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The new three-dimensional (3D) high-definition (HD) exoscope enables surgeons to perform a precise surgical dissection of the parotid region with a real 3D magnification of the anatomical structures, with low risk for iatrogenic lesions of the facial nerve, without delay in the surgical time. The 3D-HD exoscope is a light instrument, smaller than the operative microscope, that can be easily integrated into the surgical theater. Furthermore, it shows high potential for training and educational purposes as the surgical staff can easily follow the procedure on 3D monitors and better perceive the surgeon's fine gestures. The 3D-HD exoscope is a valid alternative to the surgical loupes and the operative microscope in the parotid surgery.