1. Impact of hematopoietic cell transplantation on myocardial fibrosis in young patients with sickle cell disease.
- Author
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Sharma A, Selukar S, Bi Y, Merlocco A, Morin CE, Goode C, Rai P, Towbin JA, Hankins JS, Gottschalk S, Triplett B, and Johnson JN
- Subjects
- Humans, Male, Female, Adolescent, Child, Young Adult, Cardiomyopathies etiology, Cardiomyopathies therapy, Cardiomyopathies pathology, Adult, Myocardium pathology, Magnetic Resonance Imaging, Child, Preschool, Anemia, Sickle Cell therapy, Anemia, Sickle Cell pathology, Anemia, Sickle Cell complications, Hematopoietic Stem Cell Transplantation, Fibrosis
- Abstract
Abstract: Serial cardiovascular magnetic resonance evaluation of children and young adults with SCD who underwent hematopoietic cell transplantation showed mean ECV, representing diffuse myocardial fibrosis, decreased 3.4% from baseline to 12 months posttransplantation. This trial was registered at www.clinicaltrials.gov as #NCT04362293., (© 2024 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.)
- Published
- 2024
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