménez, Francisco Javier, primary, Alañón, M. Elena, additional, del Carmen Villegas-Aguilar, María, additional, Fernández-Ochoa, Álvaro, additional, Rojas-García, Alejandro, additional, Fernández-Moreno, Patricia, additional, Arráez-Román, David, additional, de la Luz Cádiz-Gurrea, María, additional, and Segura-Carretero, Antonio, additional

Published
2023
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4. Contributors

Author

Alañón, M. Elena, primary, Amarante, Sónia J., additional, Arazo, Migdalia Caridad Rusindo, additional, Arráez-Román, David, additional, Benavides, Sergio, additional, Borges, Anabela, additional, Cáceres-Jiménez, Salud, additional, Camacho-González, Carlos Eduardo, additional, Cardoso, Susana M., additional, Catarino, Marcelo D., additional, Cotas, João, additional, de la Luz Cádiz-Gurrea, María, additional, del Carmen Villegas-Aguilar, María, additional, Del Juncal-Guzmán, Diana, additional, Dong, Hui, additional, Dong, Songtao, additional, Fernández-Moreno, Patricia, additional, Fernández-Ochoa, Álvaro, additional, Franco, Wendy, additional, García-Díez, Esther, additional, Garrido, Daniel, additional, Gonçalves, Ana M.M., additional, Hansen, Poul Erik, additional, Huamán-Castilla, Nils Leander, additional, Ibáñez, Elena, additional, Le Bourvellec, Carine, additional, Leão, Cláudia, additional, Leyva-Jiménez, Francisco Javier, additional, Lin, Xiukun, additional, Liu, Ming, additional, Liu, Xuwei, additional, López-Cárdenas, Francia Guadalupe, additional, Mariotti-Celis, María Salomé, additional, Martin, María Ángeles, additional, Mateos, Raquel, additional, Mendiola, Jose Antonio, additional, Monteiro, Pedro, additional, Montero, Lidia, additional, Moreno-Rojas, José Manuel, additional, Murillo-González, Laura, additional, Núñez, Samantha, additional, Ordóñez-Díaz, José Luis, additional, Pacheco, Diana, additional, Parada, Javier, additional, Pereira, Leonel, additional, Pereira-Caro, Gema, additional, Pérez, Ana M., additional, Pérez-Correa, José Ricardo, additional, Pérez-Jiménez, J., additional, Ramos, Sonia, additional, Rivera-Tovar, Pamela Raquel, additional, Rodríguez, Evelyn, additional, Rodríguez, Pilar Fallas, additional, Rojas-García, Alejandro, additional, Sánchez-Ayora, H., additional, Sánchez-Burgos, Jorge Alberto, additional, Sáyago-Ayerdi, Sonia Guadalupe, additional, Segura-Carretero, Antonio, additional, Silva, Artur M.S., additional, Simões, Manuel, additional, Socas-Rodríguez, Bárbara, additional, Stagos, Dimitrios, additional, and Urrutia, Arlés, additional

Published
2023
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5. List of contributors

Author

Abeijón-Mukdsi, Claudia, primary, Aggarwal, Bharat B., additional, Akhtar, Aqsa, additional, Alizadeh, Mohammad, additional, Al-Odat, Omar, additional, Amigo, Lourdes, additional, Andrada, Estefanía, additional, Araiza-Calahorra, Andrea, additional, Asghar, Waqas, additional, Aslam, Sadia, additional, Ávila-Román, Javier, additional, Baranda, Jana, additional, Batista, Jalles Arruda, additional, Ben-Romdhane, Oumaima, additional, Boddu, Revathi, additional, Boesch, Christine, additional, Borras-Linares, Isabel, additional, Canales, Paz Soledad Robert, additional, Chitren, Robert, additional, Cotabarren, Ivana M., additional, Cuevas-Rodríguez, Edith-Oliva, additional, da Silva Duarte, Graziela Biude, additional, Daneghian, Sevana, additional, de Aguiar Magalhães, Diva, additional, de Boer, Alie, additional, de Brito, Tarcisio Vieira, additional, de Sousa, Antonio Kleiton, additional, de Sousa de Lima, Fernando Mesquita, additional, Diaconeasa, Zoriţa M., additional, Díaz-Reinoso, Beatriz, additional, Domínguez, Herminia, additional, dos Reis Barbosa, André Luiz, additional, Dulf, Francisc V., additional, Fernández-Tomé, Samuel, additional, Ferreira, Helena, additional, Ferrer-Sierra, Miriam, additional, Fichna, Jakub, additional, Fogarasi, Melinda, additional, Fredes, Carolina, additional, Frcaş, Anca C., additional, Gabriele, Morena, additional, García-Gil, Sara, additional, García-Ibañez, Paula, additional, García-Tejedor, Aurora, additional, Gauffin-Cano, Paola, additional, Giacomazza, Daniela, additional, Gil, Ana M., additional, Giménez-Bastida, Juan Antonio, additional, Gok, Ilkay, additional, González-Romero, Jaime, additional, Goycoolea, Francisco M., additional, Guerra-Hernández, Eduardo Jesús, additional, Hernández-Álvarez, Alan Javier, additional, Hernández-Ledesma, Blanca, additional, Isla, María Inés, additional, Jiménez-Gordillo, María Dolores, additional, Jonnalagadda, Subash C., additional, Khalid, Nauman, additional, Kris-Etherton, Penny M., additional, Kumar, Satish, additional, Kumar, Vikas, additional, Laparra, Jose Moises, additional, Lenssen, Karin G.M., additional, Leyva-Jiménez, Francisco Javier, additional, Lozano-Sánchez, Jesús, additional, Marquez, Antonela, additional, Martin, Diana, additional, Martinez-Rodriguez, Adolfo J., additional, Martínez-Villaluenga, Cristina, additional, Medina, Roxana, additional, Minhas, Anamika, additional, Mondor, Martin, additional, Montilla, Antonia, additional, Morante, M., additional, Moreno, Diego A., additional, Motilva, Virginia, additional, Muñoz-Almagro, Nerea, additional, Navarro del Hierro, Joaquín, additional, Oh, Ester S., additional, Orfila, Caroline, additional, Oseguera-Toledo, Miguel, additional, Palla, Camila A., additional, Pandey, Manoj K, additional, Peñas, Elena, additional, Pereira, Cynthia Maria Carvalho, additional, Petersen, Kristina S., additional, Pinto, Elisabete, additional, Pop, Oana L., additional, Puangpraphant, Sirima, additional, Pucci, Laura, additional, Reis, Bruna Zavarize, additional, Rodríguez-López, Paloma, additional, Rodríguez-Luna, Azahara, additional, Rodríguez-Pérez, Celia, additional, Rogero, Marcelo Macedo, additional, Rogers, Connie J., additional, Russo, Matías, additional, Salaga, Maciej, additional, Segura-Carretero, Antonio, additional, Sharma, Rakesh, additional, Sharma, Shweta, additional, Silvan, Jose Manuel, additional, Socaci, Sonia A., additional, Sousa, Stefany Guimarães, additional, Talar, Marcin, additional, Talero, Elena, additional, Tarasiuk, Aleksandra, additional, Tomé-Sánchez, Irene, additional, ur Rahman, Hafiz Ubaid, additional, Vasconcelos, Marta W., additional, Villamiel, Mar, additional, Von Suskil, Max, additional, Zampini, Iris Catiana, additional, and Zhou, Longli, additional

Published
2022
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6. Contributors

Author

Aguilar, Cristóbal N., primary, Aires, Alfredo, additional, Al Daccache, Marina, additional, Albarelli, Juliana Q., additional, Alexandre, Elisabete Maria da Cruz, additional, Barros, Lillian, additional, Bichara, Carissa Michelle Goltara, additional, Borrás-Linares, Isabel, additional, Chañi-Paucar, Larry Oscar, additional, Chemat, Farid, additional, Coppola, Raffaele, additional, Costa, Eduardo M., additional, Cruz, Adriano G., additional, da Silva Martins, Luiza Helena, additional, De Feo, Vincenzo, additional, de Freitas, Victor, additional, de Oliveira, Johnatt Allan Rocha, additional, del Castillo-Santaella, Teresa, additional, Dias, Maria Inês, additional, Dimitrov, Krasimir, additional, Emanuelli, Tatiana, additional, Fabiano-Tixier, Anne-Sylvie, additional, Fernandes, Ana, additional, Ferreira, Isabel C.F.R., additional, Ferreira-Santos, Pedro, additional, Fratianni, Florinda, additional, Genisheva, Zlatina, additional, Komesu, Andrea, additional, Koubaa, Mohamed, additional, Liberal, Ângela, additional, López-Salas, Lucía, additional, Louka, Nicolas, additional, Lozano-Sánchez, Jesús, additional, Maroun, Richard G., additional, Mateus, Nuno, additional, Meireles, Maria Angela A., additional, Molina, Adriana K., additional, Moreira, Debora Kono Taketa, additional, Moreira, Silvia A., additional, Nazzaro, Filomena, additional, Oliveira, Ana L.S., additional, Oliveira, Hélder, additional, Paz-Arteaga, Sarah L., additional, Pereira, Carla, additional, Pereira, Ricardo N., additional, Pimentel, Tatiana Colombo, additional, Pintado, Manuela Estevez, additional, Pinto, Carlos A., additional, Pradal, Delphine, additional, Rai, Mahendra, additional, Rajha, Hiba N., additional, Ramírez-Guzmán, Nathiely, additional, Rocha, Cristina M.R., additional, Rodrigues, Rui M., additional, Santana, Ádina L., additional, Saraiva, Jorge Manuel Alexandre, additional, Segura-Carretero, Antonio, additional, Serna-Cock, Liliana, additional, Silva, Sara, additional, Teixeira, Natércia, additional, Torres-León, Cristian, additional, Vauchel, Peggy, additional, Vicente, António A., additional, Vorobiev, Eugène, additional, and Voss, Glenise Bierhalz, additional

Published
2022
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7. Phenolic compounds

Author

Villegas-Aguilar, María del Carmen, primary, Fernández-Ochoa, Álvaro, additional, Leyva-Jiménez, Francisco Javier, additional, Miranda-Segura, Ángela, additional, Cádiz-Gurrea, María de la Luz, additional, and Segura-Carretero, Antonio, additional

Published
2022
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8. Encapsulation technologies applied to bioactive phenolic compounds and probiotics with potential application on chronic inflammation

Author

Ferrer-Sierra, Miriam, primary, Rodríguez-López, Paloma, additional, Leyva-Jiménez, Francisco Javier, additional, Borras-Linares, Isabel, additional, Giacomazza, Daniela, additional, Fredes, Carolina, additional, Canales, Paz Soledad Robert, additional, Segura-Carretero, Antonio, additional, and Lozano-Sánchez, Jesús, additional

Published
2022
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9. Contributors

