1. Association of bronchial disease on CT imaging and clinical definitions of chronic bronchitis in a single-center COPD phenotyping study.
- Author
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Fat M, Andersen T, Fazio JC, Park SC, Abtin F, Buhr RG, Phillips JE, Belperio J, Tashkin DP, Cooper CB, and Barjaktarevic I
- Subjects
- Humans, Male, Female, Aged, Cross-Sectional Studies, Prospective Studies, Middle Aged, Forced Expiratory Volume physiology, Surveys and Questionnaires, Bronchitis, Chronic diagnostic imaging, Bronchitis, Chronic physiopathology, Phenotype, Pulmonary Disease, Chronic Obstructive diagnostic imaging, Pulmonary Disease, Chronic Obstructive physiopathology, Tomography, X-Ray Computed methods, Spirometry
- Abstract
Introduction: Chronic Bronchitis (CB) represents a phenotype of chronic obstructive pulmonary disease (COPD). While several definitions have been used for diagnosis, the relationship between clinical definitions and radiologic assessment of bronchial disease (BD) has not been well studied. The aim of this study was to evaluate the relationship between three clinical definitions of CB and radiographic findings of BD in spirometry-defined COPD patients., Methods: A cross-sectional analysis was performed from a COPD phenotyping study. It was a prospective observational cohort. Participants had spirometry-defined COPD and available chest CT imaging. Comparison between CB definitions, Medical Research Council (CB
MRC ), St. George's Respiratory Questionnaire (CBSGRQ ), COPD Assessment Test (CBCAT ) and CT findings were performed using Cohen's Kappa, univariate and multivariate logistic regressions., Results: Of 112 participants, 83 met inclusion criteria. Demographics included age of 70.1 ± 7.0 years old, predominantly male (59.0 %), 45.8 ± 30.8 pack-year history, 21.7 % actively smoking, and mean FEV1 61.5 ± 21.1 %. With MRC, SGRQ and CAT definitions, 22.9 %, 36.6 % and 28.0 % had CB, respectively. BD was more often present in CB compared to non-CB patients; however, it did not have a statistically significant relationship between any of the CB definitions. CBSGRQ had better agreement with radiographically assessed BD compared to the other two definitions., Conclusion: Identification of BD on CT was associated with the diagnoses of CB. However, agreement between imaging and definitions were not significant, suggesting radiologic findings of BD and criteria defining CB may not identify the same COPD phenotype. Research to standardize imaging and clinical methods is needed for more objective identification of COPD phenotypes., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: DPT has consulted with AstraZeneca, Sunovion, Mylan and Theravance. RGB reports personal consulting fees from Theravance Biopharma/Mylan and GlaxoSmithKline. JEP is employed by AMGEN. CBC reports grants from NIH/NHLBI, NIH Foundation and the COPD Foundation, during the conduct of the study; he also reports personal fees from AstraZeneca, GlaxoSmithKline, Chiesi, NUVAIRA, MGC Diagnostics, Horizon Therapeutics, Respiree, Herbalife, Verona, RS BioTherapeutics, Genentec and Cambridge University Press, outside the submitted work. IZB has consulted with Astra Zeneca, Grifols, Verona Pharma, Takeda, Sanofi/Regeneron, Inhibrx and has received funding from Viatris, Theravance, AMGEN, Takeda and Aerogen. MF, TA, JCF, SCP, FA, and JB have no reportable disclosures., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)- Published
- 2024
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