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[Aims]: The relationship between iron status, obesity and type 2 diabetes mellitus (T2DM) has scarcely been tested. This study hypothesizes that patients with obesity and T2DM have altered iron metabolism., [Methods]: 537 T2DM patients were selected from the cross-sectional DICARIVA study excluding patients with high-sensitivity-C-reactive-protein (hs-CRP) ≥ 10 mg/L. Three groups according to body mass index (BMI) and waist perimeter (WP) were analysed: a) BMI < 30 kg/m2, non-high WP (n = 105); b) BMI < 30 kg/m2, high WP (n = 202); and c) diabesity, BMI ≥ 30 kg/m2, high WP (n = 230). Group differences on cardiometabolic and iron status markers were tested., [Results]: Women had significantly lower iron, ferritin, and transferrin saturation (TSAT) but higher transferrin and total iron binding capacity than men. Triglycerides/HDL-c ratio, as insulin-resistance (IR) marker, was higher in men while hs-CRP in women. TSAT was inversely related to BMI and hs-CRP. The diabesity group showed the highest hs-CRP (p < 0.001) and IR (p < 0.001) with the lowest TSAT (p = 0.003)., [Conclusions]: Low TSAT was highly prevalent in diabesity, mainly in women, suggesting that IR, inflammation, and abdominal adiposity alter iron transport and accumulation. The convenience of iron supplementation in diabesity patients with low TSAT should be urgently assessed, due the pro-oxidant effects of excess iron.

[Background & aim]: A diet quality index (DQI) is a tool that provides an overall score of an individual's dietary intake when assessing compliance with food-based dietary guidelines. A number of DQIs have emerged, albeit their associations with health-related outcomes are debated. The aim of the present study was to assess whether adherence to dietary intervention, and the overall quality of the diet, can predict body composition changes., [Methods]: To this purpose, overweight/obese adolescents (n = 117, aged: 13–16 years; 51 males, 66 females) were recruited into a multi-component (diet, physical activity and psychological support) family-based group treatment programme. We measured the adolescents' compliance and body composition at baseline and after 2 months (intensive phase) and 13 months (extensive phase) of follow-up. Also, at baseline, after 6 months, and at the end of follow-up we calculated the DQI., [Results]: Global compliance with the dietary intervention was 37.4% during the intensive phase, and 14.3% during the extensive phase. Physical activity compliance was 94.1% at 2-months and 34.7% at 13months and psychological support compliance were growing over the intervention period (10.3% intensive phase and 45.3% during extensive phase). Adolescents complying with the meal frequency criteria at the end of the extensive phase had greater reductions in FMI z-scores than those did not complying (Cohen's d = 0.53). A statistically significant association was observed with the diet quality index. DQI-A variation explained 98.1% of BMI z-score changes and 95.1% of FMI changes., [Conclusions]: We conclude that assessment of changes in diet quality could be a useful tool in predicting body composition changes in obese adolescents involved in a diet and physical activity intervention programme backed-up by psychological and family support.

Iron deficiency anaemia is a Worldwide Public Health problem and the fortification of food with iron is the most cost-effective prevention strategy. The correct combination of iron form and food vehicle is crucial, as well as the dietary context of consumption. Combinations of iron with an enhancer of its bioavailability and avoidance of interaction with iron inhibitors are recommended. New iron fortificants, innovative complexes, coatings and nanoparticulates, and biofortification are the main research lines. Ultimately, human assays are necessary before industrial production. In this regard, precision nutrition helps to identify the vulnerable groups that, according to genotype, dietary habits, physical activity and, most recently, metagenomic profile, may benefit from a specific iron-fortified food. This review addresses the modifiers of iron bioavailability and the main aspects to take into account in the development of iron-fortified food to prevent iron deficiency.

