1. Association between the occurrence of matrix metalloproteinases 2 and 9 in parotid saliva with the degree of parotid gland damage in juvenile recurrent parotitis.
- Author
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Morales-Bozo I, Landaeta M, Urzúa-Orellana B, and Retamales P
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Electrophoresis, Polyacrylamide Gel, Female, Humans, Logistic Models, Male, Matrix Metalloproteinase 2 analysis, Matrix Metalloproteinase 9 analysis, Odds Ratio, Parotid Gland diagnostic imaging, Parotitis diagnostic imaging, Parotitis pathology, Radiography, Recurrence, Saliva enzymology, Statistics, Nonparametric, Parotid Gland pathology, Parotitis enzymology
- Abstract
Objective: The study was aimed to investigate whether the occurrence of matrix metalloproteinases (MMP) 2 and 9 in parotid saliva of juvenile recurrent parotitis (JRP) patients is associated with the degree of glandular involvement., Study Design: Thirty-three JRP patients were included. Involvement of parotid gland was assessed by sialography. Parotid saliva was assayed for MMP-2 and MMP-9 by zymography. Medical charts were examined for number of recurrences, disease laterality, and time of follow-up. Logistic regression analysis between occurrence of either MMP, the clinical parameters, and sialographic staging was conducted., Results: None of the clinical parameters under analysis were found to be associated with degree of sialographic involvement. Statistical associations were found between presence of MMP-9 and MMP-2 in parotid saliva and sialographic stage (P = .017; odds ratio [OR] 6.5, 95% confidence interval [CI] 1.4-30.4; and P = .009; OR 6.1; 95% CI 1.6-23.7; respectively)., Conclusions: Occurrence frequency of MMP-2 and MMP-9 in parotid saliva from affected glands of JRP patients was associated with degree of gland damage.
- Published
- 2008
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