Author

Alañón, María Elena, primary, Arun Kumar, V., additional, Capucho, Lohan Covre, additional, de Castro Leite Júnior, Bruno Ricardo, additional, Chen, Mo, additional, Chen, Xi, additional, da Capela, Arthur Pompilio, additional, Das, Somenath, additional, Dávila-Rodríguez, Mónica, additional, del Carmen Villegas-Aguilar, María, additional, Domingos, Manueli Monciozo, additional, Eligar, Sachin M., additional, Fernández-Ochoa, Álvaro, additional, Giraldo, Gina Alejandra Gil, additional, Gupta, Vishal, additional, Hashim, Norhashila, additional, Hernández-Figueroa, Ricardo, additional, Isla, María Inés, additional, Jena, Ipsita, additional, Jiménez-Munguía, María Teresa, additional, Kannan, T., additional, Kavalappa, Yogendra Prasad, additional, Kishima, João O.F., additional, Kudre, Tanaji G., additional, Kumar, Ajay, additional, Kumar, Akshay, additional, de la Luz Cádiz-Gurrea, María, additional, Lainez-Cerón, Elizabeth, additional, Latha, M., additional, Lepaus, Bárbara Morandi, additional, Leyva-Jiménez, Francisco Javier, additional, López-Malo, Aurelio, additional, Lorenzo-Leal, Ana C., additional, Contreras, Luciana, additional, Machado, Bruna Gasparini, additional, Mani-López, Emma, additional, Mantovan, Janaina, additional, Maradagi, Tehreem, additional, Marim, Beatriz Marjorie, additional, Maringgal, Bernard, additional, Martins, Eliane Mauricio Furtado, additional, de Melo Carlos Dias, Thainá, additional, Modi, Arpan, additional, Monciozo, Manueli Domingos, additional, Morales-Camacho, Jocksan I., additional, de Oliveira Martins, Fabiana, additional, Onwude, Daniel I., additional, Pacheco, Ana Flávia Coelho, additional, Pal, Gaurav Kumar, additional, Pal, Priya, additional, Palou, Enrique, additional, Pereira, Jéssica Fernanda, additional, Ponesakki, Ganesan, additional, Pooja, K.M., additional, Prakash, Bhanu, additional, Ramírez-Corona, Nelly, additional, Rani, Sapna, additional, Resta, Victória Gouveia, additional, Reyes-Jurado, Fatima, additional, Sandesh Suresh, K., additional, de São José, Jackline Freitas Brilhante, additional, Segura-Carretero, Antonio, additional, Selvi, Moorthy Karthika, additional, Sharma, Harshita, additional, Silva, Marcela Nobre, additional, Singh, Akanksha, additional, Singh, Prashant Kumar, additional, Singh, Prem Pratap, additional, Singh, Sandeep Kumar, additional, Singh, Vipin Kumar, additional, Soto-Reyes, Nohemí, additional, de Souza Vieira, Mariana, additional, Sowmya, B., additional, Stephen, Nimish Mol, additional, Torres, Sebastián, additional, Trevizano, Larissa Mattos, additional, Valiati, Bárbara Santos, additional, Verón, Hernán, additional, Vijayaraj, P., additional, Yu, Qingyu, additional, and Zuluaga, Mônica Yorlady Alzate, additional

Published
2022
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11. Contributors

Author

Abdullah, Mohd Azmuddin, primary, Afzal, Muhammad, additional, Ahmad, Mushtaq, additional, Ahmad, Sadaf, additional, Ahmed, Sidra Nisar, additional, Ahmed, Syed Riaz, additional, Akhtar, Majid Niaz, additional, Akram, Abida, additional, Alañón, María Elena, additional, Ali, Zulfiqar, additional, Ashraf, Asma, additional, Azeem, Farrukh, additional, Batool, Riffat, additional, Cecilia, Juan A., additional, Chaudhary, Muhammad Fahad, additional, de la Luz Cádiz-Gurrea, María, additional, del Carmen Villegas-Aguilar, María, additional, Dolzhenko, Anton V., additional, Fernández-Ochoa, Álvaro, additional, García-Sancho, Cristina, additional, Gharabeiki, Ariga, additional, Haider, Ali, additional, Hayat, Samreen, additional, Hussain, Sabir, additional, Hussein, Hanaa Ali, additional, Iftikhar, Kainat, additional, Ijaz, Usman, additional, Imran, Muhammad, additional, Irshad, Aamna, additional, Jiménez-Gómez, Carmen P., additional, Kanwal, Hira, additional, Kargari, Ali, additional, Kilic, Omer, additional, Leyva-Jiménez, Francisco Javier, additional, Maireles-Torres, Pedro, additional, Mandal, Peetam, additional, Maqbool, Fareeha, additional, Mehmood, Iqra, additional, Muzammil, Aqsa, additional, Muzammil, Saima, additional, Nadeem, Habib Ullah, additional, Nazir, Muhammad Shahid, additional, Nnamani, Daniel Okwudili, additional, Onyekere, Peculiar Feenna, additional, Peculiar-Onyekere, Chioma Obianuju, additional, Pimentel-Moral, Sandra, additional, Rasheed, Asima, additional, Rasool, Danish, additional, Rasul, Ijaz, additional, Riaz, Fatima, additional, Saha, Mitali, additional, Samra, Hafeez, additional, Segura-Carretero, Antonio, additional, Shafique, Aimen, additional, Shahzad, Tanvir, additional, Siddique, Muhammad Hussnain, additional, Sultana, Shazia, additional, Uzor, Philip F., additional, Waris, Karistofar, additional, Waseem, Muhammad, additional, Yaseen, Ghulam, additional, Zafar, Muhammad, additional, and Zubair, Muhammad, additional

Published
2021
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12. List of contributors

Author

Abia, Rocio, primary, Abouloifa, H., additional, Adriana, Morales-Martínez, additional, Aggarwal, Diwakar, additional, Aggarwal, Vaishali, additional, Alicia, Sánchez-Mendoza, additional, Andreadou, Ioanna, additional, Angeles-Lo´pez, Quetzalli D., additional, Argüelles, Sandro, additional, Asehraou, A., additional, Audi, Namaa, additional, Ayala, Antonio, additional, Ayoub, Nehad M., additional, Badiu, Diana, additional, Badria, Farid A., additional, Barbouti, Alexandra, additional, Batanero, Eva, additional, Batarseh, Yazan S., additional, Baumann, Leslie S., additional, Ben Salah, R., additional, Bermudez, Beatriz, additional, Blanco, Santos, additional, Borras-Linares, Isabel, additional, Brasca, M., additional, Brenes, Manuel, additional, Perez-Calabuig, Ana M., additional, Cancilla, John C., additional, Cano, Mercedes, additional, Carbone, Fabrizio, additional, Carrera-González, María Pilar, additional, Casas, Rosa, additional, Ceccanti, Mauro, additional, Chaldakov, George N., additional, Covas, María-Isabel, additional, Culeddu, Nicola, additional, Cumaoğlu, Ahmet, additional, Curiel, José Antonio, additional, Damiano, Fabrizio, additional, de Castro, Antonio, additional, de Felipe, Félix López, additional, de la Torre, Rafael, additional, de las Rivas, Blanca, additional, Deiana, Pierfrancesco, additional, Dekanski, Dragana, additional, Dettori, Sandro, additional, Di Stefano, Vita, additional, Domínguez-Vías, German, additional, Dore, Antonio, additional, D’hallewin, G., additional, El Sayed, Khalid A., additional, Elgazar, Abdullah A., additional, Emanuelli, Tatiana, additional, Ferraguti, Giampiero, additional, Filigheddu, Maria Rosaria, additional, Fiore, Marco, additional, Fitó, Montserrat, additional, Francisca, Pérez-Severiano, additional, Fujiwara, Yoko, additional, Galaris, Dimitrios, additional, García, Pedro, additional, Ghabbour, N., additional, Giudetti, Anna Maria, additional, Gnoni, Antonio, additional, Gnoni, Gabriele Vincenzo, additional, Goulas, Vlasios, additional, Greco, Antonio, additional, Guclu, Gamze, additional, Haghbeen, Kamahldin, additional, Handjani, Farhad, additional, Heydari, Mojtaba, additional, Hosseini Mazinani, Mehdi, additional, Ishikawa, Tomoko, additional, Iuliano, Luigi, additional, Joel, Jiménez-Gómez, additional, Joshi, Asavari, additional, Juan, M. Emília, additional, Jugreet, Bibi Sharmeen, additional, Kaddoumi, Amal, additional, Kailis, Stanley George, additional, Kanavaros, Panagiotis, additional, Karboune, S., additional, Kelebek, Hasim, additional, Kitsoulis, Panagiotis, additional, Kouka, Paraskevi, additional, Kouretas, Demetrios, additional, Ktari, N., additional, Kumar, Gaurav, additional, Kumar, Manoj, additional, Landete, José María, additional, Lauretti, Elisabetta, additional, Lemus-Conejo, Ana, additional, Lombardo, Luca, additional, Longo, Serena, additional, Pradana-Lopez, Sandra, additional, Lopez, Sergio, additional, Lopez-Millan, Belen, additional, López-López, Antonio, additional, Lozano-Sánchez, Jesús, additional, Madar, Zecharia, additional, Mahomoodally, Mohamad Fawzi, additional, Mañas, Mariano, additional, Martinez-Victoria, Emilio, additional, Martinez-Burgos, Maria Alba, additional, Martínez-Martos, José Manuel, additional, Masre, Siti Fathiah, additional, Medina, Eduardo, additional, Medina, Rafael, additional, Menendez, Javier A., additional, Millan-Linares, Maria C., additional, Mittal, Sonam, additional, Mohammadnejad, Parvin, additional, Molinu, Maria Giovanna, additional, Montaño, Alfredo, additional, Montserrat-de la Paz, Sergio, additional, Muñoz, Mario, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Nenadis, N., additional, Nychas, G.-J.E., additional, Ortega-García, Francisca, additional, Ortega-Gomez, Almudena, additional, Pacheco, Yolanda M., additional, Panagou, E.Z., additional, Papoti, V.T., additional, Pariente, Jose Antonio, additional, Parvizi, Mohammad Mahdi, additional, Pathak, Kaveri, additional, Peinado, M. Ángeles, additional, Peragón, Juan, additional, Petrella, Carla, additional, Čabarkapa-Pirkovic, Andrea, additional, Planas, Joana M., additional, Plastina, Pierluigi, additional, Praticò, Domenico, additional, Prieto, Isabel, additional, Rajendram, Rajkumar, additional, Ralli, Massimo, additional, Ramírez-Expósito, María Jesús, additional, Ramírez-Sánchez, Manuel, additional, Rasouli, Hassan, additional, Al Rihani, Sweilem B., additional, Rodríguez, Héctor, additional, Rodríguez-López, Paloma, additional, Rokni, Y., additional, Romero, Concepción, additional, Rosillo, Maria A., additional, Ruiz-Barba, José Luis, additional, Saalaoui, E., additional, Sacanella, Emilio, additional, Sadeer, Nabeelah Bibi, additional, Sak, Katrin, additional, Saki, Maryam, additional, Salimonti, Amelia, additional, Sánchez, Antonio-Higinio, additional, Santona, Mario, additional, Segarra, Ana Belén, additional, Segura-Carretero, Antonio, additional, Selli, Serkan, additional, Sergio, Montes, additional, Sethi, Gautam, additional, Seyedebrahimi, Seyede Sanaz, additional, Shahbaz, Mana, additional, Sharma, Dhvani, additional, Soares, Mario J, additional, Spremo-Potparević, Biljana, additional, Stark, Aliza Hannah, additional, Suroowan, Shanoo, additional, Suvarna, Vasanti, additional, Tahiri, Iasim, additional, Tarani, Luigi, additional, Tassou, C.C., additional, Topalović, Dijana, additional, Torrecilla, José S., additional, Tseti, Ioulia, additional, Tsimidou, M.Z., additional, Tsoumani, Maria, additional, Tuli, Hardeep Singh, additional, Varela, Lourdes M., additional, Veskoukis, Aristidis S., additional, Villalba, Mayte, additional, Weisberg, Edmund M., additional, Yago, Maria Dolores, additional, Yang, Euitaek, additional, Yerer, Mükerrem Betül, additional, Zanwar, Anand, additional, Zelasco, Samanta, additional, and Živković, Lada, additional

Published
2021
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17. Contributors