Effects of drinking a sodium bicarbonated mineral water on cardiovascular risk in young men and women with moderate cardiovascular risk were studied. Eighteen young volunteers, total cholesterol levels >5.2 mmol/L without any disease participated. The study consisted in two 8-week intervention periods. Subjects consumed, as a supplement of their usual diet, 1 L/d of a control low mineral water followed by 1 L/d of the bicarbonated mineral water (mmol/L: sodium, 48; bicarbonate, 35; and chloride, 17). Determinations were performed at the end of the control water period and weeks 4 and 8 of the bicarbonated water period. Body weight, BMI, blood pressure, dietary intake, total-cholesterol, LDL-cholesterol, HDL-cholesterol, Apo A-I, Apo B, triacylgycerols, glucose, insulin, adiponectin, high sensitivity-C reactive protein (hs-CRP), soluble adhesion molecules (sICAM and sVCAM), sodium and chloride urinary excretion, and urine pH were measured. Dietary intake, body weight and BMI showed no significant variations. Systolic blood pressure decreased significantly after 4 weeks of bicarbonated water consumption without significant differences between the weeks 4 and 8. Significant reductions were observed after bicarbonated water consumption of total cholesterol (by 6.3%, p=0.012), LDL-cholesterol (by 10% p=0.001), total/HDL-cholesterol (p=0.004), LDL/HDL-cholesterol (p=0.001), and Apo B (p=0.017). Serum triacylglycerols, Apo A-I, sICAM-1, sVCAM-1 and hs-CRP levels did not change. Serum glucose values tended to decrease during the bicarbonated water intervention (p=0.056) but insulin levels did not vary. This sodium bicarbonated mineral water improves lipid profile in moderately hypercholesterolemic young men and women and could therefore be applied in dietary interventions to reduce cardiovascular risk.

Objective The Maillard reaction and lactose isomerization may be induced during the manufacture of infant formulas. We studied the effects of dehydration and sterilization on iron bioavailability from an infant formula in suckling and weanling rats. Methods In experiment 1, a previously reconstituted powdered infant formula and an in-bottle-sterilized liquid infant formula from the same manufacturer were fed from drinking bottles to 2-wk-old suckling rat pups for 7 d. In experiment 2, the same formulas were complemented with AIN-76 and fed to weanling rats for 7 d after a 4-d adaptation period. In both experiments, intake, body weight, and fecal and urinary excretions were monitored, and the following iron indexes were calculated: apparent absorption and retention and the coefficients percentage of absorption versus intake, percentage of retention versus absorption, and percentage of retention versus intake. Results The liquid infant formula resulted in lower body weights on day 4, particularly among the younger rats that had significantly lower food intakes (P = 0.045). In weanling rats fed powdered and liquid infant formulas, food intake and body weight were not significantly different. The pups showed significantly higher absorption (percentage of absorption versus intake) and retention (percentages of retention versus absorption and retention versus intake) efficiencies than did the weanling rats (P < 0.001 for the three indexes). Hemoglobin values (P = 0.001) and liver iron concentrations (P = 0.009) were significantly higher in the weanling rats than in the pups. In contrast, erythrocyte iron concentrations and hematocrit were higher in the pups (P = 0.016 and 0.053, respectively). Conclusions In rat pups, iron bioavailability is negatively affected by the consumption of in-bottle-sterilized infant formula, possibly as the result of the content of Maillard reaction products, altered proteins, and lactulose. However, when this formula is included in a mixed die

