1. Novel tandem column method for the rapid isolation of radiostrontium from human urine.
- Author
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Hawkins CA, Shkrob IA, Mertz CJ, Dietz ML, and Kaminski MD
- Subjects
- Analytic Sample Preparation Methods, Body Burden, Environmental Exposure analysis, Humans, Ion Exchange Resins chemistry, Sodium isolation & purification, Sodium urine, Solid Phase Extraction methods, Chromatography, Ion Exchange methods, Strontium Radioisotopes isolation & purification, Strontium Radioisotopes urine, Urine chemistry
- Abstract
A method has been developed for the isolation of strontium from human urine for subsequent determination in sample volumes as low as 5-20 mL. This method involves the acidification of the sample using methanesulfonic acid and its decolorization using charcoal, treatment of the filtrate with Diphonix(®) resin, and subsequent concentration of strontium on Sr resin. Data from retention model simulations provided the initial conditions which were then optimized by actual column separations. Diphonix(®) resin was shown to be effective at removing alkali metal ions from the urine matrix under conditions that retain higher valence ions. The suggested processing method provides 99% recovery of Sr(2+), a concentration factor of 50, and an expected per sample processing time of less than 1 h., (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Published
- 2012
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