Author

Álvarez-Rivera, Gerardo, primary, Arvanitoyannis, Ioannis S., additional, Baeten, Vincent, additional, Borrás-Linares, Isabel, additional, Brodie, Christopher, additional, Cifuentes, Alejandro, additional, Dardenne, Pierre, additional, Downey, Gerard, additional, Ekezie, Flora-Glad C., additional, Fernández Pierna, Juan Antonio, additional, González-Martínez, Miguel Ángel, additional, Hilkert, Andreas, additional, Hsieh, Chang-Wei, additional, Irudayaraj, Joseph, additional, Karoui, Romdhane, additional, Kelly, Simon, additional, Kizil, Ramazan, additional, Ko, Wen-Ching, additional, Leardi, Riccardo, additional, Levin, Robert E., additional, Lozano-Sánchez, Jesús, additional, Manley, Marena, additional, Maquieira, Ángel, additional, Puchades, Rosa, additional, Castro Puyana, María, additional, Rodríguez-Sánchez, S., additional, Ruiz-Matute, A.I., additional, Sanz, M.L., additional, Sass-Kiss, Agnes, additional, Schieber, Andreas, additional, Schulz, Hartwig, additional, Segura-Carretero, Antonio, additional, Soria, A.C., additional, Su, Wen-Hao, additional, Sun, Da-Wen, additional, Wang, Kaiqiang, additional, and Xu, Jun-Li, additional

Published
2018
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19. List of Contributors

Author

Andrade, José C., primary, Area, María C., additional, Arthur, Georgina D., additional, Avila-Sosa, Raúl, additional, Burkert, Carlos A.V., additional, Carbonera, Fabiana, additional, Chalcoski, Bárbara M.S., additional, Das, Shrijita, additional, de Ávila, Amanda R.A., additional, de Queirós, Lívia D., additional, Duarte, Armando C., additional, Fontana, José D., additional, Freitas, Ana C., additional, Gómez-Caravaca, Ana María, additional, Di Maria, Francesco, additional, Gomes, Ana M., additional, Grzybowski, Adelia, additional, Kalil, Susana J., additional, Kim, Hyunook, additional, Kim, Minsoo, additional, Kim, Sang-Hyoun, additional, Koop, Heidegrid S., additional, López-Malo, Aurelio, additional, Lopes, Danielle B., additional, Macedo, Gabriela A., additional, Mahmood, Nubla, additional, Martínez-Férez, Antonio, additional, Maruyama, Swami Arêa, additional, Meger, Felipe R., additional, Monteiro, Naice E.S., additional, Moraes, Caroline C., additional, Naidoo, Kuben, additional, Narayanan, C.M., additional, Navarro-Cruz, Addí R., additional, Ochando-Pulido, Javier Miguel, additional, Ochoa-Velasco, Carlos E., additional, Orsat, Valerie, additional, Palou, Enrique, additional, Pandey, Aditi, additional, Petrov, Kaloyan, additional, Petrova, Penka, additional, Rocha-Santos, Teresa A.P., additional, Routray, Winny, additional, Sak, Katrin, additional, Sala, Luisa, additional, Santos, Oscar O., additional, Scremin, Lucas B., additional, Segura-Carretero, Antonio, additional, Shin, Joung Du, additional, Spirandelli, Ricardo, additional, Swatson, Harry, additional, Tiboni, Marcela, additional, Vagula, Julianna M., additional, Vallejos, María E., additional, Visentainer, Jesuí V., additional, Xu, Chunbao (Charles), additional, and Yobo, Kwasi S., additional

Published
2017
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20. Contributors

Author

Abbas, Ali, primary, Abdulazeez, Mansurah A., additional, Abdullahi, Abdulmalik S., additional, Abusamra, Yousef, additional, Adegoke, Gabriel Olaniran, additional, Adelakun, Oluyemisi Elizabeth, additional, Adjou, Euloge S., additional, Afolabi, M.O., additional, Ahmad, Naveed, additional, Ahmed, Nafees, additional, Al Awwad, Nasir, additional, Al-Harrasi, Ahmed, additional, Alkharfy, Khalid M., additional, Allameh, Abdolamir, additional, Almeida, Jackson Roberto Guedes da Silva, additional, Al-Sokari, Saeed S., additional, Altindal, Demet, additional, Altindal, Nüket, additional, Ameh, Sunday J., additional, Amerah, Ahmed M., additional, Ansari, Shabana Y., additional, Anwar, Farooq, additional, Anwar, Sirajudheen, additional, Ali, Nor Azah Mohamad, additional, Avila-Sosa, Raúl, additional, Ayala-Zavala, J.F., additional, Ayinde, Buniyamin A., additional, Baliga, Manjeshwar Shrinath, additional, Bandoni, Arnaldo L., additional, Barrajón-Catalán, Enrique, additional, Basti, Afshin Akhondzadeh, additional, Bekhit, Alaa El-Din Ahmed, additional, Bhat, Harshith P., additional, Bhattacharya, Sanjib, additional, Boloor, Rekha, additional, Bouajila, J., additional, Bruñá, Nuria Martí, additional, Cardoso-Ugarte, Gabriel A., additional, Chandra, Mahesh, additional, Chandrasekaran, Natarajan, additional, Chang, Chiou L., additional, Chauhan, Amit, additional, Chen, Qi-Xiong, additional, Chivandi, Eliton, additional, Chou, Su-Tze, additional, Cid-Pérez, Teresa Soledad, additional, Cimino, Francesco, additional, Cornelius, Wanjala W., additional, Costa, Emmanoel Vilaça, additional, Cruz-Valenzuela, M.R., additional, Dangarembizi, Rachael, additional, Das, Kuntal, additional, David, Jairus R.D., additional, DebMandal, Manisha, additional, Dellacassa, Eduardo, additional, Dini, Irene, additional, Ekanayake, Athula, additional, Elder, Heriberto V., additional, Emami, Seyed Ahmad, additional, Erland, Lauren A.E., additional, Erlwanger, Kennedy H., additional, Evwiehurhoma, Felix O., additional, Fang, Evandro Fei, additional, Ferhout, H., additional, Fernandes, Caio P., additional, Franco-Vega, Avelina, additional, Gandomi, Hassan, additional, Gebremedhin, Gereziher, additional, George, Thomas, additional, Ghizzoni, Roberta, additional, Ghosh, Vijayalakshmi, additional, Gibrelibanos, Mebrahtom, additional, Gilani, Anwar-ul-Hassan, additional, Goñi, María G., additional, González-Aguilar, G.A., additional, Green, Ivan R., additional, Guala, María S., additional, Guo, Hongwei, additional, Gurudutt, K.N., additional, Habibatni, Sofiane, additional, Hanani, Yousef A., additional, Haniadka, Raghavendra, additional, Ben Hassine, D., additional, Hassanzadeh, Mohammad K., additional, Hernández, Ángel, additional, Hernández, María Dolores, additional, Hussain, Hidayat, additional, Jakribettu, Ramakrishna Pai, additional, James, Bolanle D., additional, Jamil, Mailina, additional, Jin, Chee Beng, additional, Jordán, María José, additional, Joshi, Rajesh K., additional, Judžentienė, Asta, additional, Karakoç, Ömer Cem, additional, Karim, Aman, additional, Khanjari, Ali, additional, Khlifi, D., additional, Koidis, Anastasios, additional, Kokotkiewicz, Adam, additional, Kuriyama, Isoko, additional, Lapissonde, Matìas O., additional, Leyva, J.M., additional, Li, Chun, additional, Lin, Chih-Chien, additional, Li, Qing X., additional, Li, Xiaolin, additional, Li, Xiao-Wen, additional, Ložienė, Kristina, additional, López, Domingo Saura, additional, López-Malo, Aurelio, additional, Luczkiewicz, Maria, additional, Lu, Qiu, additional, Mahmoud, Soheil S., additional, Maia, José Guilherme S., additional, Malešević, Vera Krimer, additional, Mallavarapu, G.R., additional, Mandal, Manisha, additional, Mandal, Shyamapada, additional, Mariod, Abdalbasit Adam, additional, Marques, António, additional, Miao, Jing-Kun, additional, Micol, Vicente, additional, Mizushina, Yoshiyuki, additional, Morales-Soto, Aranzazu, additional, Morcia, Caterina, additional, Moreira, María R., additional, Mourão, Rosa Helena V., additional, Mukherjee, Amitava, additional, Najaran, Zahra Tayarani, additional, Nasery, Maryam, additional, Navarro-Cruz, Addí Rhode, additional, Nevárez-Moorillón, Guadalupe Virginia, additional, Ng, Tzi Bun, additional, Noori, Negin, additional, Nunes, Maria Leonor, additional, Nyakudya, Trevor T., additional, Obodozie-Ofoegbu, Obiageri, additional, Olanipekun, Bosede Folake, additional, Ortega-Ramirez, L.A., additional, Ouwehand, Arthur C., additional, Ovando-Martínez, M., additional, Oyelade, Olusegun James, additional, Chandra Padalia, Rajendra, additional, Palou, Enrique, additional, Pant, A.K., additional, Park, Yong-Lak, additional, Peričin-Starčević, Ivana, additional, Periasamy, Gomathi, additional, Polatoğlu, Kaan, additional, Ponce, Alejandra G., additional, Prakash, Om, additional, Punetha, H., additional, Qin, Lu-ping, additional, Quintans Júnior, Lucindo José, additional, Quintans, Jullyana de Sousa Siqueira, additional, Quirós-Sauceda, A.E., additional, Rabelo, Suzana Vieira, additional, Radulović-Popović, Ljiljana, additional, Rai, Manoj P., additional, Rajeswara Rao, B.R., additional, Ramadan, Mohamed F., additional, Raoelison, E.G., additional, Rasooli, Iraj, additional, Rawat, D.S., additional, Rehman, Najeeb U., additional, Reyes-Jurado, Fatima, additional, Ríos, José-Luis, additional, Rocha, Leandro, additional, Rodriguez-Garcia, I., additional, Roura, Sara I., additional, Saija, Antonella, additional, Sani, Ibrahim, additional, Segura-Carretero, Antonio, additional, Senka, Mađarev-Popovič, additional, Shih, Ying, additional, Shi, Rui-He, additional, Silva-Espinoza, B.A., additional, Sosa-Morales, Maria E., additional, Sotomayor, Jose Antonio, additional, Soumanou, Mohamed M., additional, Speciale, Antonio, additional, Stratakos, Alexandros Ch, additional, Strife, Robert J., additional, Sugumar, Saranya, additional, Sultanbawa, Yasmina, additional, Syamasundar, K.V., additional, Tak, Jun-Hyung, additional, Tapia-Rodríguez, M.R., additional, Teixeira, Bárbara, additional, Terzi, Valeria, additional, Thaliath, Andrew, additional, Candido Tietbohl, Luis Armando, additional, Tomás-Menor, Laura, additional, Torres-Muñoz, José Vinicio, additional, Tumino, Giorgio, additional, van Baren, Catalina M., additional, Vaštag, Žužana, additional, Vazquez-Armenta, F.J., additional, Velderrain-Rodríguez, G.R., additional, Venskutonis, Petras Rimantas, additional, Verma, Ram Swaroop, additional, Wagih, Mohamed E., additional, Wong, Jack Ho, additional, Wycliffe, Wanzala, additional, Zeb, Alam, additional, Zehentbauer, Gerhard N., additional, and Zheng, Cheng-jian, additional

Published
2016
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21. List of Contributors

