1. Serum β2-microglobulin is frequently elevated in type 1 Gaucher patients
- Author
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Tiago Koppe, Filippo Vairo, Matheus Camargo, Livia Paskulin, Liane Daudt, and Ida V. Schwartz
- Subjects
Serum β2-microglobulin ,Gaucher disease ,Multiple myeloma ,Chitotriosidase ,Biomarkers ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
β2-Microglobulin is the major prognostic factor in multiple myeloma, a known comorbidity of Gaucher disease. We evaluated herein serum β2-microglobulin levels of 31 type 1 Gaucher patients; for 8/31 patients, pre- and post-treatment comparisons were made. Thirteen patients (on treatment = 6) had high levels of β2-microglobulin, and showed higher chitotriosidase activity and Severity Score Index, and lower concentration of platelets, than patients with normal levels. Levels of β2-microglobulin correlated with chitotriosidase activity (ρ = 0.65; p
- Published
- 2015
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