To screen some cardiovascular risk factors in institutionalized elderly persons of the Spanish Northwest who consume the Atlantic variant of the Mediterranean diet, rich in vegetables, fruit, meat, fish, olive oil and dairy products, anthropometric and dietary measurements were carried out and serum glucose and lipoprotein values were determined in 94 subjects. Men consumed significantly more legumes, fruit, meat, alcohol and precooked foods but fewer vegetables than women. Significant positive correlations were found between total fat and MUFA consumption and HDL-cholesterol. Fish intake correlated negatively with total cholesterol (TC) and LDL-cholesterol. The prevalence of high TC, LDL-cholesterol, triglyceride and TC/HDL-cholesterol levels was 29%, 37%, 21%, 25% respectively, and that of low HDL-cholesterol was 15%. Women displayed a higher prevalence of dyslipemia, with significantly higher TC and higher LDL-cholesterol levels than men. Fifty percent of the women aged 75-80 presented concurrent hyperglycemia, excess weight and hypertriglyceridemia, predisposing them to the metabolic syndrome. Nonetheless, as regards the lipoprotein profile, the Atlantic diet appears appropriate for most institutionalized elderly persons. © 2003 Elsevier Inc. All rights reserved.

Processing of infant formulas can induce Maillard reaction or lactose isomerization, among other changes. These reactions were evaluated with furosine and lactulose, respectively. Protein alteration was assessed with sodium dodecylsulfate-polyacrylamide gel electrophoresis. Repercussions on calcium bioavailability in powder and in-bottle-sterilized liquid infant formulas were studied. Lactulose, advanced Maillard-reaction products, and denatured proteins were higher in liquid infant formula. After in vitro digestion, soluble non-dialyzed calcium was significantly higher in liquid than in powder infant formula, but there were no differences in dialyzed insoluble calcium. Two-week-old rat pups drank the powder or liquid infant formula for 7 d. Food intake and final body weight were significantly lower in those fed liquid formula. Accordingly, the intake, apparent absorption, and retention of calcium were measured; the percentages of retention versus absorption and retention versus intake were significantly lower, although calcium digestibility (percentage of absorption versus intake) was higher. These results show that, although calcium in the sterilized infant formula was available in vitro and was absorbed more efficiently in vivo, it was poorly used by suckling rats. The low acceptability of this formula and the interaction of calcium with lactulose and advanced but absorbable Maillard-reaction products might explain the results. Thus, for calcium bioavailability, we recommend the powder instead of the conventional sterilized infant formula. Copyright © 2001 Elsevier Science Inc.

This study examined the effects of an infant formula supplemented with long-chain polyunsaturated fatty acids (LCPUFA) on iron metabolism in rats. Three isocaloric diets were given to weaning rats during 28 days (150 g/kg fat): control diet (C), unsupplemented (F) and supplemented (FS) infant formula (as the only fat source) diets. Food intake and body weight evolution showed no significant differences between F and FS, but in both groups resulted lower compared to C. LCPUFA supplementation did not affect apparent iron absorption and retention nor the absorption and retention efficiencies, haemoglobin, serum iron, total iron binding capacity, haematocrit, liver and spleen iron. However, erythrocytic iron showed significant differences: FS>F>C. The results indicate that consumption of a diet containing an infant formula supplemented with LCPUFA does not affect iron metabolism in growing rats. Further studies based on the relationship between iron and lipid composition of erythrocytic membranes are required. © 2001 Elsevier Science Ltd.

An oil implicated in the Spanish 'toxic syndrome' was studied for its effect on fat digestibility and adipose-tissue composition in rats. The effects produced by the mixture of oils and those induced by the presence of oleoanilides were assessed separately. For 4 wk, Wistar rats were fed diets containing either a mixture of oils similar to that constituting the toxic oil, the same mixture of oils supplemented with oleanilides, or the toxic oil (which also contained oleoanilides) and were then compared with a group fed olive oil. Food consumption fluctuated sharply in the group fed the toxic oil, falling significantly in the last week of the study. The digestibility coefficient of the various fats was similar, although the rats fed the toxic oil did absorb less fat because of the lower intake. The nitrogen content of the periovarian adipose tissue was highest in the rats fed the toxic oil, and the adipose-tissue fatty acids most affected by this treatment were linoleic and linolenic acid. The Δ-9 desaturase activity, measured in terms of the C16:1/C16:0 and C18:1/C18:0 ratios, was significantly less in the group fed the toxic oil, which suggests functional modifications of the adipocyte related to lipogenesis.