Author

A. Meireles, M. Angela, primary, Abd El-Salam, Mohamed H., additional, Aljaloud, Sulaiman O., additional, Anokhina, Maria S., additional, Antipova, Anna S., additional, Aqil, Mohd., additional, Balanč, Bojana, additional, Basu, Santanu, additional, Belyakova, Larisa E., additional, Bhanvase, Bharat, additional, Bhattacharya, Bhaswati, additional, Binyukov, Vladimir I., additional, Bogdanova, Natalia G., additional, Bor, Tarik, additional, Bugarski, Branko, additional, Cortes-Mazatán, Gladis Yakeline, additional, Đorđević, Verica, additional, El-Shibiny, Safinaz, additional, Estrada-Ramírez, Alba Nidia, additional, Fenert, Bożena, additional, Fenyvesi, Eva, additional, Flores-Villaseñor, Sergio Enrique, additional, Fourmentin, Sophie, additional, Gaynanova, Gulnara, additional, Ghodke, Shailesh, additional, Głód, Bronisław K., additional, Grumezescu, Alexandru Mihai, additional, Gupta, Ajai Prakash, additional, Gupta, Sumit, additional, Gupta, Suphla, additional, Gyawali, Rabin, additional, Hădărugă, Daniel Ioan, additional, Hădărugă, Nicoleta Gabriela, additional, Ibrahim, Salam A., additional, Jaworek, Anatol, additional, Jiménez, Leslie Violeta Vidal, additional, Joshi, Kalpana, additional, Kalušević, Ana, additional, Kashapov, Ruslan, additional, Kasparov, Valerii V., additional, Kfoury, Miriana, additional, Khan, Saima, additional, Kumari, Nisha, additional, Kushwaha, Manoj, additional, Lević, Steva, additional, Luo, Daibing, additional, Martínez-Férez, Antonio, additional, Martirosova, Elena I., additional, Mirgorodskaya, Alla, additional, Mishra, Satyendra, additional, Muzafar, Malik, additional, Nedović, Viktor, additional, Osorio-Tobón, Juan Felipe, additional, Palmina, Nadezhda P., additional, Pandey, Shweta, additional, Pandit, Jayamanti, additional, Pashirova, Tatiana, additional, Peralta-Rodríguez, René Darío, additional, Pimentel-Moral, Sandra, additional, Polikarpov, Yurii N., additional, Rai, Nishant, additional, Ramirez-Contreras, Jorge Carlos, additional, Rawat, Purnima, additional, Robert, Paz, additional, Segura-Carretero, Antonio, additional, Semenova, Maria G., additional, Sharma, Harshita, additional, Silva, Eric Keven, additional, Singha, Siddhartha, additional, Sonawane, Shirish, additional, Sultana, Yasmin, additional, Synyashin, Oleg, additional, Szente, Lajos, additional, Talegaonkar, Sushama, additional, Trifković, Kata, additional, Variyar, Prasad S., additional, Vasilieva, Elmira, additional, Verardo, Vito, additional, Wu, Liangzhuan, additional, Yadav, Arvind Kumar, additional, Zakharova, Lucia, additional, Zarzycki, Paweł K., additional, Zelikina, Darya V., additional, Zhi, Jinfang, additional, and Zuev, Yuriy, additional

Published
2016
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22. Rockroses (Cistus sp.) Oils

Author

Barrajón-Catalán, Enrique, primary, Tomás-Menor, Laura, additional, Morales-Soto, Aranzazu, additional, Bruñá, Nuria Martí, additional, López, Domingo Saura, additional, Segura-Carretero, Antonio, additional, and Micol, Vicente, additional

Published
2016
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25. Contributors

Author

Bährs, Hanno, primary, Borczak, Barbara, additional, Caboni, Maria Fiorenza, additional, Campillo, Natalia, additional, Carle, Reinhold, additional, Chakrabarti, Shumon, additional, Dannehl, Dennis, additional, Díaz-Rubio, M Elena, additional, Fernández-Gutiérrez, Alberto, additional, Galili, Shmuel, additional, Gómez-Caravaca, Ana Maria, additional, Hovav, Ran, additional, Jáuregui, Olga, additional, Josuttis, Melanie, additional, Kammerer, Judith, additional, Kammerer, Dietmar Rolf, additional, Kontogianni, Vassiliki G., additional, Lamuela-Raventós, Rosa María, additional, Laue, Pauline, additional, Libuy, Matías, additional, Martínez-Huélamo, Miriam, additional, Pérez-Jiménez, Jara, additional, Quifer-Rada, Paola, additional, Rodrigo, Ramón, additional, Ruberto, Giuseppe, additional, Sabatino, Leonardo, additional, Salib, Josline Y., additional, Saura-Calixto, Fulgencio, additional, Schieber, Andreas, additional, Schulze-Kaysers, Nadine, additional, Scordino, Monica, additional, Segura-Carretero, Antonio, additional, Shrestha, Gajendra, additional, Sikora, Elżbieta, additional, Siracusa, Laura, additional, St Clair, Larry L., additional, Steinberg, Christian E.W., additional, Vallverdú-Queralt, Anna, additional, Verardo, Vito, additional, Viñas, Pilar, additional, and Weber, Fabian, additional

Published
2014
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26. Development of advanced phospholipid vesicles loaded with Lippia citriodora pressurized liquid extract for the treatment of gastrointestinal disorders

Author

Layva-Jiménez, Francisco Javier, Manca, Maria Letizia, Manconi, Maria, Caddeo, Carla, Vázquez, José Antonio, Carbone, Claudia, Lozano-Sánchez, Jesús, Arráez-Román, David, Segura-Carretero, Antonio, Layva-Jiménez, Francisco Javier, Manca, Maria Letizia, Manconi, Maria, Caddeo, Carla, Vázquez, José Antonio, Carbone, Claudia, Lozano-Sánchez, Jesús, Arráez-Román, David, and Segura-Carretero, Antonio

Abstract

Pressurized liquid extraction was performed to obtain a phytocomplex from Lippia citriodora leaves rich in bioactive compounds. The extract was loaded in phospholipid vesicles to improve its protective effect against oxidative stress in the intestine. The phytochemicals were identified and quantified by HPLC-ESI-TOF-MS. The extract was incorporated in liposomes and penetration enhancer-containing vesicles (PEVs) modified with glucidex, a dextrin, and a biopolymer obtained from Chimaera monstrosa. The PEVs were smaller than liposomes (~150 vs 370 nm) and more stable, according to accelerated aging tests. The integrity of the vesicles in acidic or neutral pH and high ionic strength or in milk whey was assessed. The cytocompatibility of the formulations and their ability to protect Caco-2 cells against oxidative stress were confirmed in vitro and compared with two commercial extracts of L. citriodora. The results confirmed the suitability of formulations to be used in functional foods to protect the intestine from oxidative stress

Published
2021

27. Olive oil varieties and ripening stages containing the antioxidants hydroxytyrosol and derivatives in compliance with EFSA health claim

Author

Ministerio de Economía y Competitividad (España), Deoleo, López-Huertas, Eduardo, Lozano-Sánchez, Jesús, Segura-Carretero, Antonio, Ministerio de Economía y Competitividad (España), Deoleo, López-Huertas, Eduardo, Lozano-Sánchez, Jesús, and Segura-Carretero, Antonio

Abstract

Virgin olive oils (VOO) and extra virgin olive oils (EVOO) contain a specific fraction of polyphenols (hydroxytyrosol and its derivatives) that produce beneficial physiological effects. The European Food Safety Authority (EFSA) authorised a health claim for olive oil (OO) containing at least 250 mg/Kg of those polyphenols. The specific polyphenol content of twelve varieties of EVOO extracted at three different maturation stages was investigated. The total concentration of specific polyphenols changed depending on the olive oil variety. The varieties showing the highest specific polyphenol content (all above 250 mg/Kg) were Lechín Sevilla (429.5 ± 5), Manzanilla Sevilla (407.6 ± 6) and Cornezuelo (394.0 ± 6) in the green phase; Cornicabra (362.0 ± 8), Nevadillo Negro (326.5 ± 4) and Picual 296.0 ± 6) in the turning phase; and Lechin Granada (382.8 ± 4), Picual (317.7 ± 3), Lechin Sevilla (294.4 ± 5) and Manzanilla Sevilla (278.0 ± 2) in the mature phase. These results could have potential application for the industrial production of a category of healthy antioxidant OO.

Published
2020

30. List of Contributors

Author

ABE, FUMIYOSHI, primary, ADDOLORATO, GIOVANNI, additional, ALDRED, PETER, additional, ALLER, R., additional, ALMEIDA, PAULO, additional, ÁLVAREZ, JESÚS-ROMÁN MARTÍNEZ, additional, AMERONGEN, A.V. NIEUW, additional, ANDERSEN, MOGENS L., additional, AOSHIMA, HITOSHI, additional, ARIMOTO-KOBAYASHI, SAKAE, additional, ASFAW, ALEMAYEHU, additional, AUSTIN, ERICA WEINTRAUB, additional, BACK, WERNER, additional, BAEK, SEUNG JOON, additional, BAER-DUBOWSKA, WANDA, additional, BARROS, AQUILES A., additional, BECKER, HANS, additional, BÉNÉDICTE, BAKAN, additional, BERWANGER, STEFANIE, additional, BLEICH, STEFAN, additional, BLUMBERG, JEFFREY B., additional, BOELENS, JERINA, additional, BOHR, GREGOR, additional, BRACKE, MARC, additional, BRAND, H.S., additional, BRUINS, M.L., additional, BUIATTI, STEFANO, additional, CATHARINO, RODRIGO R., additional, CERVERA, M. LUISA, additional, CHEN, CHUNG-YEN, additional, CHEN, QIAO QIAO, additional, CHEN, YUONNES, additional, COMI, GIUSEPPE, additional, CORTACERO-RAMÍREZ, SONIA, additional, DAENEN, L., additional, De COOMAN, L., additional, De LUIS, D.A., additional, De SCHUTTER, D.P., additional, DEINZER, MAX L., additional, DELVAUX, F., additional, DEMMEL, RALF, additional, DERDELINCKX, G., additional, DEY, ESTERA SZWAJCER, additional, DÍAZ-RUBIO, M.E., additional, DICKINSON, J. RICHARD, additional, DIDIER, MARION, additional, DIEL, FRIEDHELM, additional, DIEL, SUSANNE, additional, DILLER, REINHARD A., additional, DLAMINI, ZODWA, additional, DOBROWOLSKA-ZACHWIEJA, AGNIESZKA, additional, DUFOUR, JEAN-PIERRE, additional, EBERLIN, MARCOS N., additional, EFFENBERGER, KATHARINA E., additional, EYRES, GRAHAM, additional, FANTOZZI, PAOLO, additional, FEGREDO, JUSTIN A., additional, FEICK, PETER, additional, FERNÁNDEZ-GUTIÉRREZ, ALBERTO, additional, FERREIRA REQUIMTE, ISABEL M.P.L.V.O., additional, FERRULLI, ANNA, additional, FONTANA, MARTA, additional, FOX, GLEN P., additional, Da CRUZ FRANCISCO, JOSÉ, additional, FRANK, NORBERT, additional, FRANKE, ANDREAS, additional, FREEMAN BRI, GARY, additional, FRIAS, CORAZON, additional, FRÖLICH, SONJA, additional, FUCHS, DIETMAR, additional, GAMIAN, ANDRZEJ, additional, GARCÍA-FALCÓN, S., additional, GARRIGUES, SALVADOR, additional, GASBARRINI, ANTONIO, additional, GASBARRINI, GIOVANNI, additional, GERHÄUSER, CLARISSA, additional, GERLOFF, ANDREAS, additional, GHISELLI, ANDREA, additional, GIL, A.M., additional, GOÑI, I., additional, GORJANOVIĆ, STANISLAVA, additional, de la GUARDIA, MIGUEL, additional, GUERRA, N.P., additional, GUIDO, LUIS F., additional, GUPTA, SANJAY, additional, HELLBORG, LINDA, additional, HENZE, GÜNTER, additional, HERNÁNDEZ-ARTIGA, MARÍA PURIFICACIÓN, additional, HERNÁNDEZ-BORGES, JAVIER, additional, HERWALD, MARIA, additional, HILLEMACHER, THOMAS, additional, HOSSAIN, SHEIKH JULFIKAR, additional, HUGHES, PAUL, additional, HUST, STACEY J.T., additional, HUVAERE, KEVIN, additional, IACOMINO, GIUSEPPE, additional, IGNATOWICZ, EWA, additional, IKEDA, KATSUMI, additional, JANDERA, PAVEL, additional, JENETT-SIEMS, KRISTINA, additional, JUGDAOHSINGH, RAVIN, additional, KAWASAKI, MASATO, additional, KERR, WILLIAM C., additional, KHMELINSKII, IGOR, additional, KISO, YOSHINOBU, additional, KODA, HIROFUMI, additional, KOMAITIS, M., additional, KONDO, KEIJI, additional, KRAJKA-KUZNIAK, VIOLETTA, additional, KRATKY, ROBERTO, additional, KRUISSELBRINK, L. DARREN, additional, LAI, ALAN K.H., additional, LEDOCHOWSKI, M., additional, LEE, SEONG-HO, additional, LEGGIO, LORENZO, additional, LI, HUI-JING, additional, LIRDPRAPAMONGKOL, KRIENGSAK, additional, LITTLE, ALEX G., additional, LÓPEZ-MACÍAS, C., additional, LORET, SUZANNE, additional, LOUKOU, ZACHARENIA, additional, LOZANOV, VALENTIN, additional, LUST, SOFIE, additional, MABIALA-BABELA, JEAN ROBERT, additional, MANZANO, MARISA, additional, MARCONI, OMBRETTA, additional, MARQUES-VIDAL, PEDRO, additional, MARTIN, COLIN R., additional, MARTÍNEZ-CARBALLO, E., additional, MASSAMBA, ALPHONSE, additional, MAYER, HEIDI, additional, MBITA, ZUKILE, additional, Mc KINNEY, ADELE, additional, McCRAE, NIALL, additional, MENZ, GARRY, additional, MEYNELL, RACHEL, additional, MILLA, DOLORES BELLIDO, additional, MILLIGAN, STUART R., additional, MONTANARI, LUIGI, additional, MORALES, FRANCISCO J., additional, MORIWAKI, YUJI, additional, MUKAMAL, KENNETH J., additional, MURPHY, RENÉ J.L., additional, NANADOUM, MAOURA, additional, NARDINI, MIRELLA, additional, NATELLA, FAUSTA, additional, NAVARRO, SIMÓN, additional, NICOLAI, JENNIFER, additional, NOZAWA, HAJIME, additional, OFFNER, FRITZ, additional, PASTRANA-CASTRO, L.M., additional, PAULL, DOUGLAS E., additional, PAVSLER, ANDREA, additional, PEHL, C., additional, PÉREZ-JIMÉNEZ, JARA, additional, PINKLETON, BRUCE E., additional, PISKUR, JURE, additional, POHL, PAWEL, additional, POSSEMIERS, SAM, additional, POURQUIE, JACQUES, additional, POWELL, JONATHAN J., additional, PREEDY, VICTOR R., additional, PROESTOS, C., additional, PROKOP, ARAM, additional, RAINIERI, SANDRA, additional, RAJENDRAM, RAJKUMAR, additional, RAYBURN, BRITTANY B., additional, RAYBURN, WILLIAM F., additional, RIEPL, HERBERT M., additional, RODRIGUES, JOSÉ, additional, RODRIGUEZ-DELGADO, MIGUEL ÁNGEL, additional, ROSE, OLIVER, additional, ROWLAND, NEIL E., additional, RUSSO, GIAN LUIGI, additional, SAIKI, IKUO, additional, SAISON, D., additional, SAKUMA, SHUSO, additional, SAKURAI, HIROAKI, additional, SANDRA, PAT, additional, SAURA-CALIXTO, FULGENCIO, additional, SAWAYA, ALEXANDRA C.H.F., additional, SCACCINI, CRISTINA, additional, SCHENNACH, H., additional, SCHEWE, TANKRED, additional, SCHROECKSNADEL, K., additional, SCHUBERT, CAROLA, additional, SEGURA-CARRETERO, ANTONIO, additional, SEIDL, H., additional, SERRANO, JOSÉ, additional, SHIBAMOTO, TAKAYUKI, additional, SHUKLA, SANJEEV, additional, SIES, HELMUT, additional, SIKORSKA, EWA, additional, SIKORSKI, MAREK, additional, SIMAL-GÁNDARA, J., additional, SINGER, MANFRED V., additional, SOARES, EDUARDO V., additional, SRIRAJASKANTHAN, RAJAVENTHAN, additional, SUZUKI, KOJI, additional, SVASTI, JISNUSON, additional, SZAEFER, HANNA, additional, TEDESCO, IDOLO, additional, TOBE, HIROYASU, additional, TONELLI, DOMENICA, additional, TORRADO-AGRASAR, A., additional, TUBARO, FRANCO, additional, VALLS-BELLÉS, VICTORIA, additional, VANHOECKE, BARBARA, additional, VANHOENACKER, GERD, additional, VEERMAN, E.C.I., additional, VELA, NURIA, additional, VERACHTERT, H., additional, VERSTRAETE, WILLY, additional, VERSTREPEN, K.J., additional, VILLARINO-MARÍN, ANTONIO LUIS, additional, VINSON, JOE A., additional, VOLLMER, GÜNTER, additional, VRIESEKOOP, FRANK, additional, WALKER, CAROLINE, additional, WANNAMETHEE, S. GOYA, additional, WESTENDORF, JOHANNES, additional, WIBETOE, GRETHE, additional, Van De WIELE, TOM, additional, WINKLER, C., additional, WISEMAN, HELEN, additional, WONG, MAX C.Y., additional, WOODMAN, OWEN L., additional, WUNDERLICH, SASCHA, additional, XU, JIN-WEN, additional, YAJIMA, HIROAKI, additional, YAMAMOTO, TETSUYA, additional, YOSHIDA, ARUTO, additional, YOUNG, CHARLES Y.F., additional, ZANOLI, PAOLA, additional, ZAVATTI, MANUELA, additional, ZHAO, FENG, additional, ZIELINSKA-PRZYJEMSKA, MAŁGORZATA, additional, ZIERAU, OLIVER, additional, and ZOTOU, ANASTASIA, additional

Published
2009
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32. A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells

Author

Junta de Andalucía, European Commission, Ministerio de Ciencia e Innovación (España), Ministerio de Economía y Competitividad (España), Generalitat Valenciana, Instituto de Salud Carlos III, Borrás-Linares, Isabel, Lozano-Sánchez, Jesús, Cifuentes, Alejandro, Micol, Vicente, Segura-Carretero, Antonio, Junta de Andalucía, European Commission, Ministerio de Ciencia e Innovación (España), Ministerio de Economía y Competitividad (España), Generalitat Valenciana, Instituto de Salud Carlos III, Borrás-Linares, Isabel, Lozano-Sánchez, Jesús, Cifuentes, Alejandro, Micol, Vicente, and Segura-Carretero, Antonio

Abstract

Rosemary extracts have exhibited potential cytostatic or cytotoxic effects in several cancer cell models but their bioactive compounds are yet to be discovered. In this work, the anticancer activity of a rosemary-leaf extract and its fractions were assayed to identify the phenolic compounds responsible for their antiproliferative/cytotoxic effects on a panel of human colon cancer cell lines. Bioguided fractionation of the rosemary-leaf extract was achieved by semi-preparative chromatography. The rosemary extract and the compounds in the fractions were characterized and quantified by HPLC-ESI-QTOF-MS. Cellular viability in the presence of these fractions and the whole extract was determined after 24 or 48¿h incubations by using an MTT assay. Fractions containing diterpenes or triterpenes were the most active but not as much as the whole extract. In conclusion, carnosic acid, carnosol, 12-methoxycarnosic acid, taxodione, hinokione and betulinic acid were the putative candidates that contributed to the observed antiproliferative activity of rosemary in human colon cancer cells. Whether the effects of the extract and fractions are only cytostatic or cytotoxic needs to be elucidated. Nevertheless, the comparative antiproliferative study on the fractions and whole extract revealed potential synergistic effects between several components in the extract that may deserve further attention.

Published
2015

33. Global foodomics strategy to investigate the health benefits of dietary constituents

Author

Ministerio de Ciencia e Innovación (España), Ministerio de Educación y Ciencia (España), Ibáñez, Clara, Valdés, Alberto, García-Cañas, Virginia, Çelebier, Mustafa, Simó, Carolina, Rocamora-Reverte, Lourdes, Gómez-Martínez, Ángeles, Herrero, Miguel, Castro-Puyana, M., Segura-Carretero, Antonio, Ibáñez, Elena, Ferragut, José A., Cifuentes, Alejandro, Ministerio de Ciencia e Innovación (España), Ministerio de Educación y Ciencia (España), Ibáñez, Clara, Valdés, Alberto, García-Cañas, Virginia, Çelebier, Mustafa, Simó, Carolina, Rocamora-Reverte, Lourdes, Gómez-Martínez, Ángeles, Herrero, Miguel, Castro-Puyana, M., Segura-Carretero, Antonio, Ibáñez, Elena, Ferragut, José A., and Cifuentes, Alejandro

Abstract

A global methodology, called Foodomics, which allows carrying out a comprehensive evaluation of the health benefits of food ingredients is presented in this work. The new methodology is based on the combination of several analytical platforms and data processing for Transcriptomics, Proteomics and Metabolomics studies, allowing the determination of changes induced by food ingredients at molecular level. Both, the whole methodological development and its potential are presented through the investigation of a case study following a hypothesis-free strategy. Namely, the chemopreventive effect of polyphenols from rosemary was examined on the total gene, protein and metabolite expression in human HT29 colon cancer cells. Conclusions on the bioactivity of polyphenols against colon cancer cells based on the results from each single platform (Transcriptomics, Proteomics or Metabolomics) are compared with the conclusions based on the integration of the whole results from the three platforms, corroborating the interest of using a global integrative strategy as Foodomics. To our knowledge, although many papers and reviews have been published on this topic, this is the first time that Transcriptomics, Proteomics and Metabolomics platforms are put together to study the health benefits from dietary ingredients against colon cancer cells at gene, protein and metabolite level. Advantages, drawbacks and current challenges of this global analytical strategy are discussed in this work. The results from our study provide new insights on the biological mechanisms involved in the cancer risk reduction properties of dietary constituents. © 2012 Elsevier B.V.

Published
2012

34. Use of advanced techniques for the extraction of phenolic compounds from Tunisian olive leaves: Phenolic composition and cytotoxicity against human breast cancer cells

Author

Ministère de l’Enseignement Supérieur et de la Recherche Scientifique (Tunisie), Junta de Andalucía, Universidad de Granada, Ministerio de Ciencia e Innovación (España), Ministerio de Educación y Ciencia (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Herrero, Miguel, Ibáñez, Elena, Segura-Carretero, Antonio, Fernández-Gutiérrez, Alberto, Ministère de l’Enseignement Supérieur et de la Recherche Scientifique (Tunisie), Junta de Andalucía, Universidad de Granada, Ministerio de Ciencia e Innovación (España), Ministerio de Educación y Ciencia (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Herrero, Miguel, Ibáñez, Elena, Segura-Carretero, Antonio, and Fernández-Gutiérrez, Alberto

Abstract

A comparison among different advanced extraction techniques such as microwave-assisted extraction (MAE), supercritical fluid extraction (SFE) and pressurized liquid extraction (PLE), together with traditional solid-liquid extraction, was performed to test their efficiency towards the extraction of phenolic compounds from leaves of six Tunisian olive varieties. Extractions were carried out at the best selected conditions for each technique; the obtained extracts were chemically characterized using high-performance liquid chromatography (HPLC) coupled to electrospray time-of-flight mass spectrometry (ESI-TOF-MS) and electrospray ion trap tandem mass spectrometry (ESI-IT-MS 2). As expected, higher extraction yields were obtained for PLE while phenolic profiles were mainly influenced by the solvent used as optimum in the different extraction methods. A larger number of phenolic compounds, mostly of a polar character, were found in the extracts obtained by using MAE. Best extraction yields do not correlate with highest cytotoxic activity against breast cancer cells, indicating that cytotoxicity is highly dependent on the presence of certain compounds in the extracts, although not exclusively on a single compound. Therefore, a multifactorial behavior is proposed for the anticancer activity of olive leaf compounds. © 2012 Elsevier Ltd.

Published
2012

35. Comparative metabolomic study of transgenic versus conventional soybean using capillary electrophoresis–time-of-flight mass spectrometry

Author

García-Villalba, Rocío, León, Carlos, Dinelli, Giovanni, Segura-Carretero, Antonio, Fernández-Gutiérrez, Alberto, García-Cañas, Virginia, Cifuentes, Alejandro, García-Villalba, Rocío, León, Carlos, Dinelli, Giovanni, Segura-Carretero, Antonio, Fernández-Gutiérrez, Alberto, García-Cañas, Virginia, and Cifuentes, Alejandro

Abstract

In this work, capillary electrophoresis–time-of-flight mass spectrometry (CE–TOF-MS) is proposed to identify and quantify the main metabolites found in transgenic soybean and its corresponding non-transgenic parental line both grown under identical conditions. The procedure includes optimization of metabolites extraction, separation by CE, on-line electrospray-TOF-MS analysis and data evaluation. A large number of extraction procedures and background electrolytes are tested in order to obtain a highly reproducible and sensitive analytical methodology. Using this approach, a large number of metabolites were tentatively identified based on the high mass accuracy provided by TOF-MS analyzer, together with the isotopic pattern and expected electrophoretic mobility of these compounds. In general, the same metabolites and in similar amounts were found in the conventional and transgenic variety. However, significant differences were also observed in some specific cases when the conventional variety was compared with its corresponding transgenic line. The selection of these metabolites as possible biomarkers of transgenic soybean is discussed, although a larger number of samples need to be analyzed in order to validate this point. It is concluded that metabolomic procedures based on CE-MS can open new perspectives in the study of transgenic foods in order to corroborate (or not) the equivalence with their conventional counterparts.

Published
2008

36. Activation of Brown Adipose Tissue and Promotion of White Adipose Tissue Browning by Plant-based Dietary Components in Rodents: A Systematic Review.

Author

Osuna-Prieto FJ, Martinez-Tellez B, Segura-Carretero A, and Ruiz JR

Subjects
Adipose Tissue, White, Animals, Diet, Humans, Mice, Rats, Rodentia, Adipose Tissue, Brown, Thermogenesis
Abstract

Activation of brown adipose tissue (BAT) and promotion of white adipose tissue (WAT) browning is considered a potential tool to combat obesity and cardiometabolic disorders. The use of plant-based dietary components has become one of the most used strategies for activating BAT and promoting WAT browning in rodents. The main reason is because plant-based dietary components are usually recognized as safe when the dose is properly adjusted, and they can easily be administrated by being added to the diet or dissolved in water. The present systematic review aimed to study the effects of plant-based dietary components on activation of BAT and promotion of WAT browning in rodents. A systematic search of PubMed and Scopus (from 1978 to 2019) identified eligible studies. Studies assessing the effects of plant-based dietary components added to diet and/or water on uncoupling protein 1 (UCP1) expression in BAT and/or WAT were included. Studies that used dietary components of animal origin, did not specify the effects on UCP1, or were conducted in other species different from mice or rats were excluded. Of 3919 studies identified in the initial screening, 146 studies were finally included in the review. We found that tea extract catechins, resveratrol, capsaicin and capsinoids, cacao extract flavanols, and quercetin were the most studied components. Scientific evidence suggests that some of these dietary components activate BAT and promote WAT browning via activation of the AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) pathways. These findings reveal that there is strong scientific evidence supporting the use of plant-based dietary components to activate BAT and promote WAT browning in rodents and thus to potentially combat obesity and cardiometabolic disorders., (© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.)

Published
2021
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37. Zygophyllum album saponins prevent atherogenic effect induced by deltamethrin via attenuating arterial accumulation of native and oxidized LDL in rats.

Author

Feriani A, Tir M, Hachani R, Gómez-Caravaca AM, Contreras MDM, Taamalli A, Talhaoui N, Segura-Carretero A, Ghazouani L, Mufti A, Tlili N, El Feki A, Harrath AH, and Allagui MS

Subjects
Animals, Aorta immunology, Aorta metabolism, Atherosclerosis immunology, Atherosclerosis metabolism, CD36 Antigens metabolism, Cholesterol metabolism, Lipid Metabolism drug effects, Liver drug effects, Liver immunology, Liver metabolism, Male, Plant Leaves chemistry, Rats, Rats, Wistar, Receptors, LDL metabolism, Saponins isolation & purification, Tumor Necrosis Factor-alpha metabolism, Aorta drug effects, Atherosclerosis prevention & control, Environmental Pollutants toxicity, Lipoproteins, LDL blood, Nitriles toxicity, Pyrethrins toxicity, Saponins pharmacology, Zygophyllum chemistry
Abstract

The current study aimed to examine, for the first time, the relationship between exposure to deltamethrin (DLM) and atherogenic lipid profile disorders in adult Wistar rats, as well as, to verify the mechanism of the beneficial role of Zygophyllum album leaves extracts (ZALE). The experimental study was assessed using DLM (4 mg/kg b.w) either alone or co administered with ZALE (400 mg/kg b.w) orally for 90 days in rats. RP-HPLC-DAD-ESI-QTOF-MS was used to identify the bioactive metabolites present in ZALE. Plasmatic and aortic total cholesterol (TC), LDL-cholesterol (LDL-C), native LDL (LDL-apo B-100) and oxidized LDL (ox-LDL) were evaluated using auto-analyzer and a sandwich ELISA, respectively. The protein expressions of LDLR (native LDL receptor) and CD36 (Scavenger receptor class B) were evaluated in aorta or liver with a Western blot. The pathology has been confirmed with lipid stain (Oil Red O). Phytochemicals analysis revealed the presence of fifteen saponins in ZALE. Rats intoxicated with DLM revealed a significant increase in plasmatic and aortic lipid profile (TC, LDL-C, LDL-apo B-100 and ox-LDL), as well as, the concentration of the plasmatic cytokines include TNF-α, IL-2 and IL-6, compared to control. Hepatic native LDL and aortic CD36 receptor expression were increased in DLM treated group, however aortic LDL-R does not present any modification, when compared to control. The detected disturbances in lipid parameters were supported by Oil Red O applied. Due to their antioxidant activity, the bioactive compounds in ZALE as powerful agents able to prevent the pro-atherogenic effect observed in DLM-treated animals. These metabolites modulated most of inflammatory markers, prevented accumulation of lipid and lipoprotein biomarkers, regulated the major receptor regulators of hepatic cholesterol metabolism, as well as normalize lipid distribution in liver and aorta tissue., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2020
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38. The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties.

Author

Vezza T, Rodríguez-Nogales A, Algieri F, Garrido-Mesa J, Romero M, Sánchez M, Toral M, Martín-García B, Gómez-Caravaca AM, Arráez-Román D, Segura-Carretero A, Micol V, García F, Utrilla MP, Duarte J, Rodríguez-Cabezas ME, and Gálvez J

Subjects
Adipogenesis drug effects, Adipogenesis genetics, Adipose Tissue drug effects, Adipose Tissue metabolism, Animals, Anti-Obesity Agents pharmacology, Aorta, Thoracic drug effects, Aorta, Thoracic physiology, Cytokines genetics, Diet, High-Fat, Dysbiosis metabolism, Dysbiosis microbiology, Gastrointestinal Microbiome drug effects, Immunologic Factors pharmacology, Insulin Resistance, Lipids blood, Liver drug effects, Liver metabolism, Male, Mice, Inbred C57BL, NADPH Oxidases metabolism, Obesity metabolism, Obesity microbiology, Phytotherapy, Plant Extracts pharmacology, Plant Leaves, Anti-Obesity Agents therapeutic use, Dysbiosis drug therapy, Immunologic Factors therapeutic use, Obesity drug therapy, Olea, Plant Extracts therapeutic use
Abstract

Introduction: Many studies have showed the beneficial effects of the olive (Olea europaea) leaf extract (OLE) in experimental models of metabolic syndrome, which have been ascribed to the presence of phenolic compounds, like oleuropeoside. This study evaluated the effects of a chemically characterized OLE in high fat diet (HFD)-induced obesity in mice, describing the underlying mechanisms involved in the beneficial effects, with special attention to vascular dysfunction and gut microbiota composition., Methods: C57BL/6J mice were distributed in different groups: control, control-treated, obese and obese-treated with OLE (1, 10 and 25 mg/kg/day). Control mice received a standard diet, whereas obese mice were fed HFD. The treatment was followed for 5 weeks, and animal body weight periodically assessed. At the end of the treatment, metabolic plasma analysis (including lipid profile) as well as glucose and insulin levels were performed. The HFD-induced inflammatory status was studied in liver and fat, by determining the RNA expression of different inflammatory mediators by qPCR; also, different markers of intestinal epithelial barrier function were determined in colonic tissue by qPCR. Additionally, flow cytometry of immune cells from adipose tissue, endothelial dysfunction in aortic rings as well as gut microbiota composition were evaluated. Faecal microbiota transplantation (FMT) to antibiotic-treated mice fed with HFD was performed., Results: OLE administration reduced body weight gain, basal glycaemia and insulin resistance, and showed improvement in plasma lipid profile when compared with HFD-fed mice. The extract significantly ameliorated the HFD-induced altered expression of key adipogenic genes, like PPARs, adiponectin and leptin receptor, in adipose tissue. Furthermore, the extract reduced the RNA expression of Tnf-α, Il-1β, Il-6 in liver and adipose tissue, thus improving the tissue inflammatory status associated to obesity. The flow cytometry analysis in adipose tissue corroborated these observations. Additionally, the characterization of the colonic microbiota by sequencing showed that OLE administration was able to counteract the dysbiosis associated to obesity. The extract reversed the endothelial dysfunction observed in the aortic rings of obese mice. FMT from donors HFD-OLE to recipient mice fed an HFD prevented the development of obesity, glucose intolerance, insulin resistance and endothelial dysfunction., Conclusion: OLE exerts beneficial effects in HFD-induced obesity in mice, which was associated to an improvement in plasma and tissue metabolic profile, inflammatory status, gut microbiota composition and vascular dysfunction., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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39. Activation of Human Brown Adipose Tissue by Capsinoids, Catechins, Ephedrine, and Other Dietary Components: A Systematic Review.

Author

Osuna-Prieto FJ, Martinez-Tellez B, Sanchez-Delgado G, Aguilera CM, Lozano-Sánchez J, Arráez-Román D, Segura-Carretero A, and Ruiz JR

Subjects
Humans, Receptors, Adrenergic, beta metabolism, Receptors, G-Protein-Coupled metabolism, Tea chemistry, Transient Receptor Potential Channels metabolism, Adipose Tissue, Brown drug effects, Capsaicin pharmacology, Catechin pharmacology, Ephedrine pharmacology, Phytochemicals pharmacology
Abstract

Human brown adipose tissue (BAT) has attracted clinical interest not only because it dissipates energy but also for its potential capacity to counteract obesity and related metabolic disorders (e.g., insulin resistance and dyslipidemia). Cold exposure is the most powerful stimulus for activating and recruiting BAT, and this stimulatory effect is mediated by the transient receptor potential (TRP) channels. BAT can also be activated by other receptors such as the G-protein-coupled bile acid receptor 1 (GPBAR1) or β-adrenergic receptors. Interestingly, these receptors also interact with several dietary components; in particular, capsinoids and tea catechins appear to mimic the effects of cold through a TRP-BAT axis, and they consequently seem to decrease body fat and improve metabolic blood parameters. This systematic review critically addresses the evidence behind the available human studies analyzing the effect of several dietary components (e.g., capsinoids, tea catechins, and ephedrine) on BAT activity. Even though the results of these studies are consistent with the outcomes of preclinical models, the lack of robust study designs makes it impossible to confirm the BAT-activation capacity of the specified dietary components. Further investigation into the effects of dietary components on BAT is warranted to clarify to what extent these components could serve as a powerful strategy to treat obesity and related metabolic disorders., (© 2019 American Society for Nutrition.)

Published
2019
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40. Nano-liquid chromatography coupled to time-of-flight mass spectrometry for phenolic profiling: a case study in cranberry syrups.

Author

Contreras Mdel M, Arráez-Román D, Fernández-Gutiérrez A, and Segura-Carretero A

Subjects
Chromatography, Liquid instrumentation, Limit of Detection, Plant Preparations chemistry, Reproducibility of Results, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Catechols isolation & purification, Chromatography, Liquid methods, Flavonols isolation & purification, Hydroxybenzoates isolation & purification, Iridoids isolation & purification, Vaccinium macrocarpon chemistry
Abstract

A new method based on nano-liquid chromatography coupled to time-of-flight mass spectrometry (nano-LC-TOF-MS) using lock-mass calibration was developed to facilitate the accurate and routine characterization and quantification of phenolic compounds. Thus, it was applied to study cranberry syrups, in which, using negative ionization mode, a total of nine phenolic compounds were unequivocally identified using standards and 38 tentatively taking into account their retention time, accurate mass (errors<5 ppm) data and isotope pattern, as well as literature. Among them, 13 compounds, belonging to flavonols and iridoids conjugated with phenolic acids, were reported for first time in cranberry or cranberry based-products. The analytical method was also validated using chlorogenic acid, p-coumaric acid, (+)-catechin, (-)-epicatechin, procyanidin A2, quercetin 3-O-glucoside, quercetin 3-O-rhamnoside, quercetin, and myricetin standards. In this way, the analytical method showed adequate linearity, with R(2) above 0.99, and acceptable values of intra- and inter-day repeatability of the retention time and peak area. The detection limits and quantification were between 1.0-15.6 ng mL(-1) and 2.0-62.5 ng mL(-1), respectively. The method can be extended to characterize phenolic compounds in other food and plant matrices, and as well biological samples., (Copyright © 2014 Elsevier B.V. All rights reserved.)

Published
2015
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41. A new extraction approach to correct the effect of apparent increase in the secoiridoid content after filtration of virgin olive oil.

Author

Bakhouche A, Lozano-Sánchez J, Ballus CA, Bendini A, Gallina-Toschi T, Fernández-Gutiérrez A, and Segura-Carretero A

Abstract

In the current study, a new approach has been developed for correcting the effect that moisture reduction after virgin olive oil (VOO) filtration exerts on the apparent increase of the secoiridoid content by using an internal standard during extraction. Firstly, two main Spanish varieties (Picual and Hojiblanca) were submitted to industrial filtration of VOOs. Afterwards, the moisture content was determined in unfiltered and filtered VOOs, and liquid-liquid extraction of phenolic compounds was performed using different internal standards. The resulting extracts were analyzed by HPLC-ESI-TOF/MS, in order to gain maximum information concerning the phenolic profiles of the samples under study. The reduction effect of filtration on the moisture content, phenolic alcohols, and flavones was confirmed at the industrial scale. Oleuropein was chosen as internal standard and, for the first time, the apparent increase of secoiridoids in filtered VOO was corrected, using a correction coefficient (Cc) calculated from the variation of internal standard area in filtered and unfiltered VOO during extraction. This approach gave the real concentration of secoiridoids in filtered VOO, and clarified the effect of the filtration step on the phenolic fraction. This finding is of great importance for future studies that seek to quantify phenolic compounds in VOOs., (Copyright © 2014 Elsevier B.V. All rights reserved.)

Published
2014
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42. Global Foodomics strategy to investigate the health benefits of dietary constituents.

Author

Ibáñez C, Valdés A, García-Cañas V, Simó C, Celebier M, Rocamora-Reverte L, Gómez-Martínez A, Herrero M, Castro-Puyana M, Segura-Carretero A, Ibáñez E, Ferragut JA, and Cifuentes A

Subjects
Antineoplastic Agents, Phytogenic pharmacology, Cell Line, Tumor, Colonic Neoplasms genetics, Colonic Neoplasms metabolism, Humans, Metabolome drug effects, Phytotherapy, Polyphenols pharmacology, Proteome drug effects, Antineoplastic Agents, Phytogenic therapeutic use, Colonic Neoplasms prevention & control, Dietary Supplements, Metabolomics methods, Polyphenols therapeutic use, Proteomics methods, Rosmarinus chemistry, Transcriptome drug effects
Abstract

A global methodology, called Foodomics, which allows carrying out a comprehensive evaluation of the health benefits of food ingredients is presented in this work. The new methodology is based on the combination of several analytical platforms and data processing for Transcriptomics, Proteomics and Metabolomics studies, allowing the determination of changes induced by food ingredients at molecular level. Both, the whole methodological development and its potential are presented through the investigation of a case study following a hypothesis-free strategy. Namely, the chemopreventive effect of polyphenols from rosemary was examined on the total gene, protein and metabolite expression in human HT29 colon cancer cells. Conclusions on the bioactivity of polyphenols against colon cancer cells based on the results from each single platform (Transcriptomics, Proteomics or Metabolomics) are compared with the conclusions based on the integration of the whole results from the three platforms, corroborating the interest of using a global integrative strategy as Foodomics. To our knowledge, although many papers and reviews have been published on this topic, this is the first time that Transcriptomics, Proteomics and Metabolomics platforms are put together to study the health benefits from dietary ingredients against colon cancer cells at gene, protein and metabolite level. Advantages, drawbacks and current challenges of this global analytical strategy are discussed in this work. The results from our study provide new insights on the biological mechanisms involved in the cancer risk reduction properties of dietary constituents., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2012
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43. Uptake and metabolism of olive oil polyphenols in human breast cancer cells using nano-liquid chromatography coupled to electrospray ionization-time of flight-mass spectrometry.

Author

García-Villalba R, Carrasco-Pancorbo A, Oliveras-Ferraros C, Menéndez JA, Segura-Carretero A, and Fernández-Gutiérrez A

Subjects
Breast Neoplasms pathology, Cell Line, Tumor, Female, Flavonoids chemistry, Flavonoids metabolism, Flavonoids pharmacokinetics, Humans, Iridoids chemistry, Iridoids metabolism, Iridoids pharmacokinetics, Lignans chemistry, Lignans metabolism, Lignans pharmacokinetics, Middle Aged, Nanotechnology, Olive Oil, Plant Extracts metabolism, Plant Extracts pharmacokinetics, Polyphenols chemistry, Polyphenols pharmacokinetics, Breast Neoplasms metabolism, Chromatography, Liquid methods, Plant Oils chemistry, Polyphenols metabolism, Spectrometry, Mass, Electrospray Ionization methods
Abstract

Polyphenols from extra virgin olive oil (EVOO), a main component of the Mediterranean diet, have demonstrated repeatedly anti-tumor activity in several in vitro and in vivo studies. However, little is known about the efficiency of the absorption process and metabolic conversion of these compounds at cellular level. In this study, a nano liquid chromatography-electrospray ionization-time of flight mass spectrometry (nanoLC-ESI-TOF MS) method was developed to study the cellular uptake and metabolism of olive oil phenols in JIMT-1 human breast cancer cells. After incubation for different time periods with EVOO-derived phenolic extracts, culture media, cytosolic fraction and solid particles fraction were separated and analyzed. Most of the free phenols, mainly hydroxytyrosol, its secoiridoid derivatives, and the flavonoid luteolin, disappeared in the culture media in different ways and at different times. Besides, several metabolites were detected in the culture media, fact that may indicate absorption and intracellular metabolism followed by rapid cellular export. Low intracellular accumulation was observed with only traces of some compounds detected in the cytosolic and solid particles fractions. Methylated conjugates were the major metabolites detected, suggesting a catalytic action of catechol-O-methyl transferase (COMT) in cancer cells., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2012
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44. Profiles of phenolic compounds in modern and old common wheat varieties determined by liquid chromatography coupled with time-of-flight mass spectrometry.

Author

Dinelli G, Segura-Carretero A, Di Silvestro R, Marotti I, Arráez-Román D, Benedettelli S, Ghiselli L, and Fernadez-Gutierrez A

Subjects
Analysis of Variance, Cluster Analysis, Flavonoids chemistry, Genotype, Isomerism, Italy, Plant Extracts chemistry, Polyphenols chemistry, Chromatography, High Pressure Liquid methods, Flavonoids analysis, Mass Spectrometry methods, Polyphenols analysis, Triticum chemistry, Triticum classification, Triticum genetics
Abstract

The health-promoting properties of common wheat (Triticum aestivum L.) have been largely attributed to the presence of unique phytochemicals of whole grains. The aim of this study was to profile the phenolic content of 16 old and 6 modern Italian wheat varieties, cropped in the same location and growing season. High variability was observed among the investigated wheat genotypes, both in the free and bound phenolic extracts. The total polyphenol content ranged from 885.5 to 1715.9 μmol GAE/100 g of grain and, on average, the bound fraction contributed for 72.0% to the total phenolic content. As regards the flavonoid content, the free fraction ranged from 50.7 to 106.1 μmol CE/100 g of grain and the bound fraction from 78.3 to 148.9 μmol CE/100 g of grain. Moreover, the interpretation of the mass spectra allowed the characterization of 34 phenolic compounds (104 including isomer forms) belonging to the phenolic acid, flavonoid, coumarin, stilbene, proanthocyanidin and lignan chemical classes. HPLC-ESI-TOF-MS analysis highlighted remarkable differences in the phytochemical fingerprints of old and modern wheat varieties. Six ancient wheat genotypes (Bianco Nostrale, Frassineto, Gentil Rosso, Gentil Rosso Mutico, Marzuolo d'Aqui, Verna) showed phenolic profiles with a number of total compounds and isomer forms much higher than that identified in the modern cultivars. The present findings confirm that ancient wheat may represent a valuable source of biodiversity, especially as regards phenolic compounds. The investigated old wheat genotypes may be successfully used in breeding programs for developing bread wheat varieties with added value in terms of health-promoting phytochemicals., (Copyright © 2011 Elsevier B.V. All rights reserved.)

Published
2011
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45. New possibilities for the valorization of olive oil by-products.

Author

Herrero M, Temirzoda TN, Segura-Carretero A, Quirantes R, Plaza M, and Ibañez E

Subjects
Analysis of Variance, Antioxidants analysis, Antioxidants isolation & purification, Chromatography, High Pressure Liquid, Coumaric Acids, Ethanol, Flavonoids, Hot Temperature, Iridoids, Olive Oil, Phenols, Phenylethyl Alcohol analogs & derivatives, Plant Oils, Pressure, Tandem Mass Spectrometry, Water, Liquid-Liquid Extraction methods, Olea chemistry, Plant Leaves chemistry
Abstract

In this contribution, the capabilities of pressurized liquid extraction (PLE) using food-grade solvents, such as water and ethanol, to obtain antioxidant extracts rich on polyphenolic compounds from olive leaves are studied. Different extraction conditions were tested, and the PLE obtained extracts were characterized in vitro according to their antioxidant capacity (using the DPPH radical scavenging and the TEAC assays) and total phenols amounts. The most active extracts were obtained with hot pressurized water at 200 °C (EC(50) 18.6 μg/mL) and liquid ethanol at 150 °C (EC(50) 27.4 μg/mL), attaining at these conditions high extraction yields, around 40 and 30%, respectively. The particular phenolic composition of the obtained extracts was characterized by LC-ESI-MS. Using this method, 25 different phenolic compounds could be tentatively identified, including phenolic acids, secoiridoids, hydroxycinnamic acid derivatives, flavonols and flavones. Among them, hydroxytyrosol, oleuropein and luteolin-glucoside were the main phenolic antioxidants and were quantified on the extracts together with other minor constituents, by means of a UPLC-MS/MS method. Results showed that using water as extracting agent, the amount of phenolic compounds increased with the extraction temperature, being hydroxytyrosol the main phenolic component on the water PLE olive leaves extracts, reaching up to 8.542 mg/g dried extract. On the other hand, oleuropein was the main component on the extracts obtained with ethanol (6.156-2.819 mg/g extract). Results described in this work demonstrate the good possibilities of using PLE as a useful technique for the valorization of by-products from the olive oil industry, such as olive leaves., (Copyright © 2011 Elsevier B.V. All rights reserved.)

Published
2011
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46. Synthesis of caffeic acid molecularly imprinted polymer microspheres and high-performance liquid chromatography evaluation of their sorption properties.

Author

Valero-Navarro A, Gómez-Romero M, Fernández-Sánchez JF, Cormack PA, Segura-Carretero A, and Fernández-Gutiérrez A

Subjects
Adsorption, Beverages analysis, Caffeic Acids analysis, Malus chemistry, Particle Size, Pyridines chemistry, Reproducibility of Results, Sensitivity and Specificity, Caffeic Acids chemical synthesis, Caffeic Acids chemistry, Chromatography, High Pressure Liquid methods, Microspheres, Molecular Imprinting methods
Abstract

In the current work, a molecularly imprinted polymer (MIP) has been synthesised and used to enable the extraction of a naturally-occurring antioxidant from complex media. More specifically, we describe the first example of a caffeic acid (CA) MIP which has been synthesised in the form of well-defined polymer microspheres, and its use for the extraction of CA from fruit juice sample. The CA MIP was synthesised by precipitation polymerisation using 4-vinylpyridine as functional monomer, divinylbenzene-80 as crosslinker and acetonitrile:toluene (75/25, v/v) as porogen. The particle sizing and morphological characterisation of the polymers was carried out by means of scanning electron microscopy (narrow particle size distribution; ∼5 and 1.5 μm particle diameters for the MIP and NIP [non-imprinted polymer], respectively) and nitrogen sorption porosimetry (specific surface areas of 340 and 350 m(2)g(-1), and specific pore volumes of 0.17 and 0.19 cm(3)g(-1) for the MIP and NIP, respectively). The polymers were evaluated further by batch rebinding experiments, and from the derived isotherms their binding capacity and binding strength were determined (number of binding sites (N(K))=0.6 and 0.3 mmol g(-1) for the MIP and NIP, respectively, and apparent average adsorption constant (K(N))=10.0 and 1.6L mmol(-1) for the MIP and NIP, respectively). To evaluate the molecular recognition character of the MIP it was packed into a stainless steel column (50 mm × 4.6 mm i.d.) and evaluated as an HPLC-stationary phase. The mobile phase composition, flow rate, and the elution profile were then optimised in order to improve the peak shape without negatively affecting the imprinting factor (IF). Very interesting, promising properties were revealed. The imprinting factor (IF) under the optimised conditions was 11.9. Finally, when the imprinted LC column was used for the selective recognition of CA over eight related compounds, very good selectivity was obtained. This outcome enabled the direct extraction of CA in commercial apple juice samples with recoveries in excess of 81% and, rather significantly, without any need for a clean-up step prior to the extraction., (Copyright © 2011 Elsevier B.V. All rights reserved.)

Published
2011
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47. Gas chromatography-atmospheric pressure chemical ionization-time of flight mass spectrometry for profiling of phenolic compounds in extra virgin olive oil.

Author

García-Villalba R, Pacchiarotta T, Carrasco-Pancorbo A, Segura-Carretero A, Fernández-Gutiérrez A, Deelder AM, and Mayboroda OA

Subjects
Chromatography, High Pressure Liquid, Flavonoids isolation & purification, Olive Oil, Phenols isolation & purification, Reproducibility of Results, Sensitivity and Specificity, Solid Phase Extraction, Tandem Mass Spectrometry, Flavonoids analysis, Gas Chromatography-Mass Spectrometry methods, Phenols analysis, Plant Oils chemistry
Abstract

A new analytical approach based on gas chromatography coupled to atmospheric pressure chemical ionization-time of flight mass spectrometry was evaluated for its applicability for the analysis of phenolic compounds from extra-virgin olive oil. Both chromatographic and MS parameters were optimized in order to improve the sensitivity and to maximize the number of phenolic compounds detected. We performed a complete analytical validation of the method with respect to its linearity, sensitivity, precision, accuracy and possible matrix effects. The LODs ranged from 0.13 to 1.05ppm for the different tested compounds depending on their properties. The RSDs for repeatability test did not exceed 6.07% and the accuracy ranged from 95.4% to 101.5%. To demonstrate the feasibility of our method for analysis of real samples, we analyzed the extracts of three different commercial extra-virgin olive oils. We have identified unequivocally a number of phenolic compounds and obtained quantitative information for 21 of them. In general, our results show that GC-APCI-TOF MS is a flexible platform which can be considered as an interesting tool for screening, structural assignment and quantitative determination of phenolic compounds from virgin olive oil., (Copyright © 2011 Elsevier B.V. All rights reserved.)

Published
2011
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48. Metabolite profiling and quantification of phenolic compounds in methanol extracts of tomato fruit.

Author

Gómez-Romero M, Segura-Carretero A, and Fernández-Gutiérrez A

Subjects
Fruit chemistry, Fruit metabolism, Solanum lycopersicum genetics, Solanum lycopersicum metabolism, Methanol, Molecular Structure, Phenols chemistry, Phenols metabolism, Plant Extracts chemistry, Spain, Spectrometry, Mass, Electrospray Ionization methods, Solanum lycopersicum chemistry, Phenols analysis
Abstract

The consumption of tomatoes and tomato products has been associated with a reduction in the risk of contracting some types of cancer and other chronic diseases. These beneficial properties may be attributed to the presence of key metabolites and the interactions among them. We have developed and validated an analytical method for the comprehensive profiling of semi-polar metabolites in the methanol extract of three cultivars of raw tomatoes (Daniela, Raf and Rambo) grown in Almería, in south-east Spain. Diode-array and time-of-flight/ion-trap mass spectrometry detectors were used to ensure the wide detection of metabolites with highly divergent properties. The masses thus detected were assigned by matching their accurate mass-signals with tomato compounds reported in the literature, and supplemented by UV and MS/MS information, reference compounds and existing metabolite databases. In this way we were able to identify tentatively 135 compounds belonging to various structural classes, 21 of which are to our knowledge reported for the first time in the tomato fruit. Among the metabolites identified, the most abundant were phenolic compounds. This class of secondary metabolites is attracting considerable attention from producers and consumers due to their antioxidant activity and nutritional properties. Their quantitative analysis was achieved by using closely related derivatives for each family., (Copyright © 2010 Elsevier Ltd. All rights reserved.)

Published
2010
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49. Multi-component analysis (sterols, tocopherols and triterpenic dialcohols) of the unsaponifiable fraction of vegetable oils by liquid chromatography-atmospheric pressure chemical ionization-ion trap mass spectrometry.

Author

Zarrouk W, Carrasco-Pancorbo A, Zarrouk M, Segura-Carretero A, and Fernández-Gutiérrez A

Subjects
Alcohols chemistry, Atmospheric Pressure, Chromatography, Gas, Chromatography, High Pressure Liquid, Chromatography, Liquid instrumentation, Helianthus chemistry, Olive Oil, Reproducibility of Results, Glycine max chemistry, Spectrometry, Mass, Electrospray Ionization instrumentation, Triterpenes chemistry, Zea mays chemistry, Alcohols analysis, Chromatography, Liquid methods, Phytosterols analysis, Plant Oils chemistry, Spectrometry, Mass, Electrospray Ionization methods, Tocopherols analysis
Abstract

A simple and sensitive method for the analysis of sterols, tocopherols and triterpenic dialcohols from the unsaponifiable fraction from oil samples in a single analytical run using liquid chromatography coupled to mass spectrometry was developed. With this method, the compounds could be detected directly after dissolving the unsaponifiable fraction in acetonitrile without necessity of time-consuming sample pre-treatment or derivatization. Separation of the analytes was carried out at room temperature, by using a C18 column (5 microm i.d. 3.0 mm x 250 mm) with a linear gradient of acetonitrile/water (0.01% acetic acid) at a flow rate of 1.5 mL/min. The full scan mass spectra of the investigated compounds were measured by an ion trap mass spectrometer equipped with an APCI ion source. The optimized methodology was suitable for the identification of 23 compounds belonging to different families present in olive oil and other kinds of oils, as well as for the quantification of 15 analytes (vs. their commercial standards).

Published
2009
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50. Chemometric-assisted MIP-optosensing system for the simultaneous determination of monoamine naphthalenes in drinking waters.

Author

Valero-Navarro A, Damiani PC, Fernández-Sánchez JF, Segura-Carretero A, and Fernández-Gutiérrez A

Subjects
Amines analysis, Calibration, Molecular Imprinting, Naphthalenes analysis, Spectrometry, Fluorescence methods, Water Supply analysis
Abstract

In the present work a chemometric-assisted molecularly imprinted polymer (MIP)-fluorescence optosensing system has been developed for determining monoamines naphthalene compounds in drinking waters. The use of chemometrics for processing flow injection analysis with MIP fluorescence optosensor data allowed the simultaneous determination of the principal monoamine naphthalene compounds 1-naphthylamine (1-NA) and 2-naphthylamine (2-NA) even in presence of potential interferent 1-naphthalenemethylamine (1-NMA). Classical chemometrics tools such as partial least-squares (PLS-1), as well as second-order algorithms like multiway PLS (N-PLS) and unfolded PLS (U-PLS), were successfully applied, assisting fluorescence emission spectra at a fixed excitation wavelength or excitation-emission fluorescence matrices (EEM), respectively, when interferents are considered in the calibration set. The combinations of both N-PLS and U-PLS with residual bilinearization (RBL), achieving the second-order advantage, were satisfactory applied for the simultaneous determination of the main monoamine naphthalene compounds in drinking water, in the presence of a potential interferent without sample pretreatment, even when the later is not modeled in calibration set. Predictive ability, accuracy, figures of merit, as well as advantages and disadvantages of the different strategies were discussed.

Published
2009
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